Michael R Elliott, Jean M Kerver, Alexa Drew, Kaitlyn Watson, Breanna Kornatowski, Gwendolyn S Norman, Glenn E Copeland, Eva Leissou, Terri Ridenour, Shonda Kruger-Ndiaye, Tengfei Ma, Douglas Ruden, Charles Barone, Daniel P Keating, Robert J Sokol, Christine C Johnson, Nigel Paneth
{"title":"Obtaining a Probability Sample of a Pregnancy Cohort of Births: A Review of the Problem and a Practical Solution.","authors":"Michael R Elliott, Jean M Kerver, Alexa Drew, Kaitlyn Watson, Breanna Kornatowski, Gwendolyn S Norman, Glenn E Copeland, Eva Leissou, Terri Ridenour, Shonda Kruger-Ndiaye, Tengfei Ma, Douglas Ruden, Charles Barone, Daniel P Keating, Robert J Sokol, Christine C Johnson, Nigel Paneth","doi":"10.1093/aje/kwaf110","DOIUrl":"https://doi.org/10.1093/aje/kwaf110","url":null,"abstract":"<p><p>The Michigan Archive for Research on Child Health (MARCH) study produced a probability sample of Michigan births between 2017 and 2023, with data collection beginning at first prenatal visit and continuing up to age 4. Birth certificate data were used to create a sampling frame of hospitals and associated obstetric clinics, from which a probability-proportional-size sample of 10 hospitals was drawn. Close to 100 pregnancies were then recruited in clinics serving each sampled hospital, yielding a probability sample of 1,021 births. This sample was supplemented with 109 births from a certainty selection of a Flint, MI hospital, for a total sample of 1,130. The resulting response rate was high, with 100% of sampled hospitals and 65% of sampled clinics participating. Comparing the resulting sample with all 2017-2023 Michigan births showed close correspondence with respect to birth outcomes (birthweight, gestational age, Apgar scores, gestational diabetes) and mothers' demographics (age, race, education, marital status), with underrepresentation of Hispanic ethnicity and overrepresentation of reported smoking. Given the recent failures of two major prospective birth cohorts (the US National Childrens' Study and the UK Life Study), our work shows a way forward for representative pre- and post-natal studies of births.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel Stuckwisch, Aleena Bennett, Anaïs Rouanet, Lloyd J Edwards, Michael Crowe, Suzanne E Judd, D Leann Long
{"title":"The association between smoking status and aging cognitive trajectory accounting for bias in attrition.","authors":"Rachel Stuckwisch, Aleena Bennett, Anaïs Rouanet, Lloyd J Edwards, Michael Crowe, Suzanne E Judd, D Leann Long","doi":"10.1093/aje/kwaf107","DOIUrl":"https://doi.org/10.1093/aje/kwaf107","url":null,"abstract":"<p><p>Studies on the relationship between smoking and cognition yield conflicting results, potentially from survival bias. We examined the effect of smoking status on cognitive evolution, accounting for potential bias in attrition. We analyzed 21 216 Black and White participants from the REGARDS cohort study. In order to account for potential differential attrition, a sensitivity analysis compared the association between smoking status and age-sex-specific composite cognitive trajectories using linear mixed models, robust under missing at random assumption, and joint models, robust under the extended missing at random assumptions. Linear mixed model results indicated current smokers had lower overall composite cognitive scores compared to never smokers at baseline (-0.20, 95% confidence interval (CI): -0.23, -0.16) and at 14-years duration in the study (-0.26, 95% CI: -0.33, -0.20), also apparent when comparing current smokers to past smokers, and memory and verbal fluency composite scores. Joint modeling estimates yielded results similar to results from linear mixed models. Joint models are recommended as a potential means to investigate concerns about attrition, particularly in studies of factors associated with both cognition and mortality. This study provides further support that smoking is likely to have negative impacts on cognition.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of the LIBRA index with cognitive resilience to genetic susceptibility to dementia.","authors":"Maude Wagner, Jeanne Neuffer, Quentin Le Grand, Aniket Mishra, Claudine Berr, Stéphanie Debette, Catherine Helmer, Cécile Proust-Lima, Cécilia Samieri","doi":"10.1093/aje/kwaf108","DOIUrl":"https://doi.org/10.1093/aje/kwaf108","url":null,"abstract":"<p><p>The role of lifestyle and health-related factors in dementia risk has been established. However, how a combination of modifiable risk factors, as reflected by the LIBRA (LIfestyle for BRAin health) index, contributes to cognitive resilience to genetic susceptibility to dementia (CRgen) remains unclear. We selected 6,774 Three-City study participants without dementia at baseline (mean age=74 years) and with ≥2 cognitive measures over time. Genetic risk was defined through ApoE-ε4 carriage alone (ε4-carriers) or combined with high AD-specific genetic risk scores beyond ApoE (ε4-carriers/GRS-high). To define CRgen, we modeled and compared the cognitive slopes of at-risk individuals to their demographically similar peers without genetic risk; at-risk individuals with the most preserved cognition were defined as resilient (ε4-carriers [n=237]; ε4-carrier/GRS-high [n=319]), and the least preserved as non-resilient (ε4-carriers [n=866]; ε4-carrier/GRS-high [n=1,249]). Lower LIBRA risk scores at baseline, denoting healthier lifestyle and reduced dementia risk, were linearly associated with greater odds of CRgen, both in ε4-carriers (odds ratio [OR]=1.11;95%CI=1.05-1.18) and ε4-carriers/GRS-high (OR=1.16;95%CI=1.11-1.22). When examining the LIBRA components, cognitive activity and coronary heart diseases history showed the strongest independent associations with CRgen (all P≤.01). Genetically susceptible older adults can develop cognitive resilience, which may be promoted by lifestyle modifications and health management simultaneously.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of walking volume and intensity with incident gout: a population-based cohort study.","authors":"Ziying Wu, Ying Hu, Hongyi He, Yuqing Zhang, Nicola Dalbeth, Junqing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Jie Wei","doi":"10.1093/aje/kwaf109","DOIUrl":"https://doi.org/10.1093/aje/kwaf109","url":null,"abstract":"<p><p>Previous studies have reported that walking is associated with a lower risk of several metabolic diseases; however, evidence of its association with gout, a metabolic condition, is lacking. We conducted cohort studies using data from the UK Biobank (2013-2021) to examine the relationship of walking volume and intensity with the risk of incident gout. We included 92,066 participants who were free of gout and had valid baseline 7-day accelerometer data, which allowed us to derive walking volume (total steps), walking intensity (peak 30-minute cadence), and their combination (purposeful steps). Hazard ratios (HRs) for incident gout were estimated across different walking activity metrics groups using Cox proportional hazard models. During a mean follow-up period of 6.93 years, 706 participants developed incident gout. Walking volume and intensity alone showed no significant relationship to the risk of incident gout. However, compared with the low group (<5,000 steps/day) of purposeful steps, the risk of incident gout was lower in the middle group (5,000-7,999 steps/day) and high (≥8,000 steps/day) group, with adjusted HRs and 95% confidence intervals of 0.78 (0.66-0.94) and 0.72 (0.58-0.90), respectively (P for trend =0.003). These findings offer valuable insights for developing walking-based recommendations to prevent incident gout.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haesu Lee, Koji Kanayama, Kiichi Furuse, Makoto Shiraishi, Mutsumi Okazaki
{"title":"Re: \"A propensity score approach and a partitioned approach for the self-controlled case series design to evaluate safety of a 2-dose vaccine series: application to myocarditis/pericarditis following mRNA COVID-19 vaccination\".","authors":"Haesu Lee, Koji Kanayama, Kiichi Furuse, Makoto Shiraishi, Mutsumi Okazaki","doi":"10.1093/aje/kwae389","DOIUrl":"https://doi.org/10.1093/aje/kwae389","url":null,"abstract":"","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski
{"title":"Ending nuclear weapons, before they end us 1.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski","doi":"10.1093/aje/kwaf081","DOIUrl":"https://doi.org/10.1093/aje/kwaf081","url":null,"abstract":"","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariadne Rivera-Aguirre, Iván Díaz, Giselle Routhier, Cameron C McKay, Ellicott C Matthay, Samuel R Friedman, Kely M Doran, Magdalena Cerdá
{"title":"The effect of lifting eviction moratoria on fatal drug overdoses in the context of the COVID-19 pandemic in the US.","authors":"Ariadne Rivera-Aguirre, Iván Díaz, Giselle Routhier, Cameron C McKay, Ellicott C Matthay, Samuel R Friedman, Kely M Doran, Magdalena Cerdá","doi":"10.1093/aje/kwaf105","DOIUrl":"10.1093/aje/kwaf105","url":null,"abstract":"<p><p>Between May 2020 and December 2021, there were 159,872 drug overdose deaths in the US. Higher eviction rates have been associated with higher overdose mortality. Amid the economic turmoil caused by the COVID-19 pandemic, 43 states and Washington, DC, implemented eviction moratoria of varying durations. These moratoria reduced eviction filing rates, but their impact on fatal drug overdoses remains unexplored. We evaluated the effect of these policies on county-level overdose death rates by focusing on the dates the state eviction moratoria were lifted. We obtained mortality data from NCHS and eviction moratoria dates from the COVID-19 US State Policy Database. We employed a longitudinal targeted minimum-loss-based estimation with Super Learner to flexibly estimate the average treatment effect (ATE) of never lifting the moratoria. Lifting state eviction moratoria was associated with a 0.14 per 100,000 higher rate of monthly overdose mortality (95%CI: -0.03, 0.32), although confidence intervals were wide and included zero. Eviction moratoria may not be sufficient to prevent overdose mortality during crises such as the COVID-19 pandemic.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Cachón-Alonso, Laura Pulkki-Råback, Christian Hakulinen, Katja Pahkala, Suvi Rovio, Olli T Raitakari, Nina Hutri, Kaisla Komulainen, Marko Elovainio
{"title":"Association of childhood and adult socioeconomic status with adult social connection: a mediation analysis.","authors":"Laura Cachón-Alonso, Laura Pulkki-Råback, Christian Hakulinen, Katja Pahkala, Suvi Rovio, Olli T Raitakari, Nina Hutri, Kaisla Komulainen, Marko Elovainio","doi":"10.1093/aje/kwaf106","DOIUrl":"https://doi.org/10.1093/aje/kwaf106","url":null,"abstract":"<p><p>In this prospective cohort study, we explored associations of childhood socioeconomic status (SES) with social connection in adulthood, and to which extent these associations can be explained by SES in adulthood. We used data from the longitudinal Young Finns Study (n=1,775, 3-18 years at baseline). Childhood SES was assessed through parental income and educational attainment in 1980, and participants' own adult SES through income and educational attainment in 2007. The outcomes were three indicators of social connection measured in 2018-2020: 1) loneliness, 2) perceived social support and 3) frequency of social contact. SES indicators were analyzed separately using regression models and causal mediation analysis via marginal structural models. In the mediation analyses, low parental income was associated with higher loneliness, lower perceived social support, and less frequent social contact in adulthood while adjusting for parental and own educational attainment. The associations with loneliness and perceived social support were partially mediated by participants' income in adulthood. Conversely, the associations between parental educational attainment and social connection in adulthood were smaller, with confidence intervals including the null. These results emphasize that poor family financial conditions during childhood may have long-lasting implications for the development and maintenance of social connection throughout the lifespan.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erin G Sley, Tania A Desrosiers, Daniela Sotres-Alvarez, Suzan L Carmichael, Joanna Maselko, Mollie E Wood, Elizabeth C Ailes, Wendy N Nembhard, Wei Yang, Andrew F Olshan, And The National Birth Defects Prevention Study
{"title":"Association between maternal periconceptional dietary patterns and occurrence of orofacial clefts.","authors":"Erin G Sley, Tania A Desrosiers, Daniela Sotres-Alvarez, Suzan L Carmichael, Joanna Maselko, Mollie E Wood, Elizabeth C Ailes, Wendy N Nembhard, Wei Yang, Andrew F Olshan, And The National Birth Defects Prevention Study","doi":"10.1093/aje/kwaf102","DOIUrl":"https://doi.org/10.1093/aje/kwaf102","url":null,"abstract":"<p><p>Orofacial clefts (OFC) are a common birth defect with few known risk factors (e.g., smoking). Maternal diet is associated with birth defects, though the relationship with OFC is less clear as studies typically only investigate single nutrients. We assessed the association between periconceptional maternal diet and OFC in the United States, using the National Birth Defects Prevention Study (1997-2011), including 3,649 cases (2,480 cleft lip with/without palate [CL/P] and 1,169 cleft palate [CP]) and 10,584 controls (infants without a birth defect). Using latent class analysis, we derived dietary patterns based on relative consumption of self-reported food items via food frequency data. We used logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for the effect of dietary patterns on OFC. Four patterns were identified: Prudent (reference), Western, Low-Calorie Western, and Mexican. The Western diet had increased odds of CL/P (aOR: 1.3, CI: 1.2-1.5) and CP (aOR: 1.2, CI: 1.1-1.4). Low-Calorie Western (CL/P aOR: 1.2, CI: 1.0-1.4; CP aOR: 1.0, CI: 0.9-1.2) and Mexican diets (CL/P aOR: 1.1, CI: 0.9-1.3; CP aOR: 0.8, CI: 0.6-1.1) had a weaker or null association. Findings underscore the importance of further investigation into the effect of periconceptional diet on OFC occurrence.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Daniel, Lorraine T Dean, Catherine R Lesko, Harriett Telljohann, Lori E Biddle, Enrique F Schisterman, On Behalf Of The Editorial Board
{"title":"What Happens to Your Manuscript: Characteristics of Papers Published in Volume 193 of the American Journal of Epidemiology.","authors":"Sara Daniel, Lorraine T Dean, Catherine R Lesko, Harriett Telljohann, Lori E Biddle, Enrique F Schisterman, On Behalf Of The Editorial Board","doi":"10.1093/aje/kwaf104","DOIUrl":"https://doi.org/10.1093/aje/kwaf104","url":null,"abstract":"","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}