Agarose-gel coating for improving the polydopamine-based pH sensor stability in continuous pH measurements†

IF 4.1 Q2 CHEMISTRY, ANALYTICAL
Natalie Fudge, Fatemeh Keyvani, Joshua Khatri and Mahla Poudineh
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引用次数: 0

Abstract

Continuous monitoring in healthcare could transform patient care by improving patient outcomes and reducing costs through rapid detection and timely intervention. The pH of body fluids is an essential indicator for detecting acid/base imbalances and subsequent diseases, as well as monitoring organ functions. However, current pH sensors experience signal drifts over continuous measurements, inhibiting their ability to provide longitudinal body's pH status. To enable real-time, continuous pH monitoring, we developed a polydopamine (PDA)-based pH sensor and validated its performance in PBS and simulated wound fluid exudate (WFE). To increase signal stability for continuous performance, heat treatment and agarose gel coating were applied to the sensor, and we observed that the agarose coating greatly improved the signal drift.

Abstract Image

琼脂糖凝胶涂层用于提高聚多巴胺型pH传感器在连续pH测量中的稳定性
医疗保健中的持续监测可以通过快速检测和及时干预来改善患者的治疗效果并降低成本,从而改变患者护理。体液的pH值是检测酸碱失衡和随后的疾病以及监测器官功能的重要指标。然而,目前的pH传感器在连续测量中经历信号漂移,抑制了它们提供纵向体pH状态的能力。为了实现实时、连续的pH监测,我们开发了一种基于聚多巴胺(PDA)的pH传感器,并验证了其在PBS和模拟伤口渗出液(WFE)中的性能。为了提高信号的稳定性,我们对传感器进行了热处理和琼脂糖凝胶涂层,我们发现琼脂糖涂层大大改善了信号的漂移。
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CiteScore
2.30
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