PCN reports : psychiatry and clinical neurosciences最新文献

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Mental health of youth athletes during the second year of the COVID-19 pandemic in Japan: A three-wave cross-sectional study. 日本2019冠状病毒病大流行第二年青少年运动员的心理健康:一项三波横断面研究
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-16 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70187
Fumiaki Yano, Tomihisa Niitsu, Yusuke Nakata, Masaomi Iyo
{"title":"Mental health of youth athletes during the second year of the COVID-19 pandemic in Japan: A three-wave cross-sectional study.","authors":"Fumiaki Yano, Tomihisa Niitsu, Yusuke Nakata, Masaomi Iyo","doi":"10.1002/pcn5.70187","DOIUrl":"10.1002/pcn5.70187","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to examine the mental health of Japanese youth athletes during the second year of the COVID-19 pandemic and explore its associations with demographic and sport-related factors.</p><p><strong>Methods: </strong>Three cross-sectional online surveys were conducted at a public high school in Japan in Spring 2021 (baseline; <i>n</i> = 1022), Fall 2021 (<i>n</i> = 1104), and Spring 2022 (<i>n</i> = 1066). Mental health was assessed using the Kessler-6 (K6), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) scales. Participants were categorized as youth athletes (national-level competitors [NC] and local-level competitors [LC]) or nonathlete students (NAS). Logistic regression was used to identify the mental health risk factors.</p><p><strong>Results: </strong>Compared to the baseline, youth athletes showed higher rates of poor mental health indicators in the second and third surveys. Among them, female athletes showed higher risks of depression and anxiety in both later surveys, whereas upper grade athletes had an increased risk of depression in the second survey. No consistent association was found between COVID-19 infection history and mental health.</p><p><strong>Conclusion: </strong>Japanese youth athletes showed poorer mental health indicators at later points in the second year of the pandemic. Female and upper grade athletes may require targeted mental health support. Continuous monitoring is essential during extended public health emergencies.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70187"},"PeriodicalIF":0.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trichotillomania in long COVID successfully treated with escitalopram: A case report. 艾司西酞普兰治疗长冠肺炎患者拔毛症1例
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-16 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70190
Rinka Hata, Hiroko Sugawara, Reo Hayashi, Yuta Okamoto, Rei Nishihara, Tomomi Yamasaki, Akito Hatanaka, Kohei Harada, Hikaru Hori
{"title":"Trichotillomania in long COVID successfully treated with escitalopram: A case report.","authors":"Rinka Hata, Hiroko Sugawara, Reo Hayashi, Yuta Okamoto, Rei Nishihara, Tomomi Yamasaki, Akito Hatanaka, Kohei Harada, Hikaru Hori","doi":"10.1002/pcn5.70190","DOIUrl":"10.1002/pcn5.70190","url":null,"abstract":"","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70190"},"PeriodicalIF":0.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining the practical roles of psychiatrists in epilepsy care: A framework for collaboration in Japan. 重新定义精神科医生在癫痫治疗中的实际作用:日本的合作框架。
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-14 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70188
Go Taniguchi, Hirotaka Iwaki, Izumi Kuramochi, Toru Horinouchi, Shunsuke Takagi
{"title":"Redefining the practical roles of psychiatrists in epilepsy care: A framework for collaboration in Japan.","authors":"Go Taniguchi, Hirotaka Iwaki, Izumi Kuramochi, Toru Horinouchi, Shunsuke Takagi","doi":"10.1002/pcn5.70188","DOIUrl":"10.1002/pcn5.70188","url":null,"abstract":"<p><p>Psychiatric symptoms are prevalent among people with epilepsy (PWE), yet psychiatric care remains underdeveloped in epilepsy services worldwide. Many psychiatrists lack sufficient familiarity with epilepsy, contributing to gaps in care. Japan, however, has a distinctive history where psychiatrists played a central role in epilepsy treatment, especially in managing epilepsy-related psychosis. This legacy, though fading, offers valuable insights. This review proposes a renewed framework to reestablish the psychiatrist's role in epilepsy care, informed by Japan's historical context and current global trends. The framework consists of five domains: (1) the historical relationship between psychiatry and epilepsy; (2) diagnosis and treatment of psychiatric symptoms in PWE; (3) psychosocial interventions; (4) interdisciplinary collaboration; and (5) future directions in training, research, policy, and clinical integration. While psychiatry's role in epilepsy has diminished in many countries, Japan may still retain structural and cultural foundations for reintegration. By redefining psychiatric involvement, we aim to inspire general psychiatrists and trainees to engage with epilepsy care. Reaffirming the psychiatric perspective is essential for delivering comprehensive, patient-centered care to PWE.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70188"},"PeriodicalIF":0.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catatonia induced by nitrous oxide anesthesia in a healthy adolescent: A case report. 一氧化二氮麻醉致健康青少年紧张症1例。
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-13 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70189
Kenji S Kobayashi, Takuto Ishida, Hitomi Tsunashima, Takero Terayama, Eiken Yoshida, Masafumi Mizuno
{"title":"Catatonia induced by nitrous oxide anesthesia in a healthy adolescent: A case report.","authors":"Kenji S Kobayashi, Takuto Ishida, Hitomi Tsunashima, Takero Terayama, Eiken Yoshida, Masafumi Mizuno","doi":"10.1002/pcn5.70189","DOIUrl":"10.1002/pcn5.70189","url":null,"abstract":"<p><strong>Background: </strong>Catatonia can arise from various conditions, not only psychiatric but also non-psychiatric etiologies. This diversity of underlying causes makes it challenging to identify the underlying etiology, which is crucial for appropriate management. Nitrous oxide (N<sub>2</sub>O) is widely used for recreational purposes, and its adverse effects have become a growing concern. Chronic exposure can lead to vitamin B12 deficiency, which manifests both neurological and psychiatric symptoms, including catatonia. Vitamin B12 supplementation is an effective treatment, but the diverse clinical manifestations of N<sub>2</sub>O toxicity, coupled with the diverse etiologies of catatonia, can delay diagnosis and intervention.</p><p><strong>Case presentation: </strong>The patient, a healthy man in his 20s, had been receiving N<sub>2</sub>O anesthesia regularly for pain relief while undergoing cosmetic hair removal. After his seventh inhalation, he developed a catatonia and was admitted to a previous hospital. After a comprehensive examination failed to identify the etiology, he was transferred to our hospital for psychiatric assessment. Intravenous benzodiazepine failed to improve his catatonia. Re-evaluation of the underlying etiologies of benzodiazepine-refractory catatonia raised the possibility of a vitamin B12 deficiency resulting from chronic N<sub>2</sub>O exposure. Vitamin B12 supplementation promptly improved his catatonia, and the patient was discharged without any recurrence of his symptoms.</p><p><strong>Conclusion: </strong>Catatonia developed in the present patient after multiple exposures to N<sub>2</sub>O. Active vitamin B12 may be administered if N<sub>2</sub>O is suspected of causing psychotic symptoms. Moreover, reassessing the differential diagnosis is worthwhile when managing refractory catatonia.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70189"},"PeriodicalIF":0.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial central diabetes insipidus during lithium use: A case report and literature review. 锂离子使用引起的部分中枢性尿崩症1例报告及文献复习。
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-13 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70182
Mizue Ichinose, Yuri Kobayashi, Yuhei Suzuki, Yoichiro Hirata, Masayuki Goto, Sho Horikoshi, Keiko Kanno-Nozaki, Kenya Watanabe, Satoshi Takeuchi, Itaru Miura
{"title":"Partial central diabetes insipidus during lithium use: A case report and literature review.","authors":"Mizue Ichinose, Yuri Kobayashi, Yuhei Suzuki, Yoichiro Hirata, Masayuki Goto, Sho Horikoshi, Keiko Kanno-Nozaki, Kenya Watanabe, Satoshi Takeuchi, Itaru Miura","doi":"10.1002/pcn5.70182","DOIUrl":"10.1002/pcn5.70182","url":null,"abstract":"<p><strong>Background: </strong>Nephrogenic diabetes insipidus (NDI) is a well-known adverse effect of lithium, which occurs in approximately 20%-40% of long-term lithium users. Although rare, there have been reports of central diabetes insipidus (CDI) associated with lithium use. Herein, we report a patient with suspected CDI associated with chronic lithium therapy. Furthermore, we conducted a literature search for cases with CDI and discuss the pathogenesis of this case based on previous reports.</p><p><strong>Case presentation: </strong>The patient was a 73-year-old man with bipolar disorder Type I. His psychiatric symptoms had been stable for many years. However, polyuria and weakness began to appear at the age of 73. Initially, lithium-induced NDI was suspected, but in the end, partial CDI was suspected because urinary osmolality did not exceed 300 mOsm/L even after water restriction, and administration of nasal arginine vasopressin solution partially increased urinary osmolality.</p><p><strong>Conclusion: </strong>We have experienced a case in which CDI may have been induced by lithium. Although the effects of ageing and infection cannot be ruled out, it should be noted that when lithium-induced diabetes insipidus is suspected, CDI may also occur depending on the clinical context.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70182"},"PeriodicalIF":0.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors influencing the effectiveness of case management interventions for suicide attempters in a psychiatric hospital. 影响精神病院自杀未遂者个案管理干预效果的因素
IF 0.9
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-08-03 eCollection Date: 2025-09-01 DOI: 10.1002/pcn5.70173
Maiko Saito, Yuki Shiratori, Chie Yaguchi, Noriko Yamada, Takafumi Ogawa, Masahide Karashima, Takashi Mizuhiki, Takafumi Hori, Hirokazu Tachikawa
{"title":"Factors influencing the effectiveness of case management interventions for suicide attempters in a psychiatric hospital.","authors":"Maiko Saito, Yuki Shiratori, Chie Yaguchi, Noriko Yamada, Takafumi Ogawa, Masahide Karashima, Takashi Mizuhiki, Takafumi Hori, Hirokazu Tachikawa","doi":"10.1002/pcn5.70173","DOIUrl":"10.1002/pcn5.70173","url":null,"abstract":"<p><strong>Aim: </strong>Preventing suicide reattempts is important; however, few evidence-based treatments are available. In Japan, the ACTION-J study helped implement case management for suicide attempters in general hospitals and reduced suicide reattempts over a period of up to 6 months. Therefore, the current study aimed to evaluate the effectiveness of case management, modeled after the ACTION-J study, when applied in psychiatric hospitals, and examined the factors influencing suicide reattempts to propose more effective methods of support.</p><p><strong>Methods: </strong>We conducted a 1-year follow-up study on suicide reattempts after discharge among participants who received case management interventions. Baseline characteristics were extracted, and Cox regression analysis was used to identify the factors influencing suicide reattempts.</p><p><strong>Results: </strong>Of the 205 participants, 47 (22.9%) reattempted suicide during the observation period. Univariate analysis revealed that the factors significantly associated with suicide reattempts included younger age, adjustment disorder, dissociative disorder, history of previous suicide attempts, and the use of drug overdose as the method of the current attempt. Multivariate analysis showed that dissociative disorders were significant independent factors for suicide attempts.</p><p><strong>Conclusions: </strong>Factors influencing suicide reattempts among participants in the case management intervention included younger age, adjustment disorder, dissociative disorder, history of previous suicide attempts, and overdose as the method of attempt. In addition to a history of previous suicide attempts and overdoses, which were previously reported, dissociative disorder was observed to strongly influence suicide reattempts, even after case management. Therefore, additional psychotherapeutic strategies, particularly for individuals with dissociative disorders or frequent suicide attempts, may be necessary.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 3","pages":"e70173"},"PeriodicalIF":0.9,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a combined clinical and MRI-based biomarker model to differentiate mild cognitive impairment from mild Alzheimer's disease. 开发和验证基于临床和mri的生物标志物模型来区分轻度认知障碍和轻度阿尔茨海默病。
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-06-26 eCollection Date: 2025-06-01 DOI: 10.1002/pcn5.70134
Zohreh Hosseini, Alisa Mohebbi, Iman Kiani, Aydin Taghilou, Atefeh Mohammadjafari, Vajiheh Aghamollaii
{"title":"Development and validation of a combined clinical and MRI-based biomarker model to differentiate mild cognitive impairment from mild Alzheimer's disease.","authors":"Zohreh Hosseini, Alisa Mohebbi, Iman Kiani, Aydin Taghilou, Atefeh Mohammadjafari, Vajiheh Aghamollaii","doi":"10.1002/pcn5.70134","DOIUrl":"10.1002/pcn5.70134","url":null,"abstract":"<p><strong>Background: </strong>Two of the most common complaints seen in neurology clinics are Alzheimer's disease (AD) and mild cognitive impairment (MCI), characterized by similar symptoms. The aim of this study was to develop and internally validate the diagnostic value of combined neurological and radiological predictors in differentiating mild AD from MCI as the outcome variable, which helps in preventing AD development.</p><p><strong>Methods: </strong>A cross-sectional study of 161 participants was conducted in a general healthcare setting, including 30 controls, 71 mild AD, and 60 MCI. Binary logistic regression was used to identify predictors of interest, with collinearity assessment conducted prior to model development. Model performance was assessed through calibration, shrinkage, and decision-curve analyses. Finally, the combined clinical and radiological model was compared to models utilizing only clinical or radiological predictors.</p><p><strong>Results: </strong>The final model included age, sex, education status, Montreal cognitive assessment, Global Cerebral Atrophy Index, Medial Temporal Atrophy Scale, mean hippocampal volume, and Posterior Parietal Atrophy Index, with the area under the curve of 0.978 (0.934-0.996). Internal validation methods did not show substantial reduction in diagnostic performance. Combined model showed higher diagnostic performance compared to clinical and radiological models alone. Decision curve analysis highlighted the usefulness of this model for differentiation across all probability levels.</p><p><strong>Conclusion: </strong>A combined clinical-radiological model has excellent diagnostic performance in differentiating mild AD from MCI. Notably, the model leveraged straightforward neuroimaging markers, which are relatively simple to measure and interpret, suggesting that they could be integrated into practical, formula-driven diagnostic workflows without requiring computationally intensive deep learning models.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 2","pages":"e70134"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First episode of psychiatric and neuropsychiatric disease among patients infected with COVID-19: A scoping review. COVID-19感染患者中首次发作的精神和神经精神疾病:范围综述
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-06-25 eCollection Date: 2025-06-01 DOI: 10.1002/pcn5.70146
Wali Yousufzai, Alex Heo, Kyle Gu, Edward Sun, Gabriel Lopez, Shreya Balamurali, Jennifer Adjei-Mosi, Riley Shin, Daniel B Stuart, Peggy Edwards, Regina Baronia, Wail Amor, Terry McMahon
{"title":"First episode of psychiatric and neuropsychiatric disease among patients infected with COVID-19: A scoping review.","authors":"Wali Yousufzai, Alex Heo, Kyle Gu, Edward Sun, Gabriel Lopez, Shreya Balamurali, Jennifer Adjei-Mosi, Riley Shin, Daniel B Stuart, Peggy Edwards, Regina Baronia, Wail Amor, Terry McMahon","doi":"10.1002/pcn5.70146","DOIUrl":"10.1002/pcn5.70146","url":null,"abstract":"<p><p>This scoping review aims to examine the frequency and prevalence of neuropsychiatric disorders reported in patients infected with coronavirus disease 2019, and the mechanisms by which these develop during and post infection. A systematic search using relevant search terms and key words was done on six electronic databases of literature on neuropsychiatric conditions post-coronavirus disease 2019 infection from 2020 to 2023. Data were extracted following Joanna Briggs Institute guidelines, focusing on key findings, intervention details, and outcomes. We included 333 studies in the review. Studies indicated an elevated risk of neuropsychiatric disorders post-coronavirus disease 2019, with some risks remaining high 2 years after diagnosis. A significant prevalence of depressive, psychotic, and anxiety disorders, as well as post-traumatic stress symptoms were noted among coronavirus disease 2019 survivors. There was increased prevalence of insomnia and other sleep disturbances, mild to severe cognitive dysfunction, and eating disorders. Coronavirus disease 2019 infection is associated with a significant risk of developing various neuropsychiatric disorders, including schizophrenia, depressive disorders, anxiety, post-traumatic stress disorder, and cognitive dysfunction. Long-term monitoring and early interventions are essential to mitigate these risks and improve patient outcomes.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 2","pages":"e70146"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study. 神经退行性痴呆的神经软征象:DemeNSS研究的结果。
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-06-25 eCollection Date: 2025-06-01 DOI: 10.1002/pcn5.70143
Federico Emanuele Pozzi, Anna Falco, Gaia Gotti, Giuseppe Fiamingo, Giulia Remoli, Ildebrando Appollonio, Carlo Ferrarese, Lucio Tremolizzo
{"title":"Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study.","authors":"Federico Emanuele Pozzi, Anna Falco, Gaia Gotti, Giuseppe Fiamingo, Giulia Remoli, Ildebrando Appollonio, Carlo Ferrarese, Lucio Tremolizzo","doi":"10.1002/pcn5.70143","DOIUrl":"10.1002/pcn5.70143","url":null,"abstract":"<p><strong>Aim: </strong>Neurological soft signs (NSSs) encompass subtle neurological abnormalities, often indicative of impaired motor and sensory integration, observed in various neuropsychiatric conditions. NSSs have been recently investigated as potential diagnostic markers in neurodegenerative dementias. We aimed to confirm an NSS increase in subjects with cognitive decline and evaluate them in the differential diagnosis of neurodegenerative dementias.</p><p><strong>Methods: </strong>A sample of 93 subjects with dementia (34 with Alzheimer's disease [AD], 29 with frontotemporal dementia [FTD], 16 with Lewy body disease [LBD], and 14 with corticobasal syndrome [CBS]) and 93 healthy controls (HCs) were assessed using the 16-item Heidelberg NSS Scale.</p><p><strong>Results: </strong>Subjects with neurodegenerative dementias exhibited significantly higher NSS scores than HCs (20.4 ± 7.9 vs. 5.7 ± 4.2, <i>p</i> < 0.01). Notably, those with CBS/LBD showed markedly elevated NSSs compared to those with AD and FTD (26.2 ± 6.7 vs. 18.4 ± 7.1 and 16.6 ± 6.5, respectively, <i>p</i> < 0.01). Diagnosis, Mini-Mental State Examination (MMSE), Frontal Assessment Battery, and anticholinergic burden were significant predictors of NSS expression in subjects with dementia. In HCs, only age and MMSE were significant predictors. A reduced Neurological Soft Signs (rNSS) Scale, including only five items that can be administered in less than a minute, demonstrated diagnostic performances comparable to the full NSS Scale.</p><p><strong>Conclusion: </strong>NSSs are increased across neurodegenerative dementia subtypes, particularly in CBS and LBD. The Heidelberg NSS Scale, as well as its variant rNSS, may serve as quick and informative tools to be added to the visits in memory clinics.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 2","pages":"e70143"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between depression improvement and activities of daily living recovery in patients with fractures. 骨折患者抑郁改善与日常生活活动恢复的关系。
PCN reports : psychiatry and clinical neurosciences Pub Date : 2025-06-24 eCollection Date: 2025-06-01 DOI: 10.1002/pcn5.70139
Shunji Araki, Takahiro Ogawa, Yoshikazu Takaesu
{"title":"Relationship between depression improvement and activities of daily living recovery in patients with fractures.","authors":"Shunji Araki, Takahiro Ogawa, Yoshikazu Takaesu","doi":"10.1002/pcn5.70139","DOIUrl":"10.1002/pcn5.70139","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate the relationship between improvement in depressive symptoms and activities of daily living (ADL) recovery in older patients with fractures in convalescent rehabilitation wards.</p><p><strong>Methods: </strong>A retrospective observational study was conducted with 144 older patients with fractures and depressive symptoms (Geriatric Depression Scale score ≥ 5) on admission, who underwent rehabilitation at a Japanese hospital from 2018 to 2023. ADL recovery was assessed by the Functional Independence Measure (FIM). Patients were classified into three groups based on change in depressive symptoms: remission, partial improvement, and no improvement. Multivariate linear regression analysis was used to evaluate factors associated with change in the FIM score.</p><p><strong>Results: </strong>Remission (<i>β</i> = 0.184, <i>p</i> = 0.019) and partial improvement in depressive symptoms (<i>β</i> = 0.204, <i>p</i> = 0.009) were positively associated with change in the FIM score. Conversely, antidepressant use (<i>β</i> = -0.250, <i>p</i> = 0.002) was negatively associated with change in the FIM score.</p><p><strong>Conclusion: </strong>Remission and partial improvement in depressive symptoms positively contributes to ADL recovery in older patients with fractures. Comprehensive interventions addressing both depression and physical function may enhance rehabilitation outcomes. This may improve ADL recovery and long-term prognosis in older patients with fractures.</p>","PeriodicalId":74405,"journal":{"name":"PCN reports : psychiatry and clinical neurosciences","volume":"4 2","pages":"e70139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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