{"title":"Morris responds to \"Critical analyses concerning COVID-19 vaccines need to be consistently critical, and informed\".","authors":"Jeffrey S Morris","doi":"10.1093/aje/kwaf015","DOIUrl":"10.1093/aje/kwaf015","url":null,"abstract":"","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"1145-1147"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bespoke instrumental variables with nonideal reference populations.","authors":"Arvid Sjölander, Erin E Gabriel","doi":"10.1093/aje/kwae247","DOIUrl":"10.1093/aje/kwae247","url":null,"abstract":"<p><p>Recently, a bespoke instrumental variable method was proposed, which, under certain assumptions, can eliminate bias due to unmeasured confounding when estimating the causal exposure effect among the exposed. This method uses data from both the study population of interest and a reference population in which the exposure is completely absent. In this article, we extend the bespoke instrumental variable method to allow for a nonideal reference population that may include exposed individuals. Such an extension is particularly important in randomized trials with nonadherence, where even individuals in the control arm may have access to the treatment under investigation. We further scrutinize the assumptions underlying the bespoke instrumental method and caution the reader about the potential nonrobustness of the method to these assumptions.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"1106-1111"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invited commentary: race, ethnicity, and racism in epidemiologic research-perspectives from Public Health Critical Race Praxis (PHCRP).","authors":"Chandra L Ford, Whitney N L Pirtle","doi":"10.1093/aje/kwae064","DOIUrl":"10.1093/aje/kwae064","url":null,"abstract":"<p><p>In 2023, Martinez et al (Am J Epidemiol. 2023;192(3):483-496) examined trends in the inclusion, conceptualization, operationalization, and analysis of race and ethnicity among studies published in US epidemiology journals. Based on a random sample of articles (n = 1050) published from 1995-2018, the authors describe the treatment of race, ethnicity, and ethnorace in the analytic sample (n = 414, 39% of baseline sample) over time. The review supplies stark evidence of the routine omission and variability of measures of race and ethnicity in epidemiologic research. Between 32% and 19% of studies in each time stratum lacked race data; 61%-34% lacked ethnicity data. Informed by public health critical race praxis (PHCRP), this commentary discusses the implications of 4 problems the findings suggest pervade epidemiology: (1) a general lack of clarity about what race and ethnicity are; (2) the limited use of critical race or other theory; (3) an ironic lack of rigor in measuring race and ethnicity; and (4) the ordinariness of racism and White supremacy in epidemiology. The identified practices reflect neither current publication guidelines nor the state of the knowledge on race, ethnicity and racism; therefore, we conclude by offering recommendations to move epidemiology toward more rigorous research in an increasingly diverse society.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"927-935"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleanor A Medley, Leonardo Trasande, Mrudula Naidu, Yuyan Wang, Akhgar Ghassabian, Linda G Kahn, Sara Long, Yelena Afanasyeva, Mengling Liu, Kurunthachalam Kannan, Shilpi S Mehta-Lee, Whitney Cowell
{"title":"Prenatal organophosphate pesticide exposure and sex-specific estimated fetal size.","authors":"Eleanor A Medley, Leonardo Trasande, Mrudula Naidu, Yuyan Wang, Akhgar Ghassabian, Linda G Kahn, Sara Long, Yelena Afanasyeva, Mengling Liu, Kurunthachalam Kannan, Shilpi S Mehta-Lee, Whitney Cowell","doi":"10.1093/aje/kwae265","DOIUrl":"10.1093/aje/kwae265","url":null,"abstract":"<p><p>Prenatal organophosphate (OP) pesticide exposure may be associated with reduced fetal growth, although studies are limited and have mixed results. We investigated associations between prenatal OP pesticide exposure and fetal size and modification by fetal sex. Maternal urinary concentrations of dialkyl phosphate (DAP) metabolites were measured at 3 time points. Fetal biometrics were obtained from ultrasounds in the second (n = 773) and third (n = 535) trimesters. Associations between pregnancy-averaged ΣDAP and fetal biometry z scores were determined through multiple linear regression. Modification by sex was investigated through stratification and interaction. In the second trimester, one ln-unit increase in ΣDAP was associated with lower estimated fetal weight (-0.15 SD; 95% CI, -0.29 to -0.01), head circumference (-0.11 SD; CI, -0.22 to 0.01), biparietal diameter (-0.14 SD; CI, -0.27 to -0.01), and abdominal circumference (-0.12 SD; CI, -0.26 to 0.01) in females. In the third trimester, one ln-unit increase in ΣDAP was associated with lower head circumference (-0.14 SD; CI, -0.28 to 0.00) and biparietal diameter (-0.12 SD; CI, -0.26 to 0.03) in males. Our results suggest that prenatal OP pesticide exposure is negatively associated with fetal growth in a sex-specific manner, with associations present for females in mid-gestation and males in late gestation. This article is part of a Special Collection on Environmental Epidemiology.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"954-962"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerollos Nashat Wanis, Mats Julius Stensrud, Aaron Leor Sarvet
{"title":"Separable effects for adherence.","authors":"Kerollos Nashat Wanis, Mats Julius Stensrud, Aaron Leor Sarvet","doi":"10.1093/aje/kwae277","DOIUrl":"10.1093/aje/kwae277","url":null,"abstract":"<p><p>Comparing different medications is complicated when adherence to these medications differs. We can overcome the adherence issue by assessing effectiveness under sustained use, as in usual causal \"per-protocol\" estimands. However, when sustained use is challenging to satisfy in practice, the usefulness of these estimands can be limited. Here we propose a different class of estimands: separable effects for adherence. These estimands compare modified medications, holding fixed a component responsible for nonadherence. Under assumptions about treatment components' mechanisms of effect, a separable effects estimand can quantify the effectiveness of medication initiation strategies on an outcome of interest under the adherence mechanism of one of the medications. These assumptions are amenable to interrogation by subject-matter experts and can be evaluated using causal graphs. We describe an algorithm for constructing causal graphs for separable effects, illustrate how these graphs can be used to reason about assumptions required for identification, and provide semi-parametric weighted estimators. This article is part of a Special Collection on Pharmacoepidemiology.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"1122-1130"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Venkatapuram responds to \"Positive epidemiology, revisited: the case for centering human rights and economic justice\".","authors":"Sridhar Venkatapuram","doi":"10.1093/aje/kwae281","DOIUrl":"10.1093/aje/kwae281","url":null,"abstract":"<p><p>This commentary responds to the article by Qureishi et al (Am J Epidemol. 2024;193(10):1313-1317) that criticizes a new proposal for \"positive epidemiology.\" They argue that positive epidemiology, as it is being proposed and conducted, ignores supraindividual social contextual factors that constrain the well-being of some individuals more than others, and it could exacerbate inequalities if applied at a population level, among other harms. They offer an alternative approach to defining causal factors that are helpful for well-being and seek to ground their view in human rights and economic justice frameworks. This commentary considers their criticisms of positive epidemiology and suggests that their alternative, as well as all research into positive health and well-being, would benefit from drawing on the ongoing debates and literature in health equity and justice philosophy. A coherent conception of health and well-being, the link between health/well-being and theories of justice, and the capabilities approach are discussed. The efforts at conducting epidemiology for the causes and distribution of good health and well-being grounded in justice are welcomed. This article is part of a Special Collection on Mental Health.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"1140-1142"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wuyue Yu, George Thurston, Yongzhao Shao, Yian Zhang, William E Copeland, Cheryl R Stein
{"title":"Ambient air pollution and depressed mood in the National Longitudinal Study of Adolescent to Adult Health (Add Health) wave 4.","authors":"Wuyue Yu, George Thurston, Yongzhao Shao, Yian Zhang, William E Copeland, Cheryl R Stein","doi":"10.1093/aje/kwae314","DOIUrl":"10.1093/aje/kwae314","url":null,"abstract":"<p><p>Depression is a major contributor to the global burden of disease. There is limited understanding of how environmental exposures may contribute to depression etiology. We used wave 4 of the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine associations between low-level ambient air pollution exposure and depressed mood in a generally healthy population of over 10 000 24-32 year olds. Annual mean PM2.5 levels in the 2008-2009 study were close to the current US standard. In fully adjusted quasibinomial logistic regression models, there were no meaningful associations between IQR increases in air pollutant and change in depressed mood status regardless of specific pollutant or moving average lags. In interaction effects models, an IQR increase in lag day 0-30 PM2.5 resulted in 1.20 (95% CI, 1.02-1.41) times higher likelihood of having depressed mood but only for persons with chronic lung disease (interaction P = .04); the association was null for participants without chronic lung disease (OR, 0.98; 95% CI, 0.91-1.05). Our findings suggest that among persons with a lifetime history of chronic lung disease, greater exposure to even low-level PM2.5, PM10, and sulfate may be associated with modest increases in the likelihood of having depressed mood. This article is part of a Special Collection on Environmental Epidemiology.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"975-983"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thirty-five years of leaky vaccines.","authors":"M Elizabeth Halloran, Claudio J Struchiner","doi":"10.1093/aje/kwae379","DOIUrl":"10.1093/aje/kwae379","url":null,"abstract":"<p><p>Over the past 35 years, the term \"leaky vaccine\" has gained widespread use in both mathematical modeling and epidemiologic methods for evaluating vaccines. Here, we present a short history, as we recall it, of how the term was coined in the context of the history of sporozoite malaria vaccines that were thought in the 1980s to be possibly leaky. We draw a contrast with the all-or-none vaccine mechanism and review a few consequences for study design and population-level effects. We invite readers to contribute information covering the period preceding our memories in the 1980s, because we may have overlooked something.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"918-920"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin Maldonado-Cañón, Annika Möhl, Nadia Obi, Sabine Behrens, Fabian Flaßkamp, Petra Seibold, Jenny Chang-Claude, Heiko Becher
{"title":"The healthy participant effect: insights and results from a population-based case-control study on breast cancer.","authors":"Kevin Maldonado-Cañón, Annika Möhl, Nadia Obi, Sabine Behrens, Fabian Flaßkamp, Petra Seibold, Jenny Chang-Claude, Heiko Becher","doi":"10.1093/aje/kwae155","DOIUrl":"10.1093/aje/kwae155","url":null,"abstract":"<p><p>Agreement to participate in case-control studies has become low. Healthy participant bias resulting from differential response proportions in cases and controls can distort results; however, the magnitude of bias is difficult to assess. We investigated the effect in a large population-based case-control study on breast cancer, with a participation rate of 43.4% and 64.1% for controls and cases, respectively. We performed a mortality follow-up in 2020 for 3813 cases and 7335 controls recruited during 2002-2005. Standardized mortality ratios (SMRs) for overall mortality and selected causes of death were estimated. The mean age at recruitment was 63.1 years. The overall mortality for controls was 0.66 times lower (95% CI, 0.62-0.69) than for the reference population. For causes of death other than breast cancer, SMRs were similar in cases and controls (0.70 and 0.64). Higher education was associated with lower SMRs in both cases and controls. Options for adjusting the healthy participant bias are limited if the true risk factor distribution in the underlying population is unknown. However, a relevant bias in this particular case-control study is considered unlikely since a similar healthy participant effect was observed for both controls and cases.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"1058-1064"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziyi Cai, Anna Olia Papacosta, Lucy T Lennon, Peter H Whincup, Sasiwarang Goya Wannamethee, Eleanor M Simonsick, John C Mathers, Sheena E Ramsay
{"title":"Associations of social engagement and loneliness with the progression and reversal of frailty: longitudinal investigations of 2 prospective cohorts from the UK and the USA.","authors":"Ziyi Cai, Anna Olia Papacosta, Lucy T Lennon, Peter H Whincup, Sasiwarang Goya Wannamethee, Eleanor M Simonsick, John C Mathers, Sheena E Ramsay","doi":"10.1093/aje/kwae221","DOIUrl":"10.1093/aje/kwae221","url":null,"abstract":"<p><p>Social connections may impact the dynamic trajectory of frailty. Using data from the British Regional Heart Study (BRHS) in the UK (n = 715) and the US Health, Aging and Body Composition (Health ABC) Study (n = 1256), we conducted multinominal regression analyses to examine the association of baseline and change in social engagement and loneliness with progression to prefrailty and frailty, as well as their association with reversal to prefrailty and robust status among older adults. A higher level of social engagement at baseline (BRHS: relative risk ratio [RRR] 0.69 [95% CI, 0.55-0.85]; Health ABC: 0.56 [0.45-0.70]) and an increase in social engagement (BRHS: 0.73 [0.59-0.90]; Health ABC: 0.51 [0.41-0.63]) were associated with a lower risk of developing frailty. In BRHS, a higher level of loneliness at baseline (1.42 [1.10-1.83]) and an increase in loneliness (1.50 [1.18-1.90]) raised the risk of developing frailty. For reversal of frailty, higher social engagement at baseline (Health ABC: 1.63 [1.08-2.47]) and an increase in social engagement (BRHS: 1.74 [1.18-2.50]; Health ABC: 1.79 [1.17-.274]) were beneficial. Social connections may be potentially important and modifiable factors in both preventing and reversing progression of frailty in older adults.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"984-993"},"PeriodicalIF":5.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}