American journal of epidemiology最新文献_第2页

Retraction and replacement of: Depression at the intersection of race/ethnicity, sex/gender, and sexual orientation in a nationally representative sample of US adults: a design-weighted intersectional MAIHDA. 撤回和替换：在美国成年人的全国代表性样本中，种族/民族、性/性别和性取向交叉的抑郁症：设计加权交叉MAIHDA。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag143

引用次数: 0

Response to "Secundum cavere, tertium sanare in counterfactual decision-making". 对《反事实决策》中“第二个洞穴，Tertium Sanare”的回应。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag184

Amit N Sawant, Mats J Stensrud

引用次数: 0

The link between life satisfaction and outcome-wide health: evidence from the Canadian Longitudinal Study on Aging. 生活满意度与整体健康之间的联系：来自加拿大老龄化纵向研究的证据。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag088

Sofia L Panasiuk, Laura C Rosella, Elizabeth Page-Gould, Felix Cheung

{"title":"The link between life satisfaction and outcome-wide health: evidence from the Canadian Longitudinal Study on Aging.","authors":"Sofia L Panasiuk, Laura C Rosella, Elizabeth Page-Gould, Felix Cheung","doi":"10.1093/aje/kwag088","DOIUrl":"10.1093/aje/kwag088","url":null,"abstract":"A promising avenue for improving physical health and reducing health risks in older adulthood is intervening on transdiagnostic protective factors-those that form the mechanisms of several diseases. A potential candidate for a transdiagnostic protective factor is subjective well-being (SWB). Despite accumulating evidence favoring SWB as a protective factor, individual studies tend to neglect the cumulative effect of publication bias, explicitly specifying a causal model, and the possibility of alternative causal models that guide the selection of confounders. Using 3 waves of longitudinal data from the Canadian Longitudinal Study on Aging with a sample of 51 338 older adults, we tested whether the relationships between life satisfaction and 23 health outcomes (e.g., cancer, arthritis, asthma) were robust to alternative causal model specifications. An increase in life satisfaction, according to the preferred causal model, predicted a 3%-31% reduction in the risk of diagnosis for several health outcomes 3 years later-including osteoarthritis, movement disorders, and respiratory tract diseases-and predicted greater self-rated general health. Importantly, these effects persisted under different causal model specifications. These results suggest that life satisfaction is prospectively linked to multiple positive health outcomes and demonstrate the value of an analytical framework that acknowledges the uncertainty inherent in confounder selection.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2528-2536"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood poverty duration, timing, and severity from adolescence to early midlife and biological aging. 从青春期到中年早期和生物衰老的邻里贫困持续时间、时间和严重程度。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag176

Alena Sorensen D'Alessio, Kathleen Mullan Harris, Allison E Aiello, Brandt Levitt, Sylvie Tuder, Lauren Gaydosh, Chantel L Martin

{"title":"Neighborhood poverty duration, timing, and severity from adolescence to early midlife and biological aging.","authors":"Alena Sorensen D'Alessio, Kathleen Mullan Harris, Allison E Aiello, Brandt Levitt, Sylvie Tuder, Lauren Gaydosh, Chantel L Martin","doi":"10.1093/aje/kwag176","DOIUrl":"10.1093/aje/kwag176","url":null,"abstract":"Neighborhood socioeconomic disadvantage is linked to accelerated biological aging using DNA methylation; however, limited knowledge exists of the relationship between duration or timing of exposure to neighborhood poverty across life stages and biological aging, measured by epigenetic clocks. Existing research has relied on samples with limited racial and gender diversity. We examined the relationship between multiple dimensions of neighborhood poverty (duration, life stage of first exposure, life stage exposure trajectories, and severity) and biological aging using data from 3637 participants followed for 25 years in the National Longitudinal Study of Adolescent to Adult Health. We employed survey linear regression models to estimate associations for 3 epigenetic clocks: GrimAge2, PhenoAge, and DunedinPACE. In the total sample, only 8% of participants experienced neighborhood poverty across all life stages, which differed starkly by race (non-Hispanic Blacks: 26% vs non-Hispanic Whites: 4%). We found that each additional life stage of exposure to neighborhood poverty was associated with significant biological age acceleration. Experiencing neighborhood poverty in mid-adulthood was consistently associated with accelerated biological aging. Our results suggest a relationship between duration and timing of exposure to neighborhood poverty and accelerated biological aging across key biological clocks, indicating possible lasting cellular level effects of residential context.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2549-2557"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handling of multicohort data in pooled analysis of environmental exposures: confounding by cohort of the relationship between perfluoroalkyl substances and birthweight in the ECHO Program. 环境暴露汇总分析中多队列数据的处理：ECHO计划中全氟烷基物质与出生体重之间关系的队列混淆

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag131

Andreas M Neophytou, Sheryl Magzamen, Brianna F Moore, Akram Alshawabkeh, Carrie V Breton, Alison E Hipwell, Kristen Lyall, John D Meeker, Thomas G O'Connor, Emily Oken, Rita S Strakovsky, Dana Dabelea, For The Echo Cohort Consortium

{"title":"Handling of multicohort data in pooled analysis of environmental exposures: confounding by cohort of the relationship between perfluoroalkyl substances and birthweight in the ECHO Program.","authors":"Andreas M Neophytou, Sheryl Magzamen, Brianna F Moore, Akram Alshawabkeh, Carrie V Breton, Alison E Hipwell, Kristen Lyall, John D Meeker, Thomas G O'Connor, Emily Oken, Rita S Strakovsky, Dana Dabelea, For The Echo Cohort Consortium","doi":"10.1093/aje/kwag131","DOIUrl":"10.1093/aje/kwag131","url":null,"abstract":"The relationship between exposure to perfluoroalkyl substances (PFAS) and birthweight remains unclear. Pooling data across multiple cohorts can increase power, leading to more representative populations and exposure distributions, but confounding by cohort can be a major source of bias. To understand this potential bias, we assessed the relationship between exposure to 5 PFAS and birthweight utilizing data from 5480 mother-infant dyads across 17 Environmental influences on Child Health Outcomes (ECHO) Cohort sites. The relationship was assessed in several ways: covariate-adjusted models without cohort adjustment as well as adjustment via fixed and random effects. Findings from analysis with cohort adjustment resulted in significant inverse relationships for 4 of the 5 PFAS considered. Adjustment via fixed and random effects produced similar findings. Failure to adjust for cohort resulted in biases of varying directions and magnitudes depending on the PFAS considered. Results were supported in simulated data. In this study, we saw evidence of confounding bias by cohort even after adjustment for covariates, while adjustment by both fixed and random effects for cohort resulted in comparable results.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2576-2584"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148215662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme risk protection order policies and homicide risk among cohabitants of handgun owners. 极端风险保护令政策与手枪持枪者同居者凶杀风险。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag173

Nhan Tran, Yifan Zhang, Jessica Handy, Matthew Miller, Veronica A Pear, David M Studdert, Sonja A Swanson

{"title":"Extreme risk protection order policies and homicide risk among cohabitants of handgun owners.","authors":"Nhan Tran, Yifan Zhang, Jessica Handy, Matthew Miller, Veronica A Pear, David M Studdert, Sonja A Swanson","doi":"10.1093/aje/kwag173","DOIUrl":"10.1093/aje/kwag173","url":null,"abstract":"Extreme Risk Protection Orders (ERPO), known as Gun Violence Restraining Orders in California, are designed to reduce gun violence by allowing courts to temporarily remove firearms from individuals who pose a risk to themselves or others. Population-level evidence on their impacts remains limited. We used the Longitudinal Study of Handgun Ownership and Transfer, which links California voter, mortality, and firearm transaction records, to evaluate the impact of California's ERPO law on homicide risk among cohabitants of handgun owners who are not themselves handgun owners. Using a difference-in-differences design, we compared changes in 1-year homicide risks before (2012-2015) and after (2016-2021) policy implementation among adults living with handgun owners vs those in households without known handgun owners. We estimated a 1-year difference of -0.42 (95% CI, -1.86 to 1.02) homicide deaths per 100 000 persons among cohabitants of handgun owners who are not themselves handgun owners, with null findings robust across sensitivity analyses. Though our findings did not suggest substantial population-level protective effects, ERPOs may still reduce risk of homicide among cohabitants of ERPO respondents in ways not detectable at the population level. At the population level, their effectiveness may depend on more frequent or better-targeted use.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2602-2607"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reallocation of 24-hour movement behaviour composition and mortality: exploring effect modification by sleep characteristics. 24小时运动行为构成与死亡率的再分配：探索睡眠特征对效果的影响。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag249

Wenxin Bian, Matthew N Ahmadi, John J Mitchell, Raaj Kishore Biswas, Nicholas A Koemel, Dorothea Dumuid, Sebastien F M Chastin, Joanna M Blodgett, Jean-Philippe Chaput, Mark Hamer, Emmanuel Stamatakis

{"title":"Reallocation of 24-hour movement behaviour composition and mortality: exploring effect modification by sleep characteristics.","authors":"Wenxin Bian, Matthew N Ahmadi, John J Mitchell, Raaj Kishore Biswas, Nicholas A Koemel, Dorothea Dumuid, Sebastien F M Chastin, Joanna M Blodgett, Jean-Philippe Chaput, Mark Hamer, Emmanuel Stamatakis","doi":"10.1093/aje/kwag249","DOIUrl":"https://doi.org/10.1093/aje/kwag249","url":null,"abstract":"Sleep, sedentary behaviour (SB), standing, light-intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) compose the 24-hour day, and reallocating time between these behaviours is associated with premature mortality; however, whether these associations differ by sleep characteristics remains unclear. We examined associations between time reallocations across these device-measured behaviours and all-cause, cardiovascular disease (CVD) and physical activity-related cancer mortality, and potential effect modification by sleep duration and regularity. We conducted a population-based prospective cohort study among UK Biobank participants and applied compositional Cox regression. In 68 995 adults, 2668 deaths occurred over a mean follow-up of 8.0 years. Among participants meeting sleep duration guidelines, reallocating 30-minutes from sleep to standing, LPA or MVPA was favourably associated with all-cause mortality, with HRs of 0.85 (95%CI 0.79, 0.92), 0.87 (0.81, 0.94), and 0.80 (0.74, 0.87), respectively. Among short sleepers, reallocating 30-minutes from sleep to SB, standing or LPA was adversely associated with CVD mortality, with HRs of 1.18 (1.04, 1.34), 1.20 (1.04, 1.38), and 1.18 (1.03, 1.35), respectively. Beneficial associations of reallocating SB to sleep were evident among both regular sleepers and irregular sleepers. These observational findings suggest that associations between 24-hour behavioural reallocations and mortality may vary according to sleep characteristics.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging electronic health record data to evidence collider stratification bias and inform clinical epidemiology: obesity, diabetes, and rotator cuff tears. 利用电子健康记录数据来证明碰撞分层偏差并告知临床流行病学：肥胖、糖尿病和肩袖撕裂。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag117

Simone D Ueland, Til B Basnet, Wenting Liu, Henry H Ong, Srushti Gangreddi, Wei-Qi Wei, Wanqing Wen, Katherine E Hartmann, Nitin B Jain, Ayush Giri

{"title":"Leveraging electronic health record data to evidence collider stratification bias and inform clinical epidemiology: obesity, diabetes, and rotator cuff tears.","authors":"Simone D Ueland, Til B Basnet, Wenting Liu, Henry H Ong, Srushti Gangreddi, Wei-Qi Wei, Wanqing Wen, Katherine E Hartmann, Nitin B Jain, Ayush Giri","doi":"10.1093/aje/kwag117","DOIUrl":"10.1093/aje/kwag117","url":null,"abstract":"Electronic health record (EHR) data are increasingly used for case-control investigations. Using multiple control groups in de-identified EHR data, we evidence how conditioning on imaging (descendant of a collider: symptomatology) can perturb exposure estimations enough to reverse conclusions. Because imaging is often required for rotator cuff tear diagnosis, some argue imaging should be required for control selection. We constructed 2 control groups (with vs without imaging) to evaluate selection bias through collider stratification involving metabolic exposures-body mass index (BMI), type 1 diabetes (T1D), and type 2 diabetes (T2D)-and rotator cuff tears. Cases and controls were identified using validated algorithms. We compared baseline characteristics and performed multivariable logistic regression across designs. Cases were older and more likely to have arthritis (57%), ligamentous disease (9%), and prior shoulder injury (99%) than controls. Controls requiring imaging more closely resembled cases than controls not requiring imaging, with more arthritis (9% vs 1%), ligamentous disease (6% vs 2%), and prior shoulder injury (54% vs 7%). T1D prevalence was 3% in cases, 4% in controls with imaging, and 1% in controls without, compared to ~1% nationally. T1D was positively associated with tears using controls without imaging (aOR = 1.78; 95% CI, 1.64-1.92), but inversely using controls with imaging (aOR = 0.75; 0.57-0.97).","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2592-2601"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-period-cohort analysis of low birth weight, early-term delivery, induction, and cesarean-section, US births 1990-2019. 1990-2019年美国出生低出生体重、早产、引产和剖宫产的年龄-时期队列分析

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag147

Chloe A Teasdale, Sean Locke, Zachary Shahn, Saskia Rueda, Elizabeth A Kelly, Francisco Bolumar, Heidi E Jones

{"title":"Age-period-cohort analysis of low birth weight, early-term delivery, induction, and cesarean-section, US births 1990-2019.","authors":"Chloe A Teasdale, Sean Locke, Zachary Shahn, Saskia Rueda, Elizabeth A Kelly, Francisco Bolumar, Heidi E Jones","doi":"10.1093/aje/kwag147","DOIUrl":"10.1093/aje/kwag147","url":null,"abstract":"We conducted an age-period-cohort (APC) analysis to distinguish age, period, and cohort effects underlying temporal trends in low birth weight (LBW: <2500 g), early-term deliveries (ETD: 37-38 weeks), induction, and cesarean-section (c-section) using US birth records from 1994-2019 for all singleton, first, full-term (37-44 weeks gestation) births (n = 8 194 523). Using the APC-interaction method, we estimated age, period, and cohort effects as odds ratios with 95% CI. Age and period effects were observed for all outcomes. Pregnant women/people aged 40-44 years had increased odds of LBW (OR 1.23, 95% CI, 1.19-1.26), ETD (OR 1.24, 95% CI, 1.23-1.26), induction (OR 1.05, 95% CI, 1.04-1.06), and c-section (OR 2.28, 95% CI, 2.26-2.30) compared to the total population. Odds of LBW (OR 1.14, 95% CI, 1.13-1.16), ETD (OR 1.11, 95% CI, 1.10-1.12), and induction (OR 1.71, 95%,CI, 1.70-1.72) were higher in 2019 compared to the study period average. Cohort effects not explained by age and period effects were observed for women aged 40-44 years in 2019 indicated by higher odds of ETD (OR 1.08, 95% CI, 1.05-1.10), induction (1.10, 95% CI, 1.07-1.12), and c-section (OR 1.09, 95% CI, 1.06-1.11). These findings suggest obstetric management of pregnant women ≥40 years changed in recent decades in ways not expected based on age and temporal trends alone.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2640-2647"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shifting burden of childhood cancer mortality in the United States: progress and persistent inequities. 转移美国儿童癌症死亡率的负担：进步和持续的不平等。

IF 4.1 2区医学

American journal of epidemiology Pub Date : 2026-10-07 DOI: 10.1093/aje/kwag169

Jessica L Baedke, Qi Liu, Shizue Izumi, Tomoko Yoshida, Nishan Lamichhane, Sahar Aliabadi, José Miguel Martinez, I-Chan Huang, Gregory T Armstrong, Yutaka Yasui

{"title":"Shifting burden of childhood cancer mortality in the United States: progress and persistent inequities.","authors":"Jessica L Baedke, Qi Liu, Shizue Izumi, Tomoko Yoshida, Nishan Lamichhane, Sahar Aliabadi, José Miguel Martinez, I-Chan Huang, Gregory T Armstrong, Yutaka Yasui","doi":"10.1093/aje/kwag169","DOIUrl":"10.1093/aje/kwag169","url":null,"abstract":"While 5-year survival following childhood cancer rose greatly from ~60% in the mid-1970s to 85% today, inequities persist and conventional survival metrics obscure the true burden and shifting distribution of deaths. To address this, we used Surveillance, Epidemiology, and End Results registries to evaluate excess mortality rates and counts (AER and AEC), new metrics quantifying mortality attributable to childhood cancer, among 47 545 US children diagnosed before age 20 during 1975-2014, with follow-up through 2018. We quantified trends across subgroups and assessed modification by county-level income and rurality. AER declined across groups but at different magnitudes. From 1975-1979 to 2010-2014, declines were 75% in non-Hispanic White (NHW), 62% in non-Hispanic Black, and ~63% in Hispanic and Asian/Pacific Islander children. Among non-Hispanic American Indian/Alaska Native children, AER fell briefly with no clear improvement subsequently. Absolute burden shifted: AEC fell among NHW (8874 in 1990-1994 to 5134 in 2010-2014) but rose among other subgroups (4826 to 5213). By 2010-2014, non-NHW children accounted for more deaths despite >15 000 fewer diagnoses than NHW children. These findings show a shifting national burden: Despite overall survival gains, persistent and sometimes worsening inequities mean deaths are increasingly concentrated among non-NHW subgroups.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2568-2575"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0