Psychiatry research case reports最新文献

{"title":"Diagnostic challenges in a patient presenting with postictal and interictal psychosis: A case report and review","authors":"Ayyub Imtiaz ,&nbsp;Samuel Duffy ,&nbsp;Benedicto Borja","doi":"10.1016/j.psycr.2023.100202","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100202","url":null,"abstract":"<div><h3>Background</h3><p>Epilepsy and psychotic disorders have a bidirectional correlation that is established in the literature. Psychosis of epilepsy (POE) describes a group of psychoses such as interictal and postictal psychosis. We present a case of overlapping symptoms of postictal and interictal psychosis making diagnostic clarification difficult.</p></div><div><h3>Case</h3><p>A 58-year-old female with a history of epilepsy since childhood, blunt traumatic brain injury, glioma status post right temporoparietal craniotomy and resection, HIV on HAART, depression, and alcohol use disorder, presented to the emergency room with hallucinations, paranoia, delusions, and agitated behavior after a seizure. The patient had an increase in seizure frequency over the past 9 months, now having one seizure a week. The disorientation, agitation, and hallucinations would resolve spontaneously in a short period of time but have persisted after recent seizures. Recent MRI revealed focal cortical and subcortical encephalomalacia with gliosis in the right superior temporal gyrus extending into the lingual gyrus and mesial temporal sclerosis. EEG showed multifocal 1 Hz sharp discharges in a ratio of 3:1 coming from the right temporal region, not correlated to any tonic-clonic events.</p></div><div><h3>Conclusion</h3><p>This case has risk factors and presenting features for both interictal and postictal psychosis making accurate diagnostic clarification difficult during their stay. Differentiating between various POE can prove challenging as the evidence-based management differs. When an antipsychotic needs to be provided, we recommend risperidone as a suitable option given its relative safety in both seizure disorders and traumatic brain injuries secondary to neurosurgery.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223001001/pdfft?md5=51a28ccb208114101c07c059cf249fc2&pid=1-s2.0-S2773021223001001-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human immunodeficiency virus-related neurocognitive disorder with hallucinations and delusions: A case report","authors":"Junpei Igata ,&nbsp;Naomichi Okamoto ,&nbsp;Hirofumi Tesen ,&nbsp;Maya Akiyama ,&nbsp;Satoru Ide ,&nbsp;Atsuko Ikenouchi ,&nbsp;Reiji Yoshimura","doi":"10.1016/j.psycr.2023.100201","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100201","url":null,"abstract":"<div><h3>Introduction</h3><p>In patients with human immunodeficiency virus (HIV) infection, HIV-associated neurocognitive disorder (HAND) manifests in 18–50% of cases. Symptoms, including memory impairment, impaired attention, concentration, executive dysfunction, slowed motor speed, apathy, personality changes, and abnormal behavior can vary. However, psychotic symptoms, such as hallucinations and delusions, are rare. We report a case of HAND with hallucinations, delusions, abnormal behavior, irritability, and decreased motor and attention-processing speeds that were successfully treated with risperidone and aripiprazole.</p></div><div><h3>Case presentation</h3><p>A 39-year-old Japanese man with a 6-year history of HIV infection presented to our hospital with delusions, hallucinations, and cognitive dysfunction. Five years ago, he was admitted to our department with abnormal behaviors, such as trespassing in a stranger's residence and immobility. He was diagnosed with HAND after ruling out opportunistic infections secondary to HIV infection and neurodegenerative diseases. He was initially admitted with auditory and visual hallucinations, which improved with risperidone 4 mg. However, 2 years ago, he discontinued risperidone and became irritable. He was admitted to our department in October of the same year with hallucinations, delusions, slow movement, and decreased spontaneity. Misperception, delusions, abnormal behavior, and prolonged response latency were observed at the time of admission. On the third day of admission, aripiprazole was administered, and the dose was titrated to 30 mg. His-hallucinations, delusions, abnormal behavior, and irritability disappeared. One year later, in March, a cognitive function test showed that his motor speed, attention-information processing speed, and activity had improved.</p></div><div><h3>Conclusion</h3><p>This patient presented with HAND symptoms, such as hallucinations, delusions, abnormal behavior, hyperirritability, and cognitive dysfunction. Risperidone and aripiprazole effectively alleviated these symptoms, and the cognitive dysfunction showed reversible improvement. Clinicians should be aware of the possibility of rare symptoms, such as hallucinations and delusions, while treating HAND. Additionally, they should consider the possibility of improved cognitive function and provide appropriate treatments.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000998/pdfft?md5=71471f18dcc0f5eb41f373c5406d69f5&pid=1-s2.0-S2773021223000998-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138475018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-Responsive Encephalopathy associated with Autoimmune Thyroiditis (SREAT) presenting as malignant excited catatonia: A novel clinical presentation","authors":"Alicia R. Khan ,&nbsp;Jacob Carolan ,&nbsp;Mario J. Rullo ,&nbsp;Kelly L. Hamilton ,&nbsp;Tamara Movsesova ,&nbsp;Barsegh A. Barseghian ,&nbsp;Pauline Tsai ,&nbsp;Jennifer F. Schreiber","doi":"10.1016/j.psycr.2023.100198","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100198","url":null,"abstract":"<div><h3>Background</h3><p>Hashimoto Encephalopathy, more accurately known as Steroid Responsive Encephalopathy associated with Autoimmune Thyroiditis (SREAT), is an exceedingly rare and often controversial diagnosis that, when present, manifests as encephalopathy with a variety of other potential symptoms in the setting of elevated antithyroid peroxidase antibody and/or antithyroglobulin antibody. Its manifestations can include encephalopathy, seizures, myoclonus, hallucinations, stroke-like findings, and more.</p></div><div><h3>Patient case</h3><p>We present the case of a 39-year-old transgender man with autistic spectrum disorder and depression, initially presumed to be in acute psychiatric decompensation, later found to have elevated levels of anti-thyroid peroxidase antibodies, who responded well to plasma exchange (PLEX) and rituximab. On initial psychiatric admission, the patient had symptoms of suicidal ideation, confusion, and agitation. He showed little improvement on medications such as quetiapine, olanzapine, valproate, and bupropion. Due to worsening agitation and cognitive impairment, he required further medical and neurological evaluation. He later had an episode deemed to be a likely seizure. This workup included electroencephalogram (EEG), MRI Brain, and lumbar puncture, yet all were unremarkable. Laboratory values were notable for elevated serum anti-thyroid peroxidase (TPO) antibodies of 661 U/mL. The patient received intravenous high-dose steroids with transient improvement. He eventually responded dramatically to plasmapheresis and rituximab. At his post-discharge follow up, he had returned to his cognitive baseline. He successfully resumed his job and has since remained at his functional baseline.</p></div><div><h3>Conclusion</h3><p>This case is the first to our knowledge to characterize a novel presentation of SREAT mimicking malignant excited catatonia. In such cases, if initial response to glucocorticoid treatment is equivocal, plasma exchange may be an effective treatment option.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000962/pdfft?md5=cdc8a3c10578a58e5aaea2427b16d459&pid=1-s2.0-S2773021223000962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138549377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pica and coprophagia in schizophrenia: A case report","authors":"Juliana L. Vanderburg,&nbsp;Alia R. Warner,&nbsp;Alexandra N. Duran,&nbsp;Lauren A. Mordukhaev","doi":"10.1016/j.psycr.2023.100199","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100199","url":null,"abstract":"<div><h3>Background</h3><p>Little research has addressed maladaptive eating behaviors among patients with schizophrenia. Pica, the eating of nonfood items, and coprophagia, the consumption of feces, occur at higher rates in the early stages of schizophrenia; however, etiology of pica is poorly understood. Understanding primary precipitants of pica among patients with schizophrenia is integral for providing effective treatment. We present a case study on an interprofessional collaboration to ascertain primary diagnosis of a patient exhibiting symptoms of psychosis and pica/coprophagia.</p></div><div><h3>Case presentation</h3><p>A 22-year-old Hispanic male involuntarily presented to an inpatient facility. His-family reported that for 6 months prior to admission, he did not attend to self-care tasks, began consuming nonfood items, and appeared internally preoccupied. While hospitalized, he maintained similar behavior. He frequently went to the bathroom to consume his feces and urine. If disrupted, he sometimes became physically aggressive and persisted in his behavior. He reported odd beliefs related to nutrition. At times, he rubbed hand sanitizer on his face and body. He was trialed on olanzapine, haloperidol, lorazepam, and paliperidone to address agitation and psychosis. Medical rule-outs for his behavior included cognitive impairment, seizure, central nervous system (CNS) lesion, and substance/alcohol use. He was referred to psychology for an evaluation to determine his primary diagnosis. Findings indicated absence of mood episodes and OCD. His history revealed several risk factors for schizophrenia, and progression of illness was typical of schizophrenia. His pica behaviors declined following implementation of a consistent regimen of paliperidone per court ordered medication petition.</p></div><div><h3>Conclusion</h3><p>This case report presents a patient with co-occurring pica, coprophagia, and first episode psychosis, a rare and understudied combination of symptoms. He evidenced delusional beliefs related to nutrition, which precipitated maladaptive eating behaviors. The case is relevant for providers observing maladaptive eating behaviors in patients with symptoms of psychosis, suggesting that treating pica with antipsychotic medications may be efficacious. The case study also illustrates the importance of accurate diagnostics and the power of interprofessional collaboration in providing psychiatric care.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000974/pdfft?md5=0f7e23823e899b2684de76a70705875b&pid=1-s2.0-S2773021223000974-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138475017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘A course of electroconvulsive therapy in a geriatric patient with symptomatic degenerative cervical myelopathy before corrective surgery’","authors":"Amelia James,&nbsp;Emma Hack,&nbsp;Francine Moss","doi":"10.1016/j.psycr.2023.100195","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100195","url":null,"abstract":"<div><p>We report the case of a 70-year-old woman who received ECT for major depression with psychotic features. The patient was identified to have symptomatic severe cervical degenerative myelopathy during treatment and she received 21 sessions of right unilateral electroconvulsive therapy (ECT) without adverse neurological outcome. Precautions were undertaken to minimize risk of ECT-associated spinal cord injury. ECT was successfully recommenced without precautions following laminectomy.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000937/pdfft?md5=59138dffdb6b5f1921f12c8f79bca0a9&pid=1-s2.0-S2773021223000937-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138430684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hypoparathyroidism associated with catatonia in a patient with bipolar affective disorder: A case report","authors":"Tulasi Sindhuja ,&nbsp;Akash Kumar ,&nbsp;Gurveen Bhatia ,&nbsp;Snehil Gupta ,&nbsp;Ashok Kumar","doi":"10.1016/j.psycr.2023.100196","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100196","url":null,"abstract":"<div><p>Primary hypoparathyroidism is caused by parathyroid hormone (PTH) deficiency and characterized by hypocalcemia. Psychiatric manifestations such as mood disorders, however, are uncommon in primary hypoparathyroidism; therefore, neuro-psychiatric manifestations, including mood disorders, in the latter condition can pose a significant diagnostic challenge. Furthermore, co-morbid psychiatric disorders, metabolic conditions, and concurrent (psychotropic) medications can complicate the clinical picture of either of the conditions, including posing substantial diagnostic and management challenges. In this paper, we report a case of primary hypoparathyroidism with catatonia in a patient with a pre-existing bipolar affective disorder (BPAD) with poor response to mood stabilizers and antipsychotic medication for two years.</p><p>The girl, of age 18 years presented to the emergency department in a catatonic state characterized by mutism, posturing, stupor, negativism, waxy flexibility, and echolalia (Bush-Francis Catatonia Rating Scale (BFCRS) score was 16). Her symptoms responded poorly to psychotropic medications, moreover, she was overly sensitive to adverse effects of various medication (e.g., very prolonged QTc interval). Laboratory investigations showed that she had severe hypocalcemia, hypomagnesemia, hyperphosphatemia, and alkalosis. Her PTH levels were significantly low. Upon correction of dyselectrolytaemia (through calcium and magnesium supplements) and concurrent intake of tab. Olanzapine, a significant improvement in her symptoms was noticed. After excluding all causes of acquired hypoparathyroidism, we concluded it as primary hypoparathyroidism. The case highlights the importance of having a comprehensive and wider assessment of such atypical presentations of catatonia, especially if it responds poorly to conventional treatments.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000949/pdfft?md5=c71394053e1ab1f547ed7be238134814&pid=1-s2.0-S2773021223000949-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic uncertainty: Avoidant/restrictive food intake disorder and co-occurring psychosis in a severely malnourished adolescent male","authors":"Nicole Bennett ,&nbsp;Abigail Matthews","doi":"10.1016/j.psycr.2023.100197","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100197","url":null,"abstract":"<div><p>Diagnosing comorbid psychosis and avoidant/restrictive food intake disorder (ARFID) may be challenging among severely malnourished patients. Malnutrition is an identified medical cause of psychosis and in patients with ARFID, symptoms mirroring psychosis could be secondary to weight loss versus a “true” thought disorder. Conversely, dietary restriction has been demonstrated in patients with psychosis, which conceivably, could result in the development of ARFID. In this case report, we present a medically hospitalized adolescent male with severe malnutrition, diagnosed with ARFID after 12-months of food avoidance due to sensory sensitivities and fears of gastrointestinal discomfort. A significant decline in his emotional, interpersonal, and cognitive functioning was also reported and attributed to severe malnutrition. With nutritional rehabilitation, the patient's eating behaviors and mental state unexpectedly declined, and he was ultimately diagnosed with comorbid psychosis.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000950/pdfft?md5=22a726cd24b3a63c8fd9e08553a1ba1f&pid=1-s2.0-S2773021223000950-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138430685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catatonia secondary to calcineurin inhibitor exposure in a pediatric liver transplant patient","authors":"Alexander Palffy,&nbsp;Sarah Mohiuddin","doi":"10.1016/j.psycr.2023.100194","DOIUrl":"10.1016/j.psycr.2023.100194","url":null,"abstract":"<div><p>Catatonia is a syndrome characterized by a predominance of neurologic and psychiatric symptoms. There has been sparse but convincing literature building the association between catatonia and aspects of solid organ transplant, however, there have been no cases reported of pediatric catatonia post-hepatic transplant related to cyclosporine. This report summarizes the case of a 12-year-old boy with no preexisting neurodevelopmental concerns or psychiatric illness who received an orthotopic liver transplant secondary to a several year course of hepatic failure due to Budd-Chiari syndrome and went on to develop catatonia along with other neurologic complications. He had a partial response to standard treatments for catatonia; however, it was not until he was switched from a calcineurin inhibitor to another immunosuppressant that his symptoms of catatonia and other neurologic dysfunction fully resolved. Subsequently he was followed for 6 months in the outpatient setting, where he regained and maintained his previous baseline of psychosocial function while tapered off lorazepam conservatively. It is well established that catatonia is underrecognized in medically ill adults, and this is likely the case in pediatric populations as well. Early identification is important to not only begin treatment for catatonia, but to recognize that there is active neurologic dysfunction that may be due to iatrogenic or other exogenous causes.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"3 1","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000925/pdfft?md5=023492d87467061c6aab929f15a01494&pid=1-s2.0-S2773021223000925-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135670574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive therapy for psychotic depression in a patient with a deep brain stimulator: A Case Report","authors":"A. Lucardie ,&nbsp;L. Van Diermen ,&nbsp;Y. Madani ,&nbsp;D. Schrijvers","doi":"10.1016/j.psycr.2023.100193","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100193","url":null,"abstract":"<div><p>This case-report describes a patient with Parkinson's Disease (PaD) with an implanted deep brain stimulator, who received electroconvulsive therapy (ECT) for the treatment of a major depressive episode with melancholic features. There was an adequate response to treatment and a lack of significant adverse effects. ECT has shown itself to be a safe and effective treatment in these circumstances if the necessary safety precautions are taken. The effect of ECT on psychomotor features in melancholic depression are outlined and discussed, where a change in psychomotor function could be predictive for treatment outcome. Further research is warranted.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000913/pdfft?md5=053d28015f67a4e4fcc0dae1e1489b9f&pid=1-s2.0-S2773021223000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134653884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopharmacological considerations for comorbid anorexia nervosa and bipolar disorder","authors":"Christine Zhang,&nbsp;Lillian Carter,&nbsp;Carrie J McAdams","doi":"10.1016/j.psycr.2023.100192","DOIUrl":"https://doi.org/10.1016/j.psycr.2023.100192","url":null,"abstract":"<div><p>Anorexia nervosa is a serious psychiatric disorder defined by restrictive eating behaviors resulting in an unhealthy low body weight. Patients who have comorbid anorexia nervosa and bipolar disorder have more severe eating disorder symptomology as well as worse long-term prognosis. This case report follows the pharmacologic management of a patient with comorbid anorexia nervosa and bipolar disorder, highlighting important treatment considerations for this population. The patient was treated with antidepressants and mood stabilizers without consideration of the eating disorder for several years. Two psychoactive medications associated with food restriction (selegiline) and weight loss (bupropion) were prescribed after the patient reported concerns about her weight despite a normal body mass index. The bioavailability of another medication, lurasidone, depends on food intake, and the patient started feeling sedated when her restrictive eating remitted. This clinical phenomenon emphasizes the importance of careful psychopharmacological selection in more complex psychiatric patients. Effective treatment of comorbid anorexia nervosa and bipolar disorder requires continued assessment and treatment of disordered eating symptoms in conjunction with prudent psychopharmacological selection.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773021223000901/pdfft?md5=2684ae186191d766cd3d2452342a1e2b&pid=1-s2.0-S2773021223000901-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92130101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}