Radiologie (Heidelberg, Germany)最新文献_第3页

[Role of radiology for primary staging of colorectal cancer]. 【放射学在结直肠癌早期分期中的作用】。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1007/s00117-025-01458-6

Sophia Wirth, Nino Bogveradze, Katharina Lampichler

{"title":"[Role of radiology for primary staging of colorectal cancer].","authors":"Sophia Wirth, Nino Bogveradze, Katharina Lampichler","doi":"10.1007/s00117-025-01458-6","DOIUrl":"10.1007/s00117-025-01458-6","url":null,"abstract":"Background: Imaging, specifically magnetic resonance imaging (MRI), has long been the cornerstone for staging rectal cancer. In contrast, computed tomography (CT) is the standard for colon cancer staging. Primary staging is essential for individualized risk stratification and therapy planning.Objectives: To summarize current international guidelines on primary colorectal cancer staging, taking into account the advantages and disadvantages of different imaging methods.Materials and methods: Based on extensive literature research, the current state of knowledge in the staging of colorectal cancer is summarized.Results: TNM staging includes local tumor extension as well as the presence of lymph node and distant metastases. For local tumor extension, MRI is very well suited for rectal cancer. In colon cancer, CT shows significant limitations regarding the sensitivity of differentiating individual stages. Lymph node metastases can pose a major challenge for both MRI and CT, which has led to the definition of several malignancy criteria. The detection of distant metastases remains primarily within the domain of CT, except for liver metastases.Conclusions: Depending on tumor location, either MRI or CT is recommended for primary staging of colorectal cancer, and a combination of both modalities may also be appropriate. Accurate assessment of the primary tumor, lymph nodes, and organs using imaging is an essential component of the therapeutic approach to colorectal cancer.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"426-435"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Early-onset colorectal cancer : When should we start with screening?] 早发性结直肠癌：我们应该何时开始筛查？］

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 DOI: 10.1007/s00117-025-01453-x

Michael Hoffmeister, Hermann Brenner

引用次数: 0

[Chemotherapy, targeted therapy and immunotherapy of metastatic colorectal cancer : What is new?] 转移性结直肠癌的化疗、靶向治疗和免疫治疗：有什么新进展？］

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 DOI: 10.1007/s00117-025-01455-9

Mirjam Richard, Christine Koch, Jörg Trojan

引用次数: 0

[Epiphyseal space-occupying lesion in childhood]. [儿童骨骺占位性病变]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1007/s00117-025-01428-y

Laurenz Camp, Marco Saß, Anne-Sophie Becker, Marc-André Weber

引用次数: 0

[Molecular testing and liquid biopsies in colorectal cancer]. [结直肠癌的分子检测和液体活检]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 DOI: 10.1007/s00117-025-01454-w

Arndt Stahler, Sebastian Stintzing

{"title":"[Molecular testing and liquid biopsies in colorectal cancer].","authors":"Arndt Stahler, Sebastian Stintzing","doi":"10.1007/s00117-025-01454-w","DOIUrl":"10.1007/s00117-025-01454-w","url":null,"abstract":"Background: The introduction of new DNA sequencing technologies has led to the discovery of many prognostically and predictively relevant biomarkers in tumor tissue and blood from patients with colorectal cancer.Objectives: Presentation of meaningful tissue-based molecular pathological diagnostics and discussion of the clinical application of circulating tumor DNA (ctDNA) from liquid biopsies in colorectal cancer.Materials and methods: Evaluation of existing literature and congress publications, discussion of post hoc analyses of clinical studies and expert recommendations.Results: In Union for International Cancer Control (UICC) stages II/III, the tissue-based evaluation of microsatellite instability (MSI-H) contributes to individual therapy optimization through advice on adjuvant chemotherapy (colon cancer, UICC II) or, if necessary, individual neo-adjuvant therapy concepts via the use of immunotherapy (colon, rectal cancer, UICC II/III). From liquid biopsies, ctDNA was associated with minimal residual disease, which influences disease-free survival. In the metastatic stage (UICC IV), tissue-based determination of RAS and BRAF V600E mutations, MSI‑H and in the near future also HER2/neu overexpression should be performed. Broader molecular diagnostics to optimize first-line therapy (molecular hyperselection) shows little additional benefit. ctDNA can be used for longitudinal monitoring of clonal tumor evolution or as an alternative to invasive diagnostics in patients.Conclusions: Molecular pathological diagnostics from tissue and blood complement each other and should be used in a targeted and meaningful way according to the underlying question.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"410-415"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Imaging of colorectal cancer: Role of computed tomography colonography]. [结直肠癌影像学：计算机断层结肠镜的作用]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1007/s00117-025-01456-8

Thomas Mang, Nino Bogveradze, Michael Bergman, Simon Leitner, Martina Scharitzer

{"title":"[Imaging of colorectal cancer: Role of computed tomography colonography].","authors":"Thomas Mang, Nino Bogveradze, Michael Bergman, Simon Leitner, Martina Scharitzer","doi":"10.1007/s00117-025-01456-8","DOIUrl":"10.1007/s00117-025-01456-8","url":null,"abstract":"Background: Computed tomography colonography (CTC) is a minimally invasive examination for radiologic imaging of the entire colon and rectum. It has replaced the now obsolete barium enemas and represents an important option to colonoscopy for the detection of colorectal neoplasia.Objectives: The aim of this article is to review the current status of CTC for detection of colorectal cancer (CRC) and its precursors.Materials and methods: Based on an extensive literature research, the current role of CTC in colorectal cancer imaging is summarized. This includes not only CRC detection but also the role of CTC in CRC screening and surveillance.Results: CTC is a well-developed, minimally invasive examination for the identification of colorectal neoplasia. The diagnostic accuracy for colorectal adenomas and cancer is comparable to that of optical colonoscopy. Missed CRC cases are rare and typically result from perceptual or technical errors. In addition to the detection and characterization of carcinomas, CTC enables the visualization of prestenotic colonic segments and extracolonic structures. This allows for the preoperative detection of synchronous colonic neoplasms that are not endoscopically assessable as well as evaluation of abdominal tumor spread. Due to its ability to detect benign precancerous adenomas with high sensitivity, CTC can be used for opportunistic colorectal cancer screening. In CRC follow-up, CTC may be used to diagnose recurrence if colonoscopy is incomplete or not feasible.Conclusion: CTC is the radiological examination of choice for the detection of colorectal neoplasia. It is typically used in patients where colonoscopy is incomplete, contraindicated or refused. Moreover, CTC serves as a noninvasive option for opportunistic colorectal cancer screening.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"416-425"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Subarachnoid hemorrhage part 1 : Pathophysiology, diagnostics and special forms]. 蛛网膜下腔出血第1部分：病理生理、诊断和特殊形式。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1007/s00117-025-01463-9

Umut Yilmaz, Malvina Garner, Wolfgang Reith

引用次数: 0

[Update on the diagnosis and treatment of colorectal carcinoma]. 【结直肠癌的诊断和治疗进展】。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1007/s00117-025-01462-w

T Helmberger

引用次数: 0

[Anatomical variants of the petrous bone]. [岩骨的解剖变异]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-05-30 DOI: 10.1007/s00117-025-01465-7

A Haußmann

{"title":"[Anatomical variants of the petrous bone].","authors":"A Haußmann","doi":"10.1007/s00117-025-01465-7","DOIUrl":"https://doi.org/10.1007/s00117-025-01465-7","url":null,"abstract":"Clinical issue: The anatomy of the petrous bone is very complex, particularly due to the many important nervous, vascular and muscular structures that run through it, as well as the protection of hearing and balance organs. Anatomical standard variants complicate radiological interpretation, can imitate pathologies, and present surgeons with enormous challenges during surgical procedures.Standard radiological methods: Morphological imaging-based diagnostics for detecting normal anatomical variants of the petrous bone include computed tomography (CT) and/or magnetic resonance imaging (MRI). The patient's precise history of existing symptoms or previous surgery also plays a role in the assessment of the findings. Radiologists must be aware that some anatomical standard variants can mimic pathology, and therefore there is a risk of misinterpretation. The imaging helps surgeons facilitating preoperative planning and identification of possible complications.Conclusion: Precise radiological knowledge of the complex anatomical relationships of the petrous bone is crucial in routine radiological and neuroradiological practice. A detailed description of existing anatomical standard variants enables colleagues in surgical disciplines such as otolaryngology and neurosurgery to efficiently prepare the procedures and assess possible complications.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of replacing true non-contrast images with virtual non-contrast images in quantitative analysis of emphysema. 虚拟非对比图像替代真实非对比图像在肺气肿定量分析中的可行性。

Radiologie (Heidelberg, Germany) Pub Date : 2025-05-08 DOI: 10.1007/s00117-025-01448-8

Yanbing Guo, Qiuju Fan, Zhanli Ren, Nan Yu, Hui Tan, Guangming Ma

{"title":"Feasibility of replacing true non-contrast images with virtual non-contrast images in quantitative analysis of emphysema.","authors":"Yanbing Guo, Qiuju Fan, Zhanli Ren, Nan Yu, Hui Tan, Guangming Ma","doi":"10.1007/s00117-025-01448-8","DOIUrl":"https://doi.org/10.1007/s00117-025-01448-8","url":null,"abstract":"Objective: To evaluate the performance of virtual non-contrast (VNC) images in comparison with true non-contrast (TNC) images in dual-energy computed tomography (DECT) for the assessment of emphysema quantification.Materials and methods: A retrospective analysis was conducted of 57 patients who underwent three-phase chest CT. The VNC images of the arterial phase (VNC(AP)) and venous phase (VNC(VP)) were generated on an AW4.7 workstation. The objective assessment of image noise in TNC and VNC images was conducted through the quantification of image quality, which was then subjected to a double-blind review by two physicians for image quality and visual classification of emphysema. Furthermore, quantified emphysema at three distinct thresholds (950 HU, 930 HU, and 910 HU) using the three sets of images was compared. Bland-Altman plots were used to compare the quantitative discrepancies at the -950HU threshold.Results: There was no statistically significant difference in subjective image quality and emphysema visual classification between TNC and VNC images (all p > 0.05). In the quantitative measurement, no statistical difference was observed in image noise or total lung volume among the three groups. When compared with TNC, VNC(VP) images demonstrated no statistical difference in 15th percentile lung density (Perc 15), low attenuation volume (LAV), percentage of low attenuation area (LAA%), and mean lung density (MLD; all p > 0.05). The use of VNC images was found to reduce the radiation dose by 32.6%.Conclusion: The use of VNC, particularly VNC(VP) images, in chest CT has the potential to supplant TNC for the quantitative assessment of emphysema, thereby streamlining scans and reducing radiation dose.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0