Psychiatry research case reports最新文献

Using daily diary data to examine the period prior to a suicide attempt: An observational single-case study

Psychiatry research case reports Pub Date : 2025-02-12 DOI: 10.1016/j.psycr.2025.100251

Daniel Núñez , Esdras Raposo de Almeida , Arnout C. Smit , Evelien Snippe , Merel K. Muller , David van den Berg , Yuan-Pang Wang , Wim Veling , Sanne H. Booij , Johanna T.W. Wigman

{"title":"Using daily diary data to examine the period prior to a suicide attempt: An observational single-case study","authors":"Daniel Núñez , Esdras Raposo de Almeida , Arnout C. Smit , Evelien Snippe , Merel K. Muller , David van den Berg , Yuan-Pang Wang , Wim Veling , Sanne H. Booij , Johanna T.W. Wigman","doi":"10.1016/j.psycr.2025.100251","DOIUrl":"10.1016/j.psycr.2025.100251","url":null,"abstract":"<div><h3>Background</h3><div>Prevention of suicide is an important public health issue. Applying Exponential Weighted Moving Average (EWMA) control charts to time-intensive diary data could improve our understanding of the processes leading up to a suicide attempt (SA). We explored daily reports of multiple psychopathological domains, and particularly changes therein, during a period directly preceding a SA.</div></div><div><h3>Methods</h3><div>We applied an observational single-case study design on a diary data from one participant (female, age between 20 and 30 years) who attempted suicide (and survived) during participation in another study. This study included 90 daily reports of depression and anxiety symptoms, psychotic experiences, thought disturbances and a proxy for passive suicide ideation (feeling life is worthwhile). We used EWMA control charts to explore whether structural changes in these psychopathological domains preceded the upcoming SA. We first investigated the overall domains and then zoomed in on individual items.</div></div><div><h3>Results</h3><div>We detected increases in depression and anxiety symptoms, psychotic experiences, and passive suicide ideation in a time window of 6 days directly preceding the SA. Although no changes in the overall dimension of thought disturbances preceded the SA, two specific items, impulsive thoughts and persistent thoughts, did increase.</div></div><div><h3>Conclusion</h3><div>We found changes in daily reports of several (sub)dimensions of psychopathology prior to the SA. Our findings show how applying EWMA charts to diary reports may be helpful to detect signs of an upcoming SA. Improving our ability to timely signal risk for SA may inform strategies aimed at its prevention.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of combined theta burst stimulation (TBS) and intranasal esketamine in an ECT-resistant depressive patient: A case report θ爆发刺激（TBS）和鼻内注射埃斯卡他敏联合疗法对一名电痉挛疗法耐药的抑郁症患者的疗效：病例报告

Psychiatry research case reports Pub Date : 2025-02-11 DOI: 10.1016/j.psycr.2025.100250

Álvaro Moleón-Ruiz , Paloma Álvarez de Toledo , Inmaculada Pérez , Javier Narbona , Luis Gutiérrez-Rojas , Manuela Martín-Bejarano

{"title":"Efficacy of combined theta burst stimulation (TBS) and intranasal esketamine in an ECT-resistant depressive patient: A case report","authors":"Álvaro Moleón-Ruiz , Paloma Álvarez de Toledo , Inmaculada Pérez , Javier Narbona , Luis Gutiérrez-Rojas , Manuela Martín-Bejarano","doi":"10.1016/j.psycr.2025.100250","DOIUrl":"10.1016/j.psycr.2025.100250","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD) presents significant clinical challenges, often requiring innovative approaches beyond conventional pharmacotherapy and psychotherapy. This case report explores the efficacy of combined repetitive Transcranial Magnetic Stimulation (rTMS) and intranasal esketamine (IN-ESK) in a patient with TRD.</div><div>A female in her 60 s with a prolonged history of recurrent endogenous-type depressive disorder presented with severe depressive symptoms, including suicidal ideation, despite numerous pharmacotherapies, psychotherapies, and 17 sessions of ECT. The patient underwent a treatment regimen combining rTMS and IN-ESK. rTMS involved continuous theta burst stimulation (cTBS) to the right dorsolateral prefrontal cortex (DLPFC) and intermittent theta burst stimulation (iTBS) to the left DLPFC. IN-ESK was administered at 56 mg for the first two sessions and 84 mg for subsequent sessions over four weeks. The combined treatment resulted in a substantial reduction in depressive and anxiety symptoms. Pre-treatment scores on the Patient Health Questionnaire-9 (PHQ-9) and Hamilton Depression Rating Scale (HDRS) indicated severe depression (PHQ-9 score of 24) and moderate depression (HDRS score of 19). Post-treatment assessments showed significant improvement, with PHQ-9 scores decreasing to 7 (mild depression) and HDRS scores dropping to 5 (remission). Suicidal ideation and anxiety levels also showed marked reduction, with the Hamilton Anxiety Scale (HAS) score decreasing from 20 to 10. The combination of rTMS and IN-ESK demonstrated significant therapeutic benefits in this ECT-resistant depressive patient. This case highlights the potential of this combined modality as a promising treatment for TRD, warranting further research to understand the underlying mechanisms and long-term efficacy.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pharmacotherapeutic and neuroimaging case study of maladaptive daydreaming

Psychiatry research case reports Pub Date : 2025-01-26 DOI: 10.1016/j.psycr.2025.100249

Daniel Mamah, ShingShiun Chen, Ayleen Gomez-Lopez, Samantha Alexander

{"title":"A pharmacotherapeutic and neuroimaging case study of maladaptive daydreaming","authors":"Daniel Mamah, ShingShiun Chen, Ayleen Gomez-Lopez, Samantha Alexander","doi":"10.1016/j.psycr.2025.100249","DOIUrl":"10.1016/j.psycr.2025.100249","url":null,"abstract":"<div><h3>Background</h3><div>Maladaptive daydreaming (MD) is an underreported mental health condition involving prolonged, vivid fantasizing, associated with significant functional impairment or disability. The underlying neurobiology of MD is unknown, and there have been no prior neuroimaging studies in affected individuals.</div></div><div><h3>Case presentation</h3><div>A twenty-year-old woman with a history of depression and obsessive-compulsive disorder reported experiencing intense and highly distracting daydreams, exacerbated by stress and resulting in an inability to complete her studies. We describe her clinical presentation, treatment and symptom response over 120 weeks. Depression was largely treatment-resistant with antidepressants, and improvement with lamotrigine (Lamictal) augmentation was limited by poor tolerance. Antipsychotic medications (lurasidone, risperidone (Risperdal) and aripiprazole) resulted in a rapid reduction or cessation of daydreaming, and dopaminergic medications (lisdexamfetamine and bupropion) resulted in substantially increased time spent daydreaming. The patient underwent Magnetic Resonance Imaging (MRI) using a 3 Tesla scanner, and the brain's cortical thickness and functional connectivity networks were assessed and compared to a matched population of healthy individuals. We found regions of cortical thinning in the left hemisphere, primarily in the middle temporal cortex. The left default mode and cingulo-opercular networks, and the salience network bilaterally, were enlarged compared to the general population. In contrast, the left frontoparietal network was smaller.</div></div><div><h3>Conclusion</h3><div>A hyperdopaminergic state may be involved in some cases of MD. Altered development of the left brain may underlie the capacity for prolonged, vivid daydreaming. Future studies in larger patient populations are needed to validate findings.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of first-episode psychosis with catatonic features in an adolescent following THC use

Psychiatry research case reports Pub Date : 2025-01-22 DOI: 10.1016/j.psycr.2025.100248

Lily Porsa DO

引用次数: 0

Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis

Psychiatry research case reports Pub Date : 2025-01-15 DOI: 10.1016/j.psycr.2025.100247

Megan S. Barker , Neil A. Shneider , Masood Manoochehri , Edward D. Huey , Elizabeth C. Lindenberger

{"title":"Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis","authors":"Megan S. Barker , Neil A. Shneider , Masood Manoochehri , Edward D. Huey , Elizabeth C. Lindenberger","doi":"10.1016/j.psycr.2025.100247","DOIUrl":"10.1016/j.psycr.2025.100247","url":null,"abstract":"<div><div>Although amyotrophic lateral sclerosis (ALS) is defined as a neuromuscular disease, cognitive and/or behavioral symptoms are relatively common, and a portion of ALS patients will meet criteria for behavioral variant frontotemporal dementia (bvFTD). In this report, we describe the case of a man with ALS with bvFTD (ALS-FTD) presenting with excessive emotional reactivity, including severe anger, aggression, and obsessive thoughts. We contrast this case with the decreased emotional reactivity that is usually observed in patients with bvFTD without ALS. We discuss possible explanations including that: 1) the behavioral symptoms of bvFTD and ALS-FTD are the same, but the motor dysfunction influences the clinical manifestations of the behavioral symptoms in ALS-FTD; 2) the emotional and behavioral symptoms of bvFTD and ALS-FTD are the same, but ALS-FTD patients come to clinical attention earlier in the course of their FTD than bvFTD patients without ALS; and 3) the emotional and behavioral symptoms of bvFTD and ALS-FTD could differ.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

‘I wouldn't have become addicted to fruit machines if it wasn't for coin pushers’: A case report of adolescent coin pusher use leading to lifelong gambling-related harm

Psychiatry research case reports Pub Date : 2025-01-12 DOI: 10.1016/j.psycr.2025.100246

Jamie Torrance , Jessica Smith , Philip Newall

{"title":"‘I wouldn't have become addicted to fruit machines if it wasn't for coin pushers’: A case report of adolescent coin pusher use leading to lifelong gambling-related harm","authors":"Jamie Torrance , Jessica Smith , Philip Newall","doi":"10.1016/j.psycr.2025.100246","DOIUrl":"10.1016/j.psycr.2025.100246","url":null,"abstract":"<div><div>While most previous adolescent gambling research focuses on the illegal use of age-restricted products, adolescents can also often gamble legally using machines such as coin pushers (aka ‘penny falls’ machines). Using a qualitative case report design, we use an in-depth interview to complement previous findings, which have associated recollected adolescent use of coin pusher machines with levels of adult gambling-related harm. We recruited a 57-year-old male with a history of significant gambling-related harm, whose initiation into gambling involved the adolescent use of coin pusher machines. The interview was audio recorded, transcribed, and analyzed using interpretative phenomenological analysis. Three themes were identified: the structural similarities between coin pushers and traditional gambling formats, the role of proximity and normalization in facilitating progression to riskier gambling, and the participant's suggestions for population-level harm prevention measures. This novel case report highlights how a person's lifelong struggles with severe gambling-related harms began with adolescent exposure to coin pusher machines. Greater awareness of this case could encourage more gamblers to share similar experiences, alongside helping to educate parents and policymakers about the potential harmful consequences of using coin pusher machines.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could psychedelics be useful in the treatment of patients with personality disorder? A case report of psychotherapy with concomitant use of psychedelics

Psychiatry research case reports Pub Date : 2025-01-08 DOI: 10.1016/j.psycr.2025.100245

Martin Blay , Inès Benmakhlouf , Mario Speranza

{"title":"Could psychedelics be useful in the treatment of patients with personality disorder? A case report of psychotherapy with concomitant use of psychedelics","authors":"Martin Blay , Inès Benmakhlouf , Mario Speranza","doi":"10.1016/j.psycr.2025.100245","DOIUrl":"10.1016/j.psycr.2025.100245","url":null,"abstract":"<div><div>Psychotherapy enhanced by psychedelics has recently been found to be helpful for the treatment of several psychiatric disorders, notably depressive disorders. However, it has only been considered scarcely in patients suffering from personality disorders. Here, we report the case of a 37 years-old woman suffering from severe mixed personality disorder and ADHD. Alongside the beginning of her GPM-based psychotherapeutic treatment, and despite our concerns, she started closely monitored psychedelic micro-dosing, using products bought online, punctuated by occasional macro-dosing After one-year of this psychotherapy associated with concomitant independent use of psychedelics, paranoid, narcissistic and borderline personality dimensions were largely improved, as well as emotion regulation, impulsivity, mentalization abilities, and social functioning. Given the actual evidence regarding the efficacy of psychedelics to improve the latter four dimensions, given the patient's reported experience, and despite important limits, we make the hypothesis that the concomitant use of psychedelics has enhanced psychotherapy efficacy. Overall, this case asks the question of the potential usefulness of psychedelics associated with psychotherapy in patients with PD. Further pilot studies should be conducted on this issue.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An actigraphy case series: Sleep disturbance associations with suicidal ideation, self-harm and desire to live

Psychiatry research case reports Pub Date : 2025-01-04 DOI: 10.1016/j.psycr.2025.100244

Annabelle M. Mournet, Allison K. Ruork, Evan M. Kleiman, Shireen L. Rizvi

{"title":"An actigraphy case series: Sleep disturbance associations with suicidal ideation, self-harm and desire to live","authors":"Annabelle M. Mournet, Allison K. Ruork, Evan M. Kleiman, Shireen L. Rizvi","doi":"10.1016/j.psycr.2025.100244","DOIUrl":"10.1016/j.psycr.2025.100244","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep disturbances are a well-established suicide risk factor. This case series represents an investigation into the individual-level associations between objectively measured sleep using actigraphy and fatigue on next-day suicidal ideation, self-harm urges, and desire to be alive.</div></div><div><h3>Methods</h3><div>This case series utilizes data from seven adults with borderline personality disorder receiving dialectical behavioral therapy (DBT). Participants wore a Phillips HealthBand wearable device to collect actigraphy data and completed ecological momentary assessment (EMA). Data was collected for one week per month for each of the six months of treatment. We conducted a series of individual linear regressions.</div></div><div><h3>Results</h3><div>For participant 1, fatigue was associated with self-injury urges. Sleep duration and time in bed were predictive of desire to be alive. For participant 3, fatigue was associated with suicidal ideation. Sleep efficiency was predictive of desire to be alive. Participant 5′s WASO was predictive of suicidal ideation and desire to be alive. For participant 6, WASO predicted desire to be alive. For participant 7, fatigue was predictive of desire to be alive.</div></div><div><h3>Discussion</h3><div>This case series provides evidence that certain aspects of sleep, as measured by actigraphy, is predictive of SI, self-harm urges, and desire to be alive among certain DBT patients. Results points to the importance of examining actigraphy findings on an individual level. Future research should continue to utilize multimodal data to advance understanding of the associations between sleep metrics with STBs, as well as how to continue to best leverage actigraphy data in combination with other methodologies.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The many faces of psilocybin-related psychosis: A case series

Psychiatry research case reports Pub Date : 2024-12-07 DOI: 10.1016/j.psycr.2024.100243

Yumin Kim , Rachel Bigley , Aubrey DeVinney , Paul S. Nestadt

{"title":"The many faces of psilocybin-related psychosis: A case series","authors":"Yumin Kim , Rachel Bigley , Aubrey DeVinney , Paul S. Nestadt","doi":"10.1016/j.psycr.2024.100243","DOIUrl":"10.1016/j.psycr.2024.100243","url":null,"abstract":"<div><h3>Background</h3><div>Psilocybin use has been increasingly popular in the United States, and its use as a novel therapeutic treatment for psychiatric conditions has led to greater public acceptance as a recreational substance. Consequently, clinicians are faced with managing complications and adverse effects associated with psilocybin use.</div></div><div><h3>Basic Procedures/Main Findings</h3><div>We present three cases seen in a dual diagnosis inpatient psychiatry unit during a four-week period in 2023: Case 1: the case of intermittent psilocybin use associated with a particularly prolonged psychosis requiring treatment with higher doses and a longer course of neuroleptic medication; Case 2: the case of a short period of frequent psilocybin use culminating into increasing paranoia and a medically serious suicide attempt treated with neuroleptics; and Case 3: the case of long-term “microdosing” followed by mania-like symptoms including grandiosity, irritability, and physical aggression towards others, but with resolution of symptoms after discontinuing psilocybin use.</div></div><div><h3>Conclusions</h3><div>Amidst psilocybin's increasing prevalence and acceptance, clinicians are faced with managing the complications and adverse effects of psilocybin use with minimal guidelines or evidence. This case series aims to highlight varied presentations, management strategies, and treatment responses to contribute some insight into this unknown territory.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schema-therapeutic exposure for treatment resistant anxiety and obsessive-compulsive disorders: A multiple baseline case series design study

Psychiatry research case reports Pub Date : 2024-12-01 DOI: 10.1016/j.psycr.2024.100241

Nancy Peeters , Boris van Passel , Gert-Jan Hendriks , Eni Becker , Julie Krans

{"title":"Schema-therapeutic exposure for treatment resistant anxiety and obsessive-compulsive disorders: A multiple baseline case series design study","authors":"Nancy Peeters , Boris van Passel , Gert-Jan Hendriks , Eni Becker , Julie Krans","doi":"10.1016/j.psycr.2024.100241","DOIUrl":"10.1016/j.psycr.2024.100241","url":null,"abstract":"<div><div>Exposure is effective for patients with anxiety disorders or obsessive-compulsive disorders (OCD). Yet, a significant minority does not recover with current guideline treatments due to comorbid personality disorder symptoms. For these patients, no further guideline treatments exist. Schema therapy (ST) is an evidence-based treatment for personality disorders and integrating ST and exposure could provide a solution. We tested a new schema-therapeutic exposure treatment in patients with treatment-resistant anxiety or OCD. Using the latest methodological and statistical insights in a well-powered single-case experimental design (SCED; <em>N</em> = 6), we administered weekly measures of psychological malfunctioning, anxiety/OCD symptoms, and schema modes over the course of treatment (29–32 weeks). Schema-therapeutic exposure was effective for 33.33 % of our sample, with improvement on all or most outcome measures. Another 33.33 % demonstrated partial improvements, and 33.33 % remained stable. Given the historical chronicity of symptoms in our sample, these effects are highly encouraging. Secondary findings showed that changes in schema modes did not precede changes in anxiety/OCD symptoms or psychological malfunctioning, and that 66.66 % of the sample continued to improve in the second half of the treatment. Future research is wanted to unravel the interactive and additive effects of schema-therapeutic exposure to further optimize treatment.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0