Oxygen (Basel, Switzerland)最新文献_第5页

Analyzing the Effects of Multi-Layered Porous Intraluminal Thrombus on Oxygen Flow in Abdominal Aortic Aneurysms 多层多孔腔内血栓对腹主动脉瘤氧流动的影响分析

Oxygen (Basel, Switzerland) Pub Date : 2022-10-24 DOI: 10.3390/oxygen2040034

A. Throop, Durwash Badr, M. Durka, M. Bukač, Rana Zakerzadeh

{"title":"Analyzing the Effects of Multi-Layered Porous Intraluminal Thrombus on Oxygen Flow in Abdominal Aortic Aneurysms","authors":"A. Throop, Durwash Badr, M. Durka, M. Bukač, Rana Zakerzadeh","doi":"10.3390/oxygen2040034","DOIUrl":"https://doi.org/10.3390/oxygen2040034","url":null,"abstract":"Determination of abdominal aortic aneurysm (AAA) rupture risk involves the accurate prediction of mechanical stresses acting on the arterial tissue, as well as the wall strength which has a correlation with oxygen supply within the aneurysmal wall. Our laboratory has previously reported the significance of an intraluminal thrombus (ILT) presence and morphology on localized oxygen deprivation by assuming a uniform consistency of ILT. The aim of this work is to investigate the effects of ILT structural composition on oxygen flow by adopting a multilayered porous framework and comparing a two-layer ILT model with one-layer models. Three-dimensional idealized and patient-specific AAA geometries are generated. Numerical simulations of coupled fluid flow and oxygen transport between blood, arterial wall, and ILT are performed, and spatial variations of oxygen concentrations within the AAA are obtained. A parametric study is conducted, and ILT permeability and oxygen diffusivity parameters are individually varied within a physiological range. A gradient of permeability is also defined to represent the heterogenous structure of ILT. Results for oxygen measures as well as filtration velocities are obtained, and it is found that the presence of any ILT reduces and redistributes the concentrations in the aortic wall markedly. Moreover, it is found that the integration of a porous ILT significantly affects the oxygen transport in AAA and the concentrations are linked to ILT’s permeability values. Regardless of the ILT stratification, maximum variation in wall oxygen concentrations is higher in models with lower permeability, while the concentrations are not sensitive to the value of the diffusion coefficient. Based on the observations, we infer that average one-layer parameters for ILT material characteristics can be used to reasonably estimate the wall oxygen concentrations in aneurysm models.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41825753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Humidity and Light Modulate Oxygen-Induced Viability Loss in Dehydrated Haematococcus lacustris Cells 湿度和光调节氧诱导的脱水湖血球菌细胞活力损失

Oxygen (Basel, Switzerland) Pub Date : 2022-10-21 DOI: 10.3390/oxygen2040033

T. Roach, Alessandro Fambri, D. Ballesteros

{"title":"Humidity and Light Modulate Oxygen-Induced Viability Loss in Dehydrated Haematococcus lacustris Cells","authors":"T. Roach, Alessandro Fambri, D. Ballesteros","doi":"10.3390/oxygen2040033","DOIUrl":"https://doi.org/10.3390/oxygen2040033","url":null,"abstract":"Haematoccocus lacustris (previously H. pluvialis) is a desiccation-tolerant unicellular freshwater green alga. During acclimation to desiccation, astaxanthin-rich lipid bodies and low-molecular-weight antioxidants (α-tocopherol, glutathione) accumulate, while the chloroplast area and chlorophyll contents decrease, which may facilitate desiccation tolerance by preventing damage mediated by reactive oxygen species (ROS). Here, we investigated the influence of moisture, light, oxygen, and temperature on redox homeostasis and cell longevity. Respiration and unbound freezable water were detectable in cells equilibrated to ≥90% relative humidity (RH), a threshold above which viability considerably shortened. At 92.5% RH and 21 °C, antioxidants depleted over days as cells lost viability, especially in an oxygen-rich atmosphere, supporting the role of ROS production in uncoupled respiration in viability loss. At 80% RH and 21 °C, redox homeostasis was maintained over weeks, and longevity was less influenced by oxygen. Light and oxygen was a lethal combination at 92.5% RH, under which pigments bleached, while in the dark only astaxanthin bleached. Viability positively correlated with glutathione concentrations across all treatments, while correlation with α-tocopherol was weaker, indicating limited viability loss from lipid peroxidation at 80% RH. In cells equilibrated to 50% RH, longevity and redox homeostasis showed strong temperature dependency, and viability was maintained at sub-zero temperatures for up to three years, revealing cryogenic storage to be an optimal strategy to store H. lacustris germplasm.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48725196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reactive Oxygen and Sulfur Species: Partners in Crime 活性氧和硫物种：犯罪伙伴

Oxygen (Basel, Switzerland) Pub Date : 2022-10-15 DOI: 10.3390/oxygen2040032

N. Blackstone

{"title":"Reactive Oxygen and Sulfur Species: Partners in Crime","authors":"N. Blackstone","doi":"10.3390/oxygen2040032","DOIUrl":"https://doi.org/10.3390/oxygen2040032","url":null,"abstract":"The emergence of complexity requires cooperation, yet selection typically favors defectors that do not cooperate. Such evolutionary conflict can be alleviated by a variety of mechanisms, allowing complexity to emerge. Chemiosmosis is one such mechanism. In syntrophic relationships, the chemiosmotic partner benefits simply from exporting products. Failure to do this can result in highly reduced electron carriers and detrimental amounts of reactive oxygen species. Nevertheless, the role of this mechanism in the history of life (e.g., the origin of eukaryotes from prokaryotes) seems questionable because of much lower atmospheric levels of oxygen and a largely anaerobic ocean. In this context, the role of sulfur should be considered. The last eukaryotic common ancestor (LECA) was a facultative aerobe. Under anaerobic conditions, LECA likely carried out various forms of anaerobic metabolism. For instance, malate dismutation, in which malate is both oxidized and reduced, allows re-oxidizing NADH. The terminal electron acceptor, fumarate, forms succinate when reduced. When oxygen is present, an excess of succinate can lead to reverse electron flow, forming high levels of reactive oxygen species. Under anaerobic conditions, reactive sulfur species may have formed. Eliminating end products may thus have had a selective advantage even under the low atmospheric oxygen levels of the Proterozoic eon.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49506085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional Catalytic Activity of γ-NiOOH toward Oxygen Reduction and Oxygen Evolution Reactions in Alkaline Solutions γ-NiOOH对碱性溶液中氧还原和析氧反应的双功能催化活性

Oxygen (Basel, Switzerland) Pub Date : 2022-10-13 DOI: 10.3390/oxygen2040031

Ridwan P. Putra, I. B. Rachman, H. Horino, I. Rzeznicka

引用次数: 4

RONS and Oxidative Stress: An Overview of Basic Concepts RONS与氧化应激：基本概念综述

Oxygen (Basel, Switzerland) Pub Date : 2022-10-10 DOI: 10.3390/oxygen2040030

Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Yalith Lyzet Arancibia-Hernández, E. Hernández-Cruz, J. Pedraza-Chaverri

{"title":"RONS and Oxidative Stress: An Overview of Basic Concepts","authors":"Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Yalith Lyzet Arancibia-Hernández, E. Hernández-Cruz, J. Pedraza-Chaverri","doi":"10.3390/oxygen2040030","DOIUrl":"https://doi.org/10.3390/oxygen2040030","url":null,"abstract":"Oxidative stress (OS) has greatly interested the research community in understanding damaging processes occurring in cells. OS is triggered by an imbalance between reactive oxygen species (ROS) production and their elimination by the antioxidant system; however, ROS function as second messengers under physiological conditions. ROS are produced from endogenous and exogenous sources. Endogenous sources involve mitochondria, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), oxidases (NOXs), endoplasmic reticulum (ER), xanthine oxidases (XO), endothelial nitric oxide synthase (eNOs), and others. In contrast, exogenous ROS might be generated through ultraviolet (UV) light, ionizing radiation (IR), contaminants, and heavy metals, among others. It can damage DNA, lipids, and proteins if OS is not controlled. To avoid oxidative damage, antioxidant systems are activated. In the present review, we focus on the basic concepts of OS, highlighting the production of reactive oxygen and nitrogen species (RONS) derived from internal and external sources and the last elimination. Moreover, we include the cellular antioxidant system regulation and their ability to decrease OS. External antioxidants are also proposed as alternatives to ameliorate OS. Finally, we review diseases involving OS and their mechanisms.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45646336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

β-Cyclodextrin-Aided Aqueous Extraction of Antioxidant Polyphenols from Peppermint (Mentha × piperita L.) β-环糊精辅助水提取薄荷抗氧化多酚

Oxygen (Basel, Switzerland) Pub Date : 2022-09-29 DOI: 10.3390/oxygen2040029

V. Athanasiadis, D. Palaiogiannis, Eleni Bozinou, S. Lalas, D. Makris

{"title":"β-Cyclodextrin-Aided Aqueous Extraction of Antioxidant Polyphenols from Peppermint (Mentha × piperita L.)","authors":"V. Athanasiadis, D. Palaiogiannis, Eleni Bozinou, S. Lalas, D. Makris","doi":"10.3390/oxygen2040029","DOIUrl":"https://doi.org/10.3390/oxygen2040029","url":null,"abstract":"This study explored the use of β-cyclodextrin (β-CD) as an additive to improve the aqueous extraction of antioxidant polyphenols from peppermint (Mentha × piperita). For this purpose, an initial single-factor screening was performed to test the effect of β-CD concentration on the yield of polyphenol extraction. In the following step, the extraction process was optimized through response surface methodology, considering β-CD and temperature as the process variables. The experimental design included the yield in total polyphenols and total flavonoids, the ferric-reducing power and the antiradical activity as the responses. The optimization showed that each response was maximized at different levels of β-CD concentration, but in all cases, 80 °C was the optimum extraction temperature. The composition of the extracts produced was profiled by high-performance liquid chromatography (HPLC). A comparison of the β-CD extract with the aqueous and hydroethanolic extracts revealed that the addition of β-CD at a specified concentration might boost aqueous polyphenol extraction. On the other hand, the hydroethanolic extract exhibited the richest polyphenolic profile. It was also shown that the β-CD extracts might possess improved antiradical activity. It was concluded that β-CD-aided polyphenol extraction from M. piperita may provide extracts with enriched polyphenolic composition and improved antioxidant characteristics, and this technique may be considered an alternative to solvent extraction.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47812028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The Effect of Additives on the Hydrothermal Synthesis and Thermochromic Performance of Monoclinic Vanadium Dioxide Powder 添加剂对单斜二氧化钒粉体水热合成及热致变色性能的影响

Oxygen (Basel, Switzerland) Pub Date : 2022-09-28 DOI: 10.3390/oxygen2040028

L. Zouridi, E. Gagaoudakis, Eleni Mantsiou, Theodora Dragani, Xristina Maragaki, E. Aperathitis, G. Kiriakidis, V. Binas

{"title":"The Effect of Additives on the Hydrothermal Synthesis and Thermochromic Performance of Monoclinic Vanadium Dioxide Powder","authors":"L. Zouridi, E. Gagaoudakis, Eleni Mantsiou, Theodora Dragani, Xristina Maragaki, E. Aperathitis, G. Kiriakidis, V. Binas","doi":"10.3390/oxygen2040028","DOIUrl":"https://doi.org/10.3390/oxygen2040028","url":null,"abstract":"Monoclinic vanadium dioxide VO2(M) is a well-known thermochromic material, with its critical transition temperature (68 °C) being the closest to room temperature (RT). Among the variety of grown methods, hydrothermal synthesis is a simple and cost-effective technique to grow thermochromic VO2 in the form of powder. In the present work, VO2 nanoparticles were prepared by hydrothermal synthesis in mild conditions, followed by a thermal annealing process at 700 °C under nitrogen flow for two hours. Vanadium pentoxide (V2O5) was used as the vanadium precursor, while two different reducing agents, namely oxalic and succinic acid, were employed for the reduction of V2O5 to VO2. Additionally, urea as well as thiourea were used as additives, in order to investigate their effects on the thermochromic performance of VO2. As a result, the VO2 (M) phase was obtained after annealing the crystalline powder, grown hydrothermally using oxalic acid and thiourea as a reducing agent and additive, respectively. This synthesis had a high yield of 90%, and led to a VO2(M) powder of high purity and crystallinity. In particular, the VO2 (M) nanoparticles had an average crystallite size of approximately 45 nm, a critical transition temperature of approximately 68 °C and a hysteresis width of 11 °C.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41860526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Ambiguous Aspects of Oxygen 氧的模糊方面

Oxygen (Basel, Switzerland) Pub Date : 2022-09-14 DOI: 10.3390/oxygen2030027

G. Napolitano, G. Fasciolo, P. Venditti

{"title":"The Ambiguous Aspects of Oxygen","authors":"G. Napolitano, G. Fasciolo, P. Venditti","doi":"10.3390/oxygen2030027","DOIUrl":"https://doi.org/10.3390/oxygen2030027","url":null,"abstract":"For most living beings, oxygen is an essential molecule for survival, being the basis of biological oxidations, which satisfy most of the energy needs of aerobic organisms. Oxygen can also behave as a toxic agent posing a threat to the existence of living beings since it can give rise to reactive oxygen species (ROS) that can oxidise biological macromolecules, among which proteins and lipids are the preferred targets. Oxidative damage can induce cell, tissue, and organ dysfunction, which leads to severe body damage and even death. The survival of the aerobic organism depends on the development of an elaborate antioxidant defence system adapted to the normal level of atmospheric oxygen. The production of ROS in the aerobic organism can occur accidentally from exposure to pollutants or radiation, but occurs constantly during normal metabolic reactions. Cells have evolved using ROS to their advantage. Indeed, ROS are used as signalling molecules in numerous physiological processes, including muscle contraction, regulation of insulin release, and adaptation to environmental changes. Therefore, supplementation with antioxidants must be used wisely. A low level of ROS is essential for adaptation processes, so an excess of antioxidants can be harmful. Conversely, in conditions where ROS production increases, antioxidants can be useful to avoid cellular dysfunction.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47372673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Home Oxygen Therapy (HOT) in Stable Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD): Similarities, Differences and Doubts 稳定型慢性阻塞性肺病（COPD）和间质性肺病（ILD）的家庭氧疗（HOT）：相似、差异和疑问

Oxygen (Basel, Switzerland) Pub Date : 2022-09-13 DOI: 10.3390/oxygen2030026

A. Melani, R. M. Refini, S. Croce, M. Messina

{"title":"Home Oxygen Therapy (HOT) in Stable Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD): Similarities, Differences and Doubts","authors":"A. Melani, R. M. Refini, S. Croce, M. Messina","doi":"10.3390/oxygen2030026","DOIUrl":"https://doi.org/10.3390/oxygen2030026","url":null,"abstract":"This narrative paper reviews the current knowledge of Home Oxygen Therapy (HOT) in stable Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Lung Disease (ILD), two major causes of Long-Term Oxygen Therapy (LTOT) prescription. There is evidence that LTOT improves survival in COPD subjects with chronic severe respiratory failure. HOT is also used to contrast exercise and sleeping hypoxemia and to improve Quality of Life (QoL) and symptoms. Ambulatory Oxygen Therapy (AOT) did not assure generalized improvements in symptoms and Quality of Life (QoL) of COPD subjects. There is short-term evidence in a real-life study that AOT may improve QoL in ILD subjects with Exercise Oxygen Desaturation (EOD) and exertional dyspnea. There are some differences between guidelines and practices, which translate into variations in characteristics and rates of ILD and COPD subjects admitted to LTOT and AOT. Indications on titration of oxygen flow and the best oxygen delivery device for optimal management of AOT in COPD and ILD subjects are often vague or lacking. More work is needed for optimizing and customizing HOT in COPD and ILD subjects.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44428751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Plant Antioxidants Affect Human and Gut Health, and Their Biosynthesis Is Influenced by Environment and Reactive Oxygen Species 植物抗氧化剂影响人体和肠道健康，其生物合成受环境和活性氧的影响

Oxygen (Basel, Switzerland) Pub Date : 2022-09-01 DOI: 10.3390/oxygen2030025

D. Navarre, Meijun Zhu, H. Hellmann

引用次数: 0