Psychiatry research case reports最新文献

{"title":"Treatment-resistant psychosis in familial cerebral cavernous malformation: A case series","authors":"Tianyi Hui ,&nbsp;Thanita Pilunthanakul ,&nbsp;Li Keat Oon ,&nbsp;Charmaine Tang","doi":"10.1016/j.psycr.2025.100298","DOIUrl":"10.1016/j.psycr.2025.100298","url":null,"abstract":"<div><h3>Background</h3><div>Familial Cerebral Cavernous Malformations (FCCMs) are associated with symptomatic clinical findings, including neurological deficits and seizures, a positive family history, and supportive gene mutations. Current evidence on neuropsychiatric manifestations is limited to case reports, primarily describing mood and anxiety symptoms. The use of Electroconvulsive Therapy (ECT) has been limited, largely due to concerns about precipitating cavernoma bleeding. Notably, there are no documented cases of psychotic manifestations in cavernomas that are not actively haemorrhagic.</div></div><div><h3>Methods and Results</h3><div>We report on two siblings with FCCMs, diagnosed based on brain imaging and family history, who presented with rare neuropsychiatric symptoms of psychosis.</div></div><div><h3>Case 1</h3><div>A 15-year-old female presented with auditory hallucinations, delusions of erotomania and passivity, affective symptoms including overfamiliarity and disinhibition, and significant aggression toward herself and others. She demonstrated resistance to multiple trials of antipsychotics and lithium. Treatment with clozapine and ECT was required, alongside propranolol to manage blood pressure and mitigate the risk of cavernoma bleeding during ECT.</div></div><div><h3>Case 2</h3><div>A 21-year-old male presented with auditory hallucinations, delusions of guilt, and aggression. He also exhibited treatment resistance and required clozapine for symptom management.</div></div><div><h3>Conclusions</h3><div>Patients with FCCMs may exhibit genetic and clinical overlaps, posing significant medical challenges when managing psychotic symptoms. Their psychosis may demonstrate resistance to conventional treatments. ECT appears to be a novel, potentially safe, and effective therapeutic option when precautions are taken to minimize the risk of cavernoma bleeding.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Statements in previously published articles","authors":"","doi":"10.1016/j.psycr.2025.100269","DOIUrl":"10.1016/j.psycr.2025.100269","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on treatment of bipolar disorder in Late Onset Tay-Sachs disease","authors":"Rachel Bigley ,&nbsp;Ricardo Roda ,&nbsp;Sarah Collica","doi":"10.1016/j.psycr.2025.100270","DOIUrl":"10.1016/j.psycr.2025.100270","url":null,"abstract":"<div><div>Late Onset Tay-Sachs Disease (LOTS) is an autosomal recessive genetic neurodegenerative condition that is associated with neurologic symptoms such as incoordination, imbalance, tremor, dysarthria, and cognitive decline. It is known that those with this genetic condition have an increased risk of severe mental illness including Bipolar Spectrum Affective Disorder (BPAD). However, there is limited evidence for which medications are effective in treating psychiatric illness in these people without causing worsening neurologic symptoms. We present the case of a young woman who presented with rapid mood cycling following a recent diagnosis of LOTS. We show that this patient was safely and effectively treated with olanzapine (Zyprexa) and Lithium with return to her mental health baseline, no worsening of neurological symptoms, and continued stability at 5 months follow-up.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100270"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delusions of hermaphroditism and pregnancy in bipolar mania","authors":"Felipe Londoño Gómez,&nbsp;Paola Hernández Rúa,&nbsp;Kelly Duica,&nbsp;Camilo Andrés Agudelo V","doi":"10.1016/j.psycr.2025.100294","DOIUrl":"10.1016/j.psycr.2025.100294","url":null,"abstract":"<div><div>Delusional misidentification syndromes are a group of rare psychiatric phenomena involving disturbances in the recognition of oneself or others. Among them, delusional hermaphroditism and delusional pregnancy are exceptionally uncommon. We present the case of a 58-year-old male with bipolar disorder in a manic episode, who has a persistent belief of possessing both male and female genitalia and experiencing multiple pregnancies and miscarriages. The patient's delusional symptoms proved refractory to antipsychotic treatment, necessitating electroconvulsive therapy (ECT), which led to complete symptom resolution. This case underscores the clinical relevance of rare delusional presentations in bipolar mania and highlights the therapeutic role of ECT in treatment-resistant cases.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100294"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145323276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond stabilization: Augmenting LAI aripiprazole with xanomeline–trospium in schizophrenia – A case series","authors":"Parinda Parikh ,&nbsp;Aatish Dutta Bhatta ,&nbsp;Alisha Arul Alphonse ,&nbsp;Jeremy Kays ,&nbsp;Shaurya Kumar Singh ,&nbsp;Himani J Suthar ,&nbsp;Arnesh Shukla ,&nbsp;Mahiya Buddhavarapu ,&nbsp;Arushi Kaushik-Chandra ,&nbsp;Zoe Gellert ,&nbsp;Mina Oza","doi":"10.1016/j.psycr.2025.100285","DOIUrl":"10.1016/j.psycr.2025.100285","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is a chronic psychiatric disorder characterized by positive symptoms (e.g., hallucinations, delusions), negative symptoms (e.g., avolition, blunted affect), and general psychopathology (e.g., anxiety, cognitive deficits). Long-acting injectable (LAI) antipsychotics such as aripiprazole are effective for controlling positive symptoms, yet negative symptoms and general psychopathology often persist, impairing functional recovery and quality of life. Interest has grown in treatments that target non-dopaminergic pathways. Xanomeline–trospium chloride (KarXT, Cobenfy™)—a central M1/M4 muscarinic agonist combined with a peripheral anticholinergic—represents a novel adjunctive approach. This case series describes the use of KarXT in patients maintained on LAI aripiprazole who had persistent negative and general psychopathology symptoms, with the aim of exploring potential clinical benefit through cholinergic modulation.</div></div><div><h3>Cases</h3><div>Four male patients (ages 20–29) with schizophrenia, all stabilized on LAI aripiprazole, presented with residual negative symptoms such as avolition, blunted affect, and emotional withdrawal, along with general psychopathology symptoms, despite adequate control of positive symptoms. Adjunctive KarXT (xanomeline 50 mg / trospium 20 mg BID, titrated to xanomeline 100 mg / trospium 20 mg BID) was administered for 10 weeks. Positive and Negative Syndrome Scale (PANSS) assessments were conducted by trained raters. Across cases, reductions were observed in total PANSS scores (mean reduction 32.1 %), with the largest changes in negative and general psychopathology subscales. Patients also reported subjective improvements in motivation, social engagement, and emotional expressiveness.</div></div><div><h3>Discussion</h3><div>Findings from prior randomized controlled trials have shown KarXT to reduce PANSS scores, though its effects on negative symptoms remain under investigation. In this small, uncontrolled case series, observed improvements may reflect potential benefit, but causality cannot be inferred. The absence of a control group, potential placebo effects, and concurrent treatments are important limitations. Compared with options such as clozapine, which may be limited by side effects and monitoring requirements, KarXT may represent a tolerable adjunctive strategy warranting further controlled study.</div></div><div><h3>Conclusion</h3><div>Adjunctive KarXT in patients with schizophrenia stabilized on LAI aripiprazole was associated with observed improvements in negative and general psychopathology symptoms in this small case series. These preliminary findings support further investigation in larger, randomized controlled trials to determine efficacy, safety, and optimal use in real-world clinical settings.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Statements in previously published articles","authors":"","doi":"10.1016/j.psycr.2025.100266","DOIUrl":"10.1016/j.psycr.2025.100266","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric sequelae of osmotic demyelination syndrome: a literature review and novel case of mania","authors":"Hager Koraym,&nbsp;Patrick Drummond,&nbsp;Kasra Manoocheri,&nbsp;Liliya Gershengoren,&nbsp;Robert Mazgaj,&nbsp;Brian Hanrahan","doi":"10.1016/j.psycr.2025.100287","DOIUrl":"10.1016/j.psycr.2025.100287","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100287"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thought broadcasting associated with seizure aura from bleeding cerebral cavernous malformation: a case report","authors":"Bailey H. Brown ,&nbsp;Stephan F. Taylor","doi":"10.1016/j.psycr.2025.100283","DOIUrl":"10.1016/j.psycr.2025.100283","url":null,"abstract":"<div><div>It is well known that temporal lobe epilepsy (TLE), particularly of the mesial temporal lobe, is associated with peri‑ictal (including preictal, ictal, and postictal) and interictal psychosis. We present a case of a 38-year-old male with new-onset seizures secondary to a sporadically bleeding, inoperable temporal lobe cavernous malformation (CM). Followed over 17 years, he experienced recurrent seizures with auras intermittently associated with episodes of thought broadcasting. This case shows, in the absence of a primary psychotic disorder, a discrete temporal lobe lesion occurring with an isolated psychotic symptom during aura. We explore possible mechanisms for this phenomenon.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Pharmacogenetic testing utility in psychiatry: A case report of serotonin syndrome” [Psychiatry Research Case Reports Volume 2, Issue 1, June 2023, 100128]","authors":"A.G. Mohiuddin ,&nbsp;J. Howie ,&nbsp;D. Herbert ,&nbsp;C.A. Bousman ,&nbsp;J.L. Kennedy","doi":"10.1016/j.psycr.2025.100274","DOIUrl":"10.1016/j.psycr.2025.100274","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100274"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of new-onset mania in older adulthood related to cannabidiol and low-dose prescription stimulant use","authors":"Nsomma Alilonu ,&nbsp;Kali Smolen ,&nbsp;Sebastian Kolaj ,&nbsp;Jeffrey Reed","doi":"10.1016/j.psycr.2025.100300","DOIUrl":"10.1016/j.psycr.2025.100300","url":null,"abstract":"<div><div>This is a case study of a 57-year-old female admitted to the inpatient psychiatry ward for new-onset mania following a recent increase in cannabidiol (CBD) use and prescribed low-dose dextroamphetamine-amphetamine for newly diagnosed attention-deficit/hyperactivity disorder (ADHD). The psychiatric implications from using cannabis products and prescription stimulants are active areas of investigation, especially given the increase in recreational cannabis use and stimulant prescriptions in recent years. Substance-induced bipolar disorder represents one such psychiatric condition that can result from using these substances, typically resolving with the cessation of their use. Substance-induced psychosis resulting from either stimulant or cannabis use, conferred by the psychoactive component tetrahydrocannabinol (THC), is well-represented in the literature. However, substance-induced bipolar disorder in the setting of increased CBD use and concurrent low-dose stimulant use in patients 40 years and older without a personal or family history of bipolar disorder has not been significantly studied. This case study explores a case of substance-induced bipolar disorder in an older adult associated with use of prescription stimulants and cannabidiol products. We show that this patient was effectively treated with cessation of dextroamphetamine-amphetamine and CBD products in conjunction with use of olanzapine for four months following presentation without recurrence of mania at 15 months follow-up.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100300"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}