Camille de Thierry de Faletans, Maxime Misericordia, Jean-Marc Vallier, Pascale Duché, Eric Watelain
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The hypothesis was that this simulator would induce MS, reflecting the susceptibility of subjects in real-life conditions, meaning the more susceptible individuals were to MS in real conditions, the more severe and rapid their symptoms would be in the simulator.</p><p><strong>Methods: </strong>A total of 65 subjects with varying degrees of MS susceptibility (MS Susceptibility Questionnaire Short form) were exposed to a seasickness simulator for a maximum of 10 min. Measurements of subjective symptoms (Visual Analog Scale and time to onset of first symptoms) and physiological variables (heart rate and temperature) were taken.</p><p><strong>Results: </strong>Subjects covered the full range of MS susceptibility (from 0-100%). The average time in the simulator before the first symptoms of MS was 7.41 min ± 2.56 min. The time to onset of the first symptoms, the intensity of the symptoms, and heart rate were significantly correlated with the degree of susceptibility of subjects in real-life conditions.</p><p><strong>Discussion: </strong>The simulator induced varying intensity of MS depending on the subjects' susceptibility. It thus replicates real-life conditions and can serve as a useful tool for facilitating the research of devices, techniques, and medications to combat MS. de Thierry de Faletans C, Misericordia M, Vallier J-M, Duché P, Watelain E. Seasickness simulator to assess anti-motion sickness devices. 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引用次数: 0
摘要
实验室里有各种各样的运动病(MS)模拟器,但它们诱发MS症状的条件与现实生活条件不同。本研究旨在设计一种接近生态条件,易于设置,成本适中,能够快速诱导MS症状的晕船模拟器,以评估防晕船装置的效果。我们的假设是这个模拟器会诱发多发性硬化症,反映了受试者在现实条件下的易感性,即在现实条件下对多发性硬化症越敏感的个体,在模拟器中的症状就会越严重、越迅速。方法:将65名不同程度MS易感性的受试者(MS易感性问卷简表)暴露在晕船模拟器中最长10分钟,测量主观症状(视觉模拟量表和首次症状出现时间)和生理变量(心率和体温)。结果:受试者覆盖了MS敏感性的全部范围(0-100%)。MS首次出现症状前在模拟器中的平均时间为7.41 min±2.56 min。MS首次出现症状的时间、症状强度和心率与受试者在现实条件下的易感程度显著相关。讨论:模拟器根据受试者的敏感性诱导不同强度的MS。因此,它复制了现实生活中的条件,可以作为一个有用的工具,促进设备、技术和药物的研究,以对抗ms de Thierry de Faletans C, Misericordia M, Vallier J-M, duch P, Watelain E.晕船模拟器评估抗晕动病设备。航空航天Med Hum Perform. 2025;96(3): 212 - 218。
Seasickness Simulator to Assess Anti-Motion Sickness Devices.
Introduction: There are various motion sickness (MS) simulators in the laboratory, but the conditions under which they induce MS symptoms are different from real-life conditions. This study aimed to design a seasickness simulator, close to ecological conditions, easy to set up, at a modest cost, and capable of rapidly inducing MS symptoms, to evaluate the effect of anti-motion sickness devices. The hypothesis was that this simulator would induce MS, reflecting the susceptibility of subjects in real-life conditions, meaning the more susceptible individuals were to MS in real conditions, the more severe and rapid their symptoms would be in the simulator.
Methods: A total of 65 subjects with varying degrees of MS susceptibility (MS Susceptibility Questionnaire Short form) were exposed to a seasickness simulator for a maximum of 10 min. Measurements of subjective symptoms (Visual Analog Scale and time to onset of first symptoms) and physiological variables (heart rate and temperature) were taken.
Results: Subjects covered the full range of MS susceptibility (from 0-100%). The average time in the simulator before the first symptoms of MS was 7.41 min ± 2.56 min. The time to onset of the first symptoms, the intensity of the symptoms, and heart rate were significantly correlated with the degree of susceptibility of subjects in real-life conditions.
Discussion: The simulator induced varying intensity of MS depending on the subjects' susceptibility. It thus replicates real-life conditions and can serve as a useful tool for facilitating the research of devices, techniques, and medications to combat MS. de Thierry de Faletans C, Misericordia M, Vallier J-M, Duché P, Watelain E. Seasickness simulator to assess anti-motion sickness devices. Aerosp Med Hum Perform. 2025; 96(3):212-218.
期刊介绍:
The peer-reviewed monthly journal, Aerospace Medicine and Human Performance (AMHP), formerly Aviation, Space, and Environmental Medicine, provides contact with physicians, life scientists, bioengineers, and medical specialists working in both basic medical research and in its clinical applications. It is the most used and cited journal in its field. It is distributed to more than 80 nations.