Clozapine-related obsessive compulsive symptoms in an adolescent with bipolar disorder

We presented a case in which clozapine-related obsessive compulsive (OC) symptoms emerged in an adolescent patient with treatment-resistant bipolar disorder with psychotic features. The initial subthreshold OC symptoms accompanying the manic and psychotic features, intensified by the 2nd month of clozapine regimen. Accordingly, a treatment plan targeting clozapine-related OC symptoms was implemented. OC symptoms significantly improved by the inclusion of cognitive and behavioral treatment techniques into the treatment regimen.