American journal of epidemiology最新文献_第10页

Updated CP*Trends: an online tool to compare cohort and period trends across cancer sites. 更新的 CP*Trends：比较不同癌症部位的队列和时期趋势的在线工具。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae398

Theodore R Holford, Huann-Sheng Chen, Michael J Kane, Martin Krapcho, David Annett, Len Esclamado, Asya Melkonyan, Eric J Feuer

{"title":"Updated CP*Trends: an online tool to compare cohort and period trends across cancer sites.","authors":"Theodore R Holford, Huann-Sheng Chen, Michael J Kane, Martin Krapcho, David Annett, Len Esclamado, Asya Melkonyan, Eric J Feuer","doi":"10.1093/aje/kwae398","DOIUrl":"10.1093/aje/kwae398","url":null,"abstract":"CP*Trends is a widely used Surveillance, Epidemiology, and End Results Program (SEER) website used to explore temporal effects of period and cohort on cancer incidence and mortality. It provides a graphical display of smoothed rates, and a C-P score that helps to assess the magnitude of the effect of cohort and period. This update provides results for African Americans and Whites. The C-P score has an intrinsic bias favoring cohort because there are many more cohorts than periods. An adjusted C-P score removes some of this advantage. Bootstrap confidence intervals are given, which allow one to see the effects of different sample sizes on the model results. Finally, users may control window size used in the smoothing algorithm, which helps to avoid oversmoothing or masking of trends. The method is illustrated using data on cervical cancer incidence trends for African Americans and Whites, 1975-2018. Rates are higher for African Americans, and both races have contributions for cohort. However, the period effect is only strongly evident in Whites. Visual inspection of White trends suggests possible differences for those older and younger than age 50. These methods are applied in an interactive website displaying incidence and mortality trends for over 20 cancer sites in the United States.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2144-2149"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time experiences of racism and stress in association with postpartum weight retention: a longitudinal ecological momentary assessment study. 种族主义和压力的实时体验与产后体重保持的关系：一项纵向生态瞬间评估研究。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae424

Dara M Méndez, Amanda L Tapia, Sarah A Sanders, Andrea D Casas, Marquita Smalls, Esa M Davis, Stephen L Rathbun, Tiffany L Gary-Webb, Lora E Burke, Serwaa S Omowale, Linda A Adodoadji, John J Gianakas, Y Lai, Maisa Feghali, Meredith L Wallace

{"title":"Real-time experiences of racism and stress in association with postpartum weight retention: a longitudinal ecological momentary assessment study.","authors":"Dara M Méndez, Amanda L Tapia, Sarah A Sanders, Andrea D Casas, Marquita Smalls, Esa M Davis, Stephen L Rathbun, Tiffany L Gary-Webb, Lora E Burke, Serwaa S Omowale, Linda A Adodoadji, John J Gianakas, Y Lai, Maisa Feghali, Meredith L Wallace","doi":"10.1093/aje/kwae424","DOIUrl":"10.1093/aje/kwae424","url":null,"abstract":"Racial inequities in postpartum weight have been documented with limited studies on the influences of racism and other forms of discrimination. In a prospective longitudinal study applying ecological momentary assessment (EMA) and ambulatory assessment of weight, we measured the association between discrimination, stress, and postpartum weight change. The Postpartum Mothers Mobile Study is a cohort of 313 pregnant and birthing individuals who were followed during their second and third trimesters through 1 year postpartum. They were recruited in clinical settings between 2017 and 2020 in a major city center in Pennsylvania. Measures of racism and gender-based discrimination were collected via random EMA surveys throughout pregnancy and postpartum, and weight was collected via Bluetooth-enabled scales at least weekly. Among Black participants, a 10% increase in the number of days a participant experienced racial discrimination in the past month was associated with retaining 0.3 more pounds, a 10% increase in EMA gender discrimination was associated with retaining 0.4 more pounds, and EMA stress reported in the past month was associated with decreased weight retention. Chronic experiences of racial and gender discrimination may contribute to weight retention immediately after pregnancy and beyond.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2200-2210"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive associations of cannabis and alcohol outlet densities with assault injuries in California: a spatiotemporal analysis. 加利福尼亚州大麻和酒类销售点密度与袭击伤害的互动关联：时空分析。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae384

Ellicott C Matthay, Rafael Charris, Jennifer Ahern, Dorie E Apollonio, Victoria Jent, Laurie M Jacobs, Shelley Jung, Laura A Schmidt, Paul Gruenewald

{"title":"Interactive associations of cannabis and alcohol outlet densities with assault injuries in California: a spatiotemporal analysis.","authors":"Ellicott C Matthay, Rafael Charris, Jennifer Ahern, Dorie E Apollonio, Victoria Jent, Laurie M Jacobs, Shelley Jung, Laura A Schmidt, Paul Gruenewald","doi":"10.1093/aje/kwae384","DOIUrl":"10.1093/aje/kwae384","url":null,"abstract":"Recreational cannabis outlets may influence rates of interpersonal violence, but research has yielded inconsistent findings. Modification by alcohol outlet density may help explain inconsistencies. We estimated the impacts of recreational cannabis outlets on neighborhood-level assault injury rates in California and evaluated whether alcohol outlet density moderated these associations. We applied Bayesian spatiotemporal analyses to ZIP code-level statewide data on alcohol outlets, recreational cannabis outlets, and injuries and deaths due to firearm and nonfirearm assault, from 2017 to 2019, accounting for confounders and spatial autocorrelation. Using the model posteriors, we estimated parameters corresponding to hypothetical shifts in outlet densities, overall and by age, sex, and race/ethnicity. If recreational cannabis outlets were never introduced, we estimated that nonfirearm assault injuries would have been 1.63 per 100 000 lower (95% CI, -3.08 to 0.01), but we observed no association with firearm assault injuries (risk difference [RD] per 100 000: -0.07; 95% CI, -0.34 to 0.21). These associations did not depend on alcohol outlet density, but a hypothetical 20% reduction in alcohol outlet densities was associated with fewer firearm (RD per 100 000: -1.89; 95% CI, -0.46 to 0.09) and nonfirearm (RD per 100 000: -5.67; 95% CI, -7.44 to -3.95) assault injuries. The introduction of recreational cannabis outlets may have contributed to a small increase in nonfirearm assault injuries.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2304-2314"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using overlap weights to address extreme propensity scores in estimating restricted mean counterfactual survival times. 在估算受限平均反事实生存时间时使用重叠权重解决极端倾向得分问题。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae416

Zhiqiang Cao, Lama Ghazi, Claudia Mastrogiacomo, Laura Forastiere, F Perry Wilson, Fan Li

{"title":"Using overlap weights to address extreme propensity scores in estimating restricted mean counterfactual survival times.","authors":"Zhiqiang Cao, Lama Ghazi, Claudia Mastrogiacomo, Laura Forastiere, F Perry Wilson, Fan Li","doi":"10.1093/aje/kwae416","DOIUrl":"10.1093/aje/kwae416","url":null,"abstract":"Although inverse probability of treatment weighting (IPTW) is a commonly used approach for treatment comparisons in observational data, the resulting estimates may be subject to bias and excessively large variance under lack of overlap. By smoothly down-weighting units with extreme propensity scores (ie, those that are close, or equal, to 0 or 1), overlap weighting (OW) can help mitigate the bias and variance issues associated with IPTW. Although theoretical and simulation results have supported the use of OW with continuous and binary outcomes, its performance with survival outcomes remains to be further investigated, especially when the target estimand is defined based on the restricted mean survival time (RMST). We combine propensity score weighting and inverse probability of censoring weighting to estimate the restricted mean counterfactual survival times, and provide computationally efficient variance estimators when the propensity scores are estimated by logistic regression and the censoring process is estimated by Cox regression. We conduct simulations to compare the performance of weighting methods in terms of bias, variance, and 95% interval coverage, under various degrees of overlap. Under moderate and weak overlap, we demonstrate the advantage of OW over IPTW, trimming and truncation, with respect to bias, variance, and coverage when estimating RMST.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2402-2411"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing metabolomic signatures related to coffee and tea consumption and their association with incidence and dynamic progression of type 2 diabetes: a multi-state analysis. 描述与饮用咖啡和茶有关的代谢组特征及其与 2 型糖尿病发病率和动态进展的关系：多州分析。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae400

Guzhengyue Zheng, Shanshan Ran, Zhengmin Qian, Fei Tian, Hui Shi, Michael Elliott, Maya Tabet, Yin Yang, Hualiang Lin

{"title":"Characterizing metabolomic signatures related to coffee and tea consumption and their association with incidence and dynamic progression of type 2 diabetes: a multi-state analysis.","authors":"Guzhengyue Zheng, Shanshan Ran, Zhengmin Qian, Fei Tian, Hui Shi, Michael Elliott, Maya Tabet, Yin Yang, Hualiang Lin","doi":"10.1093/aje/kwae400","DOIUrl":"10.1093/aje/kwae400","url":null,"abstract":"The impact of tea and coffee consumption and related metabolomic signatures on dynamic transitions from diabetes-free status to incident type 2 diabetes (T2D), and subsequently to T2D-related complications and death, was investigated. We included data on 438 970 participants in the UK Biobank who were free of diabetes and diabetes complications at baseline. Of these participants, 212 146 had information on all metabolic biomarkers. We identified tea- and coffee-related metabolomic signatures using elastic net regression models and examined associations of tea and coffee intake and related metabolomic signatures with the onset and progression of T2D, using multistate regression models. Tea and coffee consumption and related metabolomic signatures were inversely associated with the risk of 5 T2D transitions. For example, hazard ratios (95% CIs) per SD increase of the tea-related metabolomic signature were 0.87 (0.85-0.89), 0.97 (0.95-0.99), 0.91 (0.90-0.92), 0.92 (0.91-0.94), and 0.91 (0.90-0.92) for transitions from a diabetes-free state to incident T2D, from a diabetes-free state to all-cause death, from incident T2D to T2D complications, from incident T2D to death, and from T2D complications to death, respectively. These findings highlight the benefit of tea and coffee intake in reducing the risk of occurrence and progression of T2D.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2385-2393"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Education, health-based selection, and the widening mortality gap between Americans with and without a 4-year college degree. 教育、基于健康的选择以及拥有和未拥有四年制大学学位的美国人之间不断扩大的死亡率差距。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae420

Anne Case, Angus Deaton

{"title":"Education, health-based selection, and the widening mortality gap between Americans with and without a 4-year college degree.","authors":"Anne Case, Angus Deaton","doi":"10.1093/aje/kwae420","DOIUrl":"10.1093/aje/kwae420","url":null,"abstract":"Gaps in life expectancy between Americans with and without a college degree have widened markedly over the past 3 decades. One explanation points to increasing educational attainment changing the type of people with and without a degree. If preexisting health condition in the 2 education groups changes as the fraction with a degree changes, health selection might explain the widening mortality gap. We examined this explanation using (1) education and mortality in each birth cohort of men and women from 1940 to 1988, and (2) the natural experiment caused by the Vietnam War, which increased the fractions of men with a degree in affected birth cohorts. For each cohort, we examined the relationship between the mortality gap and the fraction of the study population with a degree. We found no relationship between the fraction of a birth cohort with a degree and the corresponding mortality gap. For men, the large increase in college attendance spurred by the Vietnam War has no perceptible counterpart in the mortality gap. The evidence from the natural experiment induced by the Vietnam War does not support a health-selection explanation for the widening mortality gap. This article is part of a Special Collection on Methods in Social Epidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2281-2286"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health care access domains and treatment as mediators of ovarian cancer racial disparities in survival: a structural equation modeling analysis in SEER-Medicare. 作为卵巢癌种族生存差异中介因素的医疗服务领域和治疗：SEER-Medicare 的结构方程模型分析。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae404

Clare Meernik, Quan Chen, Lauren E Wilson, Ashwini Joshi, Fariha Rahman, Maria Pisu, Margaret Liang, Kevin C Ward, Margaret Gates Kuliszewski, Thomas Tucker, Andrew Berchuck, Bin Huang, Tomi Akinyemiju

{"title":"Health care access domains and treatment as mediators of ovarian cancer racial disparities in survival: a structural equation modeling analysis in SEER-Medicare.","authors":"Clare Meernik, Quan Chen, Lauren E Wilson, Ashwini Joshi, Fariha Rahman, Maria Pisu, Margaret Liang, Kevin C Ward, Margaret Gates Kuliszewski, Thomas Tucker, Andrew Berchuck, Bin Huang, Tomi Akinyemiju","doi":"10.1093/aje/kwae404","DOIUrl":"10.1093/aje/kwae404","url":null,"abstract":"Racial differences in health care access (HCA) may contribute to disparities in ovarian cancer (OC) survival. We used structural equation models (SEMs) to examine associations between race and HCA domains (affordability, availability, accessibility) in relation to overall and OC-specific mortality. Non-Hispanic (NH)-Black and non-Black (Hispanic, NH-White) women diagnosed with OC in 2008-2015 were identified from Surveillance, Epidemiology, and End Results-Medicare. Cox proportional hazards regression was used to conduct mediation analysis for associations between race and HCA domains with overall and OC-specific mortality. SEM models adjusting for demographic and clinical covariates were used to estimate hazard ratios (HRs) and 95% CIs. A total of 4629 eligible patients with OC were identified, including 255 (5.5%) patients who were NH-Black. In SEM adjusting for demographic, clinical, and HCA latent variables, there was a total effect of NH-Black race on overall (HR, 1.11, 95% CI, 1.03-1.19) and OC-specific mortality (HR, 1.16; 95% CI, 1.08, 1.24), which was primarily driven by a direct effect. There was a modest indirect association between NH-Black race and mortality through decreased treatment receipt, though not through HCA. There is a need for studies investigating additional social and biological mechanisms that contribute to worse cancer survival among NH-Black patients. This article is part of a Special Collection on Gynecological Cancer.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2230-2240"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competing classes confront competing risks: unraveling mortality inequities with parametric g-computation. 竞争阶层面对竞争风险：用参数 g 计算揭示死亡率的不平等。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae417

Jerzy Eisenberg-Guyot, Audrey Renson

引用次数: 0

Mechanisms linking prenatal environment and linear growth: the case of Ramadan during pregnancy. 产前环境与线性生长的关联机制：孕期斋月的案例。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae386

Fabienne Pradella, Reyn van Ewijk

{"title":"Mechanisms linking prenatal environment and linear growth: the case of Ramadan during pregnancy.","authors":"Fabienne Pradella, Reyn van Ewijk","doi":"10.1093/aje/kwae386","DOIUrl":"10.1093/aje/kwae386","url":null,"abstract":"Despite established links between prenatal nutritional deprivation and impaired offspring growth, the underlying dynamics and potential moderators remain largely unexplored. This study investigates the dynamics underlying Ramadan during pregnancy and its associations with children's linear growth, using data from the Indonesian Family Life Survey (1993-2015). We exploit Ramadan during pregnancy as a natural experiment, separating exposure from maternal background characteristics and season of birth effects. Using ordinary least squares and logistic regressions, we explore 2 key mechanisms predicted by medical theory. First, the realization of health impairments in response to prenatal shocks is influenced by postnatal circumstances. Our results reveal significant growth impairments primarily in children raised in poor sanitary conditions, which, by itself, is a risk factor for diminished linear growth. Second, we assess whether prenatal exposure to Ramadan prompts epigenetic shifts toward earlier reproductive activity, potentially at the expense of height growth. Our data show that women prenatally exposed to a Ramadan tend to have their first childbirth at a younger age, though menarche onset remains unaffected. These results suggest postnatal environments play a crucial role in mitigating sensitivity to prenatal shocks, highlighting the critical need for favorable living conditions for all children.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2315-2324"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank. 异质负荷与大脑白质加速老化之间的关系：英国生物库的研究结果。

IF 4.8 2区医学

American journal of epidemiology Pub Date : 2025-08-05 DOI: 10.1093/aje/kwae396

Li Feng, Zhenyao Ye, Zewen Du, Yezhi Pan, Travis Canida, Hongjie Ke, Song Liu, Shuo Chen, L Elliot Hong, Peter Kochunov, Jie Chen, David K Y Lei, Edmond Shenassa, Tianzhou Ma

{"title":"Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.","authors":"Li Feng, Zhenyao Ye, Zewen Du, Yezhi Pan, Travis Canida, Hongjie Ke, Song Liu, Shuo Chen, L Elliot Hong, Peter Kochunov, Jie Chen, David K Y Lei, Edmond Shenassa, Tianzhou Ma","doi":"10.1093/aje/kwae396","DOIUrl":"10.1093/aje/kwae396","url":null,"abstract":"White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on WM brain aging remains unknown. In this study, we assessed cumulative stress using a multi-system composite allostatic load (AL) index based on inflammatory, anthropometric, respiratory, lipidemia, and glucose metabolism measures, and investigated its association with WM brain age gap (BAG), computed from diffusion tensor imaging data using a machine learning model, among 22 951 European ancestries aged 40 to 69 (51.40% women) from UK Biobank. Linear regression, Mendelian randomization, along with inverse probability weighting, and doubly robust methods, were used to evaluate the impact of AL on WM BAG adjusting for age, sex, socioeconomic, and lifestyle behaviors. We found increasing one AL score unit significantly increased WM BAG by 0.29 years in association analysis and by 0.33 years in Mendelian analysis. The age- and sex-stratified analysis showed consistent results among participants 45-54 and 55-64 years old, with no significant sex difference. This study demonstrated that higher chronic stress was significantly associated with accelerated brain aging, highlighting the importance of stress management in reducing dementia and neurodegenerative disease risks.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"2376-2384"},"PeriodicalIF":4.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0