{"title":"精神病和紧张症的肌酸代谢：一例报告和文献复习","authors":"Sophie Scharner , Terrance M Dolan , Eric P Hazen","doi":"10.1016/j.psycr.2025.100260","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation.</div></div><div><h3>Basic Procedures and Main Findings</h3><div>We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency.</div></div><div><h3>Principal Conclusions</h3><div>This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100260"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Creatine metabolism in psychosis and catatonia: A case report and review of the literature\",\"authors\":\"Sophie Scharner , Terrance M Dolan , Eric P Hazen\",\"doi\":\"10.1016/j.psycr.2025.100260\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation.</div></div><div><h3>Basic Procedures and Main Findings</h3><div>We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency.</div></div><div><h3>Principal Conclusions</h3><div>This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.</div></div>\",\"PeriodicalId\":74594,\"journal\":{\"name\":\"Psychiatry research case reports\",\"volume\":\"4 1\",\"pages\":\"Article 100260\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatry research case reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2773021225000173\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry research case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773021225000173","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Creatine metabolism in psychosis and catatonia: A case report and review of the literature
Background
In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation.
Basic Procedures and Main Findings
We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency.
Principal Conclusions
This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.
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