Sensors & diagnostics最新文献_第7页

Aptamer-functionalized nanopipettes: a promising approach for viral fragment detection via ion current rectification† 色素功能化纳米移液管：通过离子电流整流检测病毒片段的有效方法

Sensors & diagnostics Pub Date : 2024-05-10 DOI: 10.1039/D4SD00097H

Shekemi Denuga, Dominik Duleba, Pallavi Dutta, Guerrino Macori, Damion K. Corrigan, Séamus Fanning and Robert P. Johnson

引用次数: 0

Application of breathomics in pediatric asthma: a review 呼吸组学在小儿哮喘中的应用：综述

Sensors & diagnostics Pub Date : 2024-05-09 DOI: 10.1039/D3SD00286A

Lei Chi, Xiaoli Wang, Yuxia Shan, Chonghui Zhu, Ling Leng, Rong Chen, Qing Xie, Zhenze Cui and Minghui Yang

{"title":"Application of breathomics in pediatric asthma: a review","authors":"Lei Chi, Xiaoli Wang, Yuxia Shan, Chonghui Zhu, Ling Leng, Rong Chen, Qing Xie, Zhenze Cui and Minghui Yang","doi":"10.1039/D3SD00286A","DOIUrl":"10.1039/D3SD00286A","url":null,"abstract":"Breathomics involves the use of non-invasive methods for diagnosing asthma by analyzing exhaled breath. While significant progress has been made in applying this approach to adult asthma, extending its application to pediatric asthma is crucial due to the increasing concern in this population. This review delineates five potential clinical applications: asthma diagnosis, differential diagnosis of asthma, assessment of asthma control levels, prediction of asthma exacerbation, and asthma phenotyping. Additionally, it highlights the moderate to reasonable predictive accuracy of exhaled breath volatile organic compounds (VOCs) breathomics in childhood asthma. However, it acknowledges that this field is still in its nascent stage of development, with particularly limited data available for Asian populations. Moreover, the identification of VOC biomarkers in pediatric asthma patients remains inconclusive, with varying reports. Therefore, large-scale data collection and standardization are imperative. Refinement and methodological improvements are necessary before integrating breathomics into clinical practice. This article provides clear directions for future research to optimize the clinical applicability of breathomics in evaluating asthma in children.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d3sd00286a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140931257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in electrochemical sensors for real-time glucose monitoring 用于实时葡萄糖监测的电化学传感器的进展

Sensors & diagnostics Pub Date : 2024-05-08 DOI: 10.1039/D4SD00086B

Md. Harun-Or-Rashid, Most. Nazmin Aktar, Veronica Preda and Noushin Nasiri

{"title":"Advances in electrochemical sensors for real-time glucose monitoring","authors":"Md. Harun-Or-Rashid, Most. Nazmin Aktar, Veronica Preda and Noushin Nasiri","doi":"10.1039/D4SD00086B","DOIUrl":"10.1039/D4SD00086B","url":null,"abstract":"Technological advancements are revolutionizing diabetic care worldwide, particularly in the realm of glucose monitoring. Traditionally invasive and cumbersome, glucose monitoring is shifting towards less invasive methods, enhancing patient quality of life and reducing risks associated with hypo- and hyperglycemia. Wearable biosensors, focusing on sweat and interstitial fluid, offer novel avenues for early disease detection and personalized point-of-care testing. This review paper provides a comprehensive overview of recent strides in wearable sweat sensors, including historical perspectives, electrochemical sensing mechanisms, material advancements, and the role of nanomaterials in enhancing sensor performance. By examining the evolution of glucose monitoring devices and highlighting commercially available devices, the review underscores the wide-ranging utility of electrochemical sensors in glucose monitoring. Enzymatic and non-enzymatic sensing mechanisms, potentiometric, amperometric/voltammetric sensors, ion-selective electrodes, and biosensors are discussed in detail, alongside various materials employed to optimize sensor performance. The burgeoning interest in nanomaterial-enabled sensor platforms signifies a promising future for sweat-based glucose monitoring, with potential implications for personalized healthcare and disease management.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00086b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140931302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contactless vital sign monitoring systems: a comprehensive survey of remote health sensing for heart rate and respiration in internet of things and sleep applications 非接触式生命体征监测系统：全面调查

IF 3.5

Sensors & diagnostics Pub Date : 2024-05-08 DOI: 10.1039/D4SD00073K

Muhammad Salman Raheel, Faisel Tubbal, Raad Raad, Philip Ogunbona, James Coyte, Christopher Patterson, Dana Perlman, Saeid Iranmanesh, Nidhal Odeh and Javad Foroughi

{"title":"Contactless vital sign monitoring systems: a comprehensive survey of remote health sensing for heart rate and respiration in internet of things and sleep applications","authors":"Muhammad Salman Raheel, Faisel Tubbal, Raad Raad, Philip Ogunbona, James Coyte, Christopher Patterson, Dana Perlman, Saeid Iranmanesh, Nidhal Odeh and Javad Foroughi","doi":"10.1039/D4SD00073K","DOIUrl":"10.1039/D4SD00073K","url":null,"abstract":"With the coronavirus pandemic, companies and governments around the world have been investing millions of dollars in the development of contactless sensor technologies that minimize the need for physical interactions between patients and healthcare providers. This has led to rapid progress in healthcare research on innovative contactless technologies, particularly for infants and elderly individuals with chronic diseases that require continuous, real-time monitoring and control. The combination of sensing technology and wireless communication has emerged as a promising research area, as patients often find it unpleasant or anxiety-provoking to wear sensor devices, and physical contact can exacerbate the spread of contagious diseases. To address these issues, research has focused on sensor-less or contactless technology to send and analyse wireless signals to remotely monitor and measure vital signs without requiring physical contact or sensor devices. Herein, we have provided a comprehensive survey and study of non-invasive/contactless vital sign monitoring systems, particularly the heart rate and the respiration rate monitoring systems to achieve accurate and reliable measurements. We have found that there is a lack of a comprehensive comparison and analysis over existing contactless vital sign monitoring systems. Therefore, we first present and classify the existing non-invasive monitoring designs based on their approaches and techniques, and then compare them based on the performance and accuracy.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00073k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140931263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical immunomagnetic assay for interleukin-6 detection in human plasma 用于检测人体血浆中白细胞介素-6 的电化学免疫磁分析法

Sensors & diagnostics Pub Date : 2024-05-08 DOI: 10.1039/D4SD00058G

Grace Buckey, Olivia E. Owens, Hannah A. Richards and David E. Cliffel

引用次数: 0

Recent developments in pyrene-based fluorescence recognition and imaging of Ag+ and Pb2+ ions: Synthesis, applications and challenges 基于芘的 Ag+ 和 Pb2+ 离子荧光识别和成像的最新进展：合成、应用与挑战

Sensors & diagnostics Pub Date : 2024-05-07 DOI: 10.1039/D3SD00289F

Suvendu Paul, Prasenjit Barman, Nilanjan Dey and Michael Watkinson

{"title":"Recent developments in pyrene-based fluorescence recognition and imaging of Ag+ and Pb2+ ions: Synthesis, applications and challenges","authors":"Suvendu Paul, Prasenjit Barman, Nilanjan Dey and Michael Watkinson","doi":"10.1039/D3SD00289F","DOIUrl":"10.1039/D3SD00289F","url":null,"abstract":"Contamination of heavy metals in the environment is a burning and contemporary issue of modern life. Whilst lead contamination is historic, the ongoing extensive use of lead in batteries is likely to continue to cause serious environmental problems. Silver ions also present multiple environmental issues, such as bioaccumulation and toxicity. As a result, these two heavy metal ions have a high impact from an environmental and industrial point of view. Thus, the colorimetric and fluorescence detection of these two metal ions has been the subject of intense research during the last decade and pyrene-based fluorophores have played a crucial role in their detection. This review article summarizes the recent chronological progress on pyrene moiety integrated small molecule chemosensors for the colorimetric and fluorescent detection of silver and lead ions. Herein, the different strategies that have been utilized for the recognition of lead and silver ions are discussed. Throughout, the juxtaposition of structural aspects of the chemosensors and their sensitivity has been scrutinized together with an overview and future vision.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d3sd00289f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140931262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxypyridinone based chelators: a molecular tool for fluorescence sensing and sensitization 基于羟基吡啶酮的螯合剂：荧光传感和敏化的分子工具

Sensors & diagnostics Pub Date : 2024-05-06 DOI: 10.1039/D3SD00346A

Shalini Singh, Neha Kumari, B. K. Kanungo and Minati Baral

{"title":"Hydroxypyridinone based chelators: a molecular tool for fluorescence sensing and sensitization","authors":"Shalini Singh, Neha Kumari, B. K. Kanungo and Minati Baral","doi":"10.1039/D3SD00346A","DOIUrl":"10.1039/D3SD00346A","url":null,"abstract":"Among the currently developed analytical tools, sensors based on fluorescence detection have received immense recognition owing to their high sensitivity, low cost, fast response, and simplicity. The design and synthesis of fluorescence chemosensors to sense metals that are of environmental and biological relevance are of appreciable interest. The efficacy of fluorescent sensors relies on two crucial features: a metal binding unit and a fluorophore that can absorb and emit light. The electronic structure of the sensor is altered upon complexation, leading to a change in light emission or absorption intensity and wavelength. Hydroxypyridinones, a class of N-heterocyclic metal chelators, are appreciated as magnificent chemical tools in metal chelation with a higher affinity towards hard metals, displaying various medical, biological, and industrial applications. However, such compounds are scarcely used as sensors. This article outlines the recent invention of fluorescence chemosensors related to hydroxypyridinone based chelators for the selective sensing of analytes of biological and environmental importance. This discussion involves the structural parameters, coordination mode, and other approaches that helped develop highly selective fluorescence sensors for the ions. In addition, the luminescence properties of the hydroxypyridinones in the energy transfer process of lanthanide chelates as sensitizers are determined.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d3sd00346a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An imidazo[1,2-a]pyridine-functionalized xanthene fluorescent probe for naked-eye detection of Hg2+ and its application in cell imaging and test strips† 用于裸眼检测 Hg2+ 的咪唑并[1,2-a]吡啶功能化氧杂蒽荧光探针及其在细胞成像和试纸中的应用

Sensors & diagnostics Pub Date : 2024-05-05 DOI: 10.1039/D4SD00090K

Xu-Hong Han, Piao Zhao, Meng-Ke Tang, Lei Yang, Qing Wang and Shu-Sheng Zhang

{"title":"An imidazo[1,2-a]pyridine-functionalized xanthene fluorescent probe for naked-eye detection of Hg2+ and its application in cell imaging and test strips†","authors":"Xu-Hong Han, Piao Zhao, Meng-Ke Tang, Lei Yang, Qing Wang and Shu-Sheng Zhang","doi":"10.1039/D4SD00090K","DOIUrl":"10.1039/D4SD00090K","url":null,"abstract":"An imidazo[1,2-a]pyridine-functionalized xanthene dye (Rh-Ip) was designed and developed as a fluorescent probe (Rh-Ip-Hy) for Hg2+ by introducing spirolactam to the molecule. The probe Rh-Ip-Hy with a ring-closed spirolactam structure reacts with Hg2+ to form a fluorescent ring-opened spirolactone structure. Due to its asymmetric structure and the presence of a Lewis base site, the probe exhibits a larger Stokes shift and higher pH tolerance than the traditional xanthene dyes and probes. Furthermore, the probe is highly selective to Hg2+ within a wide pH range of 5.0–11.0. The probe Rh-Ip-Hy also exhibits low cytotoxicity and can be used for the detection of Hg2+ in living HeLa cells through fluorescence imaging. Finally, a paper-based test strip was prepared and successfully applied for the detection of Hg2+ in tap water and lake water samples.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00090k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active loading of cyanine 5.5 derivatives into liposomes for deep self-quenching and their applications in deep tissue imaging† 具有深度自淬灭特性的活性负载脂质体蓝 5.5 衍生物及其在深部组织成像中的应用

Sensors & diagnostics Pub Date : 2024-05-03 DOI: 10.1039/D3SD00325F

Chong-Yan Chen, Cheng-Bang Jian, Hua-De Gao, Xu-En Yu, Yuan-Chih Chang, Shwee Khuan Leong, Jiun-Jie Shie and Hsien-Ming Lee

{"title":"Active loading of cyanine 5.5 derivatives into liposomes for deep self-quenching and their applications in deep tissue imaging†","authors":"Chong-Yan Chen, Cheng-Bang Jian, Hua-De Gao, Xu-En Yu, Yuan-Chih Chang, Shwee Khuan Leong, Jiun-Jie Shie and Hsien-Ming Lee","doi":"10.1039/D3SD00325F","DOIUrl":"10.1039/D3SD00325F","url":null,"abstract":"Visualizing liposome release profiles in small animals is important for evaluating the pharmacokinetic influence of vesicles. Encapsulating near-infrared (NIR) fluorescent dyes to visualize and report liposomal cargo release in vivo, which necessitates high encapsulation with deep self-quenching, is highly desirable in advanced (such as targeting or trigger-release) liposome development. However, passive loading of NIR dyes usually yields low encapsulation efficiencies (1–5%), causing significant wastage and cost-ineffectiveness while using expensive NIR fluorescent dyes. It would be highly beneficial if an active loading method, which typically has an encapsulation efficiency of nearly 100%, is developed. This research describes an active loading approach for two cyanine 5.5 (Cy5.5) derivatives. We discovered that using ammonium sucrose octasulfate (ASO) as a trapping agent allows for nearly 100% encapsulation for both Cy5.5 dyes, accompanied by the formation of nanoprecipitates inside the liposome, as evidenced by cryogenic electron microscopy. Fluorescence spectroscopy confirmed deep fluorescence self-quenching after active loading and a 60–100-fold fluorescence enhancement upon full content release via liposome rupture. Cellular uptake experiments showed that the fluorescence of Cy5.5-loaded liposomes recovered and plateaued after 9 hours of incubation with cells. In vivo fluorescence imaging (IVIS) demonstrated the same fluorescence activation in tumor-bearing mice intratumorally injected with the liposome. We believe that the developed active loading method will enable Cy5.5-loaded liposomes to be a deep tissue-compatible and cost-effective NIR fluorescence release-reporting platform.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d3sd00325f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplexed aptasensor for detection of acute myocardial infraction (AMI) biomarkers† 用于检测急性心肌梗死 (AMI) 生物标记物的多重 Aptasensor

Sensors & diagnostics Pub Date : 2024-04-27 DOI: 10.1039/D4SD00010B

Duygu Beduk, Tutku Beduk, Abdellatif Ait Lahcen, Veerappan Mani, Emine Guler Celik, Gamze Iskenderoglu, Ferhat Demirci, Soysal Turhan, Oner Ozdogan, Su Ozgur, Tuncay Goksel, Kutsal Turhan, Khaled Nabil Salama and Suna Timur

{"title":"Multiplexed aptasensor for detection of acute myocardial infraction (AMI) biomarkers†","authors":"Duygu Beduk, Tutku Beduk, Abdellatif Ait Lahcen, Veerappan Mani, Emine Guler Celik, Gamze Iskenderoglu, Ferhat Demirci, Soysal Turhan, Oner Ozdogan, Su Ozgur, Tuncay Goksel, Kutsal Turhan, Khaled Nabil Salama and Suna Timur","doi":"10.1039/D4SD00010B","DOIUrl":"10.1039/D4SD00010B","url":null,"abstract":"Acute myocardial infarction (AMI) is a leading global cause of death. Diagnosis is challenging as cardiac biomarkers are only detectable for a few hours after AMI onset, and current methods are time-consuming and lack selectivity. Therefore, multiple immunological test systems have great importance for rapid and accurate diagnosis. In this context, we developed a rapid immunodiagnostic sensor platform for simultaneous electrochemical detection of cardiac troponin T (cTnT), troponin I (cTnI), and C-reactive protein (CRP) using nanostructured gold-modified laser-scribed graphene (LSG). Aptamer sensors were integrated into the LSG platform for selective AMI biomarkers sensing. Clinical validation was performed on biomarkers from blood samples of 51 AMI patients and 9 healthy controls. Limits of detection were 1.65 ng mL−1 cTnT, 2.58 ng mL−1 cTnI, and 1.84 ng mL−1 CRP. The analytical results determined by the developed platform were compared with the routine standard values of the same patients to prove the accuracy of aptasensors. Sensor results agreed well with standard laboratory assays, highlighting the accuracy of the test platform. The cTnT, cTnI and CRP multiplexed sensor platform demonstrates excellent performance for rapid and sensitive AMI screening.","PeriodicalId":74786,"journal":{"name":"Sensors & diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/sd/d4sd00010b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0