Oxygen (Basel, Switzerland)最新文献_第4页

Nanoparticles, a Double-Edged Sword with Oxidant as Well as Antioxidant Properties—A Review 纳米颗粒是一把既有氧化剂又有抗氧化性能的双刃剑——综述

Oxygen (Basel, Switzerland) Pub Date : 2022-11-15 DOI: 10.3390/oxygen2040039

A. Samrot, Sanjay Preeth Ram Singh, R. Deenadhayalan, Vinod Vincent Rajesh, Sathiyamoorthy Padmanaban, K. Radhakrishnan

引用次数: 17

Understanding Hydrogen: Lessons to Be Learned from Physical Interactions between the Inert Gases and the Globin Superfamily 理解氢：从惰性气体和球蛋白超家族之间的物理相互作用中学到的教训

Oxygen (Basel, Switzerland) Pub Date : 2022-11-08 DOI: 10.3390/oxygen2040038

J. Hancock, Grace Russell, T. Craig, J. May, H. Morse, J. Stamler

{"title":"Understanding Hydrogen: Lessons to Be Learned from Physical Interactions between the Inert Gases and the Globin Superfamily","authors":"J. Hancock, Grace Russell, T. Craig, J. May, H. Morse, J. Stamler","doi":"10.3390/oxygen2040038","DOIUrl":"https://doi.org/10.3390/oxygen2040038","url":null,"abstract":"Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe), for example, is a well-known anesthetic. The direct targets of these gases, in most cases, remain elusive. Myoglobin and hemoglobin are known for their roles in the transport of gases through coordinate interactions with metals (O2, NO, CO) and covalent modifications of thiols (NO, H2S) and amines (CO2). These are well exemplified in biotrophic reactions of NO with heme iron (to form iron nitrosyl heme) and cysteine (to form bioactive S-nitrosothiols) essential for tissue oxygenation. Here, we consider an alternative “third mode” of gas transport in what have been dubbed “Xenon pockets”, whereby inert gases may have functional effects. Many proteins have similar cavities, and possible effects include alterations in allosteric properties of proteins (potentially altering protein hydration). Here, it is suggested that similar to other inert gases, H2 also has biological effects by utilizing these protein structures. This ought to be investigated further, in a range of species, to determine if this is the mode of action of H2.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45304544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of Acute Beetroot Juice Ingestion on Reactive Agility Performance 甜菜根汁急性摄入对反应敏捷性的影响

Oxygen (Basel, Switzerland) Pub Date : 2022-11-07 DOI: 10.3390/oxygen2040037

R. Rogers, Ashleigh M. Davis, Ashley E. Rice, C. Ballmann

{"title":"Effects of Acute Beetroot Juice Ingestion on Reactive Agility Performance","authors":"R. Rogers, Ashleigh M. Davis, Ashley E. Rice, C. Ballmann","doi":"10.3390/oxygen2040037","DOIUrl":"https://doi.org/10.3390/oxygen2040037","url":null,"abstract":"Beetroot juice (BRJ) is high in inorganic nitrate (NO3) which has been shown to enhance vascular function, cognition, and physical performance. Acute BRJ supplementation has been reported to enhance explosive resistance exercise performance and simple reaction time in diseased populations. However, it remains unknown if acute BRJ supplementation can enhance agility and reactive drills in healthy individuals, which are relevant to many sports. The purpose of this study was to investigate the effects of acute BRJ supplementation on simple reaction time and reactive agility performance. In a counterbalanced double-blinded manner, physically active males completed two trials each with a differing single-dose treatment: (1) Placebo (PL), (2) BRJ. Each treatment was consumed 2-hrs before experimental testing. Plasma Nitrate (NO3) and Nitrite (NO2) were measured via capillary blood sampling and colorimetric assay. Reaction time was assessed using a simple reaction time light test. Reactive agility was measured via a semi-circle drill and a get-up-and-go drill. All tests used FITLIGHT LED sensors to record response time. Each visit was separated by a 72-h washout period. Acute BRJ ingestion resulted in significantly greater plasma NO3 (p < 0.001) and NO2 (p = 0.008) compared to PL. BRJ significantly improved response time during the semi-circle drill (p = 0.011) and get-up and go drill (p = 0.027) compared to PL. No differences between treatments were observed for simple reaction time (p = 0.279). Collectively, these findings suggest that acute BRJ ingestion may improve reactive agility performance likely mediated by systemic increases in NO3/NO2. Future research is needed to investigate how these findings translate to game-play and sports competition.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42897028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oxidative Stress as an Underlying Mechanism of Bacteria-Inflicted Damage to Male Gametes 氧化应激是细菌对雄性配子损伤的潜在机制

Oxygen (Basel, Switzerland) Pub Date : 2022-11-06 DOI: 10.3390/oxygen2040036

E. Tvrdá, F. Benko, M. Ďuračka

引用次数: 6

Optimization of Pulsed Electric-Field-Based Total Polyphenols’ Extraction from Elaeagnus pungens ‘Limelight’ Leaves Using Hydroethanolic Mixtures 基于脉冲电场的水乙醇混合物提取胡颓子‘Limelight’叶中总多酚的工艺优化

Oxygen (Basel, Switzerland) Pub Date : 2022-10-31 DOI: 10.3390/oxygen2040035

Vasileios M. Pappas, D. Palaiogiannis, V. Athanasiadis, Theodoros G. Chatzimitakos, Eleni Bozinou, D. Makris, S. Lalas

{"title":"Optimization of Pulsed Electric-Field-Based Total Polyphenols’ Extraction from Elaeagnus pungens ‘Limelight’ Leaves Using Hydroethanolic Mixtures","authors":"Vasileios M. Pappas, D. Palaiogiannis, V. Athanasiadis, Theodoros G. Chatzimitakos, Eleni Bozinou, D. Makris, S. Lalas","doi":"10.3390/oxygen2040035","DOIUrl":"https://doi.org/10.3390/oxygen2040035","url":null,"abstract":"In this study, the use of pulsed electric field (PEF) for the extraction of polyphenols from mature Elaeagnus pungens ‘Limelight’ leaves is discussed. Optimization of the main parameters that affect the extraction process was carried out. More specifically, the composition of the solvent (ethanol, water, and mixtures of the two at a 25% v/v step gradient) and the main PEF-related parameters (i.e., pulse duration, pulse period, and electric field intensity) was optimized. The obtained extracts were examined for their polyphenol content with the Folin–Ciocalteu assay and individual polyphenols were also assessed with high-performance liquid chromatography. The extracts obtained with PEF were compared to the extract compared without PEF, in terms of total polyphenols. According to the results, the optimum extraction parameters were found to be a pulse duration of 10 μs, a pulse period of 1000 μs, and an electric field intensity of 0.85 kV cm−1 after 20 min of extraction. The optimum solvent was found to be the 50% (v/v) ethanol/water mixture. The extract prepared under the optimum conditions was found to contain 58% more polyphenols compared with the extract prepared without PEF. Moreover, an increase of up to 92% was recorded for specific polyphenols. Based on the above, it was evidenced that the examined parameters influenced the recovery of polyphenols, suggesting that such parameters should be also examined in similar studies, in order to maximize the extraction yield of polyphenols.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45653883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analyzing the Effects of Multi-Layered Porous Intraluminal Thrombus on Oxygen Flow in Abdominal Aortic Aneurysms 多层多孔腔内血栓对腹主动脉瘤氧流动的影响分析

Oxygen (Basel, Switzerland) Pub Date : 2022-10-24 DOI: 10.3390/oxygen2040034

A. Throop, Durwash Badr, M. Durka, M. Bukač, Rana Zakerzadeh

{"title":"Analyzing the Effects of Multi-Layered Porous Intraluminal Thrombus on Oxygen Flow in Abdominal Aortic Aneurysms","authors":"A. Throop, Durwash Badr, M. Durka, M. Bukač, Rana Zakerzadeh","doi":"10.3390/oxygen2040034","DOIUrl":"https://doi.org/10.3390/oxygen2040034","url":null,"abstract":"Determination of abdominal aortic aneurysm (AAA) rupture risk involves the accurate prediction of mechanical stresses acting on the arterial tissue, as well as the wall strength which has a correlation with oxygen supply within the aneurysmal wall. Our laboratory has previously reported the significance of an intraluminal thrombus (ILT) presence and morphology on localized oxygen deprivation by assuming a uniform consistency of ILT. The aim of this work is to investigate the effects of ILT structural composition on oxygen flow by adopting a multilayered porous framework and comparing a two-layer ILT model with one-layer models. Three-dimensional idealized and patient-specific AAA geometries are generated. Numerical simulations of coupled fluid flow and oxygen transport between blood, arterial wall, and ILT are performed, and spatial variations of oxygen concentrations within the AAA are obtained. A parametric study is conducted, and ILT permeability and oxygen diffusivity parameters are individually varied within a physiological range. A gradient of permeability is also defined to represent the heterogenous structure of ILT. Results for oxygen measures as well as filtration velocities are obtained, and it is found that the presence of any ILT reduces and redistributes the concentrations in the aortic wall markedly. Moreover, it is found that the integration of a porous ILT significantly affects the oxygen transport in AAA and the concentrations are linked to ILT’s permeability values. Regardless of the ILT stratification, maximum variation in wall oxygen concentrations is higher in models with lower permeability, while the concentrations are not sensitive to the value of the diffusion coefficient. Based on the observations, we infer that average one-layer parameters for ILT material characteristics can be used to reasonably estimate the wall oxygen concentrations in aneurysm models.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41825753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Humidity and Light Modulate Oxygen-Induced Viability Loss in Dehydrated Haematococcus lacustris Cells 湿度和光调节氧诱导的脱水湖血球菌细胞活力损失

Oxygen (Basel, Switzerland) Pub Date : 2022-10-21 DOI: 10.3390/oxygen2040033

T. Roach, Alessandro Fambri, D. Ballesteros

{"title":"Humidity and Light Modulate Oxygen-Induced Viability Loss in Dehydrated Haematococcus lacustris Cells","authors":"T. Roach, Alessandro Fambri, D. Ballesteros","doi":"10.3390/oxygen2040033","DOIUrl":"https://doi.org/10.3390/oxygen2040033","url":null,"abstract":"Haematoccocus lacustris (previously H. pluvialis) is a desiccation-tolerant unicellular freshwater green alga. During acclimation to desiccation, astaxanthin-rich lipid bodies and low-molecular-weight antioxidants (α-tocopherol, glutathione) accumulate, while the chloroplast area and chlorophyll contents decrease, which may facilitate desiccation tolerance by preventing damage mediated by reactive oxygen species (ROS). Here, we investigated the influence of moisture, light, oxygen, and temperature on redox homeostasis and cell longevity. Respiration and unbound freezable water were detectable in cells equilibrated to ≥90% relative humidity (RH), a threshold above which viability considerably shortened. At 92.5% RH and 21 °C, antioxidants depleted over days as cells lost viability, especially in an oxygen-rich atmosphere, supporting the role of ROS production in uncoupled respiration in viability loss. At 80% RH and 21 °C, redox homeostasis was maintained over weeks, and longevity was less influenced by oxygen. Light and oxygen was a lethal combination at 92.5% RH, under which pigments bleached, while in the dark only astaxanthin bleached. Viability positively correlated with glutathione concentrations across all treatments, while correlation with α-tocopherol was weaker, indicating limited viability loss from lipid peroxidation at 80% RH. In cells equilibrated to 50% RH, longevity and redox homeostasis showed strong temperature dependency, and viability was maintained at sub-zero temperatures for up to three years, revealing cryogenic storage to be an optimal strategy to store H. lacustris germplasm.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48725196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reactive Oxygen and Sulfur Species: Partners in Crime 活性氧和硫物种：犯罪伙伴

Oxygen (Basel, Switzerland) Pub Date : 2022-10-15 DOI: 10.3390/oxygen2040032

N. Blackstone

{"title":"Reactive Oxygen and Sulfur Species: Partners in Crime","authors":"N. Blackstone","doi":"10.3390/oxygen2040032","DOIUrl":"https://doi.org/10.3390/oxygen2040032","url":null,"abstract":"The emergence of complexity requires cooperation, yet selection typically favors defectors that do not cooperate. Such evolutionary conflict can be alleviated by a variety of mechanisms, allowing complexity to emerge. Chemiosmosis is one such mechanism. In syntrophic relationships, the chemiosmotic partner benefits simply from exporting products. Failure to do this can result in highly reduced electron carriers and detrimental amounts of reactive oxygen species. Nevertheless, the role of this mechanism in the history of life (e.g., the origin of eukaryotes from prokaryotes) seems questionable because of much lower atmospheric levels of oxygen and a largely anaerobic ocean. In this context, the role of sulfur should be considered. The last eukaryotic common ancestor (LECA) was a facultative aerobe. Under anaerobic conditions, LECA likely carried out various forms of anaerobic metabolism. For instance, malate dismutation, in which malate is both oxidized and reduced, allows re-oxidizing NADH. The terminal electron acceptor, fumarate, forms succinate when reduced. When oxygen is present, an excess of succinate can lead to reverse electron flow, forming high levels of reactive oxygen species. Under anaerobic conditions, reactive sulfur species may have formed. Eliminating end products may thus have had a selective advantage even under the low atmospheric oxygen levels of the Proterozoic eon.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49506085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional Catalytic Activity of γ-NiOOH toward Oxygen Reduction and Oxygen Evolution Reactions in Alkaline Solutions γ-NiOOH对碱性溶液中氧还原和析氧反应的双功能催化活性

Oxygen (Basel, Switzerland) Pub Date : 2022-10-13 DOI: 10.3390/oxygen2040031

Ridwan P. Putra, I. B. Rachman, H. Horino, I. Rzeznicka

引用次数: 4

RONS and Oxidative Stress: An Overview of Basic Concepts RONS与氧化应激：基本概念综述

Oxygen (Basel, Switzerland) Pub Date : 2022-10-10 DOI: 10.3390/oxygen2040030

Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Yalith Lyzet Arancibia-Hernández, E. Hernández-Cruz, J. Pedraza-Chaverri

{"title":"RONS and Oxidative Stress: An Overview of Basic Concepts","authors":"Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Yalith Lyzet Arancibia-Hernández, E. Hernández-Cruz, J. Pedraza-Chaverri","doi":"10.3390/oxygen2040030","DOIUrl":"https://doi.org/10.3390/oxygen2040030","url":null,"abstract":"Oxidative stress (OS) has greatly interested the research community in understanding damaging processes occurring in cells. OS is triggered by an imbalance between reactive oxygen species (ROS) production and their elimination by the antioxidant system; however, ROS function as second messengers under physiological conditions. ROS are produced from endogenous and exogenous sources. Endogenous sources involve mitochondria, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), oxidases (NOXs), endoplasmic reticulum (ER), xanthine oxidases (XO), endothelial nitric oxide synthase (eNOs), and others. In contrast, exogenous ROS might be generated through ultraviolet (UV) light, ionizing radiation (IR), contaminants, and heavy metals, among others. It can damage DNA, lipids, and proteins if OS is not controlled. To avoid oxidative damage, antioxidant systems are activated. In the present review, we focus on the basic concepts of OS, highlighting the production of reactive oxygen and nitrogen species (RONS) derived from internal and external sources and the last elimination. Moreover, we include the cellular antioxidant system regulation and their ability to decrease OS. External antioxidants are also proposed as alternatives to ameliorate OS. Finally, we review diseases involving OS and their mechanisms.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45646336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42