Psychiatry research case reports最新文献_第2页

Case report: Well-tolerated MDMA-assisted therapy in a 32-year old female patient with advanced alcohol-induced liver cirrhosis 病例报告：32岁晚期酒精性肝硬化女性患者经mdma辅助治疗耐受良好

Psychiatry research case reports Pub Date : 2025-02-25 DOI: 10.1016/j.psycr.2025.100252

Elias Kraus , Stephanie Suter , Margit Proescholdt , Felix Müller , Matthias E. Liechti , Markus Heim , Undine Lang , Marc Vogel

{"title":"Case report: Well-tolerated MDMA-assisted therapy in a 32-year old female patient with advanced alcohol-induced liver cirrhosis","authors":"Elias Kraus , Stephanie Suter , Margit Proescholdt , Felix Müller , Matthias E. Liechti , Markus Heim , Undine Lang , Marc Vogel","doi":"10.1016/j.psycr.2025.100252","DOIUrl":"10.1016/j.psycr.2025.100252","url":null,"abstract":"<div><h3>Background</h3><div>Several studies have examined 3,4-Methylenedioxymethamphetamine (MDMA) as a therapeutic adjunct in the treatment of post-traumatic stress disorders (PTSD). Alcohol use disorder (AUD) is common in patients with PTSD and can lead to alcohol-induced liver cirrhosis. There is a concern that MDMA, which is associated with liver toxicity in some cases, may not be tolerated by PTSD-patients with pre-existing, alcohol-induced liver cirrhosis. There is currently no data available to asses this risk.</div></div><div><h3>Case presentation</h3><div>We present the case of a 32-year old female patient with post-traumatic stress disorder and advanced alcohol-induced liver cirrhosis who received MDMA-assisted therapy. MDMA was administered twice (50 mg, 100 mg) over the course of two weeks. Apart from one episode of vomiting and the subjective sensation of numb and swollen fingers (without clinical findings) under the influence of MDMA, there were no adverse effects. Laboratory values did not show any signs of acute MDMA-induced liver injury.</div></div><div><h3>Conclusions</h3><div>There were no signs of acute MDMA-induced liver injury in our patient, despite advanced, pre-existing liver cirrhosis due to alcohol use. This finding is on a case level and cannot be generalized, but is encouraging for future research in patients with liver disorders. Further research is necessary to confirm the safety of MDMA-assisted therapy in patients with pre-existing, alcohol-induced liver cirrhosis.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-onset Kleine-Levin syndrome in adolescent: A case report and review of literature 青少年早发型克莱因-莱文综合征：病例报告和文献综述

Psychiatry research case reports Pub Date : 2025-02-25 DOI: 10.1016/j.psycr.2025.100253

Yuejiao Ma, Jianping Lu

引用次数: 0

Potential link between copy number variation and abnormal genome wide DNA methylation profile in an individual with severe ADHD and a strong response to micronutrient treatment 严重ADHD患者拷贝数变异与异常全基因组DNA甲基化谱之间的潜在联系以及对微量营养素治疗的强烈反应

Psychiatry research case reports Pub Date : 2025-02-25 DOI: 10.1016/j.psycr.2025.100254

Aaron J. Stevens , Martin A. Kennedy , Kit Doudney , Alexa Kidd , Julia J. Rucklidge

{"title":"Potential link between copy number variation and abnormal genome wide DNA methylation profile in an individual with severe ADHD and a strong response to micronutrient treatment","authors":"Aaron J. Stevens , Martin A. Kennedy , Kit Doudney , Alexa Kidd , Julia J. Rucklidge","doi":"10.1016/j.psycr.2025.100254","DOIUrl":"10.1016/j.psycr.2025.100254","url":null,"abstract":"<div><div>Identifying and understanding the genetic contributors to mental health conditions remains a challenge. This is partially due to the complex, polygenic nature of these conditions and the range of underlying genetic variants, including copy number variants (CNV), that contribute to risk. Here we report an individual with severe ADHD who displayed an unusual blood methylome profile, and a strongly positive response during a treatment trial of micronutrients for this condition. The unusual methylome profile prompted a search for structural variants in the genome of this individual, leading to the discovery of two large, rare CNVs, which may help to account for the clinical and epigenetic aspects observed in this case. These CNVs impacted several genes, including <em>RNF4</em> and <em>EHMT1,</em> both of which encode enzymes involved in DNA methylation, and <em>CACNA1B</em>, which is implicated in neuropsychiatric phenotypes. These CNVs are classified as variants of unknown significance and are likely benign in the clinical setting. Although there is no strong clinical evidence to suggest reclassification of these CNVs, gene regions adjacent to the CNV have been implicated in neuropsychiatric conditions. It seems reasonable to suggest that these rare CNVs may drive the observed perturbation in this individual's methylome profile, and may partially contribute to their ADHD phenotype.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using daily diary data to examine the period prior to a suicide attempt: An observational single-case study 使用每日日记数据来检查自杀企图前的一段时间：一项观察性单例研究

Psychiatry research case reports Pub Date : 2025-02-12 DOI: 10.1016/j.psycr.2025.100251

Daniel Núñez , Esdras Raposo de Almeida , Arnout C. Smit , Evelien Snippe , Merel K. Muller , David van den Berg , Yuan-Pang Wang , Wim Veling , Sanne H. Booij , Johanna T.W. Wigman

{"title":"Using daily diary data to examine the period prior to a suicide attempt: An observational single-case study","authors":"Daniel Núñez , Esdras Raposo de Almeida , Arnout C. Smit , Evelien Snippe , Merel K. Muller , David van den Berg , Yuan-Pang Wang , Wim Veling , Sanne H. Booij , Johanna T.W. Wigman","doi":"10.1016/j.psycr.2025.100251","DOIUrl":"10.1016/j.psycr.2025.100251","url":null,"abstract":"<div><h3>Background</h3><div>Prevention of suicide is an important public health issue. Applying Exponential Weighted Moving Average (EWMA) control charts to time-intensive diary data could improve our understanding of the processes leading up to a suicide attempt (SA). We explored daily reports of multiple psychopathological domains, and particularly changes therein, during a period directly preceding a SA.</div></div><div><h3>Methods</h3><div>We applied an observational single-case study design on a diary data from one participant (female, age between 20 and 30 years) who attempted suicide (and survived) during participation in another study. This study included 90 daily reports of depression and anxiety symptoms, psychotic experiences, thought disturbances and a proxy for passive suicide ideation (feeling life is worthwhile). We used EWMA control charts to explore whether structural changes in these psychopathological domains preceded the upcoming SA. We first investigated the overall domains and then zoomed in on individual items.</div></div><div><h3>Results</h3><div>We detected increases in depression and anxiety symptoms, psychotic experiences, and passive suicide ideation in a time window of 6 days directly preceding the SA. Although no changes in the overall dimension of thought disturbances preceded the SA, two specific items, impulsive thoughts and persistent thoughts, did increase.</div></div><div><h3>Conclusion</h3><div>We found changes in daily reports of several (sub)dimensions of psychopathology prior to the SA. Our findings show how applying EWMA charts to diary reports may be helpful to detect signs of an upcoming SA. Improving our ability to timely signal risk for SA may inform strategies aimed at its prevention.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of combined theta burst stimulation (TBS) and intranasal esketamine in an ECT-resistant depressive patient: A case report θ爆发刺激（TBS）和鼻内注射埃斯卡他敏联合疗法对一名电痉挛疗法耐药的抑郁症患者的疗效：病例报告

Psychiatry research case reports Pub Date : 2025-02-11 DOI: 10.1016/j.psycr.2025.100250

Álvaro Moleón-Ruiz , Paloma Álvarez de Toledo , Inmaculada Pérez , Javier Narbona , Luis Gutiérrez-Rojas , Manuela Martín-Bejarano

{"title":"Efficacy of combined theta burst stimulation (TBS) and intranasal esketamine in an ECT-resistant depressive patient: A case report","authors":"Álvaro Moleón-Ruiz , Paloma Álvarez de Toledo , Inmaculada Pérez , Javier Narbona , Luis Gutiérrez-Rojas , Manuela Martín-Bejarano","doi":"10.1016/j.psycr.2025.100250","DOIUrl":"10.1016/j.psycr.2025.100250","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD) presents significant clinical challenges, often requiring innovative approaches beyond conventional pharmacotherapy and psychotherapy. This case report explores the efficacy of combined repetitive Transcranial Magnetic Stimulation (rTMS) and intranasal esketamine (IN-ESK) in a patient with TRD.</div><div>A female in her 60 s with a prolonged history of recurrent endogenous-type depressive disorder presented with severe depressive symptoms, including suicidal ideation, despite numerous pharmacotherapies, psychotherapies, and 17 sessions of ECT. The patient underwent a treatment regimen combining rTMS and IN-ESK. rTMS involved continuous theta burst stimulation (cTBS) to the right dorsolateral prefrontal cortex (DLPFC) and intermittent theta burst stimulation (iTBS) to the left DLPFC. IN-ESK was administered at 56 mg for the first two sessions and 84 mg for subsequent sessions over four weeks. The combined treatment resulted in a substantial reduction in depressive and anxiety symptoms. Pre-treatment scores on the Patient Health Questionnaire-9 (PHQ-9) and Hamilton Depression Rating Scale (HDRS) indicated severe depression (PHQ-9 score of 24) and moderate depression (HDRS score of 19). Post-treatment assessments showed significant improvement, with PHQ-9 scores decreasing to 7 (mild depression) and HDRS scores dropping to 5 (remission). Suicidal ideation and anxiety levels also showed marked reduction, with the Hamilton Anxiety Scale (HAS) score decreasing from 20 to 10. The combination of rTMS and IN-ESK demonstrated significant therapeutic benefits in this ECT-resistant depressive patient. This case highlights the potential of this combined modality as a promising treatment for TRD, warranting further research to understand the underlying mechanisms and long-term efficacy.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pharmacotherapeutic and neuroimaging case study of maladaptive daydreaming 不适应白日梦的药物治疗和神经影像学案例研究

Psychiatry research case reports Pub Date : 2025-01-26 DOI: 10.1016/j.psycr.2025.100249

Daniel Mamah, ShingShiun Chen, Ayleen Gomez-Lopez, Samantha Alexander

{"title":"A pharmacotherapeutic and neuroimaging case study of maladaptive daydreaming","authors":"Daniel Mamah, ShingShiun Chen, Ayleen Gomez-Lopez, Samantha Alexander","doi":"10.1016/j.psycr.2025.100249","DOIUrl":"10.1016/j.psycr.2025.100249","url":null,"abstract":"<div><h3>Background</h3><div>Maladaptive daydreaming (MD) is an underreported mental health condition involving prolonged, vivid fantasizing, associated with significant functional impairment or disability. The underlying neurobiology of MD is unknown, and there have been no prior neuroimaging studies in affected individuals.</div></div><div><h3>Case presentation</h3><div>A twenty-year-old woman with a history of depression and obsessive-compulsive disorder reported experiencing intense and highly distracting daydreams, exacerbated by stress and resulting in an inability to complete her studies. We describe her clinical presentation, treatment and symptom response over 120 weeks. Depression was largely treatment-resistant with antidepressants, and improvement with lamotrigine (Lamictal) augmentation was limited by poor tolerance. Antipsychotic medications (lurasidone, risperidone (Risperdal) and aripiprazole) resulted in a rapid reduction or cessation of daydreaming, and dopaminergic medications (lisdexamfetamine and bupropion) resulted in substantially increased time spent daydreaming. The patient underwent Magnetic Resonance Imaging (MRI) using a 3 Tesla scanner, and the brain's cortical thickness and functional connectivity networks were assessed and compared to a matched population of healthy individuals. We found regions of cortical thinning in the left hemisphere, primarily in the middle temporal cortex. The left default mode and cingulo-opercular networks, and the salience network bilaterally, were enlarged compared to the general population. In contrast, the left frontoparietal network was smaller.</div></div><div><h3>Conclusion</h3><div>A hyperdopaminergic state may be involved in some cases of MD. Altered development of the left brain may underlie the capacity for prolonged, vivid daydreaming. Future studies in larger patient populations are needed to validate findings.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of first-episode psychosis with catatonic features in an adolescent following THC use 青少年四氢大麻酚使用后首发精神病伴紧张性特征1例

Psychiatry research case reports Pub Date : 2025-01-22 DOI: 10.1016/j.psycr.2025.100248

Lily Porsa DO

引用次数: 0

Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis 行为变异性额颞叶痴呆伴肌萎缩侧索硬化症一例过度情绪反应

Psychiatry research case reports Pub Date : 2025-01-15 DOI: 10.1016/j.psycr.2025.100247

Megan S. Barker , Neil A. Shneider , Masood Manoochehri , Edward D. Huey , Elizabeth C. Lindenberger

{"title":"Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis","authors":"Megan S. Barker , Neil A. Shneider , Masood Manoochehri , Edward D. Huey , Elizabeth C. Lindenberger","doi":"10.1016/j.psycr.2025.100247","DOIUrl":"10.1016/j.psycr.2025.100247","url":null,"abstract":"<div><div>Although amyotrophic lateral sclerosis (ALS) is defined as a neuromuscular disease, cognitive and/or behavioral symptoms are relatively common, and a portion of ALS patients will meet criteria for behavioral variant frontotemporal dementia (bvFTD). In this report, we describe the case of a man with ALS with bvFTD (ALS-FTD) presenting with excessive emotional reactivity, including severe anger, aggression, and obsessive thoughts. We contrast this case with the decreased emotional reactivity that is usually observed in patients with bvFTD without ALS. We discuss possible explanations including that: 1) the behavioral symptoms of bvFTD and ALS-FTD are the same, but the motor dysfunction influences the clinical manifestations of the behavioral symptoms in ALS-FTD; 2) the emotional and behavioral symptoms of bvFTD and ALS-FTD are the same, but ALS-FTD patients come to clinical attention earlier in the course of their FTD than bvFTD patients without ALS; and 3) the emotional and behavioral symptoms of bvFTD and ALS-FTD could differ.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

‘I wouldn't have become addicted to fruit machines if it wasn't for coin pushers’: A case report of adolescent coin pusher use leading to lifelong gambling-related harm “如果不是因为推币机，我不会对水果机上瘾”：一份青少年使用推币机导致终身赌博相关伤害的案例报告

Psychiatry research case reports Pub Date : 2025-01-12 DOI: 10.1016/j.psycr.2025.100246

Jamie Torrance , Jessica Smith , Philip Newall

{"title":"‘I wouldn't have become addicted to fruit machines if it wasn't for coin pushers’: A case report of adolescent coin pusher use leading to lifelong gambling-related harm","authors":"Jamie Torrance , Jessica Smith , Philip Newall","doi":"10.1016/j.psycr.2025.100246","DOIUrl":"10.1016/j.psycr.2025.100246","url":null,"abstract":"<div><div>While most previous adolescent gambling research focuses on the illegal use of age-restricted products, adolescents can also often gamble legally using machines such as coin pushers (aka ‘penny falls’ machines). Using a qualitative case report design, we use an in-depth interview to complement previous findings, which have associated recollected adolescent use of coin pusher machines with levels of adult gambling-related harm. We recruited a 57-year-old male with a history of significant gambling-related harm, whose initiation into gambling involved the adolescent use of coin pusher machines. The interview was audio recorded, transcribed, and analyzed using interpretative phenomenological analysis. Three themes were identified: the structural similarities between coin pushers and traditional gambling formats, the role of proximity and normalization in facilitating progression to riskier gambling, and the participant's suggestions for population-level harm prevention measures. This novel case report highlights how a person's lifelong struggles with severe gambling-related harms began with adolescent exposure to coin pusher machines. Greater awareness of this case could encourage more gamblers to share similar experiences, alongside helping to educate parents and policymakers about the potential harmful consequences of using coin pusher machines.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could psychedelics be useful in the treatment of patients with personality disorder? A case report of psychotherapy with concomitant use of psychedelics 迷幻药对治疗人格障碍患者有用吗？心理治疗同时使用致幻剂一例报告

Psychiatry research case reports Pub Date : 2025-01-08 DOI: 10.1016/j.psycr.2025.100245

Martin Blay , Inès Benmakhlouf , Mario Speranza

{"title":"Could psychedelics be useful in the treatment of patients with personality disorder? A case report of psychotherapy with concomitant use of psychedelics","authors":"Martin Blay , Inès Benmakhlouf , Mario Speranza","doi":"10.1016/j.psycr.2025.100245","DOIUrl":"10.1016/j.psycr.2025.100245","url":null,"abstract":"<div><div>Psychotherapy enhanced by psychedelics has recently been found to be helpful for the treatment of several psychiatric disorders, notably depressive disorders. However, it has only been considered scarcely in patients suffering from personality disorders. Here, we report the case of a 37 years-old woman suffering from severe mixed personality disorder and ADHD. Alongside the beginning of her GPM-based psychotherapeutic treatment, and despite our concerns, she started closely monitored psychedelic micro-dosing, using products bought online, punctuated by occasional macro-dosing After one-year of this psychotherapy associated with concomitant independent use of psychedelics, paranoid, narcissistic and borderline personality dimensions were largely improved, as well as emotion regulation, impulsivity, mentalization abilities, and social functioning. Given the actual evidence regarding the efficacy of psychedelics to improve the latter four dimensions, given the patient's reported experience, and despite important limits, we make the hypothesis that the concomitant use of psychedelics has enhanced psychotherapy efficacy. Overall, this case asks the question of the potential usefulness of psychedelics associated with psychotherapy in patients with PD. Further pilot studies should be conducted on this issue.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 1","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0