Rheumatology and immunology research最新文献

{"title":"CD209 gene polymorphism and its clinical correlation with susceptibility to rheumatoid arthritis among Egyptian patients: A case-control study.","authors":"Rasha Mokhtar Elnagar, Amira M Sultan, Mohammed Elshaer, Alaa A Awad, Dalia Kamal Nassar","doi":"10.1515/rir-2025-0027","DOIUrl":"10.1515/rir-2025-0027","url":null,"abstract":"<p><strong>Background and objectives: </strong>Certain genetic traits increase the likelihood of developing rheumatoid arthritis (RA); nevertheless, the association between RA and polymorphisms in the CD209 gene is ambiguous. This study sought to investigate the correlation between RA susceptibility and the CD209 single nucleotide polymorphisms rs4804803 (AG) and rs735239 (AG) within the Egyptian population.</p><p><strong>Methods: </strong>This case-control study was conducted between January and October 2024 and included 108 participants. Of these, 54 patients were diagnosed with RA according to the 2010 classification criteria of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Two CD209 promoter regions rs4804803 (-336A/G) and rs735239 (-871A/G) were genotyped for single nucleotide polymorphisms (SNPs) using multiplex polymerase chain reaction (PCR) and double amplification refractory system (dARMS).</p><p><strong>Results: </strong>Patients with RA showed significantly higher frequencies of the CD209 rs4804803 SNP in the AG (<i>P</i> = 0.036) and GG (<i>P</i> = 0.006) genotypes compared to controls. Under the dominant paradigm, those with CD209 rs4804803 genotypes (AG+GG) had an elevated risk of RA (<i>P</i> = 0.003). In recessive inheritance model, RA patients had a greater frequency of the rs4804803 GG polymorphism than controls (<i>P</i> = 0.017). Additionally, relative to the A allele, the rs4804803 G allele raised the risk of RA (<i>P</i> = 0.001). No significant difference was observed between the two groups in the distribution of rs735239 genotypes. However, RA patients carrying the rs4804803 AG or GG genotypes exhibited significantly higher rates of morning stiffness (<i>P</i> = 0.001) and elevated CRP levels (<i>P</i> = 0.009).</p><p><strong>Conclusions: </strong>This work highlights the significant role of the CD209 rs4804803 polymorphism, particularly the G allele, in the elevated susceptibility to RA among Egyptians.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"220-231"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhage or thrombosis? Adrenal involvements in a patient with antiphospholipid syndrome.","authors":"Lingshan Liu, Qin Wang, Ying Jiang, Can Huang","doi":"10.1515/rir-2025-0032","DOIUrl":"10.1515/rir-2025-0032","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"250-252"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the manual disease activity score (MDAS) for rheumatoid arthritis.","authors":"Babur Salim, Amjad Nasim, Saira Jahan, Shahida Perveen, Saba Samreen, Haris Gul, Ali Afzal, Noor Ul Ain Rizwan, Maryam Ahmed, Saira Yasmin","doi":"10.1515/rir-2025-0031","DOIUrl":"10.1515/rir-2025-0031","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"246-249"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of IgG4-related sclerosing mesenteritis: A Chinese cohort study and literature review.","authors":"Jialei Zhang, Yuxue Nie, Jingna Li, Nianyi Zhang, Xinli Yang, Jialing Jiang, Yifei Wang, Qinhuan Luo, Jiaxin Zhou, Linyi Peng, Wen Zhang","doi":"10.1515/rir-2025-0026","DOIUrl":"10.1515/rir-2025-0026","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to summarize the features of IgG4-related sclerosing mesenteritis (IgG4-SM) based on both our large prospective IgG4-related disease (IgG4-RD) cohort and literature-reported IgG4-SM cases.</p><p><strong>Methods: </strong>We applied a mixed-methods approach, integrating data from 29 patients with IgG4-SM and 87 matched IgG4-RD patients without mesenteritis, all enrolled in a prospective cohort of IgG4-RD from Peking Union Medical College Hospital (PUMCH) since 2011. Additionally, we included 32 IgG4-SM cases reported in public databases since 2011. Demographic, clinical, laboratory, imaging and treatment data were systematically compared.</p><p><strong>Results: </strong>Compared with IgG4-RD without mesenteritis, IgG4-SM predominantly affected elderly males and accompanied with more organ involvement (<i>P</i> = 0.019) and elevated responder index (RI) scores and Physician Global Assessment (PGA) scores (<i>P</i> = 0.005 and <i>P</i> = 0.018, respectively). Compared to the literature-reported cases, IgG4-SM patients in our cohort exhibited a lower prevalence of abdominal pain (<i>P</i> < 0.001) but a higher frequency of submandibular gland (<i>P</i> < 0.001) and lacrimal gland enlargement (<i>P</i> < 0.001). Imaging features included a spectrum of mesenteric abnormalities, ranging from misty opacities to soft-tissue masses on computed tomography (CT), with significantly increased ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake on positron emission tomography-computed tomography (PET-CT). Despite divergent treatments (glucocorticoids/immunosuppressants in our cohort <i>vs</i>. surgical resection in reported cases, <i>P</i> < 0.001), long-term relapse rates were comparable (<i>P</i> = 0.17).</p><p><strong>Conclusions: </strong>IgG4-SM is a significant but under-recognized manifestation of IgG4-RD, characterized by a predilection for elderly males, multi-organ involvement, higher disease activity and distinct imaging features. Systemic radiological evaluation, including PET-CT could assist diagnosis and treatment monitoring. Glucocorticoid-based therapy achieved outcomes comparable to surgery, challenging the necessity of invasive interventions. This study expands the clinical spectrum of IgG4-SM and advocates for personalized, non-surgical management strategies in most cases.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"210-219"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mystery of the blue toe.","authors":"Jing Wang, Dachen Zuo, Shengnan Yu, Sha Ma","doi":"10.1515/rir-2025-0029","DOIUrl":"10.1515/rir-2025-0029","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"240-242"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spondyloarthritis recognition for primary care: A simplified diagnostic and referral pathway for general physicians.","authors":"Anum Khan, Babur Salim, Shahida Perveen, Samina Mushtaq, Saba Samreen, Haris Gul","doi":"10.1515/rir-2025-0030","DOIUrl":"10.1515/rir-2025-0030","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"243-245"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal deposition disease of the shoulder at uncommon sites: Diagnostic challenges and nomenclature issues in the absence of synovial fluid analysis.","authors":"Angelo Nigro","doi":"10.1515/rir-2025-0025","DOIUrl":"10.1515/rir-2025-0025","url":null,"abstract":"<p><p>Calcium pyrophosphate deposition (CPPD) disease is a common, age-related crystalline arthropathy with diverse clinical presentations. While the knees and wrists are most frequently affected, shoulder involvement is increasingly recognized, occurring in up to 13% of cases, though often underdiagnosed. This mini-review provides a comprehensive overview of the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of shoulder CPPD, contextualized by an illustrative case of a 78-year-old woman with atypical calcifications in the axillary recess and supraspinatus muscle. A key focus is the diagnostic challenge when synovial fluid analysis, the gold standard for crystal confirmation, is technically unfeasible, a common scenario in clinical practice. We systematically discuss modern imaging techniques (ultrasound, dual-energy computed tomography [CT], conventional radiography) and demonstrate the practical application of the 2023 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for establishing probable CPPD when crystal analysis is unavailable. The review addresses critical differential diagnosis considerations, particularly distinguishing CPPD from basic calcium phosphate (BCP) deposition disease, and summarizes evidence-based therapeutic strategies for acute pseudogout flares and chronic inflammatory arthritis, including emerging biologic therapies targeting the interleukin-1 (IL-1) pathway. This comprehensive resource aids clinicians managing shoulder calcifications in the absence of definitive crystal confirmation.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 4","pages":"203-209"},"PeriodicalIF":2.5,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ficolin single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han Population.","authors":"Feng Yin, Jinhua Gu, Ping Zhao, Jie Chen","doi":"10.1515/rir-2025-0023","DOIUrl":"10.1515/rir-2025-0023","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 3","pages":"195-198"},"PeriodicalIF":2.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of tripartite motif containing-21 and interleukin-6 in pro-Inflammatory symptom-associated heterogeneity within primary Sjögren's syndrome.","authors":"Lauren R Scott, Joe Berry, Kyle Thompson, Jessica Tarn, Karl Wood, John Casement, Wan-Fai Ng","doi":"10.1515/rir-2025-0019","DOIUrl":"10.1515/rir-2025-0019","url":null,"abstract":"<p><strong>Background and objectives: </strong>In Primary Sjögren's Syndrome (pSS) clinical heterogeneity is a challenge to both treatment and disease understanding. Variations in symptoms may be driven by different underlying biological pathways. Tripartite motif containing-21 (TRIM21) and interleukin-6 (IL-6) have been implicated in autoimmunity and inflammation, with links to chronic interferon activity. We assess the levels of TRIM21 and IL-6 in the context of anti-Ro autoantibody status, and in different symptom-based pSS subgroups we have previously described, to explore whether they may contribute to the clinical heterogeneity in pSS.</p><p><strong>Methods: </strong>We measured serum IL-6 concentrations for 193 pSS patients and 18 healthy controls, and analysed available microarray data for TRIM21 transcript expression in 184 pSS patients and 33 healthy controls. Levels of IL-6 and TRIM21 were analysed in the context of symptom-based subgroups, anti-Ro autoantibody status and symptom scores.</p><p><strong>Results: </strong>TRIM21 and IL-6 levels were significantly raised in pSS patients compared to healthy controls. TRIM21 expression was similar between symptom-based subgroups, whilst IL-6 concentrations were significantly increased in the high symptom burden group compared to the low symptom burden group. TRIM21 levels were significantly increased in Ro+ autoantibody groups compared to Ro-, whilst IL-6 levels were similar between groups.</p><p><strong>Conclusions: </strong>Our results suggest a potential role for IL-6 in the pathogenesis of the high symptom burden group. Increased TRIM21 transcript levels in the Ro+ group supports the hypothesis of suggests autoantibody targeting of the TRIM21 protein leading to aberrant type I interferon (IFN) production which in turn may drive further TRIM21 transcript production.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 3","pages":"159-167"},"PeriodicalIF":2.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How will we treat systemic lupus erythematosus in the next 5 years?","authors":"Jiuliang Zhao, Xinping Tian, Mengtao Li, Xiaofeng Zeng","doi":"10.1515/rir-2025-0016","DOIUrl":"10.1515/rir-2025-0016","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"6 3","pages":"117-119"},"PeriodicalIF":2.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}