Physical activity and nutrition最新文献_第3页

Effects of public transportation use on non-exercise activity thermogenesis and health promotion: a mini-review. 使用公共交通对非运动活动产热和健康促进的影响：微型综述。

Physical activity and nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0005

Sung-Woo Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Taeho Kim, Jongwon Kim, Inseop Shin, Kiwon Lim

{"title":"Effects of public transportation use on non-exercise activity thermogenesis and health promotion: a mini-review.","authors":"Sung-Woo Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Taeho Kim, Jongwon Kim, Inseop Shin, Kiwon Lim","doi":"10.20463/pan.2024.0005","DOIUrl":"10.20463/pan.2024.0005","url":null,"abstract":"Purpose: Public transportation (PT) systems significantly shape urban mobility and have garnered attention owing to their potential impact on public health, particularly the promotion of physical activity. Beyond their transportation functions, PT systems also affect daily energy expenditure through non-exercise activity thermogenesis (NEAT). This mini-review surveys the existing literature to explore the effects of PT use on NEAT levels and subsequent health outcomes.Methods: A comprehensive literature search was conducted using the electronic databases PubMed, Google Scholar, and Web of Science. Keywords including \"public transportation,\" \"non-exercise activity thermogenesis,\" \"physical activity,\" \"health promotion,\" and related terms were used to identify relevant studies.Results: This review highlights the multifaceted relationship between PT use and health promotion, emphasizing the potential benefits and challenges of increasing NEAT through public transit utilization. Overall, the findings suggest that PT use contributes positively to NEAT levels, and thus improves health outcomes. However, the extent of this impact may vary depending on individual and contextual factors.Conclusion: Interventions promoting active transportation modes, including public transit, hold promise for addressing sedentary behavior and fostering healthier lifestyles at the population level.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of blood flow restriction with low-intensity resistance training in patients with osteoarthritis and rheumatoid arthritis: a systematic review and meta-analysis based on randomized controlled trials. 低强度阻力训练对骨关节炎和类风湿性关节炎患者的血流限制效果：基于随机对照试验的系统回顾和荟萃分析。

Physical activity and nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0002

Junzhen Huang, Hun-Young Park

{"title":"Effect of blood flow restriction with low-intensity resistance training in patients with osteoarthritis and rheumatoid arthritis: a systematic review and meta-analysis based on randomized controlled trials.","authors":"Junzhen Huang, Hun-Young Park","doi":"10.20463/pan.2024.0002","DOIUrl":"10.20463/pan.2024.0002","url":null,"abstract":"Purpose: This study evaluated the effects of blood flow restriction with low-intensity resistance training (BFR + LIRT) on pain, adverse events, muscle strength, and function in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) through a systematic review and meta-analysis.Methods: This study adhered to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 (PRISMA 2020) and applied the A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR2) standards to ensure the high quality of the systematic review. A comprehensive literature search was conducted until August 2023 using four selected keywords (osteoarthritis, rheumatoid arthritis, blood flow restriction training, and resistance training) across five search engines (PubMed, Embase, Web of Science, CENTRAL, and PEDro).Results: Ten studies were analyzed. The results showed that BFR + LIRT had similar effects on pain, risk of adverse events, muscle strength, self-reported function, and physical function compared with resistance training (RT).Conclusion: This systematic review and meta-analysis further support the potential of BFR + LIRT in the disease management of patients with OA or RA. According to this analysis, BFR + LIRT had a lower risk of adverse events than high-intensity resistance training (HIRT) and may be a safer training modality. BFR + LIRT offers greater advantages in improving physical function than LIRT and was able to provide similar benefits to HIRT without increasing the training load. These findings suggest that BFR + LIRT is a safe and effective strategy for treating patients with OA or RA. However, owing to the limited number of studies covered in this analysis, additional higher-quality studies are needed to strengthen this conclusion.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of sitting time on pulmonary function in computerusing office workers. 久坐对电脑办公人员肺功能的影响

Physical activity and nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0003

Aditi Upmanyu, Amit Kumar, Varun Kalia

{"title":"Influence of sitting time on pulmonary function in computerusing office workers.","authors":"Aditi Upmanyu, Amit Kumar, Varun Kalia","doi":"10.20463/pan.2024.0003","DOIUrl":"10.20463/pan.2024.0003","url":null,"abstract":"Purpose: We aimed to identify the changes in pulmonary function after prolonged sitting. Pulmonary function tests (PFTs) allow physicians to assess the respiratory capability of patients under numerous clinical circumstances and when there are risk factors for lung sickness, occupational exposure, and pulmonary toxicity. PFTs are routinely performed in the standing or high sitting position because of the devices and patient comfort.Methods: A total of 180 asymptomatic office workers were recruited as eligibility criteria and divided into three groups according to their daily sitting duration (group 1:2-4 h, group 2:4-6 h, and group 3: > 6 h). PFTs were performed twice consecutively to determine the mean of the readings. A Helios 401 spirometer was used to quantify lung function. The parameters were \"forced expiratory volume in 1 s (FEV1)\", \"forced vital capacity (FVC)\", \"peak expiratory flow rate (PEFR)\", and the \"ratio of FEV1 to FVC (FEV1/FVC)\".Results: Our results suggest that noteworthy changes were present in the lung function of all the participants. For individuals with > 6 h of sitting; FVC, FEV1, and PEFR were higher compared to those of the participants with 2-4 h and 4-6 h of sitting. The FEV1/FVC ratio was also reduced in individuals with prolonged hours of sitting.Conclusion: Body position impacts the result of PFTs; however, that as it may, the ideal position and extent of advantage changed between the review populaces. These results suggested that noteworthy changes occur in the lung function of healthy individuals exposed to sitting time.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of post-exercise intake of exogenous lactate on energy substrate utilization at rest. 运动后摄入外源性乳酸盐对静息时能量底物利用的影响。

Physical activity and nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0001

Taeho Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Sung-Woo Kim, Hun-Young Park, Kiwon Lim, Charyong Kim, Jisu Kim

{"title":"Effects of post-exercise intake of exogenous lactate on energy substrate utilization at rest.","authors":"Taeho Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Sung-Woo Kim, Hun-Young Park, Kiwon Lim, Charyong Kim, Jisu Kim","doi":"10.20463/pan.2024.0001","DOIUrl":"10.20463/pan.2024.0001","url":null,"abstract":"Purpose: This study investigated the effects of exogenous lactate intake on energy metabolism during 1 h of rest after acute exercise.Methods: Eight-week-old ICR mice were randomly divided into four groups: SED (no treatment), EXE (exercise only), LAC (post-exercise oral lactate administration), and SAL (post-exercise saline administration) (n=8 per group). The exercise intensity was at VO2max 80% at 25 m/min and 15° slope for 50 min. After acute exercise, the LAC and SAL groups ingested lactate and saline orally, respectively, and were allowed to rest in a chamber. Energy metabolism was measured for 1 h during the resting period.Results: LAC and SAL group mice ingested lactate and saline, respectively, after exercise and the blood lactate concentration was measured 1 h later through tail blood sampling. Blood lactate concentration was not significantly different between the two groups. Energy metabolism measurements under stable conditions revealed that the respiratory exchange ratio in the LAC group was significantly lower than that in the SAL group. Additionally, carbohydrate oxidation in the LAC group was significantly lower than that in the SAL group at 10-25 min. No significant difference was observed in the fat oxidation level between the two groups.Conclusion: We found that post-exercise lactate intake modified the respiratory exchange ratio after 1 h of rest. In addition, acute lactate ingestion inhibits carbohydrate oxidation during the post-exercise recovery period.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional knowledge, eating habits, factors affecting muscle damage, and antioxidant enzyme levels of Korean wrestlers. 韩国摔跤运动员的营养知识、饮食习惯、影响肌肉损伤的因素以及抗氧化酶水平。

Physical activity and nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0008

Yun-Seok Lee, Dong-Ryul Lee, Hyoung-Rok Lee, Jun-Young Sung

{"title":"Nutritional knowledge, eating habits, factors affecting muscle damage, and antioxidant enzyme levels of Korean wrestlers.","authors":"Yun-Seok Lee, Dong-Ryul Lee, Hyoung-Rok Lee, Jun-Young Sung","doi":"10.20463/pan.2024.0008","DOIUrl":"10.20463/pan.2024.0008","url":null,"abstract":"Purpose: The aim in this study was to investigate the diet and nutritional knowledge of elite Korean wrestlers and verify the differences in their exercise performance , muscle damage indicators, and antioxidant enzyme levels according to wrestler level.Methods: A 7-day dietary and nutrition knowledge survey was administered to 30 adult male elite wrestlers (national team: n=11; professional team: n=19). The Wingate test was conducted for 60 seconds to analyze muscle damage indicators and antioxidant levels. Blood and blood lactate concentration analyses were performed four times; the statistical significance level of all data was p<0.05.Results: Significant differences were found in general nutrition knowledge questionnaire (GNKQ) scores (p=0.043), diet (p=0.001), anaerobic performance (p=0.001), muscle damage indicators (p=0.026), antioxidant levels, and blood lactic acid concentrations (30 min after exercise, p=0.007; 90 min after exercise, p=0.038) between the national and the professional groups.Conclusion: To the findings confirm the relationship between the differences in diet, nutrition, and motor function for wrestlers of different expertise levels. In a follow-up, a comprehensive study on nutrition knowledge, athlete training , and weight loss is needed that considers a wider scope of subjects and analyzes additional variables.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cranberry supplementation improves physiological markers of performance in trained runners. 补充蔓越莓可改善训练有素的跑步者的生理指标。

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0032

Francis Parenteau, Veronica Furno Puglia, Mary Roberts, Alain Steve Comtois, Andreas Bergdahl

{"title":"Cranberry supplementation improves physiological markers of performance in trained runners.","authors":"Francis Parenteau, Veronica Furno Puglia, Mary Roberts, Alain Steve Comtois, Andreas Bergdahl","doi":"10.20463/pan.2023.0032","DOIUrl":"10.20463/pan.2023.0032","url":null,"abstract":"Purpose: Cranberries have the highest polyphenol and antioxidant capacity among fruits and vegetables and may protect against exercise-induced free radical production, consequently improving performance. This study aimed to investigate the effect of polyphenol-rich cranberry extract (CE) on time-trial performance and lactate response following exercise.Methods: A total of 14 trained runners were tested at i) baseline, ii) 2 h following an acute CE dose (0.7 g/kg of body mass), and iii) 4 weeks after daily supplement consumption (0.3 g/kg of body mass). At each time point, runners performed a 1500-m race followed by a 400-m race where the live vastus lateralis oxygenation changes were determined by near-infrared spectroscopy and blood lactate was measured at rest and 1 and 3 min after each trial. The Shapiro-Wilk test and repeated-measures analysis of variance were used to establish significance (P <0.05).Results: Cranberry supplementation over 28 d improved aerobic performance during the 1500-m time trial, whereas the acute dose had no effect. More specifically, muscle reoxygenation rates were significantly faster after 28 d compared to baseline (P = 0.04; η² = 0.29), and a trend towards slower deoxygenation rate was observed (P = 0.13; η² = 0.20). Chronic CE consumption also buffered the post-exercise lactate response for the 400-m race (P = 0.01; η² = 0.27), while no effects were seen for the longer race.Conclusion: Our results suggest that cranberry supplementation may have ergogenic effects, as it improves physiological markers of performance during short- and long-distance running.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 4","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10844722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential involvement of neutrophils on exercise effects in breast cancer malignancy. 中性粒细胞对乳腺癌恶性肿瘤运动效应的潜在影响

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0036

Kangeun Ko, Song Won Woo, Young Chan Chae, Minchul Lee, Hyo Youl Moon

{"title":"Potential involvement of neutrophils on exercise effects in breast cancer malignancy.","authors":"Kangeun Ko, Song Won Woo, Young Chan Chae, Minchul Lee, Hyo Youl Moon","doi":"10.20463/pan.2023.0036","DOIUrl":"10.20463/pan.2023.0036","url":null,"abstract":"Purpose: This review aimed to comprehensively explore and elucidate multifaceted neutrophils in breast cancer, particularly in the context of physical activity. Neutrophils play a critical role in the tumor microenvironment and systemic immune response, despite their short half-life and terminal differentiation. Through a thorough review of research related to changes in immunity in breast cancer during exercise, this review aims to provide comprehensive insights into immunological changes, especially focusing on neutrophils. Recognizing that much of the existing research has predominantly focused on T cells and nature killer (NK) cells, our review seeks to shift the spotlight toward understanding how exercise affects neutrophils, a less-explored but critical immune response component in breast cancer.Methods: This study involved an extensive review of the literature (from 2000 to 2023) using the PubMed, Science Direct, and Google Scholar databases. The keywords chosen for the searches were \"immune cells and exercise,\" \"exercise and breast cancer,\" \"tumor microenvironment and neutrophils,\" and \"neutrophils and exercise and breast cancers.\"Results: Neutrophils in the tumor microenvironment can exhibit distinct phenotypes and functions. These differences have yielded conflicting results regarding tumor progression. Exercise plays a positive role in breast cancer and alters the immune system. Physical activity can quantitatively and functionally regulate neutrophils under various conditions such as metabolic disruption or senescence.Conclusion: This short communication outlines exercise-induced neutrophil diversification and its role in breast cancer progression, both within and systemically within the tumor microenvironment. Exercise may provide benefits through the potential neutrophil involvement in breast cancer.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 4","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10844724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of resistance training and protein supplementation interventions on muscle volume and muscle function: sex differences in humans. 阻力训练和蛋白质补充干预对肌肉体积和肌肉功能的影响：人类的性别差异。

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0033

Ki-Woong Noh, Sok Park

{"title":"Effects of resistance training and protein supplementation interventions on muscle volume and muscle function: sex differences in humans.","authors":"Ki-Woong Noh, Sok Park","doi":"10.20463/pan.2023.0033","DOIUrl":"10.20463/pan.2023.0033","url":null,"abstract":"Purpose: This review aimed to identify differences in the effects of co-intervention with resistance training (RT) and protein supplementation according to sex and provide meaningful information for future research on the development of exercise programs to improve muscle volume and muscle function.Methods: PubMed, Science Direct, and Google Scholar were searched to identify clinical and nonclinical studies that assessed the effects of RT in older adults with sarcopenia; these studies were published between 1990 and 2023. Cross-sectional and double-blind studies (randomized controlled trials, RCTs) were examined in this review.Results: The effects of parallel intervention with RT and protein supplementation on muscle volume and physical function were found to differ according to sex. Both males and females had improvements in muscle strength, muscle mass, and physical function after RT and protein supplementation; however, many studies found a greater increase in muscle volume and function in males than in females. Such difference may be due to differences in physiological characteristics between males and females.Conclusion: Based on the findings of this review, the effects of combined intervention with RT and protein supplementation on muscle strength, muscle mass, and physical function to differ according to sex. Owing to these sex differences in the response and physiological characteristics caused by the parallel intervention of RT and protein supplementation, such differences must be considered to maximize the effects of RT and protein supplementation.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 4","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosae multiflorae fructus regulates the lipogenesis in high-fat diet-induced NAFLD mice model. 多花蔷薇果能调节高脂饮食诱导的非酒精性脂肪肝小鼠模型的脂肪生成。

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0038

Kibong Kim, Hyun Joo Jang, Suji Baek, Sang-Hyun Ahn

{"title":"Rosae multiflorae fructus regulates the lipogenesis in high-fat diet-induced NAFLD mice model.","authors":"Kibong Kim, Hyun Joo Jang, Suji Baek, Sang-Hyun Ahn","doi":"10.20463/pan.2023.0038","DOIUrl":"10.20463/pan.2023.0038","url":null,"abstract":"Purpose: Exercise helps modify the lipid profile in the body, partly through its impact on sterol regulatory element binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ). Individual differences in response to exercise and genetic variations may influence the response to PA. Therefore, this study explored Rosae multiflorae fructus (RMF) as a supplement candidate that improves exercise capacity and controls non-alcoholic fatty liver disease (NAFLD) by suppressing lipogenesis and controlling lipid peroxidation.Methods: RMF is a natural herbal medicine used in Dongui Bogam. RMF has antioxidant, anti-inflammatory, and anti-allergic effects. However, the effects of RMF on NAFLD have not yet been investigated. In this study, we examined the effects of RMF in a mouse model of high-fat diet-induced NAFLD. Mouse livers were isolated and analyzed using H&E staining and immunohistochemistry.Results: RMF downregulated lipid peroxidation markers, such as CYP2E1, in the livers of mice with high-fat diet-induced NAFLD. Additionally, the RMF significantly reduced the lipid accumulation-related protein expression of CD36, SREBP-1, and PPAR-γ.Conclusion: RMF exerts anti-lipid peroxidation and anti-lipogenic effects in a high-fat diet-induced NAFLD mouse model.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 4","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10844720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A sport supplement candidate of Erigeron breviscapus extract regulates lipogenesis in vitro and in vivo. 一种候选的运动补充剂--鲂鱼提取物可在体外和体内调节脂肪生成。

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0039

Kibong Kim, Suji Baek, Solomon Ko, Seungjae Moon, Kang Pa Lee, Sanghyun Ahn

{"title":"A sport supplement candidate of Erigeron breviscapus extract regulates lipogenesis in vitro and in vivo.","authors":"Kibong Kim, Suji Baek, Solomon Ko, Seungjae Moon, Kang Pa Lee, Sanghyun Ahn","doi":"10.20463/pan.2023.0039","DOIUrl":"10.20463/pan.2023.0039","url":null,"abstract":"Purpose: One of the urgent research projects in exercise science should focus on sports supplements for obese people who lack exercise and physical activity. In this study, we explored the efficacy in non-alcoholic fatty liver disease (NAFLD) mice models using a Korean herbal medicine Erigeron breviscapus (EB).Methods: Gene ontology analyses of active compounds in EB were performed using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP) and Cytoscape program, respectively. PA-induced acid (PA) induced-lipid droplets in HepG2 cells were analyzed using a 3D-hologram. To analyze the fat-suppressing efficacy of EB in animal experiments, NAFLD was induced through a 24-week high-fat diet. Subsequently, the same diet was continued for an additional 8 weeks, with concurrent co-administration of drugs for efficacy analysis. In the 8-week experiment, mice were administered saline alone, metformin (17 mg/kg/day), or EB (26 mg/kg/day). The mice were sacrificed and the liver tissue was isolated. The liver tissues were stained with H&E and specific antibodies such as sterol regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor- γ (PPAR-γ).Results: Seventeen EB-active compounds were identified by whole-body analysis. EB downregulated lipid droplets in PA-treated HepG2 cells. EB regulates lipid accumulation in liver tissue of HFD-fed NAFLD mice Metformin and EB significantly reduced the expression of SREBP-1 and PPAR-γ in liver tissue.Conclusion: We suggest that EB is a candidate for the management of NAFLD and is an effective exercise supplement owing to its ability to inhibit lipid accumulation.","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 4","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10844721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0