快速眼动精炼和拯救记忆表征:一个新理论。

Alessandra E Shuster, Allison Morehouse, Elizabeth A McDevitt, Pin-Chun Chen, Lauren N Whitehurst, Jing Zhang, Negin Sattari, Tracy Uzoigwe, Ali Ekhlasi, Denise Cai, Katherine Simon, Niels Niethard, Sara C Mednick
{"title":"快速眼动精炼和拯救记忆表征:一个新理论。","authors":"Alessandra E Shuster, Allison Morehouse, Elizabeth A McDevitt, Pin-Chun Chen, Lauren N Whitehurst, Jing Zhang, Negin Sattari, Tracy Uzoigwe, Ali Ekhlasi, Denise Cai, Katherine Simon, Niels Niethard, Sara C Mednick","doi":"10.1093/sleepadvances/zpaf004","DOIUrl":null,"url":null,"abstract":"<p><p>Despite extensive evidence on the roles of nonrapid eye movement (NREM) and REM sleep in memory processing, a comprehensive model that integrates their complementary functions remains elusive due to a lack of mechanistic understanding of REM's role in offline memory processing. We present the REM Refining and Rescuing (RnR) Hypothesis, which posits that the principal function of REM sleep is to increase the signal-to-noise ratio within and across memory representations. As such, REM sleep selectively enhances essential nodes within a memory representation while inhibiting the majority (<i>Refine</i>). Additionally, REM sleep modulates weak and strong memory representations so they fall within a similar range of recallability (<i>Rescue</i>). Across multiple NREM-REM cycles, tuning functions of individual memory traces get sharpened, allowing for integration of shared features across representations. We hypothesize that REM sleep's unique cellular, neuromodulatory, and electrophysiological milieu, marked by greater inhibition and a mixed autonomic state of both sympathetic and parasympathetic activity, underpins these processes. The RnR Hypothesis offers a unified framework that explains diverse behavioral and neural outcomes associated with REM sleep, paving the way for future research and a more comprehensive model of sleep-dependent cognitive functions.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf004"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954447/pdf/","citationCount":"0","resultStr":"{\"title\":\"REM refines and rescues memory representations: a new theory.\",\"authors\":\"Alessandra E Shuster, Allison Morehouse, Elizabeth A McDevitt, Pin-Chun Chen, Lauren N Whitehurst, Jing Zhang, Negin Sattari, Tracy Uzoigwe, Ali Ekhlasi, Denise Cai, Katherine Simon, Niels Niethard, Sara C Mednick\",\"doi\":\"10.1093/sleepadvances/zpaf004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Despite extensive evidence on the roles of nonrapid eye movement (NREM) and REM sleep in memory processing, a comprehensive model that integrates their complementary functions remains elusive due to a lack of mechanistic understanding of REM's role in offline memory processing. We present the REM Refining and Rescuing (RnR) Hypothesis, which posits that the principal function of REM sleep is to increase the signal-to-noise ratio within and across memory representations. As such, REM sleep selectively enhances essential nodes within a memory representation while inhibiting the majority (<i>Refine</i>). Additionally, REM sleep modulates weak and strong memory representations so they fall within a similar range of recallability (<i>Rescue</i>). Across multiple NREM-REM cycles, tuning functions of individual memory traces get sharpened, allowing for integration of shared features across representations. We hypothesize that REM sleep's unique cellular, neuromodulatory, and electrophysiological milieu, marked by greater inhibition and a mixed autonomic state of both sympathetic and parasympathetic activity, underpins these processes. The RnR Hypothesis offers a unified framework that explains diverse behavioral and neural outcomes associated with REM sleep, paving the way for future research and a more comprehensive model of sleep-dependent cognitive functions.</p>\",\"PeriodicalId\":74808,\"journal\":{\"name\":\"Sleep advances : a journal of the Sleep Research Society\",\"volume\":\"6 1\",\"pages\":\"zpaf004\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954447/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep advances : a journal of the Sleep Research Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/sleepadvances/zpaf004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep advances : a journal of the Sleep Research Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/sleepadvances/zpaf004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

尽管有大量证据表明非快速眼动(NREM)和快速眼动(REM)睡眠在记忆加工中的作用,但由于缺乏对快速眼动(REM)在离线记忆加工中的作用的机制理解,整合它们互补功能的综合模型仍然难以实现。我们提出了快速眼动精炼和挽救(RnR)假说,该假说认为快速眼动睡眠的主要功能是增加记忆表征内部和之间的信噪比。因此,快速眼动睡眠选择性地增强了记忆表征中的基本节点,同时抑制了大多数节点(Refine)。此外,快速眼动睡眠调节弱记忆和强记忆表征,使它们处于相似的可回忆性范围内。在多个NREM-REM周期中,单个记忆轨迹的调优功能得到强化,从而允许跨表示集成共享特征。我们假设,快速眼动睡眠独特的细胞、神经调节和电生理环境,以更大的抑制和交感神经和副交感神经活动的混合自主状态为特征,支撑了这些过程。RnR假说提供了一个统一的框架,解释了与快速眼动睡眠相关的各种行为和神经结果,为未来的研究和更全面的睡眠依赖认知功能模型铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
REM refines and rescues memory representations: a new theory.

Despite extensive evidence on the roles of nonrapid eye movement (NREM) and REM sleep in memory processing, a comprehensive model that integrates their complementary functions remains elusive due to a lack of mechanistic understanding of REM's role in offline memory processing. We present the REM Refining and Rescuing (RnR) Hypothesis, which posits that the principal function of REM sleep is to increase the signal-to-noise ratio within and across memory representations. As such, REM sleep selectively enhances essential nodes within a memory representation while inhibiting the majority (Refine). Additionally, REM sleep modulates weak and strong memory representations so they fall within a similar range of recallability (Rescue). Across multiple NREM-REM cycles, tuning functions of individual memory traces get sharpened, allowing for integration of shared features across representations. We hypothesize that REM sleep's unique cellular, neuromodulatory, and electrophysiological milieu, marked by greater inhibition and a mixed autonomic state of both sympathetic and parasympathetic activity, underpins these processes. The RnR Hypothesis offers a unified framework that explains diverse behavioral and neural outcomes associated with REM sleep, paving the way for future research and a more comprehensive model of sleep-dependent cognitive functions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.10
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信