Arul Sangani , Pegah Yakhchalian , Kimia Mondegari , Olivia Erickson , Fahad Molla
{"title":"Exploring Neuropsychiatric Sequelae Arising from Complications of Serotonin Syndrome: A Case Report","authors":"Arul Sangani , Pegah Yakhchalian , Kimia Mondegari , Olivia Erickson , Fahad Molla","doi":"10.1016/j.psycr.2025.100290","DOIUrl":"10.1016/j.psycr.2025.100290","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction notice to “COVID-19-induced new-onset psychosis: a case report” [Psychiatry Research Case Reports, Volume 1, Issue 2, December 2022, 100048]","authors":"Xiaoyi Gao, Noam Grysman, Mirela Marcu","doi":"10.1016/j.psycr.2025.100263","DOIUrl":"10.1016/j.psycr.2025.100263","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complete resolution of urge urinary incontinence following treatment of ADHD with lisdexamfetamine: a case report","authors":"Adem T. Can , Jim Lagopoulos","doi":"10.1016/j.psycr.2025.100284","DOIUrl":"10.1016/j.psycr.2025.100284","url":null,"abstract":"<div><div>This case report describes the complete and sustained resolution of urge urinary incontinence in a 50-year-old woman diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) Level 1, and complex post-traumatic stress disorder (cPTSD), following initiation of lisdexamfetamine. The patient experienced urge urinary incontinence for years, which resolved entirely within weeks of commencing lisdexamfetamine at a therapeutic dose for ADHD. This clinical observation raises the possibility of a previously unrecognised neuroregulatory effect of stimulant pharmacotherapy on central bladder control mechanisms. This case suggests the need for further investigation into the interplay between neurodevelopmental disorders, psychiatric comorbidity, and lower urinary tract function.</div><div>No published data to date have identified lisdexamfetamine as a modulator of continence. Limited evidence exists for atomoxetine in paediatric nocturnal enuresis, but stimulant effects on adult urge incontinence remain undocumented.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alonso Elías Garrido-Pinzás , Marcelo Cruzalegui , Cynthia Cabrejos Novoa
{"title":"Clozapine withdrawal syndrome; a case report","authors":"Alonso Elías Garrido-Pinzás , Marcelo Cruzalegui , Cynthia Cabrejos Novoa","doi":"10.1016/j.psycr.2025.100279","DOIUrl":"10.1016/j.psycr.2025.100279","url":null,"abstract":"<div><h3>Introduction</h3><div>Abrupt clozapine discontinuation can trigger a rare withdrawal syndrome characterized by psychosis, serotonergic symptoms, catatonia, and cholinergic rebound symptoms.</div></div><div><h3>Case presentation</h3><div>We report a 37-year-old woman with schizoaffective disorder who accidentally stopped clozapine abruptly, leading to severe psychomotor agitation, psychosis, catatonia, and dysautonomia, requiring hospitalization. Differential diagnoses, including neuroleptic malignant syndrome, were considered. Symptoms gradually improved upon reintroducing clozapine, confirming the diagnosis of clozapine withdrawal syndrome.</div></div><div><h3>Discussion</h3><div>Clozapine withdrawal syndrome may be underdiagnosed. The most effective treatment is to restart clozapine; gradual tapering is preferred to avoid complications when discontinuation is necessary.</div></div><div><h3>Conclusion</h3><div>Awareness of clozapine withdrawal is crucial for early diagnosis and treatment.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100279"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniele Cavaleri , Filippo Fabio Barbieri , Alessandra Bartoccetti , Massimiliano Manzato , Marco Otto Maria Toscano , Giuseppe Carrà , Francesco Bartoli
{"title":"Rapid-onset black hairy tongue following clomipramine initiation and rechallenge: A case report","authors":"Daniele Cavaleri , Filippo Fabio Barbieri , Alessandra Bartoccetti , Massimiliano Manzato , Marco Otto Maria Toscano , Giuseppe Carrà , Francesco Bartoli","doi":"10.1016/j.psycr.2025.100289","DOIUrl":"10.1016/j.psycr.2025.100289","url":null,"abstract":"<div><div>Black hairy tongue (BHT), a benign condition characterized by hypertrophy of the filiform papillae and discoloration of the dorsal tongue, is commonly associated with antibiotic use, poor oral hygiene, lifestyle factors, and general health issues. By contrast, psychotropic drug-induced BHT is rare and typically emerges weeks to months after treatment initiation. We report the case of a 42-year-old male patient with recurrent major depressive disorder and prior use of different psychotropic medications who developed BHT within days of initiating clomipramine on two separate occasions. In the first trial, BHT resolved shortly after clomipramine discontinuation. On the second occasion, considering the effectiveness of the treatment, the absence of concerning symptoms, and the exclusion of other causes through multidisciplinary evaluation, the patient remained on clomipramine. Despite oral hygiene measures, BHT persisted. Close temporal association, reproducibility upon re-challenge, resolution upon discontinuation during the first trial, and absence of alternative explanations supported a definite causal link, as indicated by the Expanded Naranjo Adverse Drug Reaction Probability Scale. Chronic smoking and prolonged chlorhexidine mouthwash use may have contributed, though these were unlikely the individual causes. To our knowledge, this is the first report of clomipramine-induced BHT with such rapid onset and recurrence. This case highlights the importance of recognizing BHT as a potential early-onset side effect of tricyclic antidepressants, particularly clomipramine. Prompt recognition, interdisciplinary assessment, and consideration of the risk-benefit balance are essential. Although an idiosyncratic reaction – independent of clomipramine-induced xerostomia – can be hypothesized, further research is needed to clarify the mechanisms underlying antidepressant-induced BHT.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim Abdulrahman Alsuwailem , Abdullah Alsubhi , Lama Faiz Aljuaid
{"title":"Cariprazine for hyperactive delirium in a medically complex ICU Patient: A case report","authors":"Ibrahim Abdulrahman Alsuwailem , Abdullah Alsubhi , Lama Faiz Aljuaid","doi":"10.1016/j.psycr.2025.100286","DOIUrl":"10.1016/j.psycr.2025.100286","url":null,"abstract":"<div><h3>Background</h3><div>Hyperactive delirium is a dangerous and under-studied complication in critically ill patients. Management is often complicated by QTc (corrected QT interval) prolongation associated with standard antipsychotics. Cariprazine, a dopamine D₂/D₃ partial agonist with minimal cardiac risk, may offer an alternative, though its role in delirium remains unexplored. Emerging real-world evidence supports cariprazine’s use in treatment-resistant psychiatric conditions, providing indirect support for its consideration in medically complex patients (Martiadis et al., 2024)</div></div><div><h3>Case Presentation</h3><div>A 33-year-old male with end-stage renal disease, sepsis, and prolonged QTc developed severe hyperactive delirium during an ICU admission. Despite trials of olanzapine (Zyprexa), lorazepam (2 mg IV q6h), and haloperidol (5 mg IV q6h), his agitation persisted. He required intubation for safety and sedation. Supportive care included dialysis, broad-spectrum antibiotics, oxygen supplementation (nasal cannula, high-flow, then intubation), IV fluids, and enteral feeding. Psychiatry was re-consulted on June 3 and confirmed hyperactive delirium. On June 4, cariprazine 1.5 mg was administered via NG tube (capsule powder dissolved in 30 mL water). Within 48–72 h, his behavior improved, coinciding with correction of metabolic derangements, resolution of sepsis, and stabilization of renal function. He was successfully extubated and discharged psychiatrically and medically stable.</div></div><div><h3>Conclusion</h3><div>This case suggests that cariprazine may be a potential alternative in ICU patients with hyperactive delirium and QTc concerns. However, clinical improvement was multifactorial, reflecting both psychiatric pharmacotherapy and comprehensive ICU management. This single case highlights the importance of multidisciplinary care and should be considered hypothesis-generating.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TammieLee Demler , TammieLee Demler , Samara White
{"title":"Retraction notice to “Exploring the Risk of Magnesium Use for Antipsychotic Induced Constipation: A Case study for consideration” [Psychiatry Research Case Reports Volume 2, Issue 1, June 2023, 100132]","authors":"TammieLee Demler , TammieLee Demler , Samara White","doi":"10.1016/j.psycr.2025.100277","DOIUrl":"10.1016/j.psycr.2025.100277","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100277"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction notice to “Diagnosis of unsuspected catatonia with an inadvertent lorazepam challenge test” [Volume 1, Issue 2, December 2022, 100073]","authors":"Ila Gautham , Annise Wilson","doi":"10.1016/j.psycr.2025.100272","DOIUrl":"10.1016/j.psycr.2025.100272","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction notice to “Pseudocyesis in a deployed military member” [Psychiatry Research Case Reports Volume 2, Issue 2, December 2023, 100183]","authors":"Ezie Nguyen , Allison Watkins , Lauren Wells","doi":"10.1016/j.psycr.2025.100275","DOIUrl":"10.1016/j.psycr.2025.100275","url":null,"abstract":"","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100275"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The feasibility and acceptability of metacognitive therapy in a forensic setting: a case report of chronic paranoid schizophrenia with persistent depressive symptoms","authors":"Riitta Kuokkanen","doi":"10.1016/j.psycr.2025.100282","DOIUrl":"10.1016/j.psycr.2025.100282","url":null,"abstract":"<div><div>There is increasing evidence that metacognitive therapy (MCT; Wells, 2009) results in significant benefits in various disorders, including depression and psychosis, and may even surpass the efficacy of cognitive behavioral therapy (CBT), currently recommended in treatment guidelines. The implementation of advanced new forms of treatment, and especially research into the effectiveness of these new treatments, is often more challenging in forensic psychiatric treatment and with difficult-to-treat patients. The evidence on the effectiveness of psychological interventions in this population is still limited and research on MCT in this context is non-existent. As a first step in evaluating MCT’s feasibility and acceptability in this context, this paper describes a case example of the treatment of persistent depressive symptoms of chronic paranoid schizophrenia augmented with MCT in a forensic mental health setting. In addition to treatment as usual, i.e. medication, regular conversations with a designated nurse, and a social skills group, 18 weekly sessions of MCT following a depression treatment plan, targeting rumination/worry, attentional control, metacognitive beliefs, and dysfunctional behaviors, were delivered. The same person conducted the assessments and therapy. Clinically significant reductions in depressive symptoms and delusions were observed, assessed at pre- and post-therapy. In addition, a prominent decline in rumination, dysfunctional metacognitive beliefs and coping behaviors took place. Although the specific contribution of MCT cannot be established, it is concluded that MCT may be a useful supplement to treatment options in the treatment of difficult-to-treat patients and in a forensic setting.</div></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"4 2","pages":"Article 100282"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}