American journal of epidemiology最新文献_第4页

Causal effects of competing obstetrical interventions: mediators of placental abruption and perinatal mortality. 相互竞争的产科干预措施的因果效应：胎盘早破和围产期死亡率的中介因素。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae273

Cande V Ananth, Wen Wei Loh

{"title":"Causal effects of competing obstetrical interventions: mediators of placental abruption and perinatal mortality.","authors":"Cande V Ananth, Wen Wei Loh","doi":"10.1093/aje/kwae273","DOIUrl":"10.1093/aje/kwae273","url":null,"abstract":"Placental abruption, the premature placental separation, confers increased perinatal mortality risk with preterm delivery as an important pathway through which the risk appears mediated. Although pregnancies complicated by abruption are often delivered through an obstetrical intervention, many deliver spontaneously. We examined the contributions of clinician-initiated (PTDIND) and spontaneous (PTDSPT) preterm delivery at < 37 weeks as competing causal mediators of the abruption-perinatal mortality association. Using the Consortium for Safe Labor (2002-2008) data (n = 203 990; 1.6% with abruption), we applied a potential outcomes-based mediation analysis to decompose the total effect into direct and mediator-specific indirect effects through PTDIND and PTDSPT. Each mediated effect describes the reduction in the counterfactual mortality risk if that preterm delivery subtype was shifted from its distribution under abruption to without abruption. The total effect risk ratio (RR) of abruption on perinatal mortality was 5.4 (95% CI, 4.6-6.3). The indirect effect RRs for PTDIND and PTDSPT were 1.5 (95% CI, 1.4-1.6) and 1.5 (95% CI, 1.5-1.6), respectively; these corresponded to mediated proportions of 25% each. These findings underscore that PTDIND and PTDSPT each play essential roles in shaping perinatal mortality risks associated with placental abruption.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"625-634"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between long-term PM2.5 exposure and risk for pancreatic cancer: an application of social informatics. 长期 PM2.5 暴露与胰腺癌风险之间的关系：社会信息学的应用

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae271

Nrupen A Bhavsar, Kay Jowers, Lexie Z Yang, Sharmistha Guha, Xuan Lin, Sarah Peskoe, Hannah McManus, Lisa McElroy, Mercedes Bravo, Jerome P Reiter, Eric Whitsel, Christopher Timmins

{"title":"The association between long-term PM2.5 exposure and risk for pancreatic cancer: an application of social informatics.","authors":"Nrupen A Bhavsar, Kay Jowers, Lexie Z Yang, Sharmistha Guha, Xuan Lin, Sarah Peskoe, Hannah McManus, Lisa McElroy, Mercedes Bravo, Jerome P Reiter, Eric Whitsel, Christopher Timmins","doi":"10.1093/aje/kwae271","DOIUrl":"10.1093/aje/kwae271","url":null,"abstract":"There is a profound need to identify modifiable risk factors to screen and prevent pancreatic cancer. Air pollution, including fine particulate matter (PM2.5), is increasingly recognized as a risk factor for cancer. We conducted a case-control study using data from the electronic health record (EHR) of Duke University Health System, 15-year residential history, NASA satellite fine particulate matter (PM2.5), and neighborhood socioeconomic data. Using deterministic and probabilistic linkage algorithms, we linked residential history and EHR data to quantify long-term PM2.5 exposure. Logistic regression models quantified the association between a 1 interquartile range (IQR) increase in PM2.5 concentration and pancreatic cancer risk. The study included 203 cases and 5027 controls (median age of 59 years, 62% female, 26% Black). Individuals with pancreatic cancer had higher average annual exposure (9.4 μg/m3) as compared to an IQR increase in average annual PM2.5, which was associated with greater odds of pancreatic cancer (odds ratio = 1.20; 95% CI, 1.00-1.44). These findings highlight the link between elevated PM2.5 exposure and increased pancreatic cancer risk. They may inform screening strategies for high-risk populations and guide air pollution policies to mitigate exposure. This article is part of a Special Collection on Environmental Epidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"730-737"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the effectiveness of systemic heparin during arteriovenous fistula creation by emulating a target trial. 通过模仿目标试验评估动静脉瘘创建过程中全身使用肝素的效果。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae098

Patrick Heindel, James J Fitzgibbon, Eric A Secemsky, Michael Belkin, C Keith Ozaki, Mohamad A Hussain

{"title":"Evaluating the effectiveness of systemic heparin during arteriovenous fistula creation by emulating a target trial.","authors":"Patrick Heindel, James J Fitzgibbon, Eric A Secemsky, Michael Belkin, C Keith Ozaki, Mohamad A Hussain","doi":"10.1093/aje/kwae098","DOIUrl":"10.1093/aje/kwae098","url":null,"abstract":"Most of the 800 000 people living with end-stage kidney disease in the United States rely on a functioning vascular access to provide life-sustaining hemodialysis, yet one-third of arteriovenous fistulas experience early failures. Determining the safety and effectiveness of systemic heparin during fistula creation could improve the quality and quantity of life for these vulnerable patients. In this article, a pragmatic randomized trial was emulated to assess the effect of systemic heparin administration (vs none) during radiocephalic arteriovenous fistula creation on early bleeding and thrombosis, using data from 2 international, multicenter, randomized trials performed between 2014 and 2019. Marginal risks were estimated using inverse probability weighted parametric survival analysis and CIs were generated with bootstrapping. A total of 914 patients were enrolled and 61% received systemic heparin; their median (IQR) age was 58 (49, 67) years and 45% were on hemodialysis at enrollment. No difference in the risk of bleeding events was observed, with a risk difference (95% CI) at 14 days of -0.1% (-1.6 to 1.4). The risk of access thrombosis was lower in the heparin group, with a risk of 3.7% (2.6-4.8) after heparin and 5.3% (3.4-7.4) without heparin at 14 days (risk ratio = 0.72; 95% CI, 0.50-0.98). Trial registration: ClinicalTrials.gov. Identifiers: NCT02110901 and NCT02414841.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"651-658"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediating pathways between neighborhood disadvantage and cardiovascular risk: quasi-experimental evidence from a Danish refugee dispersal policy. 邻里劣势与心血管风险之间的中介途径：来自丹麦难民分散政策的准实验证据。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae158

Min Hee Kim, Trine Frøslev, Justin S White, M Maria Glymour, Sindana D Ilango, Henrik T Sørensen, Lars Pedersen, Rita Hamad

{"title":"Mediating pathways between neighborhood disadvantage and cardiovascular risk: quasi-experimental evidence from a Danish refugee dispersal policy.","authors":"Min Hee Kim, Trine Frøslev, Justin S White, M Maria Glymour, Sindana D Ilango, Henrik T Sørensen, Lars Pedersen, Rita Hamad","doi":"10.1093/aje/kwae158","DOIUrl":"10.1093/aje/kwae158","url":null,"abstract":"Research has documented that neighborhood disadvantage is associated with increased cardiovascular disease risk, but it is unclear which mechanistic pathways mediate this association across the life course. Leveraging a natural experiment in which refugees to Denmark were quasi-randomly assigned to neighborhoods across the country during 1986-1998, and using 30 years of follow-up data from population and health registers, we assessed whether and how individual-level poverty, unstable employment, and poor mental health mediate the relation between neighborhood disadvantage and the risk of hypertension, hyperlipidemia, and type 2 diabetes among Danish refugees (n = 40 811). Linear probability models using the discrete time-survival framework showed that neighborhood disadvantage was associated with increased risk of hypertension (0.05 percentage points [pp] per year [95% CI, -0.00 to 0.10]); hyperlipidemia (0.03 pp per year [95% CI, -0.01 to 0.07]), and diabetes (0.01 pp per year [95% CI, -0.02 to 0.03]). The Baron-Kenny product-of-coefficients method for counterfactual mediation analysis indicated that cumulative income mediated 6%-28% of the disadvantage effect on these outcomes. We find limited evidence of mediation by unstable employment and poor mental health. This study informs our theoretical understanding of the pathways linking neighborhood disadvantage with cardiovascular disease risk and identifies income security as a promising point of intervention to be studied in future research.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"635-644"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term PM2.5 exposure and peak expiratory flow in middle-aged and older people in China: a quasi-experimental study. 中国中老年人长期暴露于 PM2.5 与呼气流量峰值的关系：一项准实验研究。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae146

Zirong Ye, Xueru Li, Yafei Wu, Ya Fang

{"title":"Long-term PM2.5 exposure and peak expiratory flow in middle-aged and older people in China: a quasi-experimental study.","authors":"Zirong Ye, Xueru Li, Yafei Wu, Ya Fang","doi":"10.1093/aje/kwae146","DOIUrl":"10.1093/aje/kwae146","url":null,"abstract":"China's Clean Air Act (CCAA) has been demonstrated to reduce the public health burden of ambient air pollution. Few studies have assessed the health effects of CCAA on lung function. We aimed to investigate the effects of CCAA and PM2.5 exposures on peak expiratory flow (PEF) in middle-aged and older people in China. Three waves (2011, 2013, and 2015) of the China Health and Retirement Longitudinal Study (CHARLS) were included in this study. We performed a difference-in-difference (DID) model and mixed-effect method to assess the association between CCAA, PM2.5, and PEF. To increase the reliability, multiple environmental factors were considered, and spline function was utilized to fit the spatial autocorrelations. We found that the risk of decreased PEF in the policy intervention group was reduced by 46% (95% confidence interval [CI], 23% ~ 62%). The estimate showed a 10 μg/m3 increase in PM2.5 would increase the risk of decreased PEF by 10% (95% CI, 3% ~ 18%). The results of the mixed-effect model showed a 10 μg/m3 increase in PM2.5 concentration was associated with a 2.23% (95% CI, 1.35% ~ 3.06%) decrease in the PEF. These results contributed to the limited epidemiology evidence on demonstrating the effect of PM2.5 on lung function. This article is part of a Special Collection on Environmental Epidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"738-745"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical feminist epidemiology in action: reflections from a multidisciplinary partnership between Mujeres Unidas y Activas and academic researchers. 行动中的批判女权主义流行病学：Mujeres Unidas y Activas 与学术研究人员之间的多学科合作反思。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae286

Alison K Cohen, Juanita Flores, María Jiménez, Kathleen M Coll, Nathalie López, Taina B Quiles, Beda Castillo, Sajia Darwish, Amy Rich, Marina Franco

{"title":"Critical feminist epidemiology in action: reflections from a multidisciplinary partnership between Mujeres Unidas y Activas and academic researchers.","authors":"Alison K Cohen, Juanita Flores, María Jiménez, Kathleen M Coll, Nathalie López, Taina B Quiles, Beda Castillo, Sajia Darwish, Amy Rich, Marina Franco","doi":"10.1093/aje/kwae286","DOIUrl":"10.1093/aje/kwae286","url":null,"abstract":"Critical feminist research addresses social inequities, encourages equitable partnerships between researchers and participants, and acknowledges that research can be inherently political. Building upon critical feminist research practices, community-based participatory research, and social and structural epidemiology, we propose the approach of critical feminist epidemiology. A critical feminist epidemiology approach can study community and population health inequities with an eye toward identifying interventions that reduce inequities, through research processes that center the lived experiences of people from minoritized genders. We describe how our interdisciplinary, community-led team used a critical feminist epidemiology approach for an applied public health research project. Mujeres Unidas y Activas, a community organizing nonprofit led by and for Latina and Indigenous immigrant women, partnered with academic researchers to conduct community-led research on how their approach to building community power affected the health and well-being of organization members and their families. Critical feminist epidemiology is a promising approach for conducting research that is grounded in and relevant to the lives of women and gender-expansive people. Building upon social epidemiology and community-based participatory research, critical feminist epidemiology can be a useful research approach to generate novel evidence to inform action toward health equity for communities and populations. This article is part of a Special Collection on Methods in Social Epidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"557-561"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frandsen et al. respond to "A note on variable adjustments".

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwaf026

Clarissa L B Frandsen, Mathilde Gottschau, Bugge Nøhr, Jakob H Viuff, Susanne Rosthøj, Susanne K Kjær, Allan Jensen, Pernille F Svendsen

{"title":"Frandsen et al. respond to \"A note on variable adjustments\".","authors":"Clarissa L B Frandsen, Mathilde Gottschau, Bugge Nøhr, Jakob H Viuff, Susanne Rosthøj, Susanne K Kjær, Allan Jensen, Pernille F Svendsen","doi":"10.1093/aje/kwaf026","DOIUrl":"https://doi.org/10.1093/aje/kwaf026","url":null,"abstract":"In response to M. Naylor's valuable critique of our study \"Polycystic Ovary Syndrome and Endometrial Cancer Risk: Results from a Nationwide Cohort Study,\" we recognize the merit in the suggested areas. We recognize that including information on hormone therapy may have added to the understanding of the relationship between polycystic ovary syndrome (PCOS) and endometrial cancer risk. We further acknowledge the importance of the frequency of gynecological visits, which we have treated as a mediator rather than a confounder, given its role in reflecting PCOS severity and management. This approach, however, may introduce surveillance bias by influencing early cancer detection rates. Although the Danish health care system is fully subsidized, our exclusive use of hospital records may miss some PCOS cases managed in primary or specialized care settings outside the hospital, potentially leading to underestimation of the true association. Incorporating these variables in future studies could enhance analytical scope, though it would involve complex methodologies. We appreciate the comprehensive feedback, which underscores the necessity for further studies to elucidate the links between PCOS and endometrial cancer. These insights will inform future research and advance understanding in this area.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abuse-deterrent formulations and opioid-related harms in North Carolina, 2010-2018. 2010-2018 年北卡罗来纳州的抑制滥用制剂和阿片类药物相关危害。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae252

Bethany L DiPrete, Nabarun Dasgupta, G Yeon Oh, Daniela C Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W Pence, Shabbar I Ranapurwala

{"title":"Abuse-deterrent formulations and opioid-related harms in North Carolina, 2010-2018.","authors":"Bethany L DiPrete, Nabarun Dasgupta, G Yeon Oh, Daniela C Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W Pence, Shabbar I Ranapurwala","doi":"10.1093/aje/kwae252","DOIUrl":"10.1093/aje/kwae252","url":null,"abstract":"Abuse-deterrent formulations of opioid analgesics (ADFs) were introduced to reduce opioid-related harms among pain patients, but postmarketing study results have been mixed. However, these studies may be subject to bias from selection criteria, comparator choice, and potential confounding by \"indication,\" highlighting the need for thorough study design considerations. In a sample of privately insured patients prescribed ADF or non-ADF extended-release/long-acting (ER/LA) opioids in North Carolina, we implemented a version of the prevalent new-user design to evaluate the relationship between ADFs and opioid use disorder (OUD, n = 235) and opioid overdose (n = 18) through 6 months of follow-up using inverse probability-weighted cumulative incidence functions and Fine-Gray models. The weighted hazard ratio (HRw) of opioid overdose among patients initiating ADFs was 0.87 (95% CI, 0.23-3.24) times as high as among patients who initiated, restarted, or continued non-ADF ER/LA opioids. We observed a short-term benefit of ADFs for incident OUD (HRw = 0.58; 95% CI, 0.35-0.93) compared to non-ADF ER/LA opioids in the first 6 weeks of follow-up, but this benefit disappeared later in follow-up (HRw = 1.30; 95% CI, 0.86-1.95). In summary, our findings add to the expanding body of evidence that there is no clear long-term reduction in harm from ADF opioids among patients in outpatient use. This article is part of a Special Collection on Pharmacoepidemiology.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"680-690"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaping transitions and incident depressive symptoms among young adults: a marginal structural model analysis. 年轻成年人的吸食过渡和抑郁症状：边际结构模型分析》。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae225

Alyssa F Harlow, Andrew C Stokes, Dae-Hee Han, Adam M Leventhal, Jessica L Barrington-Trimis

{"title":"Vaping transitions and incident depressive symptoms among young adults: a marginal structural model analysis.","authors":"Alyssa F Harlow, Andrew C Stokes, Dae-Hee Han, Adam M Leventhal, Jessica L Barrington-Trimis","doi":"10.1093/aje/kwae225","DOIUrl":"10.1093/aje/kwae225","url":null,"abstract":"The extent to which vaping influences depression is unclear but could be estimated through application of novel epidemiologic methods. Among a prospective cohort of young adults from California who screened negative for depression, we estimated repeated-measures marginal structural models to examine the association of 4 vaping transitions from time T to T + 1 (persistent use, discontinuation, initiation, persistent nonuse) with risk of clinically significant depressive symptoms at T + 1, simultaneously across three ~ 1.5-year time intervals between 2017 and 2021. Stabilized inverse probability of treatment and censoring weights adjusted for time-dependent confounders and selection bias. Among n = 3496 observations (1806 participants, mean pooled baseline age = 19.5), 8.1% reported persistent vaping from T to T + 1, 6.2% reported discontinuation (ie, use at T and no use at T + 1), 6.5% initiated e-cigarettes (ie, no use at T and use at T + 1), and 79.2% reported persistent nonuse at both time points. Compared to persistent vaping at 2 waves, persistent nonuse (relative risk [RR] = 0.76; 95% CI, 0.62-0.93) and discontinuation (RR = 0.71; 95% CI, 0.52-0.96) were associated with lower risk of depression. Associations were robust to sensitivity analyses, including restricting to tobacco-naive participants and varying temporal assumptions to reduce potential for reverse causation. Young adults who consistently avoid or discontinue vaping may be protected from depressive symptom occurrence.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"746-754"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity, fitness, and cardiac autonomic function among adults born postterm. 早产儿的体育活动、体能和心脏自主神经功能。

IF 5 2区医学

American journal of epidemiology Pub Date : 2025-03-04 DOI: 10.1093/aje/kwae150

Päivi Oksanen, Marjaana Tikanmäki, Mikko P Tulppo, Maisa Niemelä, Raija Korpelainen, Eero Kajantie

{"title":"Physical activity, fitness, and cardiac autonomic function among adults born postterm.","authors":"Päivi Oksanen, Marjaana Tikanmäki, Mikko P Tulppo, Maisa Niemelä, Raija Korpelainen, Eero Kajantie","doi":"10.1093/aje/kwae150","DOIUrl":"10.1093/aje/kwae150","url":null,"abstract":"Recent studies have suggested that adverse outcomes of postterm birth (≥42 completed weeks of gestation), including increased cardiometabolic risk factors, impaired glucose metabolism, and obesity, may extend into adulthood. We studied interconnected determinants of cardiovascular health, including physical activity (PA; based on accelerometry for 2 weeks), muscular strength (measured by handgrip strength), cardiorespiratory fitness (CRF; measured by 4-min step test), and cardiac autonomic function (heart rate [HR] recovery, HR variability, and baroreflex sensitivity) among 46-year-old adults from the Northern Finland Birth Cohort born postterm (n = 805) and at term (n = 2645). Adults born postterm undertook vigorous PA 2.0 min day-1 (95% CI, 0.4-3.7) less than term-born adults when adjusted for sex, age, and maternal- and pregnancy-related covariates in multiple linear regression. Postterm birth was associated with reduced CRF, based on a higher peak HR (2.1 bpm; 95% CI, 0.9-3.4) and slower HR recovery 30 s after the step test (-0.7 bpm; 95% CI, -1.3 to -0.1). Postterm birth was associated with less PA of vigorous intensity and CRF and slower HR recovery in middle age. Our findings reinforce previous suggestions that postterm birth should be included as a perinatal risk factor for adult cardiometabolic disease.","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":"766-778"},"PeriodicalIF":5.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0