Psychiatry research case reports最新文献

{"title":"Marchiafava-Bignami disease presenting with psychiatric symptoms: A case report","authors":"Doğancan Sönmez ,&nbsp;Çiçek Hocaoğlu","doi":"10.1016/j.psycr.2023.100174","DOIUrl":"10.1016/j.psycr.2023.100174","url":null,"abstract":"<div><p>Marchiafava-Bignami disease (MBD), characterized by corpus callosum degeneration due to chronic patient with alcohol dependence, is a rare condition. In its clinical appearance, two main subtypes have been identified. It is known as the mild type that progresses with severe and mild symptoms that cause changes in consciousness and coma and can easily be overlooked among the signs of alcohol withdrawal. Although there are some difficulties in the diagnosis and differential diagnosis, early diagnosis and appropriate treatment approaches can prevent permanent disability and the development of coma. There are opinions that the administration of high doses of thiamine, vitamin B complexes, and steroids may be beneficial. In the diagnostic approach, corpus callosum degeneration is detected in brain neuroimaging. The prognosis of MBD may vary from patient to patient. This study, a fifty-six-year-old male patient who presented with atypical psychiatric complaints and was followed up with the diagnosis of MDD with alcohol use disorder is presented. It is aimed to contribute to the literature by discussing the patient's clinical appearance, diagnosis, and treatment in light of current literature findings.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47204702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive Therapy For Malignant Catatonia Due To Clozapine Withdrawal—A Case Series","authors":"Sean Allan ,&nbsp;Humaira Shoaib ,&nbsp;Andrew Spitzberg ,&nbsp;Joanna Drucker ,&nbsp;Xavier Jimenez ,&nbsp;Georgios Petrides ,&nbsp;Sohag Sanghani","doi":"10.1016/j.psycr.2023.100175","DOIUrl":"10.1016/j.psycr.2023.100175","url":null,"abstract":"<div><h3>Background</h3><p>Clozapine, a pharmacologically complex second-generation antipsychotic, is the standard of care for treatment resistant schizophrenia. Abrupt cessation of clozapine can lead to severe medical complications like cholinergic rebound, psychiatric decompensation, and the development or reappearance of catatonia. Malignant catatonia, an acute and life-threatening form of catatonia with autonomic dysfunction and instability, has been observed to occur secondary to clozapine withdrawal. Malignant catatonia has a significant mortality rate and requires prompt diagnosis and treatment with lorazepam and/or electroconvulsive therapy. There have been few published cases observing malignant catatonia secondary to clozapine withdrawal, and even fewer cases reporting successful treatment with electroconvulsive therapy</p></div><div><h3>Objectives</h3><p>To identify and present new cases of malignant catatonia secondary to clozapine withdrawal that were successfully treated with electroconvulsive therapy.</p></div><div><h3>Methods</h3><p>We present a series of 3 cases (3 case reports) of patients who developed catatonic symptoms with autonomic instability after abruptly discontinuing clozapine.</p></div><div><h3>Results</h3><p>In all three cases, malignant catatonia was diagnosed and initially treated with lorazepam with little effect. With worsening autonomic instability and catatonic symptoms, and minimal improvement with lorazepam, patients were ultimately effectively treated with electroconvulsive therapy.</p></div><div><h3>Conclusion</h3><p>Malignant catatonia should be considered early in patients presenting with catatonic symptoms, abnormal behavior, and autonomic dysfunction in the setting of abrupt clozapine discontinuation. Although the first line treatment for catatonia and malignant catatonia is lorazepam, benzodiazepine medications alone may not be sufficient in cases of clozapine withdrawal. Electroconvulsive therapy has been shown to be an effective treatment in managing malignant catatonia in the setting of clozapine withdrawal.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42474461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low frequency transcranial magnetic stimulation for cognitive recovery after traumatic brain injury: A case report","authors":"Kelly A Durbin ,&nbsp;Katharine G Marder ,&nbsp;Andrew C Wilson ,&nbsp;Thuc Doan Ngo ,&nbsp;Juliana Corlier ,&nbsp;Nikita Vince-Cruz ,&nbsp;Robert Bilder ,&nbsp;Paul Vespa ,&nbsp;Reza Tadayonnejad ,&nbsp;Jonathan C Lee ,&nbsp;Nathaniel D Ginder ,&nbsp;Scott A Wilke ,&nbsp;Jennifer Levitt ,&nbsp;David Krantz ,&nbsp;Andrew F Leuchter","doi":"10.1016/j.psycr.2023.100173","DOIUrl":"10.1016/j.psycr.2023.100173","url":null,"abstract":"<div><h3>Introduction</h3><p>Repetitive Transcranial Magnetic Stimulation (rTMS) shows promise for treating sequelae of traumatic brain injury (TBI) including headache and depression. The few studies examining rTMS for cognitive recovery after TBI have reported mixed outcomes. The role of rTMS in cognitive recovery remains unclear.</p></div><div><h3>Case presentation</h3><p>A 23-year-old woman with persistent executive dysfunction after severe TBI primarily affecting the right prefrontal region underwent 19 sessions of rTMS treatment (2,000 pulses of 1 Hz stimulation delivered to right dorsolateral prefrontal cortex [DLPFC]) 12 months after the injury while continuing cognitive rehabilitation. Response to treatment was evaluated using neuropsychological testing, EEG, and rehabilitation assessments. Significant improvements were observed in basic attention, working memory, processing speed, and executive function. EEG changes were consistent with suppression of pathologic and enhancement of normal neurophysiologic activity in the prefrontal regions. The patient made significantly more progress in rehabilitation in the six months following conclusion of rTMS treatment.</p></div><div><h3>Discussion</h3><p>This case demonstrates that low frequency rTMS delivered to right DLPFC can produce significant changes in oscillatory activity and in basic attention, working memory, and executive functioning after TBI, and may enhance rehabilitation outcomes. This case further demonstrates that neuropsychological testing and EEG may be employed to guide rTMS treatment of cognitive deficits following TBI.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45769368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory Charles Bonnet syndrome and psychosis: Is there a relation? – A case report","authors":"Olga Martínez Piera ,&nbsp;Josefina Pérez-Blanco ,&nbsp;Mar Carceller-Sindreu","doi":"10.1016/j.psycr.2023.100172","DOIUrl":"10.1016/j.psycr.2023.100172","url":null,"abstract":"<div><h3>Background</h3><p>Auditory hallucinations are relatively frequent in schizophrenia. Musical hallucinations are a specific hallucination type often observed in patients with hearing impairment and also known as auditory Charles Bonnet syndrome. Here, we present the case of a patient whose clinical course illustrates the often forgotten and overlooked association between hearing loss and psychotic symptoms.</p></div><div><h3>Case presentation</h3><p>This case report describes a 37-year-old woman without a previous psychiatric history who presented with delusional beliefs and auditory hallucinations on hospital admission. Despite partial remission of some psychotic symptoms with antipsychotic medication, her auditory hallucinations remained constant and disturbing. Unexpectedly, after several years of treatment, the patient developed musical hallucinations. Further investigations revealed bilateral hearing loss due to otosclerosis, thus suggesting a possible link between her hearing impairment and the hallucinations. Surgical intervention was performed to treat otosclerosis and led to complete remission of hallucinatory phenomena.</p></div><div><h3>Conclusions</h3><p>The purpose of this case report is to increase awareness of hearing impairment as a potentially reversible contributor to, or comorbidity with, psychosis. Prompt diagnosis and early intervention can have transformative effects on patients' mental health, functioning, and quality of life.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43411131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using online videos to target defeatist beliefs: Changing I can't to I can with a veteran living with serious mental illness","authors":"Jay A. Gorman ,&nbsp;Brian J. Stevenson ,&nbsp;Erin D. Reilly","doi":"10.1016/j.psycr.2023.100169","DOIUrl":"10.1016/j.psycr.2023.100169","url":null,"abstract":"<div><p>Preparing persons diagnosed with Serious Mental Illness (SMI) for vocational rehabilitation can require the coordination of multiple resources and interventions. This case report depicts a supplementary intervention utilizing YouTube to help intervene in the cycle of defeatist beliefs fueling negative symptoms, decrease employment-related anxiety, increase openness to a variety of work responsibilities, and increase job-seeking behaviors. Options for integrating technology into work readiness preparation are also discussed. Quantitative assessment, qualitative information, and a Subjective Units of Distress Scale (SUDS) are used to capture this person's vocational rehabilitation journey.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44244480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Myxedema psychosis caused by subclinical hypothyroidism","authors":"Vera Alves Barata,&nbsp;João Bastos,&nbsp;Rita Felício,&nbsp;Catarina Cativo,&nbsp;Patrícia Gonçalves","doi":"10.1016/j.psycr.2023.100170","DOIUrl":"10.1016/j.psycr.2023.100170","url":null,"abstract":"<div><p>Acute psychosis is a rare but possible clinical manifestation of hypothyroidism. Often referred to as myxedema psychosis, it is less frequently reported in the subclinical form of hypothyroidism compared to the clinical form, and rarely presents as its first manifestation, in the absence of any physical symptoms or signs. Our case report concerns a 46-year-old woman, with a medical history of a total thyroidectomy and irregular adherence to thyroxine treatment, who presented with a first-episode psychosis of subacute onset dominated by persecutory delusional ideas, formal thought disorder and emotional lability, without evident hypothyroidism signs or symptoms. Investigations revealed an elevated thyroid-stimulating hormone (TSH) and a normal free T4 (FT4). Other medical causes of acute psychosis were excluded, and the diagnosis of psychosis associated with subclinical hypothyroidism was assumed. Treatment with oral levothyroxine combined with olanzapine was initiated, leading to a rapid improvement, with complete remission of symptoms after ten days, concurrently with a gradual normalization of thyroid function. Antipsychotic treatment was suspended three months after discharge, with maintained remission of psychotic symptoms during the two-year follow-up. This clinical case highlights the importance of considering hypothyroidism in the differential diagnosis of a first-episode psychosis, even in the subclinical form and in the absence of physical signs or symptoms. The hormonal replacement therapy, combined or not with antipsychotic medication, leads to excellent prognosis in the majority of cases.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44068147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme overdose of haloperidol decanoate and a lengthy but full recovery: A case report","authors":"Beatriz Chao Calixto,&nbsp;Arthur Tolentino,&nbsp;Leandro X.C. Schlittler,&nbsp;Paulo Dalgalarrondo,&nbsp;Claudio E.M. Banzato","doi":"10.1016/j.psycr.2023.100168","DOIUrl":"10.1016/j.psycr.2023.100168","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43415126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Now I know my CBDs; cases of psychiatric admissions after delta-8-tetrahydrocannabinol (delta-8-THC, Δ⁸-THC) product usage","authors":"Matthew J Johnson ,&nbsp;Carly Swenson ,&nbsp;Ilona Fishkin ,&nbsp;Andrew Malanga","doi":"10.1016/j.psycr.2023.100166","DOIUrl":"10.1016/j.psycr.2023.100166","url":null,"abstract":"<div><p>Cannabis contains many chemical entities, including trace amounts of delta-8-tetrahydrocannabinol (Δ⁸-THC). Δ⁸-THC is either naturally extracted from cannabis or synthesized from cannabidiol (CBD) and marketed to consumers over the counter as a legal and “milder” high compared to other THC-containing products. Despite this perception among Δ⁸-THC users, the FDA and CDC have cautioned against Δ⁸-THC ingestion due to reports of serious adverse events, including psychiatric presentations. We describe two patients, aged 19 and 20, who presented with acute psychiatric concerns following reported ingestion of Δ⁸-THC. One patient had manic symptoms only in the context of Δ⁸-THC ingestion and without any previous psychiatric history. The second patient described had impulsive and psychotomimetic symptoms grossly out of proportion to, and more severe than, the symptoms he previously experienced. Both patient's symptoms resolved while abstinent from Δ⁸-THC. These cases demonstrate a potential temporal association between ingestion of Δ⁸-THC containing products and the development of manic or psychotic symptoms, as well as a likely dose-response relationship. They also highlight a growing need for drug-use histories that include specific questions around Δ⁸-THC use. Further investigation is needed regarding the risks associated with Δ⁸-THC use, especially in those with existing psychiatric diagnoses and those at increased risk for psychiatric disorders, and to better understand potential interactions with psychiatric medications.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48179302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of severe ketamine-induced neuropsychiatric side effects by lamotrigine in a patient with treatment resistant bipolar depression: A case report","authors":"Brian S. Barnett ,&nbsp;Amit Anand","doi":"10.1016/j.psycr.2023.100167","DOIUrl":"10.1016/j.psycr.2023.100167","url":null,"abstract":"<div><p>Though usually mild, neuropsychiatric side effects of intravenous ketamine for depression occasionally result in treatment discontinuation. Two small clinical trials of healthy subjects have indicated that lamotrigine pre-treatment may attenuate these side effects, though two other trials, one in patients with unipolar depression and one in healthy male volunteers, did not support these findings. While case reports and observational studies have documented successful treatment of patients with bipolar depression receiving lamotrigine and ketamine, none have reported on cessation of neuropsychiatric side effects from ketamine after lamotrigine initiation in this patient population. Here we present the case of a patient with treatment resistant bipolar depression successfully pre-treated with lamotrigine to prevent previously experienced severe neuropsychiatric side effects from ketamine. She tolerated the ketamine infusion well and her depressed mood improved rapidly. This case suggests that concurrent treatment with lamotrigine may present an effective tolerability improvement strategy for patients with bipolar depression who have previously experienced neuropsychiatric side effects from ketamine.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48973228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on Urethral Polyembolokoilomania from Sri Lanka-psychiatric perspective","authors":"Janith Galhenage ,&nbsp;Lahiru Yasas Akuratiyage ,&nbsp;Iresha Perera ,&nbsp;Saumya Madhri Senanayake","doi":"10.1016/j.psycr.2023.100158","DOIUrl":"10.1016/j.psycr.2023.100158","url":null,"abstract":"<div><h3>Background</h3><p>: Urethral Polyembolokoilomania is self-insertion of foreign bodies for sexual gratification. Although it is not an infrequent urological emergency, this is the first case reported in available literature from Sri Lanka.</p></div><div><h3>Case presentation</h3><p>: A 17-year-old male adolescent presented to surgical emergency due to lower abdominal pain and dysuria of 9 days duration. Imaging revealed a foreign body within the bladder. On questioning, he divulged having inserted a piece of wire through the urethra for autoerotic stimulation. He was referred for psychiatric assessment and the foreign body was extracted under general anaesthesia by the genito-urinary team. The psychiatric diagnosis was of Fetishistic Paraphilic Disorder in a patient with borderline IQ. Pharmacotherapy and cognitive behaviour therapy were commenced. The patient defaulted follow-up from the point of discharge from hospital.</p></div><div><h3>Conclusion</h3><p>: Timely referral of patients with genito-urinary foreign bodies to psychiatric services is important as this presentation is associated with underlying psychiatric disorders. Detection and treatment of underlying psychiatric disorders would mitigate the risk of recurrence.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}