Psychiatry research case reports最新文献

{"title":"Removal notice to “Announcing Suicide on the Internet: A Case Report” [Psychiatry Research Case Reports Volume 1, Issue 1, June 2022, 100010]","authors":"John F. Gunn III , David Lester","doi":"10.1016/j.psycr.2025.100278","DOIUrl":"10.1016/j.psycr.2025.100278","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100278"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “A vulnerable young adult using cannabis for therapeutic purposes despite emerging psychosis” [Psychiatry Research Case Reports 1 (2022) 100037]","authors":"Jill M Williams ,&nbsp;Mary Barna Bridgeman ,&nbsp;Lisa Laitman","doi":"10.1016/j.psycr.2025.100264","DOIUrl":"10.1016/j.psycr.2025.100264","url":null,"abstract":"<div><div>This article has been retracted: please see Elsevier policy on article withdrawal (<span><span>https://www.elsevier.com/about/policies-and-standards/article-withdrawal</span><svg><path></path></svg></span>).</div><div>A post-publication investigation conducted by Elsevier's Research Integrity &amp; Publishing Ethics team on behalf of the journal determined that the patient or nominated representative of the patient did not provide informed consent for this publication in line with the journal's policy. The editor has decided to retract the article.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early psychiatric symptoms as an early indicator of amyotrophic lateral sclerosis: A case report","authors":"Jeffrey Hauck,&nbsp;Niraj Mehta","doi":"10.1016/j.psycr.2025.100255","DOIUrl":"10.1016/j.psycr.2025.100255","url":null,"abstract":"<div><div>Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disorder primarily characterized by the progressive loss of motor neurons, leading to muscle weakness and atrophy. Recent studies have highlighted the association between ALS and various neuropsychiatric comorbidities, including depression, schizophrenia, frontotemporal dementia, and Parkinson dementia. This case report presents a 63-year-old Hispanic male with a complex neuropsychiatric history, including schizoaffective disorder. The patient presented to the hospital following a fall from his mobility scooter, leading to the discovery of characteristic ALS symptoms during his inpatient hospital stay. The patient exhibited pseudobulbar affect, dysarthria, tongue fasciculations, and muscle atrophy, raising suspicion of ALS. A thorough review of his medical history revealed a pattern of neuropsychiatric symptoms that likely preceded his ALS diagnosis. Subsequent outpatient electromyography confirmed ALS, leading clinicians to believe his diagnosis of ALS was initially missed. This case report highlights the importance of a thorough physical examination and history in all patients regardless of presentation, and that neuropsychiatric symptoms can manifest before and after a diagnosis of ALS.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schema-therapeutic exposure for treatment resistant anxiety and obsessive-compulsive disorders: A multiple baseline case series design study","authors":"Nancy Peeters ,&nbsp;Boris van Passel ,&nbsp;Gert-Jan Hendriks ,&nbsp;Eni Becker ,&nbsp;Julie Krans","doi":"10.1016/j.psycr.2024.100241","DOIUrl":"10.1016/j.psycr.2024.100241","url":null,"abstract":"<div><div>Exposure is effective for patients with anxiety disorders or obsessive-compulsive disorders (OCD). Yet, a significant minority does not recover with current guideline treatments due to comorbid personality disorder symptoms. For these patients, no further guideline treatments exist. Schema therapy (ST) is an evidence-based treatment for personality disorders and integrating ST and exposure could provide a solution. We tested a new schema-therapeutic exposure treatment in patients with treatment-resistant anxiety or OCD. Using the latest methodological and statistical insights in a well-powered single-case experimental design (SCED; <em>N</em> = 6), we administered weekly measures of psychological malfunctioning, anxiety/OCD symptoms, and schema modes over the course of treatment (29–32 weeks). Schema-therapeutic exposure was effective for 33.33 % of our sample, with improvement on all or most outcome measures. Another 33.33 % demonstrated partial improvements, and 33.33 % remained stable. Given the historical chronicity of symptoms in our sample, these effects are highly encouraging. Secondary findings showed that changes in schema modes did not precede changes in anxiety/OCD symptoms or psychological malfunctioning, and that 66.66 % of the sample continued to improve in the second half of the treatment. Future research is wanted to unravel the interactive and additive effects of schema-therapeutic exposure to further optimize treatment.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An actigraphy case series: Sleep disturbance associations with suicidal ideation, self-harm and desire to live","authors":"Annabelle M. Mournet,&nbsp;Allison K. Ruork,&nbsp;Evan M. Kleiman,&nbsp;Shireen L. Rizvi","doi":"10.1016/j.psycr.2025.100244","DOIUrl":"10.1016/j.psycr.2025.100244","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep disturbances are a well-established suicide risk factor. This case series represents an investigation into the individual-level associations between objectively measured sleep using actigraphy and fatigue on next-day suicidal ideation, self-harm urges, and desire to be alive.</div></div><div><h3>Methods</h3><div>This case series utilizes data from seven adults with borderline personality disorder receiving dialectical behavioral therapy (DBT). Participants wore a Phillips HealthBand wearable device to collect actigraphy data and completed ecological momentary assessment (EMA). Data was collected for one week per month for each of the six months of treatment. We conducted a series of individual linear regressions.</div></div><div><h3>Results</h3><div>For participant 1, fatigue was associated with self-injury urges. Sleep duration and time in bed were predictive of desire to be alive. For participant 3, fatigue was associated with suicidal ideation. Sleep efficiency was predictive of desire to be alive. Participant 5′s WASO was predictive of suicidal ideation and desire to be alive. For participant 6, WASO predicted desire to be alive. For participant 7, fatigue was predictive of desire to be alive.</div></div><div><h3>Discussion</h3><div>This case series provides evidence that certain aspects of sleep, as measured by actigraphy, is predictive of SI, self-harm urges, and desire to be alive among certain DBT patients. Results points to the importance of examining actigraphy findings on an individual level. Future research should continue to utilize multimodal data to advance understanding of the associations between sleep metrics with STBs, as well as how to continue to best leverage actigraphy data in combination with other methodologies.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VPS13A disease: Bridging motor dysfunction and psychiatric symptoms – A case report","authors":"Gisela Simões ,&nbsp;Helena Felgueiras ,&nbsp;Ana Inês Gomes ,&nbsp;Rita Silva ,&nbsp;Maria João Malaquias","doi":"10.1016/j.psycr.2025.100257","DOIUrl":"10.1016/j.psycr.2025.100257","url":null,"abstract":"<div><div>Neuroacanthocytosis encompasses a group of disorders with basal ganglia pathology leading to characteristic movement disorders and a high prevalence of psychiatric manifestations. VPS13A disease (VPS13A-D), formerly known as Chorea-acanthocytosis (ChAc), is a rare autosomal recessive disorder caused by pathogenic variants in the <em>vacuolar protein sorting 13 homolog A</em> (VPS13A) gene that leads to chorein loss and affects the basal ganglia, especially the caudate nucleus.</div><div>The available literature reveals a gap in the exploration of the coexistence of neuropsychiatric symptoms, with only a few clinical reports described in psychiatric literature. To improve the understanding of this particular genetic disease, this article reports a clinical case of VPS13A-D and discusses its comorbid neuropsychiatric manifestations by analyzing the presentation, laboratory and imaging findings, and by briefly addressing the distinct neurobiology and neuropathology of this disorder concerning psychiatric manifestations, according to the relevant literature.</div><div>We present a 35-year-old male diagnosed with VPS13A-D with an involuntary movement presentation and neuropsychiatric symptoms, including orobuccal self-mutilation, anxiety and obsessive-compulsive traits. The patient received treatment with tetrabenazine (for better control of chorea) and fluvoxamine (to address psychiatric symptoms), showing symptomatic improvement during outpatient follow-up. The discussion delves into the neurobiological framework of VPS13A-D, emphasizing the role of the basal ganglia in both motor and neuropsychiatric manifestations. Psychopathological aspects such as dysexecutive syndrome and obsessive‒compulsive symptoms are explored, highlighting the impact of frontal-subcortical circuits in these presentations.</div><div>This case underscores the complexity of neuropsychiatric symptoms associated with VPS13A-D and highlights the challenges in distinguishing between movement anomalies and psychopathology, accentuating the need for a comprehensive approach through multidisciplinary collaboration for improved patient care and outcomes.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using daily diary data to examine the period prior to a suicide attempt: An observational single-case study","authors":"Daniel Núñez ,&nbsp;Esdras Raposo de Almeida ,&nbsp;Arnout C. Smit ,&nbsp;Evelien Snippe ,&nbsp;Merel K. Muller ,&nbsp;David van den Berg ,&nbsp;Yuan-Pang Wang ,&nbsp;Wim Veling ,&nbsp;Sanne H. Booij ,&nbsp;Johanna T.W. Wigman","doi":"10.1016/j.psycr.2025.100251","DOIUrl":"10.1016/j.psycr.2025.100251","url":null,"abstract":"<div><h3>Background</h3><div>Prevention of suicide is an important public health issue. Applying Exponential Weighted Moving Average (EWMA) control charts to time-intensive diary data could improve our understanding of the processes leading up to a suicide attempt (SA). We explored daily reports of multiple psychopathological domains, and particularly changes therein, during a period directly preceding a SA.</div></div><div><h3>Methods</h3><div>We applied an observational single-case study design on a diary data from one participant (female, age between 20 and 30 years) who attempted suicide (and survived) during participation in another study. This study included 90 daily reports of depression and anxiety symptoms, psychotic experiences, thought disturbances and a proxy for passive suicide ideation (feeling life is worthwhile). We used EWMA control charts to explore whether structural changes in these psychopathological domains preceded the upcoming SA. We first investigated the overall domains and then zoomed in on individual items.</div></div><div><h3>Results</h3><div>We detected increases in depression and anxiety symptoms, psychotic experiences, and passive suicide ideation in a time window of 6 days directly preceding the SA. Although no changes in the overall dimension of thought disturbances preceded the SA, two specific items, impulsive thoughts and persistent thoughts, did increase.</div></div><div><h3>Conclusion</h3><div>We found changes in daily reports of several (sub)dimensions of psychopathology prior to the SA. Our findings show how applying EWMA charts to diary reports may be helpful to detect signs of an upcoming SA. Improving our ability to timely signal risk for SA may inform strategies aimed at its prevention.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained remission of treatment-resistant depression following two inhalations of nitrous oxide: A case report","authors":"Barbora Provaznikova,&nbsp;Sebastian Olbrich,&nbsp;Erich Seifritz,&nbsp;MaximilianDominik Haas,&nbsp;Golo Kronenberg","doi":"10.1016/j.psycr.2025.100261","DOIUrl":"10.1016/j.psycr.2025.100261","url":null,"abstract":"<div><div>Nitrous oxide (N2O, laughing gas) is a colorless gas commonly used as an anesthetic and analgesic, delivered in an oxygen mixture to prevent hypoxia, with concentrations up to 70 % considered as safe (Knuf and Maani, 2024). Recently, N2O has gained significant attention in psychiatry as a promising new treatment for patients suffering from treatment-resistant depression (TRD). Rapid antidepressant effects similar to ketamine have been reported, although more research is still needed in particular in regard to the long-term efficacy of N2O (e.g., Kronenberg et al., 2024). This report presents the case of a 65-year-old woman with generalized anxiety disorder and chronic major depression, who underwent two 30 min N2O treatment sessions. Following treatment, she achieved remission and reported sustained well-being without signs of depression or anxiety at a three-month follow-up.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive therapy for neuropsychiatric symptoms in a patient with posterior cortical atrophy associated with Alzheimer's disease and a history of depression: A case report and review of the literature","authors":"Beatriz Pozuelo Moyano ,&nbsp;Kevin Swierkosz-Lenart ,&nbsp;Jean-Pierre Schuster ,&nbsp;Nicole Rey Piedra Garcia ,&nbsp;Olivier Rouaud ,&nbsp;Pierre Vandel ,&nbsp;Armin von Gunten","doi":"10.1016/j.psycr.2025.100256","DOIUrl":"10.1016/j.psycr.2025.100256","url":null,"abstract":"<div><div>Posterior cortical atrophy (PCA) is a common type of early-onset Alzheimer's disease (AD). The most common neuropsychiatric symptoms (NPS) in PCA are depression, anxiety, apathy, and irritability. Our patient had a history of depression and was diagnosed with PCA at the age of 58 years. Three years after the diagnosis, the patient's cognitive functions rapidly declined, and she was referred to our psychogeriatric service due to significant agitation and ongoing extrapyramidal side effects.</div><div>During the hospitalization, the old-age psychiatrist observed depressive symptoms and severe behavioral disturbances (especially aggressiveness and irritability) that were resistant to pharmacological treatment. The old-age psychiatrist initiated electroconvulsive therapy (ECT) treatment, which resulted in a reduction of both NPS and the prescription of psychotropic drugs. ECT was effective and safe in the treatment of depression and other NPS in this case of PCA. However, further research is needed to determine the most effective stimulation parameters and the efficacy of ECT stratified according to the different etiopathologies of dementia.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine metabolism in psychosis and catatonia: A case report and review of the literature","authors":"Sophie Scharner ,&nbsp;Terrance M Dolan ,&nbsp;Eric P Hazen","doi":"10.1016/j.psycr.2025.100260","DOIUrl":"10.1016/j.psycr.2025.100260","url":null,"abstract":"<div><h3>Background</h3><div>In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation.</div></div><div><h3>Basic Procedures and Main Findings</h3><div>We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency.</div></div><div><h3>Principal Conclusions</h3><div>This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}