Advances in Virology最新文献_第8页

Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya. 肯尼亚曼德拉县和瓦吉尔县单峰骆驼和小反刍动物中的小反刍兽疫。

IF 2.2

Advances in Virology Pub Date : 2019-03-04 eCollection Date: 2019-01-01 DOI: 10.1155/2019/4028720

R N Omani, G C Gitao, J Gachohi, P K Gathumbi, B A Bwihangane, K Abbey, V J Chemweno

{"title":"Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya.","authors":"R N Omani, G C Gitao, J Gachohi, P K Gathumbi, B A Bwihangane, K Abbey, V J Chemweno","doi":"10.1155/2019/4028720","DOIUrl":"https://doi.org/10.1155/2019/4028720","url":null,"abstract":"A study was conducted to determine the presence of Peste des petits ruminants (PPR) in camel population kept together with small ruminants in Isiolo, Mandera, Marsabit, and Wajir counties of Kenya. This was done in the wake of a disease with unknown etiology \"Camel Sudden Death Syndrome\" camels in the horn of Africa. Thirty-eight (38) samples, 12, 8, 15, and 3 samples, were collected from Mandera, Wajir, Isiolo, and Marsabit, respectively, from 25 camels, 7 goats, and 4 sheep. One camel in Mandera and one goat in Wajir were confirmed positive for PPR virus (PPRV) through reverse Polymerase Chain Reaction. The analysis of sequences revealed closest nucleotide identities of obtained sequences from both goat and camel to the lineage III of PPRV albeit with 60.29% of nucleotide identity. This study establishes that camels in the study area suffer with PPR manifest clinical signs that are mainly characterized by inappetence, loss of body condition, and general weakness terminally leading to diarrhea, conjunctivitis, and ocular nasal discharges preceding death. These clinical signs are similar to those observed in small ruminants with slight variations of manifestations such as keratoconjunctivitis as well as edema of the ventral surface of the abdomen. This shows that camels could be involved in the epidemiology of PPR in the region and that PPRV could be involved in the epidemics of Camel Sudden Death syndrome. There is therefore a need for resources to be dedicated in understanding the role camels play in the epidemiology of PPR and the role of the disease in Camels Sudden death syndrome.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/4028720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37291243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Genetic Diversity and Phylogenetic Analysis of Citrus tristeza virus Isolates from Turkey. 柑桔衰退病毒土耳其分离株的遗传多样性和系统发育分析。

IF 2.2

Advances in Virology Pub Date : 2019-01-01 DOI: 10.1155/2019/7163747

Gözde Erkiş-Güngör, Bayram Çevik

{"title":"Genetic Diversity and Phylogenetic Analysis of Citrus tristeza virus Isolates from Turkey.","authors":"Gözde Erkiş-Güngör, Bayram Çevik","doi":"10.1155/2019/7163747","DOIUrl":"10.1155/2019/7163747","url":null,"abstract":"The presence of Citrus tristeza virus (CTV) in Turkey has been known since the 1960s and the virus was detected in all citrus growing regions of the country. Even though serological and biological characteristics of CTV have been studied since the 1980s, molecular characteristics of CTV isolates have not been studied to date in Turkey. In this study, molecular characteristics of 15 CTV isolates collected from different citrus growing regions of Turkey were determined by amplification, cloning, and sequencing of their major coat protein (CP) genes. The sequence analysis showed that the CP genes were highly conserved among Turkish isolates. However, isolates from different regions showed more genetic variation than isolates from the same region. Turkish isolates were clustered into three phylogenetic groups showing no association with geographical origins, host, or symptoms induced in indicator plants. Phylogenetic analysis of Turkish isolates with isolates from different citrus growing regions of the world including well-characterized type isolates of previously established strain specific groups revealed that some Turkish isolates were closely related to severe quick decline or stem pitting isolates. The results demonstrated that although CTV isolates from Turkey are considered biologically mild, majority of them contain severe components potentially causing quick decline or stem pitting.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/7163747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37084986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells. 人肺上皮A549细胞不同亚型甲型流感病毒对PB1-F2蛋白的凋亡和早期先天免疫应答

IF 2.2

Advances in Virology Pub Date : 2018-12-31 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5057184

Gunisha Pasricha, Sanjay Mukherjee, Alok K Chakrabarti

{"title":"Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells.","authors":"Gunisha Pasricha, Sanjay Mukherjee, Alok K Chakrabarti","doi":"10.1155/2018/5057184","DOIUrl":"https://doi.org/10.1155/2018/5057184","url":null,"abstract":"PB1-F2 is a multifunctional protein and contributes to the pathogenicity of influenza A viruses. PB1-F2 is known to have strain and cell specific functions. In this study we have investigated the apoptotic and inflammatory responses of PB1-F2 protein from influenza viruses of diverse pathogenicities in A549 lung epithelial cells. Overexpression of PB1-F2 resulted in apoptosis and heightened inflammatory response in A549 cells. Comparison revealed that the response varied with each subtype. PB1-F2 protein from highly pathogenic H5N1 virus induced least apoptosis but maximum inflammatory response. Results indicated that apoptosis was mediated through death receptor ligands TNFα and TRAIL via Caspase 8 activation. Significant induction of cytokines/chemokines CXCL10, CCL5, CCL2, IFNα, and IL-6 was noted in A549 cells transfected with PB1-F2 gene construct of 2008 West Bengal H5N1 virus (H5N1-WB). On the contrary, PB1-F2 construct from 2007 highly pathogenic H5N1 isolate (H5N1-M) with truncated N-terminal region did not evoke as exuberant inflammatory response as the other H5N1-WB with full length PB1-F2, signifying the importance of N-terminal region of PB1-F2. Sequence analysis revealed that PB1-F2 proteins derived from different influenza viruses varied at multiple amino acid positions. The secondary structure prediction showed each of the PB1-F2 proteins had distinct helix-loop-helix structure. Thus, our data substantiate the notion that the contribution of PB1-F2 to influenza pathogenicity is greatly strain specific and involves multiple host factors. This data demonstrates that PB1-F2 protein of influenza A virus, when expressed independently is minimally apoptotic and strongly influences the early host response in A549 cells.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/5057184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36901276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook. 尼日利亚新城疫病毒基因型多样性:疾病控制挑战和未来展望

IF 2.2

Advances in Virology Pub Date : 2018-12-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6097291

Muhammad Bashir Bello, Khatijah Mohd Yusoff, Aini Ideris, Mohd Hair-Bejo, Ben P H Peeters, Abdurrahman Hassan Jibril, Farouk Muhammad Tambuwal, Abdul Rahman Omar

{"title":"Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook.","authors":"Muhammad Bashir Bello, Khatijah Mohd Yusoff, Aini Ideris, Mohd Hair-Bejo, Ben P H Peeters, Abdurrahman Hassan Jibril, Farouk Muhammad Tambuwal, Abdul Rahman Omar","doi":"10.1155/2018/6097291","DOIUrl":"https://doi.org/10.1155/2018/6097291","url":null,"abstract":"Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other production related losses. The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are serologically grouped into a single serotype but genetically classified into a total of 19 genotypes, owing to the continuous emergence and evolution of the virus. In Nigeria, molecular characterization of NDV is generally very scanty and majorly focuses on the amplification of the partial F gene for genotype assignment. However, with the introduction of the most objective NDV genotyping criteria which utilize complete fusion protein coding sequences in phylogenetic taxonomy, the enormous genetic diversity of the virus in Nigeria became very conspicuous. In this review, we examine the current ecological distribution of various NDV genotypes in Nigeria based on the available complete fusion protein nucleotide sequences (1662 bp) in the NCBI database. We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. Finally, we suggest future directions in the war against the economically devastating ND in Nigeria.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6097291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36842421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Quasispecies Changes with Distinctive Point Mutations in the Hepatitis C Virus Internal Ribosome Entry Site (IRES) Derived from PBMCs and Plasma. 来自pbmc和血浆的丙型肝炎病毒内部核糖体进入位点(IRES)不同点突变的准种变化

IF 2.2

Advances in Virology Pub Date : 2018-11-19 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4835252

Luca Mercuri, Emma C Thomson, Joseph Hughes, Peter Karayiannis

{"title":"Quasispecies Changes with Distinctive Point Mutations in the Hepatitis C Virus Internal Ribosome Entry Site (IRES) Derived from PBMCs and Plasma.","authors":"Luca Mercuri, Emma C Thomson, Joseph Hughes, Peter Karayiannis","doi":"10.1155/2018/4835252","DOIUrl":"10.1155/2018/4835252","url":null,"abstract":"The 5' untranslated region (UTR) of the hepatitis C virus (HCV) genome contains the internal ribosome entry site (IRES), a highly conserved RNA structure essential for cap-independent translation of the viral polyprotein. HCV, apart from the liver, is thought to be associated with lymphocyte subpopulations of peripheral blood mononuclear cells (PBMCs), in lymph nodes and brain tissue. In this study, RT-PCR, cloning, and sequence analysis were employed to investigate the quasispecies nature of the 5'UTR following extraction of viral RNA from PBMCs and plasma of HCV infected individuals. The nucleotide variation between IRES-derived sequences from PBMCs and plasma indicated the existence of polymorphic sites within the IRES. HCV isolates had divergent variants with unique mutations particularly at positions 107, 204, and 243 of the IRES. Most of the PBMC-derived sequences contained an A-A-A variant at these positions. The mutations associated with the IRESes suggested the presence of unique quasispecies populations in PBMCs compared with plasma.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4835252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36810653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Prevalence of Human Sapovirus in Low and Middle Income Countries. 中低收入国家人类萨帕病毒的流行情况。

IF 2.2

Advances in Virology Pub Date : 2018-09-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5986549

Mpho Magwalivha, Jean-Pierre Kabue, Afsatou Ndama Traore, Natasha Potgieter

{"title":"Prevalence of Human Sapovirus in Low and Middle Income Countries.","authors":"Mpho Magwalivha, Jean-Pierre Kabue, Afsatou Ndama Traore, Natasha Potgieter","doi":"10.1155/2018/5986549","DOIUrl":"https://doi.org/10.1155/2018/5986549","url":null,"abstract":"Background: Sapovirus (SV) infection is a public health concern which plays an important role in the burden of diarrhoeal diseases, causing acute gastroenteritis in people of all ages in both outbreaks and sporadic cases worldwide.Objective/study design: The purpose of this report is to summarise the available data on the detection of human SV in low and middle income countries. A systematic search on PubMed and ScienceDirect database for SV studies published between 2004 and 2017 in low and middle income countries was done. Studies of SV in stool and water samples were part of the inclusion criteria.Results: From 19 low and middle income countries, 45 published studies were identified. The prevalence rate for SV was 6.5%. A significant difference (P=0) in SV prevalent rate was observed between low income and middle income countries. Thirty-three (78.6%) of the studies reported on children and 8 (19%) studies reported on all age groups with diarrhoea. The majority (66.7%) of studies reported on hospitalised patients with acute gastroenteritis. Sapovirus GI was shown as the dominant genogroup, followed by SV-GII.Conclusion: The detection of human SV in low and middle income countries is evident; however the reports on its prevalence are limited. There is therefore a need for systematic surveillance of the circulation of SV, and their role in diarrhoeal disease and outbreaks, especially in low and middle income countries.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/5986549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36517818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus-Specific Primer Panels. 利用De Novo设计的多重属特异性引物面板研究鸟类样本中的病毒RNA多样性。

IF 2.2

Advances in Virology Pub Date : 2018-08-12 eCollection Date: 2018-01-01 DOI: 10.1155/2018/3248285

Andrey A Ayginin, Ekaterina V Pimkina, Alina D Matsvay, Anna S Speranskaya, Marina V Safonova, Ekaterina A Blinova, Ilya V Artyushin, Vladimir G Dedkov, German A Shipulin, Kamil Khafizov

{"title":"The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus-Specific Primer Panels.","authors":"Andrey A Ayginin, Ekaterina V Pimkina, Alina D Matsvay, Anna S Speranskaya, Marina V Safonova, Ekaterina A Blinova, Ilya V Artyushin, Vladimir G Dedkov, German A Shipulin, Kamil Khafizov","doi":"10.1155/2018/3248285","DOIUrl":"https://doi.org/10.1155/2018/3248285","url":null,"abstract":"Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases. However, unlike the metagenomic studies using 16S rRNA for the detection of bacteria, it is impossible to create universal oligonucleotides to target all known and novel viruses, owing to their genomic diversity and variability. On the other hand, sequencing the entire genome is still expensive and has relatively low sensitivity for such applications. The existing approaches for the design of oligonucleotides for targeted enrichment are usually involved in the development of primers for the PCR-based detection of particular viral species or genera, but not for families or higher taxonomic orders. In this study, we have developed a computational pipeline for designing the oligonucleotides capable of covering a significant number of known viruses within various taxonomic orders, as well as their novel variants. We have subsequently designed a genus-specific oligonucleotide panel for targeted enrichment of viral nucleic acids in biological material and demonstrated the possibility of its application for virus detection in bird samples. We have tested our panel using a number of collected samples and have observed superior efficiency in the detection and identification of viral pathogens. Since a reliable, bioinformatics-based analytical method for the rapid identification of the sequences was crucial, an NGS-based data analysis module was developed in this study, and its functionality in the detection of novel viruses and analysis of virome diversity was demonstrated.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/3248285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36439572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Alternanthera mosaic potexvirus: Several Features, Properties, and Application. Alternathera mosaic potexvirus：几个特征、特性和应用。

IF 2.2

Advances in Virology Pub Date : 2018-06-19 DOI: 10.1155/2018/1973705

Ekaterina Donchenko, Ekaterina Trifonova, Nikolai Nikitin, Joseph Atabekov, Olga Karpova

{"title":"Alternanthera mosaic potexvirus: Several Features, Properties, and Application.","authors":"Ekaterina Donchenko, Ekaterina Trifonova, Nikolai Nikitin, Joseph Atabekov, Olga Karpova","doi":"10.1155/2018/1973705","DOIUrl":"10.1155/2018/1973705","url":null,"abstract":"Alternanthera mosaic virus (AltMV) is a typical member of the Potexvirus genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stable in a wide range of conditions, including sera of laboratory animals. AltMV VLPs can assemble at various pH and ionic strengths. Furthermore, AltMV virions and VLPs demonstrate high immunogenicity, enhancing the immune response to the target antigen thus offering the possibility of being used as potential adjuvants. Recently, for the first time for plant viruses, we showed the structural difference between morphologically similar viral and virus-like particles on AltMV virions and VLPs. In this review, we discuss the features of AltMV virions, AltMV VLP assembly, and their structure and properties, as well as the characteristics of AltMV isolates, host plants, infection symptoms, AltMV isolation and purification, genome structure, viral proteins, and AltMV-based vectors.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/1973705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36321233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients. HIV+患者尿细胞外囊泡中HIV-1和人蛋白的检测

IF 2.2

Advances in Virology Pub Date : 2018-03-12 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7863412

Samuel I Anyanwu, Akins Doherty, Michael D Powell, Chamberlain Obialo, Ming B Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W Newman

{"title":"Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients.","authors":"Samuel I Anyanwu, Akins Doherty, Michael D Powell, Chamberlain Obialo, Ming B Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W Newman","doi":"10.1155/2018/7863412","DOIUrl":"https://doi.org/10.1155/2018/7863412","url":null,"abstract":"Background: Extracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. Our goal was to identify HIV and human proteins (HPs) in urinary EVs from HIV+ patients and compare them to HIV- samples.Methods: Urine samples were collected from HIV+ (n = 35) and HIV- (n = 12) individuals. EVs were isolated by ultrafiltration and characterized using transmission electron microscopy, tandem mass spectrometry (LC/MS/MS), and nanoparticle tracking analysis (NTA). Western blots confirmed the presence of HIV proteins. Gene ontology (GO) analysis was performed using FunRich and HIV Human Interaction database (HHID).Results: EVs from urine were 30-400 nm in size. More EVs were in HIV+ patients, P < 0.05, by NTA. HIV+ samples had 14,475 HPs using LC/MS/MS, while only 111 were in HIV-. HPs in the EVs were of exosomal origin. LC/MS/MS showed all HIV+ samples contained at least one HIV protein. GO analysis showed differences in proteins between HIV+ and HIV- samples and more than 50% of the published HPs in the HHID interacted with EV HIV proteins.Conclusion: Differences in the proteomic profile of EVs from HIV+ versus HIV- samples were found. HIV and HPs in EVs could be used to detect infection and/or diagnose HIV disease syndromes.","PeriodicalId":7473,"journal":{"name":"Advances in Virology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7863412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36067200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1). 质疑猴B病毒(机器α疱疹病毒1型)的极端神经毒力。

IF 2.2

Advances in Virology Pub Date : 2018-01-01 DOI: 10.1155/2018/5248420

R Eberle, L Jones-Engel

引用次数: 19