Aerospace medicine and human performance最新文献

{"title":"Actigraphy-Driven Biomathematical Fatigue Modeling in British Military Rotary-Wing Pilots.","authors":"Andrew Pelham, Martie Van Tongeren, Heidi Arnold, Pierluigi Cocco","doi":"10.3357/AMHP.6532.2025","DOIUrl":"10.3357/AMHP.6532.2025","url":null,"abstract":"<p><strong>Introduction: </strong>A study of fatigue in British military rotary-wing pilots was conducted to determine the utility of actigraphy-driven fatigue modeling in the military rotary-wing environment.</p><p><strong>Methods: </strong>A total of 48 pilots were recruited across the 3 military services of the United Kingdom. Objective fatigue was predicted using wearable actigraphy and the Sleep Activity Fatigue Task Effectiveness (SAFTE) fatigue model. Subjective data were collected from daily questionnaires completed by the study subjects, including an assessment of their own fatigue level using Samn-Perelli Scale scores. The relationship between these two data sets was then assessed with correlation and linear regression modeling.</p><p><strong>Results: </strong>There were 38 men and 2 women recruited. The mean age was 36.4 yr (standard deviation ± 6.5, range 26-52 yr). In total, 200 flights were undertaken, with a mean flight time of 156 min (± 77.1, range 15-480); the mean landing time of these flights was 18:45 (range 11:00-02:30). The data included 37 d of pilots deployed on exercise. SAFTE scores were shown to decline for night flying, especially if landing after 22:00. With increasing subjective levels of fatigue, the relationship between SAFTE and Samn-Perelli Scale scores in subjects weakened.</p><p><strong>Discussion: </strong>Actigraphy-driven modeling has a role in specific aspects of military rotary-wing aviation. Consideration should be given to its use in specific scenarios, including night-flying and flights undertaken when deployed on exercise. Pelham A, Van Tongeren M, Arnold H, Cocco P. Actigraphy-driven biomathematical fatigue modeling in British military rotary-wing pilots. Aerosp Med Hum Perform. 2025; 96(3):206-211.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 3","pages":"206-211"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Physical Requirements for Astronauts.","authors":"Philippe St-Martin, François Lalonde, Félix Bouchard-Lévesque, Isabelle J Dionne","doi":"10.3357/AMHP.6560.2025","DOIUrl":"10.3357/AMHP.6560.2025","url":null,"abstract":"<p><strong>Introduction: </strong>Through the Artemis program, space agencies and astronauts are preparing for extended durations in space and on planetary surfaces, expanding their occupational tasks. Although standardized laboratory tests are effective in assessing health and mitigating deconditioning, their reliability in forecasting occupational performance is uncertain. Consequently, a recent shift in exercise testing has emerged, shifting focus from health-oriented criteria to operational performance. This involves identifying the physical demands associated with components of an astronaut's tasks and determining a minimum level of performance, referred to as Physical Employment Standards. The aim of this systematic review is to provide an updated overview of the scientific literature on astronaut occupational tasks and physiological requirements.</p><p><strong>Methods: </strong>A search was conducted spanning from 1970 to October 2023. Articles meeting the inclusion criteria underwent screening using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for an evidence-based systematic review.</p><p><strong>Results: </strong>There were 10 studies selected for inclusion in the current review and pertinent information was extracted. There were 14 tasks physiologically assessed: ambulation on various terrains, physical abilities field, device operations/activity board, re-entry and landing, hatch opening, capsule egress, recovery from fall, jump down, ladder climb, material transfer, emergency crewmember drag, hand drilling, construction wrenching, and upper-limb weighted tasks.</p><p><strong>Discussion: </strong>Physical Employment Standards for astronauts have yet to be established; however, certain tasks have been identified, enabling tailored occupational assessments for astronauts, increasingly recognized as tactical athletes. The results of this literature review lay the foundations for scientific task analysis and the development of operational physical tests for astronauts. St-Martin P, Lalonde F, Bouchard-Lévesque F, Dionne IJ. Occupational physical requirements for astronauts. Aerosp Med Hum Perform. 2025; 96(3):234-250.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 3","pages":"234-250"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Altitude Acute Hypoxia Endurance and Comprehensive Lung Function in Pilots.","authors":"Bowen Li, Yue Xu, Dong Wang, Baodi Wei, Huijing Zhu, Mengdi Wu, Xiaohua Lan, Qiaoxiang Yin, Yanjie Cao","doi":"10.3357/AMHP.6551.2025","DOIUrl":"10.3357/AMHP.6551.2025","url":null,"abstract":"<p><strong>Introduction: </strong>High-altitude hypoxia remains one of the primary causes endangering flight safety to this day. This study explores the correlation between pilots' acute hypoxia endurance at high altitude and their comprehensive pulmonary function to help with pilot selection, training, and operations.</p><p><strong>Methods: </strong>We selected 175 pilots (all men) at the Air Force Medical Center from January 2022 to March 2023. They underwent comprehensive pulmonary function tests and a simulated 22,965-ft (7000-m) hypoxia tests which were categorized into long-time (>360 s) or short-time (180 -360 s) groups based on endurance time. A multivariate Cox proportional risk model analyzed the link between lung function and hypoxia endurance.</p><p><strong>Results: </strong>All pilots completed the tests with a median hypoxia endurance time of 260 s. The long-time group consisted of 50.3% of the pilots and the short-time group consisted of 49.7%. The Cox model indicated that higher alveolar volume as a percentage of predicted and lower residual volume to total lung capacity ratio as a percentage of predicted significantly influenced hypoxia endurance time, while other variables showed no significant impact.</p><p><strong>Discussion: </strong>Pilots with higher alveolar volume as a percentage of predicted and lower residual volume to total lung capacity ratio as a percentage of predicted in comprehensive lung function are likely to have better gas exchange efficiency and lung function, leading to longer acute high-altitude hypoxia endurance time. Li B, Xu Y, Wang D, Wei B, Zhu H, Wu M, Lan X, Yin Q, Cao Y. High-altitude acute hypoxia endurance and comprehensive lung function in pilots. Aerosp Med Hum Perform. 2025; 96(3):191-197.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 3","pages":"191-197"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Roles of Resilience and Stress in Emotion Regulation Strategies and Pilot Job Burnout.","authors":"Yanzeng Zhao, Keyong Zhu, Hongmin Cai, Ziyu Liu, Rui Xiong, Lijing Wang","doi":"10.3357/AMHP.6581.2025","DOIUrl":"10.3357/AMHP.6581.2025","url":null,"abstract":"<p><strong>Introduction: </strong>Pilot burnout significantly affects flight safety. Despite research on related factors, the intrinsic links between pilots' emotion regulation and burnout are not thoroughly analyzed. The distinctive work environment necessitates advanced emotional regulation skills. Exploring these mechanisms is crucial for understanding and addressing pilot burnout effectively.</p><p><strong>Methods: </strong>The study performed a path analysis on survey data from 106 Chinese civil aviation pilots to explore the relationship between emotion regulation strategies and job burnout.</p><p><strong>Results: </strong>The findings indicate that cognitive reappraisal affects job burnout through perceived stress and psychological resilience while expressive suppression impacts it via perceived stress. Family-work conflict and organizational stress significantly contribute to burnout, with the model showing a high fit (Comparative Fit Index = 0.99) and an R2 exceeding 0.5.</p><p><strong>Discussion: </strong>This research pioneers an emotion regulation perspective in pilot job burnout analysis, suggesting innovative interventions. It emphasizes the need for holistic strategies, addressing psychological resilience enhancement and organizational culture issues to mitigate job burnout effectively. By enriching the theoretical and practical foundations in pilot job burnout management, this study offers crucial insights for the field's development. Zhao Y, Zhu K, Cai H, Liu Z, Xiong R, Wang L. Mediating roles of resilience and stress in emotion regulation strategies and pilot job burnout. Aerosp Med Hum Perform. 2025; 96(3):219-227.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 3","pages":"219-227"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasickness Simulator to Assess Anti-Motion Sickness Devices.","authors":"Camille de Thierry de Faletans, Maxime Misericordia, Jean-Marc Vallier, Pascale Duché, Eric Watelain","doi":"10.3357/AMHP.6403.2025","DOIUrl":"10.3357/AMHP.6403.2025","url":null,"abstract":"<p><strong>Introduction: </strong>There are various motion sickness (MS) simulators in the laboratory, but the conditions under which they induce MS symptoms are different from real-life conditions. This study aimed to design a seasickness simulator, close to ecological conditions, easy to set up, at a modest cost, and capable of rapidly inducing MS symptoms, to evaluate the effect of anti-motion sickness devices. The hypothesis was that this simulator would induce MS, reflecting the susceptibility of subjects in real-life conditions, meaning the more susceptible individuals were to MS in real conditions, the more severe and rapid their symptoms would be in the simulator.</p><p><strong>Methods: </strong>A total of 65 subjects with varying degrees of MS susceptibility (MS Susceptibility Questionnaire Short form) were exposed to a seasickness simulator for a maximum of 10 min. Measurements of subjective symptoms (Visual Analog Scale and time to onset of first symptoms) and physiological variables (heart rate and temperature) were taken.</p><p><strong>Results: </strong>Subjects covered the full range of MS susceptibility (from 0-100%). The average time in the simulator before the first symptoms of MS was 7.41 min ± 2.56 min. The time to onset of the first symptoms, the intensity of the symptoms, and heart rate were significantly correlated with the degree of susceptibility of subjects in real-life conditions.</p><p><strong>Discussion: </strong>The simulator induced varying intensity of MS depending on the subjects' susceptibility. It thus replicates real-life conditions and can serve as a useful tool for facilitating the research of devices, techniques, and medications to combat MS. de Thierry de Faletans C, Misericordia M, Vallier J-M, Duché P, Watelain E. Seasickness simulator to assess anti-motion sickness devices. Aerosp Med Hum Perform. 2025; 96(3):212-218.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 3","pages":"212-218"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health of Astronauts in Short- and Long-Term Missions in Space.","authors":"Massimo Del Fabbro, Shahnawaz Khijmatgar, Bart Vandenberghe, Edward Kijak, Malgorzata Kulesa-Mrowiecka, Ishita Singhal, Felice Lorusso, Basil B Xavier, Victoria Sampson, Giovanni Marfia, Dirk Neefs, Gianluca M Tartaglia","doi":"10.3357/AMHP.6372.2025","DOIUrl":"10.3357/AMHP.6372.2025","url":null,"abstract":"<p><strong>Introduction: </strong>Space exploration presents unique challenges to human health due to space radiation, reduced gravity, and prolonged isolation. Astronauts should be prepared to manage medical and dental emergencies. This scoping review maps the evidence on oral health alterations and dental emergencies faced by astronauts during short- and long-term space missions.</p><p><strong>Methods: </strong>A \"Topical Team\" assembled by the European Space Agency performed the review described herein. An electronic search was conducted on scientific databases, reference lists of relevant papers, specific textbooks, and space agencies' databases. Inclusion criteria encompassed studies related to dental medicine in microgravity or outer orbital space conditions. Results are presented through narrative format.</p><p><strong>Results: </strong>Out of 23,686 studies identified, 467 were considered eligible and 80 (54 reviews and 26 human-based studies) were included. The latter were classified into three broad topics: microbiology, space physiology and medicine, and space dentistry. Among the studies involving human subjects, 17 involved individuals who had spent time in space. There are only a few studies about oral health modifications and issues during spaceflight and those have limited evidence. Dental emergencies in space are relatively rare events that tend to increase with mission duration.</p><p><strong>Discussion: </strong>The impact of microgravity on oral health requires further investigation. Preflight and in-flight measures should focus on prevention and treatment protocols for various dental issues to ensure crew safety and mission success. Understanding and addressing factors affecting oral health in microgravity will enhance the well-being of astronauts and the success of human exploration missions in space. Del Fabbro M, Khijmatgar S, Vandenberghe B, Kijak E, Kulesa-Mrowiecka M, Singhal I, Lorusso F, Xavier BB, Sampson V, Marfia G, Neefs D, Tartaglia GM. Oral health of astronauts in short- and long-term missions in space. Aerosp Med Hum Perform. 2025; 96(2):168-179.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 2","pages":"168-179"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-flight Neuromusculoskeletal Injuries in Astronauts.","authors":"Gavin H Ward, Danielle N Anderson, Richard A Scheuring","doi":"10.3357/AMHP.6501.2025","DOIUrl":"10.3357/AMHP.6501.2025","url":null,"abstract":"<p><strong>Introduction: </strong>The space sector is growing remarkably fast. Its value is expected to increase from $447 billion in 2022 to $2.7 trillion by 2040. The demand for astronauts and astro-civilians is growing, and there will be an increased need for experts who understand the effects of spaceflight on the neuromusculoskeletal (NMSK) system. Orthopedic specialists in space medicine are sparsely reported in the literature, and standards of care for astro-civilians are not well established. This review discusses the current prevalence of peri-flight NMSK injuries in astronauts, the role of orthopedic specialists, and considerations for standards of care for astro-civilians.</p><p><strong>Methods: </strong>A systematic review using PubMed, MEDLINE, and NASA Technical Report Server was performed to identify original research containing NMSK injuries in astronauts.</p><p><strong>Results: </strong>There were 29 studies included in the review. In 2388 documented injuries, the prevalence of injuries during preflight is 46.5%, in flight is 37.0%, and postflight is 16.5%. In 2081 documented injury locations, the prevalence of injuries in the upper extremity is 32.4%, in the shoulder is 31.4%, in the back is 26.4%, in the lower extremity is 5.5%, and in the neck is 2.3%.</p><p><strong>Discussion: </strong>Common peri-flight injuries involve the shoulder, back, and hand, such as shoulder tendonitis, space adaptation back pain, and herniated nucleus pulposus. It is critical to consider NMSK injuries for the growing space sector. As public interest grows, costs related to space are expected to decrease. Decreased costs increase accessibility to space and, consequently, the risk of NMSK injuries, increasing the demand for medical standards and experts in orthopedics and space medicine. Ward GH, Anderson DN, Scheuring RA. Peri-flight neuromusculoskeletal injuries in astronauts. Aerosp Med Hum Perform. 2025; 96(2):155-167.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 2","pages":"155-167"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Causes of Disqualification in Portuguese Air Force Pilots.","authors":"Joana Certo Pereira, José Monge, André Baptista, Pedro Reis, Helder Dores","doi":"10.3357/AMHP.6557.2025","DOIUrl":"10.3357/AMHP.6557.2025","url":null,"abstract":"<p><strong>Introduction: </strong>Aviation is a high-risk activity, particularly in pilots with cardiovascular (CV) disease. The occurrence of acute clinical events during flight may have catastrophic implications, justifying the relevance of cardiological evaluation in aviation medicine. However, evidence of the impact of CV diseases in this population is scarce. The aim of this study was to analyze the cardiac causes of disqualification among pilot candidates and pilots of the Portuguese Air Force (PoAF) over a period of 20 yr.</p><p><strong>Methods: </strong>Retrospective analysis of cardiac causes of disqualification between 1999-2018, both in PoAF candidates and pilots.</p><p><strong>Results: </strong>In this period, the overall number of candidates was 2529 and the number of PoAF pilots was 760. Among the candidates, 41% (N = 1047) were considered unfit, of which 4% (N = 39) were due to cardiac causes (all men aged 17-25), namely valvular diseases (N = 27) and conduction/heart rhythm disturbances (N = 12). Among the pilots, 2% (N = 18) were considered unfit, mainly due to cardiac disease (50%; N = 9)-all men with mean age of 47 ± 9 (30-60) yr old, all unfit due to acute myocardial infarction, none occurring during flight.</p><p><strong>Discussion: </strong>Cardiac diseases were an uncommon cause of disqualification among the pilot aviator candidates, but it was the main cause among the pilots of the PoAF over two decades, all due to acute myocardial infarction. Cardiac evaluation in aviation medicine is essential, focusing on CV risk stratification and preclinical detection of coronary artery disease. Certo Pereira J, Monge J, Baptista A, Reis P, Dores H. Cardiac causes of disqualification in Portuguese Air Force pilots. Aerosp Med Hum Perform. 2025; 96(2):128-134.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 2","pages":"128-134"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Contributing to Fatalities in Helicopter Emergency Medical Service Accidents.","authors":"Jenna Korentsides, Joseph R Keebler, Mihhail Berezovski, Alex Chaparro","doi":"10.3357/AMHP.6461.2025","DOIUrl":"10.3357/AMHP.6461.2025","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to update and reinforce previous research on helicopter emergency medical service accidents in the United States. By investigating predictors of fatalities after helicopter emergency medical service crashes through the application of machine learning techniques, we updated existing data sets and sought to uncover patterns that traditional analysis might not reveal.</p><p><strong>Methods: </strong>Using the National Transportation Safety Board database, the authors analyzed a dataset of 267 helicopter emergency medical service accidents between 1991-2022. We first calculated fatalities odds ratios for each condition. We then plotted geospatial locations of all reported accidents. Finally, we used XGBoost regression to understand the most important features contributing to fatality after an accident.</p><p><strong>Results: </strong>The findings reaffirm previous research and identify significant predictors of fatalities in helicopter emergency medical service accidents. Key factors such as adverse flight conditions (weather), the absence of a copilot, and postcrash fires are highlighted as critical to understanding and mitigating risks of fatality.</p><p><strong>Discussion: </strong>These findings emphasize the utility of machine learning in extracting meaningful insights from accident data, suggesting that such techniques offer a more nuanced understanding of the conditions leading to fatalities. It points out the potential of these methods to not only enhance aviation safety but also to be applied across other sectors. We conclude by underlining the significant potential of techniques like XGBoost in advancing safety measures within helicopter emergency medical service and possibly other aviation sectors. Korentsides J, Keebler JR, Berezovski M, Chaparro A. Factors contributing to fatalities in helicopter emergency medical service accidents. Aerosp Med Hum Perform. 2025; 96(2):111-115.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 2","pages":"111-115"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerance of Centrifuge-Simulated Spaceflight in Individuals with Diabetes Mellitus.","authors":"Samantha A King, Rebecca S Blue","doi":"10.3357/AMHP.6490.2025","DOIUrl":"10.3357/AMHP.6490.2025","url":null,"abstract":"<p><strong>Introduction: </strong>There is increasing interest in the screening and evaluation of individuals with underlying medical conditions for participation in commercial spaceflight, including those with diabetes mellitus. Diabetes risks incapacitation through hypoglycemic or hyperglycemic events. Limited analog data exist regarding tolerance of spaceflight in diabetics; here we evaluated diabetic tolerance of centrifuge-simulated spaceflight.</p><p><strong>Methods: </strong>Aggregated data from diabetic volunteers in prior studies of centrifuge-simulated spaceflight were compared to nondiabetic subjects. There were 20 (3 women) diabetic volunteers, with glycemic control methods including diet, oral medications, and insulin, who met screening criteria for inclusion and participated in up to 7 centrifuge profiles. Heart rate data collected prior to and during centrifuge spins and subjective postspin symptom questionnaires were analyzed.</p><p><strong>Results: </strong>Diabetic layperson subjects demonstrated similar hypergravity tolerance compared to nondiabetic laypersons. Two diabetic subjects did not complete all available profiles: one for nausea and one for scheduling constraints. Glycemic control methods (insulin vs. noninsulin) were not associated with differences in tolerance. There were no statistical differences in vital signs or symptoms. One subject had transient symptoms possibly related to hypoglycemia in the setting of decreased oral intake.</p><p><strong>Discussion: </strong>Diabetes poses a risk of incapacitation in high performance environments. Even so, these data suggest that, with appropriate screening and stratification, diabetic individuals can successfully tolerate spaceflight hypergravity exposures. Further research may allow for inclusion of diabetic individuals in future spaceflight. King SA, Blue RS. Tolerance of centrifuge-simulated spaceflight in individuals with diabetes mellitus. Aerosp Med Hum Perform. 2025; 96(2):101-110.</p>","PeriodicalId":7463,"journal":{"name":"Aerospace medicine and human performance","volume":"96 2","pages":"101-110"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}