American journal of epidemiology最新文献_第2页

DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study. DNA 甲基化是连接童年逆境与健康的可能因果机制：双样本亡羊补牢随机研究的结果。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae072

Isabel K Schuurmans, Erin C Dunn, Alexandre A Lussier

{"title":"DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study.","authors":"Isabel K Schuurmans, Erin C Dunn, Alexandre A Lussier","doi":"10.1093/aje/kwae072","DOIUrl":"10.1093/aje/kwae072","url":null,"abstract":"Childhood adversity is an important risk factor for adverse health across the life course. Epigenetic modifications, such as DNA methylation (DNAm), are a hypothesized mechanism linking adversity to disease susceptibility. Yet, few studies have determined whether adversity-related DNAm alterations are causally related to future health outcomes or if their developmental timing plays a role in these relationships. Here, we used 2-sample mendelian randomization to obtain stronger causal inferences about the association between adversity-associated DNAm loci across development (ie, birth, childhood, adolescence, and young adulthood) and 24 mental, physical, and behavioral health outcomes. We identified particularly strong associations between adversity-associated DNAm and attention-deficit/hyperactivity disorder, depression, obsessive-compulsive disorder, suicide attempts, asthma, coronary artery disease, and chronic kidney disease. More of these associations were identified for birth and childhood DNAm, whereas adolescent and young adulthood DNAm were more closely linked to mental health. Childhood DNAm loci also had primarily risk-suppressing relationships with health outcomes, suggesting that DNAm might reflect compensatory or buffering mechanisms against childhood adversity rather than acting solely as an indicator of disease risk. Together, our results suggest adversity-related DNAm alterations are linked to both physical and mental health outcomes, with particularly strong impacts of DNAm differences emerging earlier in development.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of algorithms in studies based on routinely collected health data: general principles. 在基于常规收集的健康数据的研究中验证算法：一般原则。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae071

Vera Ehrenstein, Maja Hellfritzsch, Johnny Kahlert, Sinéad M Langan, Hisashi Urushihara, Danica Marinac-Dabic, Jennifer L Lund, Henrik Toft Sørensen, Eric I Benchimol

{"title":"Validation of algorithms in studies based on routinely collected health data: general principles.","authors":"Vera Ehrenstein, Maja Hellfritzsch, Johnny Kahlert, Sinéad M Langan, Hisashi Urushihara, Danica Marinac-Dabic, Jennifer L Lund, Henrik Toft Sørensen, Eric I Benchimol","doi":"10.1093/aje/kwae071","DOIUrl":"10.1093/aje/kwae071","url":null,"abstract":"Clinicians, researchers, regulators, and other decision-makers increasingly rely on evidence from real-world data (RWD), including data routinely accumulating in health and administrative databases. RWD studies often rely on algorithms to operationalize variable definitions. An algorithm is a combination of codes or concepts used to identify persons with a specific health condition or characteristic. Establishing the validity of algorithms is a prerequisite for generating valid study findings that can ultimately inform evidence-based health care. In this paper, we aim to systematize terminology, methods, and practical considerations relevant to the conduct of validation studies of RWD-based algorithms. We discuss measures of algorithm accuracy, gold/reference standards, study size, prioritization of accuracy measures, algorithm portability, and implications for interpretation. Information bias is common in epidemiologic studies, underscoring the importance of transparency in decisions regarding choice and prioritizing measures of algorithm validity. The validity of an algorithm should be judged in the context of a data source, and one size does not fit all. Prioritizing validity measures within a given data source depends on the role of a given variable in the analysis (eligibility criterion, exposure, outcome, or covariate). Validation work should be part of routine maintenance of RWD sources. This article is part of a Special Collection on Pharmacoepidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide deaths involving opioid poisoning in the United States, by sex, 1999-2021. 1999 - 2021 年按性别分列的美国阿片类药物中毒自杀死亡人数。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae094

Rachel A Hoopsick, R Andrew Yockey, Benjamin M Campbell, Tonazzina H Sauda, Tourna N Khan

{"title":"Suicide deaths involving opioid poisoning in the United States, by sex, 1999-2021.","authors":"Rachel A Hoopsick, R Andrew Yockey, Benjamin M Campbell, Tonazzina H Sauda, Tourna N Khan","doi":"10.1093/aje/kwae094","DOIUrl":"10.1093/aje/kwae094","url":null,"abstract":"Suicide remains a leading cause of death in the United States, and recent data suggest suicide deaths involving opioids are increasing. Given unprecedented increases in drug-poisoning deaths, suicidality, and suicide deaths in recent years, an updated examination of the trends in suicide deaths involving opioids is warranted. In this descriptive epidemiologic analysis, we leverage final and provisional mortality data from the US Centers for Disease Control and Prevention's WONDER database to examine trends in suicide deaths involving opioid poisoning from 1999 to 2021 by biological sex. Results reveal complex changes over time: the number and age-adjusted rate of suicide deaths involving opioid poisoning among male and female residents tended to track together, and both increased through 2010, but then diverged, with the number and rate of suicide deaths involving opioid poisoning among female residents outpacing that of male residents. However, the number and rate of suicide deaths involving opioid poisoning among male residents then began to stabilize, while that of female residents declined, closing the sex-based gap. Across all years of data, the proportion of suicide deaths that involved opioid poisoning was consistently higher among female decedents (5.8%-11.0%) compared with male decedents (1.4%-2.8%). Findings have implications for improved suicide prevention and harm reduction efforts. This article is part of a Special Collection on Mental Health.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building transparency and reproducibility into the practice of pharmacoepidemiology and outcomes research. 在药物流行病学和结果研究实践中提高透明度和可重复性。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae087

Shirley V Wang, Anton Pottegård

{"title":"Building transparency and reproducibility into the practice of pharmacoepidemiology and outcomes research.","authors":"Shirley V Wang, Anton Pottegård","doi":"10.1093/aje/kwae087","DOIUrl":"10.1093/aje/kwae087","url":null,"abstract":"Real-world evidence (RWE) studies are increasingly used to inform policy and clinical decisions. However, there remain concerns about the credibility and reproducibility of RWE studies. While there is universal agreement on the critical importance of transparent and reproducible science, the building blocks of open science practice that are common across many disciplines have not yet been built into routine workflows for pharmacoepidemiology and outcomes researchers. Observational researchers should highlight the level of transparency of their studies by providing a succinct statement addressing study transparency with the publication of every paper, poster, or presentation that reports on an RWE study. In this paper, we propose a framework for an explicit transparency statement that declares the level of transparency a given RWE study has achieved across 5 key domains: (1) protocol, (2) preregistration, (3) data, (4) code-sharing, and (5) reporting checklists. The transparency statement outlined in the present paper can be used by research teams to proudly display the open science practices that were used to generate evidence designed to inform public health policy and practice. While transparency does not guarantee validity, such a statement signals confidence from the research team in the scientific choices that were made.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood adversity and time to pregnancy in a preconception cohort. 孕前队列中的童年逆境与怀孕时间。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae085

Sharonda M Lovett, Olivia R Orta, Renée Boynton-Jarrett, Amelia K Wesselink, Collette N Ncube, Yael I Nillni, Elizabeth E Hatch, Lauren A Wise

{"title":"Childhood adversity and time to pregnancy in a preconception cohort.","authors":"Sharonda M Lovett, Olivia R Orta, Renée Boynton-Jarrett, Amelia K Wesselink, Collette N Ncube, Yael I Nillni, Elizabeth E Hatch, Lauren A Wise","doi":"10.1093/aje/kwae085","DOIUrl":"10.1093/aje/kwae085","url":null,"abstract":"We examined the association between childhood adversity and fecundability (the per-cycle probability of conception), and the extent to which childhood social support modified this association. We used data from 6318 female participants aged 21-45 years in Pregnancy Study Online (PRESTO), a North American prospective preconception cohort study (2013-2022). Participants completed a baseline questionnaire, bimonthly follow-up questionnaires (until pregnancy or a censoring event), and a supplemental questionnaire on experiences across the life course including adverse childhood experiences (ACEs) and social support (using the modified Berkman-Syme Social Network Index [SNI]). We used proportional probabilities regression models to compute fecundability ratios (FRs) and 95% CIs, adjusting for potential confounders and precision variables. Adjusted FRs for ACE scores 1-3 and ≥4 vs 0 were 0.91 (95% CI, 0.85-0.97) and 0.84 (95% CI, 0.77-0.91), respectively. The FRs for ACE scores ≥4 vs 0 were 0.86 (95% CI, 0.78-0.94) among participants reporting high childhood social support (SNI ≥4) and 0.78 (95% CI, 0.56-1.07) among participants reporting low childhood social support (SNI <4). Our findings confirm results from 2 previous studies and indicate that high childhood social support slightly buffered the effects of childhood adversity on fecundability.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying target populations to align with decision-makers' needs. 确定目标人群，以满足决策者的需求。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae129

Jennifer L Lund, Anthony A Matthews

{"title":"Identifying target populations to align with decision-makers' needs.","authors":"Jennifer L Lund, Anthony A Matthews","doi":"10.1093/aje/kwae129","DOIUrl":"10.1093/aje/kwae129","url":null,"abstract":"Randomized trials estimate the average treatment effect within individuals who are eligible, invited, and agree to enroll. However, decision-makers often require evidence that extends beyond the trial's enrolled population to inform policy or actions for their specific target population. Each decision-maker has distinct target populations, the composition of which may not often align with that of the trial population. As researchers, we should identify a decision-maker for whom we aim to generate evidence early in the research process. We can then specify a target population of their interest and determine if a policy or action can be informed using results from a trial alone, or if additional complementary real-world data and analysis are required. In this commentary, we outline 5 key groupings of decision-makers: policymakers, payers, purchasers, providers, and patients. We then specify relevant target populations for decision-makers interested in the effectiveness of beta-blockers after a myocardial infarction with preserved ejection fraction. Finally, we summarize the scenarios in which results from a randomized trial may or may not apply to these target populations and suggest relevant analytic approaches that can generate evidence to better align with a decision-maker's needs. This article is part of a Special Collection on Pharmacoepidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial cancer survival in populations of African descent. 非洲裔人口的子宫内膜癌存活率。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae086

Heidy N Medina, Frank J Penedo, Jacqueline Deloumeaux, Clarisse Joachim, Tulay Koru-Sengul, Jonathan Macni, Bernard Bhakkan, Jessica Peruvien, Matthew P Schlumbrecht, Paulo S Pinheiro

{"title":"Endometrial cancer survival in populations of African descent.","authors":"Heidy N Medina, Frank J Penedo, Jacqueline Deloumeaux, Clarisse Joachim, Tulay Koru-Sengul, Jonathan Macni, Bernard Bhakkan, Jessica Peruvien, Matthew P Schlumbrecht, Paulo S Pinheiro","doi":"10.1093/aje/kwae086","DOIUrl":"10.1093/aje/kwae086","url":null,"abstract":"To examine whether the endometrial cancer (EC) survival disadvantage among Black populations is US-specific, a comparison between African-descent populations from different countries with a high development index is warranted. We analyzed 28 213 EC cases from cancer registries in Florida (2005-2018) and the French Caribbean islands of Martinique (2005-2018) and Guadeloupe (2008-2018) combined. Kaplan-Meier and all-cause Cox proportional hazards models were used to compare survival. Models were stratified by EC histology type and the main predictor examined was race/ethnicity (non-Hispanic White [NHW] and no-Hispanic Black [NHB] women in the United States versus Black women residing in the Caribbean). For endometrioid and nonendometrioid EC, after adjusting for age, histology, stage at diagnosis, receipt of surgery, period of diagnosis, and poverty level, US NHB women and Caribbean Black women had a higher risk of death relative to US NHW women. There was no difference between US NHB and Caribbean Black women (hazard ratio [HR] = 1.07; 95% CI, 0.88-1.30) with endometrioid EC. However, Caribbean Black women with nonendometrioid carcinomas had a 40% higher risk of death (HR = 1.40; 95% CI, 1.13-1.74) than US NHB women. The low EC survival among US Black women extends to foreign populations of African descent. For the aggressive nonendometrioid ECs, survival among Caribbean Black women outside of the United States is considerably worse. This article is part of a Special Collection on Gynecological Cancers.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residential proximity to agricultural pesticide use and cardiovascular disease risk factors among adult Latina women in California's Salinas Valley. 加利福尼亚州萨利纳斯河谷拉丁裔成年妇女居住地与使用农业杀虫剂的距离和心血管疾病风险因素。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae118

Lucia Calderon, Marcella Warner, Robert B Gunier, Stephen Rauch, Kimberly G Hazard, Katherine Kogut, Brenda Eskenazi, Jacqueline M Torres

{"title":"Residential proximity to agricultural pesticide use and cardiovascular disease risk factors among adult Latina women in California's Salinas Valley.","authors":"Lucia Calderon, Marcella Warner, Robert B Gunier, Stephen Rauch, Kimberly G Hazard, Katherine Kogut, Brenda Eskenazi, Jacqueline M Torres","doi":"10.1093/aje/kwae118","DOIUrl":"10.1093/aje/kwae118","url":null,"abstract":"Cardiovascular disease is a leading cause of death worldwide. There is limited evidence that exposure to current-use pesticides may contribute to cardiovascular disease risk. We examined the association between residential proximity to the application of agricultural pesticides and cardiovascular risk factors among 484 adult women in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study, a cohort based in an agricultural region of California. Outcome assessment was completed between 2010 and 2013. Using participant residential addresses and California's Pesticide Use Reporting database, we estimated agricultural pesticide use within 1 km of residences during the 2-year period preceding outcome assessment. We used Bayesian hierarchical modeling to evaluate associations between exposure to 14 agricultural pesticides and continuous measures of waist circumference, body mass index, and blood pressure. Each 10-fold increase in paraquat application around homes was associated with increased diastolic blood pressure (β = 2.60 mm Hg; 95% credible interval [CrI], 0.27-4.89) and each 10-fold increase in glyphosate application was associated with increased pulse pressure (β = 2.26 mm Hg; 95% CrI, 0.09-4.41). No meaningful associations were observed for the other pesticides examined. Our results suggest that paraquat and glyphosate pesticides may affect cardiovascular disease development in women with chronic environmental exposure. This article is part of a Special Collection on Environmental Epidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted learning with an undersmoothed LASSO propensity score model for large-scale covariate adjustment in health-care database studies. 在医疗保健数据库研究中使用下平滑拉索倾向得分模型进行有针对性的学习，以进行大规模协方差调整。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-11-04 DOI: 10.1093/aje/kwae023

Richard Wyss, Mark van der Laan, Susan Gruber, Xu Shi, Hana Lee, Sarah K Dutcher, Jennifer C Nelson, Sengwee Toh, Massimiliano Russo, Shirley V Wang, Rishi J Desai, Kueiyu Joshua Lin

{"title":"Targeted learning with an undersmoothed LASSO propensity score model for large-scale covariate adjustment in health-care database studies.","authors":"Richard Wyss, Mark van der Laan, Susan Gruber, Xu Shi, Hana Lee, Sarah K Dutcher, Jennifer C Nelson, Sengwee Toh, Massimiliano Russo, Shirley V Wang, Rishi J Desai, Kueiyu Joshua Lin","doi":"10.1093/aje/kwae023","DOIUrl":"10.1093/aje/kwae023","url":null,"abstract":"Least absolute shrinkage and selection operator (LASSO) regression is widely used for large-scale propensity score (PS) estimation in health-care database studies. In these settings, previous work has shown that undersmoothing (overfitting) LASSO PS models can improve confounding control, but it can also cause problems of nonoverlap in covariate distributions. It remains unclear how to select the degree of undersmoothing when fitting large-scale LASSO PS models to improve confounding control while avoiding issues that can result from reduced covariate overlap. Here, we used simulations to evaluate the performance of using collaborative-controlled targeted learning to data-adaptively select the degree of undersmoothing when fitting large-scale PS models within both singly and doubly robust frameworks to reduce bias in causal estimators. Simulations showed that collaborative learning can data-adaptively select the degree of undersmoothing to reduce bias in estimated treatment effects. Results further showed that when fitting undersmoothed LASSO PS models, the use of cross-fitting was important for avoiding nonoverlap in covariate distributions and reducing bias in causal estimates.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of adolescent to midlife weight change with age at natural menopause: a population study of 263,586 women in Norway. 青春期至中年期体重变化与自然绝经年龄的关系：一项针对 263,586 名挪威女性的人口研究。

IF 5 2区医学

American journal of epidemiology Pub Date : 2024-10-31 DOI: 10.1093/aje/kwae426

Julie R Langås, Anne Eskild, Solveig Hofvind, Elisabeth K Bjelland

{"title":"The association of adolescent to midlife weight change with age at natural menopause: a population study of 263,586 women in Norway.","authors":"Julie R Langås, Anne Eskild, Solveig Hofvind, Elisabeth K Bjelland","doi":"10.1093/aje/kwae426","DOIUrl":"https://doi.org/10.1093/aje/kwae426","url":null,"abstract":"Age at menopause varies considerably among women and is linked to health after menopause. Body mass index is associated with age at natural menopause, but the influence of weight change remains unclear. Thus, we studied associations of adolescent to midlife weight change with age at natural menopause. We performed a retrospective population-based cohort study of 263,586 women aged 50-69 years attending BreastScreen Norway (2006-2015). The associations were estimated as hazard ratios (HRs) for having reached menopause using Cox proportional hazard models. We included nine categories of weight change based on recalls of adolescent weight compared to peers and quartiles of midlife weight in kilograms. We adjusted for year and country of birth, education, number of childbirths, height, smoking, and exercise. Women with the largest estimated weight loss had highest hazard of reaching menopause (adjusted HR 1.11, 95% CI: 1.06-1.17) compared to women with estimated stable average weight. Conversely, women with the largest estimated weight gain had lower hazard (adjusted HR 0.96, 95% CI: 0.93-0.99). Women with estimated stable high weight had lowest hazard of reaching menopause (adjusted HR 0.93, 95% CI: 0.90-0.95). Our findings suggest that changes in body weight across the life course may influence the timing of menopause.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0