Psychiatry research case reports最新文献

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Auditory Charles Bonnet syndrome and psychosis: Is there a relation? – A case report 听觉Charles Bonnet综合征与精神病:有关系吗案例报告
Psychiatry research case reports Pub Date : 2023-08-29 DOI: 10.1016/j.psycr.2023.100172
Olga Martínez Piera , Josefina Pérez-Blanco , Mar Carceller-Sindreu
{"title":"Auditory Charles Bonnet syndrome and psychosis: Is there a relation? – A case report","authors":"Olga Martínez Piera ,&nbsp;Josefina Pérez-Blanco ,&nbsp;Mar Carceller-Sindreu","doi":"10.1016/j.psycr.2023.100172","DOIUrl":"10.1016/j.psycr.2023.100172","url":null,"abstract":"<div><h3>Background</h3><p>Auditory hallucinations are relatively frequent in schizophrenia. Musical hallucinations are a specific hallucination type often observed in patients with hearing impairment and also known as auditory Charles Bonnet syndrome. Here, we present the case of a patient whose clinical course illustrates the often forgotten and overlooked association between hearing loss and psychotic symptoms.</p></div><div><h3>Case presentation</h3><p>This case report describes a 37-year-old woman without a previous psychiatric history who presented with delusional beliefs and auditory hallucinations on hospital admission. Despite partial remission of some psychotic symptoms with antipsychotic medication, her auditory hallucinations remained constant and disturbing. Unexpectedly, after several years of treatment, the patient developed musical hallucinations. Further investigations revealed bilateral hearing loss due to otosclerosis, thus suggesting a possible link between her hearing impairment and the hallucinations. Surgical intervention was performed to treat otosclerosis and led to complete remission of hallucinatory phenomena.</p></div><div><h3>Conclusions</h3><p>The purpose of this case report is to increase awareness of hearing impairment as a potentially reversible contributor to, or comorbidity with, psychosis. Prompt diagnosis and early intervention can have transformative effects on patients' mental health, functioning, and quality of life.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43411131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using online videos to target defeatist beliefs: Changing I can't to I can with a veteran living with serious mental illness 利用在线视频打击失败者的信念:与一名患有严重精神疾病的退伍军人一起将“我不能”改为“我可以”
Psychiatry research case reports Pub Date : 2023-08-23 DOI: 10.1016/j.psycr.2023.100169
Jay A. Gorman , Brian J. Stevenson , Erin D. Reilly
{"title":"Using online videos to target defeatist beliefs: Changing I can't to I can with a veteran living with serious mental illness","authors":"Jay A. Gorman ,&nbsp;Brian J. Stevenson ,&nbsp;Erin D. Reilly","doi":"10.1016/j.psycr.2023.100169","DOIUrl":"10.1016/j.psycr.2023.100169","url":null,"abstract":"<div><p>Preparing persons diagnosed with Serious Mental Illness (SMI) for vocational rehabilitation can require the coordination of multiple resources and interventions. This case report depicts a supplementary intervention utilizing YouTube to help intervene in the cycle of defeatist beliefs fueling negative symptoms, decrease employment-related anxiety, increase openness to a variety of work responsibilities, and increase job-seeking behaviors. Options for integrating technology into work readiness preparation are also discussed. Quantitative assessment, qualitative information, and a Subjective Units of Distress Scale (SUDS) are used to capture this person's vocational rehabilitation journey.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44244480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Myxedema psychosis caused by subclinical hypothyroidism 亚临床甲状腺功能减退所致黏液性水肿精神病病例报告
Psychiatry research case reports Pub Date : 2023-08-22 DOI: 10.1016/j.psycr.2023.100170
Vera Alves Barata, João Bastos, Rita Felício, Catarina Cativo, Patrícia Gonçalves
{"title":"Case report: Myxedema psychosis caused by subclinical hypothyroidism","authors":"Vera Alves Barata,&nbsp;João Bastos,&nbsp;Rita Felício,&nbsp;Catarina Cativo,&nbsp;Patrícia Gonçalves","doi":"10.1016/j.psycr.2023.100170","DOIUrl":"10.1016/j.psycr.2023.100170","url":null,"abstract":"<div><p>Acute psychosis is a rare but possible clinical manifestation of hypothyroidism. Often referred to as myxedema psychosis, it is less frequently reported in the subclinical form of hypothyroidism compared to the clinical form, and rarely presents as its first manifestation, in the absence of any physical symptoms or signs. Our case report concerns a 46-year-old woman, with a medical history of a total thyroidectomy and irregular adherence to thyroxine treatment, who presented with a first-episode psychosis of subacute onset dominated by persecutory delusional ideas, formal thought disorder and emotional lability, without evident hypothyroidism signs or symptoms. Investigations revealed an elevated thyroid-stimulating hormone (TSH) and a normal free T4 (FT4). Other medical causes of acute psychosis were excluded, and the diagnosis of psychosis associated with subclinical hypothyroidism was assumed. Treatment with oral levothyroxine combined with olanzapine was initiated, leading to a rapid improvement, with complete remission of symptoms after ten days, concurrently with a gradual normalization of thyroid function. Antipsychotic treatment was suspended three months after discharge, with maintained remission of psychotic symptoms during the two-year follow-up. This clinical case highlights the importance of considering hypothyroidism in the differential diagnosis of a first-episode psychosis, even in the subclinical form and in the absence of physical signs or symptoms. The hormonal replacement therapy, combined or not with antipsychotic medication, leads to excellent prognosis in the majority of cases.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44068147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme overdose of haloperidol decanoate and a lengthy but full recovery: A case report 癸酸氟哌啶醇过量服用和漫长但完全的康复:一例报告
Psychiatry research case reports Pub Date : 2023-08-22 DOI: 10.1016/j.psycr.2023.100168
Beatriz Chao Calixto, Arthur Tolentino, Leandro X.C. Schlittler, Paulo Dalgalarrondo, Claudio E.M. Banzato
{"title":"Extreme overdose of haloperidol decanoate and a lengthy but full recovery: A case report","authors":"Beatriz Chao Calixto,&nbsp;Arthur Tolentino,&nbsp;Leandro X.C. Schlittler,&nbsp;Paulo Dalgalarrondo,&nbsp;Claudio E.M. Banzato","doi":"10.1016/j.psycr.2023.100168","DOIUrl":"10.1016/j.psycr.2023.100168","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43415126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Now I know my CBDs; cases of psychiatric admissions after delta-8-tetrahydrocannabinol (delta-8-THC, Δ⁸-THC) product usage 现在我知道了我的CBD;德尔塔-8-四氢大麻酚(德尔塔-8-THC,Δ⁸-THC)产品使用
Psychiatry research case reports Pub Date : 2023-08-20 DOI: 10.1016/j.psycr.2023.100166
Matthew J Johnson , Carly Swenson , Ilona Fishkin , Andrew Malanga
{"title":"Now I know my CBDs; cases of psychiatric admissions after delta-8-tetrahydrocannabinol (delta-8-THC, Δ⁸-THC) product usage","authors":"Matthew J Johnson ,&nbsp;Carly Swenson ,&nbsp;Ilona Fishkin ,&nbsp;Andrew Malanga","doi":"10.1016/j.psycr.2023.100166","DOIUrl":"10.1016/j.psycr.2023.100166","url":null,"abstract":"<div><p>Cannabis contains many chemical entities, including trace amounts of delta-8-tetrahydrocannabinol (Δ⁸-THC). Δ⁸-THC is either naturally extracted from cannabis or synthesized from cannabidiol (CBD) and marketed to consumers over the counter as a legal and “milder” high compared to other THC-containing products. Despite this perception among Δ⁸-THC users, the FDA and CDC have cautioned against Δ⁸-THC ingestion due to reports of serious adverse events, including psychiatric presentations. We describe two patients, aged 19 and 20, who presented with acute psychiatric concerns following reported ingestion of Δ⁸-THC. One patient had manic symptoms only in the context of Δ⁸-THC ingestion and without any previous psychiatric history. The second patient described had impulsive and psychotomimetic symptoms grossly out of proportion to, and more severe than, the symptoms he previously experienced. Both patient's symptoms resolved while abstinent from Δ⁸-THC. These cases demonstrate a potential temporal association between ingestion of Δ⁸-THC containing products and the development of manic or psychotic symptoms, as well as a likely dose-response relationship. They also highlight a growing need for drug-use histories that include specific questions around Δ⁸-THC use. Further investigation is needed regarding the risks associated with Δ⁸-THC use, especially in those with existing psychiatric diagnoses and those at increased risk for psychiatric disorders, and to better understand potential interactions with psychiatric medications.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48179302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuation of severe ketamine-induced neuropsychiatric side effects by lamotrigine in a patient with treatment resistant bipolar depression: A case report 拉莫三嗪对治疗难治性双相抑郁症患者氯胺酮诱导的严重神经精神副作用的衰减:1例报告
Psychiatry research case reports Pub Date : 2023-08-20 DOI: 10.1016/j.psycr.2023.100167
Brian S. Barnett , Amit Anand
{"title":"Attenuation of severe ketamine-induced neuropsychiatric side effects by lamotrigine in a patient with treatment resistant bipolar depression: A case report","authors":"Brian S. Barnett ,&nbsp;Amit Anand","doi":"10.1016/j.psycr.2023.100167","DOIUrl":"10.1016/j.psycr.2023.100167","url":null,"abstract":"<div><p>Though usually mild, neuropsychiatric side effects of intravenous ketamine for depression occasionally result in treatment discontinuation. Two small clinical trials of healthy subjects have indicated that lamotrigine pre-treatment may attenuate these side effects, though two other trials, one in patients with unipolar depression and one in healthy male volunteers, did not support these findings. While case reports and observational studies have documented successful treatment of patients with bipolar depression receiving lamotrigine and ketamine, none have reported on cessation of neuropsychiatric side effects from ketamine after lamotrigine initiation in this patient population. Here we present the case of a patient with treatment resistant bipolar depression successfully pre-treated with lamotrigine to prevent previously experienced severe neuropsychiatric side effects from ketamine. She tolerated the ketamine infusion well and her depressed mood improved rapidly. This case suggests that concurrent treatment with lamotrigine may present an effective tolerability improvement strategy for patients with bipolar depression who have previously experienced neuropsychiatric side effects from ketamine.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48973228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report on Urethral Polyembolokoilomania from Sri Lanka-psychiatric perspective 斯里兰卡尿道多栓子症一例报告-精神病学观点
Psychiatry research case reports Pub Date : 2023-08-18 DOI: 10.1016/j.psycr.2023.100158
Janith Galhenage , Lahiru Yasas Akuratiyage , Iresha Perera , Saumya Madhri Senanayake
{"title":"A case report on Urethral Polyembolokoilomania from Sri Lanka-psychiatric perspective","authors":"Janith Galhenage ,&nbsp;Lahiru Yasas Akuratiyage ,&nbsp;Iresha Perera ,&nbsp;Saumya Madhri Senanayake","doi":"10.1016/j.psycr.2023.100158","DOIUrl":"10.1016/j.psycr.2023.100158","url":null,"abstract":"<div><h3>Background</h3><p>: Urethral Polyembolokoilomania is self-insertion of foreign bodies for sexual gratification. Although it is not an infrequent urological emergency, this is the first case reported in available literature from Sri Lanka.</p></div><div><h3>Case presentation</h3><p>: A 17-year-old male adolescent presented to surgical emergency due to lower abdominal pain and dysuria of 9 days duration. Imaging revealed a foreign body within the bladder. On questioning, he divulged having inserted a piece of wire through the urethra for autoerotic stimulation. He was referred for psychiatric assessment and the foreign body was extracted under general anaesthesia by the genito-urinary team. The psychiatric diagnosis was of Fetishistic Paraphilic Disorder in a patient with borderline IQ. Pharmacotherapy and cognitive behaviour therapy were commenced. The patient defaulted follow-up from the point of discharge from hospital.</p></div><div><h3>Conclusion</h3><p>: Timely referral of patients with genito-urinary foreign bodies to psychiatric services is important as this presentation is associated with underlying psychiatric disorders. Detection and treatment of underlying psychiatric disorders would mitigate the risk of recurrence.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A salty dilemma: A case report of anorexia with osmotic demyelination syndrome due to hypernatremia 盐的困境:高钠血症引起的厌食症伴渗透性脱髓鞘综合征1例
Psychiatry research case reports Pub Date : 2023-08-14 DOI: 10.1016/j.psycr.2023.100165
Hanieh Radkhah , Sadaf Parvin , Bahareh Shateri Amiri
{"title":"A salty dilemma: A case report of anorexia with osmotic demyelination syndrome due to hypernatremia","authors":"Hanieh Radkhah ,&nbsp;Sadaf Parvin ,&nbsp;Bahareh Shateri Amiri","doi":"10.1016/j.psycr.2023.100165","DOIUrl":"10.1016/j.psycr.2023.100165","url":null,"abstract":"<div><h3>Background</h3><p>Osmotic demyelination syndrome (ODS<span><sup>1</sup></span>) is a rare neurological condition characterized by rapid demyelination of neural cells. It often occurs due to aggressive correction of chronic hyponatremia. However, it might develop in other osmotic stresses like hypernatremia.</p><p>Wernicke-Korsakoff syndrome (WKS<span><sup>2</sup></span>) is a complication of thiamine deficiency. It mainly occurs in alcoholic patients, but conditions such as malnutrition might also lead to it.</p><p>Here we present a case of anorexia due to a possible major depressive disorder who developed signs and symptoms of hypernatremic ODS and WKS in the setting of chronic malnutrition.</p></div><div><h3>Case presentation</h3><p>The patient is a 39-year-old woman with a history of anorexia for seven months due to a possible major depressive disorder episode following her mother's death. She was admitted due to impaired consciousness and generalized weakness. On admission, her sodium level was 179 mEq/L, and her MRI showed signs of ODS and WKS. Intravenous fluid gradually dropped the sodium level to 149 mEq/L. Thiamine (1 g IV BID) was also administered due to signs of WKS from day 1. Despite treatments, her consciousness level worsened, and eventually, she died of septic shock followed by cardiac arrest and brain death on the sixth day.</p></div><div><h3>Conclusion</h3><p>To date, hypernatremia has been argued as a rare cause of ODS. However, the risk of hypernatremic ODS increase when other comorbidities (e.g., malnutrition) are present. Thiamine deficiency might lead to WKS that overlaps with ODS in patients with malnutrition. Primary care physicians are encouraged to detect early signs of major depressive disorder to prevent catastrophic medical and psychiatric complications. Also, Careful monitoring of electrolytes and vitamins and early detection of neurological symptoms are the keys to managing anorexia patients.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45419098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved cognitive performance, increased theta, alpha, beta and decreased delta powers after cognitive rehabilitation augmented with tDCS in a patient with post-COVID-19 cognitive impairment (brain-fog) covid -19后认知障碍(脑雾)患者经tDCS增强认知康复后认知表现改善,θ、α、β增强,δ功率降低
Psychiatry research case reports Pub Date : 2023-08-12 DOI: 10.1016/j.psycr.2023.100164
Adam Wysokiński, Ewa Szczepocka, Adrianna Szczakowska
{"title":"Improved cognitive performance, increased theta, alpha, beta and decreased delta powers after cognitive rehabilitation augmented with tDCS in a patient with post-COVID-19 cognitive impairment (brain-fog)","authors":"Adam Wysokiński,&nbsp;Ewa Szczepocka,&nbsp;Adrianna Szczakowska","doi":"10.1016/j.psycr.2023.100164","DOIUrl":"10.1016/j.psycr.2023.100164","url":null,"abstract":"<div><h3>Objective</h3><p>COVID-19 is associated with neuropsychiatric symptoms, including delirium, confusion and neurocognitive disorders. The main aim of this report is to present results of 3-week cognitive rehabilitation augmented with transcranial direct current stimulation (tDCS) in a patients with post-COVID-19 cognitive impairments. We also presented results of quantitative EEG analysis.</p></div><div><h3>Methods</h3><p>We have complete a non-blinded, 3-week, single-case experimental study consisting of daily cognitive rehabilitation augmented with tDCS stimulation (current: 2.0 mA, anode: left dorsolateral prefrontal cortex (DLPFC), cathode: right DLPFC, duration: 1200 s). Major cognitive functions were evaluated a day before (V1), a day after the 3-week rehabilitation program (V2) and 8 weeks later (V3) using CANTAB cognitive research software. Routine 20-minutes eyes-closed resting EEG were recorded three times at V1, V2 and V3.</p></div><div><h3>Results</h3><p>Visual memory scores improved at V2 and returned to the baseline level at V3. Mixed results were observed for multitasking, emotion recognition, response speed, attention. No changes or transient decrease at V2 were seen for working memory. There was a significant delta band power decrease (at F4) and increase (at F3), and increase (at F3 and F4) of theta, alpha, and beta band powers after tDCS.</p></div><div><h3>Conclusions</h3><p>tDCS combined with computer-assisted cognitive rehabilitation may be an effective therapeutic options for patients with COVID-19-related brain-fog. Increased alpha power may be an underlying mechanism or marker of cognitive improvement. Reduced delta band power may be interpreted as normalization of EEG recordings due to tDCS stimulation.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46953864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the use of nirmatrelvir/ritonavir and considerations regarding its drug interactions in COVID-19 positive patients at an adult inpatient state psychiatric facility 评估州精神病院成人住院COVID-19阳性患者使用尼马特利韦/利托那韦的情况及其药物相互作用的考虑
Psychiatry research case reports Pub Date : 2023-08-12 DOI: 10.1016/j.psycr.2023.100159
Carolyn O'Donnell , Tammie Lee Demler
{"title":"Assessing the use of nirmatrelvir/ritonavir and considerations regarding its drug interactions in COVID-19 positive patients at an adult inpatient state psychiatric facility","authors":"Carolyn O'Donnell ,&nbsp;Tammie Lee Demler","doi":"10.1016/j.psycr.2023.100159","DOIUrl":"10.1016/j.psycr.2023.100159","url":null,"abstract":"<div><p>Introduction: Patients with mental illness have a high risk of COVID-19 progression into severe illness, which makes them a candidate for nirmatrelvir/ritonavir therapy. However, certain psychiatric medications are contraindicated with nirmatrelvir/ritonavir. Between January 6th and January 24th, 2022, five patients at an inpatient state psychiatric facility were prescribed nirmatrelvir/ritonavir. Two patients had psychiatric drug interactions with nirmatrelvir/ritonavir that required alteration to their psychiatric medication regimen. One patient's divalproex and haloperidol doses were decreased, and the patient was able to complete their course of nirmatrelvir/ritonavir therapy, then resume their psychiatric medications at their usual doses. Another patient's lurasidone was discontinued and their long-acting injection dosing was decreased. This patient refused to take nirmatrelvir/ritonavir therapy, became more psychotic and delusional, and began refusing all medications. Her nirmatrelvir/ritonavir was discontinued without the patient completing the course and the patient continued to experience paranoia, delusions, and hallucinations. No patients were hospitalized for COVID-19. Although nirmatrelvir/ritonavir is highly effective at reducing COVID-19 hospitalizations and death, it is unclear as to its use for psychiatric patients who have psychotropic drug interactions who have the possibility of decompensating if their psychiatric medication regimen is altered.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42500837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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