Oxygen (Basel, Switzerland)最新文献

Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities. 子宫肌瘤中的缺氧：病理生物学中的作用和治疗机会。

Oxygen (Basel, Switzerland) Pub Date : 2024-06-01 Epub Date: 2024-05-28 DOI: 10.3390/oxygen4020013

Sydney L Olson, Razeen J Akbar, Adrianna Gorniak, Laura I Fuhr, Mostafa A Borahay

{"title":"Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities.","authors":"Sydney L Olson, Razeen J Akbar, Adrianna Gorniak, Laura I Fuhr, Mostafa A Borahay","doi":"10.3390/oxygen4020013","DOIUrl":"10.3390/oxygen4020013","url":null,"abstract":"<p><p>Uterine fibroids are the most common tumors in females affecting up to 70% of women world-wide, yet targeted therapeutic options are limited. Oxidative stress has recently surfaced as a key driver of fibroid pathogenesis and provides insights into hypoxia-induced cell transformation, extracellular matrix pathophysiology, hypoxic cell signaling cascades, and uterine biology. Hypoxia drives fibroid tumorigenesis through (1) promoting myometrial stem cell proliferation, (2) causing DNA damage propelling transformation of stem cells to tumor initiating cells, and (3) driving excess extracellular matrix (ECM) production. Common fibroid-associated DNA mutations include MED12 mutations, HMGA2 overexpression, and Fumarate hydratase loss of function. Evidence suggests an interaction between hypoxia signaling and these mutations. Fibroid development and growth are promoted by hypoxia-triggered cell signaling via various pathways including HIF-1, TGFβ, and Wnt/β-catenin. Fibroid-associated hypoxia persists due to antioxidant imbalance, ECM accumulation, and growth beyond adequate vascular supply. Current clinically available fibroid treatments do not take advantage of hypoxia-targeting therapies. Growing pre-clinical and clinical studies identify ROS inhibitors, anti-HIF-1 agents, Wnt/β-catenin inhibition, and TGFβ cascade inhibitors as agents that may reduce fibroid development and growth through targeting hypoxia.</p>","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Dysfunction and Nanocarrier-Based Treatments in Chronic Obstructive Pulmonary Disease (COPD) 慢性阻塞性肺疾病(COPD)的线粒体功能障碍和纳米载体治疗

Oxygen (Basel, Switzerland) Pub Date : 2023-11-14 DOI: 10.3390/oxygen3040026

Kiyoshi Sato, Hiroyoshi Kawakami

引用次数: 0

The Influence of the Atmospheric Electric Field on Soil Redox Potential 大气电场对土壤氧化还原电位的影响

Oxygen (Basel, Switzerland) Pub Date : 2023-10-19 DOI: 10.3390/oxygen3040025

Konstantinos Kourtidis, Michel Vorenhout

{"title":"The Influence of the Atmospheric Electric Field on Soil Redox Potential","authors":"Konstantinos Kourtidis, Michel Vorenhout","doi":"10.3390/oxygen3040025","DOIUrl":"https://doi.org/10.3390/oxygen3040025","url":null,"abstract":"Atmospheric electric fields (AEFs) have recently been proposed to link to biogeochemical processes below the Earth’s surface by means of a charge separation. Despite the potential importance of such a process, up to now we almost completely lack the relevant measurements. Here, we extend the database with 2 months of concurrent soil redox and atmospheric electric field measurements. It appears that the changes that occur in the order of days in soil redox are at periods anticorrelated with the logarithm of the positive values of the AEF. However, weather conditions might be driving the anticorrelation rather than a direct link, as the synoptic weather conditions appear to influence soil redox. Soil redox does not respond to changes in the AEF that are of shorter duration, either minutes or several hours, except in some cases of very negative AEFs or very high field strengths in the presence of moderate rainfall. In such a case, the variation in soil redox could be associated with a mechanism that transfers charge to the ground or brings ions towards the ground’s surface. To reach firmer conclusions on the effect of the AEF on soil redox, we need to extend the range of collocated soil redox and AEF measurements so that they cover at least one year.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Kelch/Nrf2 Antioxidant System as a Target for Some Marine Fungal Metabolites Kelch/Nrf2抗氧化系统作为一些海洋真菌代谢物的靶点

Oxygen (Basel, Switzerland) Pub Date : 2023-09-28 DOI: 10.3390/oxygen3040024

Ekaterina A. Yurchenko, Olga O. Khmel, Liliana E. Nesterenko, Dmitry L. Aminin

引用次数: 0

Exploring the Impact of Training Methods on Repeated Sprints in Hypoxia Training Effects 探讨缺氧训练中重复冲刺训练方式对训练效果的影响

Oxygen (Basel, Switzerland) Pub Date : 2023-09-08 DOI: 10.3390/oxygen3030023

Daniel Rojas-Valverde, Aldo A. Vasquez-Bonilla, Rafael Timón, Joan M. Feliu-Ilvonen, Ismael Martínez-Guardado, Guillermo Olcina

{"title":"Exploring the Impact of Training Methods on Repeated Sprints in Hypoxia Training Effects","authors":"Daniel Rojas-Valverde, Aldo A. Vasquez-Bonilla, Rafael Timón, Joan M. Feliu-Ilvonen, Ismael Martínez-Guardado, Guillermo Olcina","doi":"10.3390/oxygen3030023","DOIUrl":"https://doi.org/10.3390/oxygen3030023","url":null,"abstract":"Background: Emerging evidence suggests that the outcomes of hypoxia training may be influenced by various factors, contingent upon the chosen method, such as chamber, tent, or mask. This study aimed to examine how different training methods influence the effects of Repeated Sprints in Hypoxia (RSH) training. Methods: Sixteen well-trained cyclists were divided into two groups, experimental (tent; n = 8) and control (mask; n = 8), and carried out eight RSH sessions for four weeks. Training sessions consisted of three bouts of high-intensity sprints using a cycle ergometer. The indoor ambient conditions (CO2, temperature, and humidity), performance variables (power and relative power output), arterial oxygen saturation, local muscle oxygen of vastus lateralis, heart rate, core temperature, and physiological variables (perception of effort) were measured in each training session. Results: The experimental group reported significantly higher CO2 (p < 0.001 ES = 0.784), humidity levels (p < 0.001 ES = 0.750), thermal discomfort (p = 0.003 ES = 0.266), dehydration (p 0.025 ES = 0.097), heart rate (p = 0.017 ES = 0.113), and lower muscle oxygen amplification (p = 0.002 ES = 0.181) than the control group. Conclusion: According to the responses observed, interval training performed under hypoxic conditions inside a chamber induces a more severe physiological response.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136362212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases 与氧化应激相关的胃肠道疾病有关的离子通道

Oxygen (Basel, Switzerland) Pub Date : 2023-08-21 DOI: 10.3390/oxygen3030022

Maria Rosaria Miranda, Vincenzo Vestuto, O. Moltedo, M. Manfra, P. Campiglia, G. Pepe

{"title":"The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases","authors":"Maria Rosaria Miranda, Vincenzo Vestuto, O. Moltedo, M. Manfra, P. Campiglia, G. Pepe","doi":"10.3390/oxygen3030022","DOIUrl":"https://doi.org/10.3390/oxygen3030022","url":null,"abstract":"The pathogenesis of various gastrointestinal (GI) disorders, including gastritis, ulcers, inflammatory bowel disease (IBD) and cancer, can be linked to oxidative stress. It is known that reactive species carry out a crucial role in the genesis and progression of these pathologies; however, the contribution of ionic channels in their development is still under discussion. The function of ion channels in the gastrointestinal tract influences a variety of cellular processes. Acid-base balance, mucus layer, microbiota and mucosal blood flow are only some of the essential features for maintaining the mucosal integrity of the cellular barrier in the intestine, allowing for the preservation of proper permeability and ensuring tissue homeostasis. As the functional modulation of several ion channels is altered during oxidative stress conditions associated with gastrointestinal inflammation, this review focuses on contributing new insight into the roles of and the relationship between ion channels and oxidative stress in GI diseases. The association between ion channels and oxidative stress conditions could be used in diagnostics and the development of new pharmacological treatments for major gastrointestinal diseases.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41423202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision 类胡萝卜素和活性氧的光化学和光物理性质：与皮肤和视觉有关的矛盾

Oxygen (Basel, Switzerland) Pub Date : 2023-08-03 DOI: 10.3390/oxygen3030021

Fritz Boehm, R. Edge, T. Truscott

引用次数: 0

Hypoxia-Driven Responses in Chronic Kidney Disease 慢性肾脏疾病的缺氧驱动反应

Oxygen (Basel, Switzerland) Pub Date : 2023-07-12 DOI: 10.3390/oxygen3030020

V. Miguel, Alba Rojo

引用次数: 0

Oxygen in the Earth System 地球系统中的氧

Oxygen (Basel, Switzerland) Pub Date : 2023-06-27 DOI: 10.3390/oxygen3030019

K. Hocke

引用次数: 1

Successive Solvent Extraction of Polyphenols and Flavonoids from Cistus creticus L. Leaves 肉苁蓉叶多酚和黄酮类化合物的连续溶剂萃取

Oxygen (Basel, Switzerland) Pub Date : 2023-06-23 DOI: 10.3390/oxygen3030018

D. Palaiogiannis, Theodoros G. Chatzimitakos, V. Athanasiadis, Eleni Bozinou, D. Makris, S. Lalas

{"title":"Successive Solvent Extraction of Polyphenols and Flavonoids from Cistus creticus L. Leaves","authors":"D. Palaiogiannis, Theodoros G. Chatzimitakos, V. Athanasiadis, Eleni Bozinou, D. Makris, S. Lalas","doi":"10.3390/oxygen3030018","DOIUrl":"https://doi.org/10.3390/oxygen3030018","url":null,"abstract":"The aim of this study was to evaluate the efficiency of successive extraction (using solvents of increasing polarity, namely hexane, ethyl acetate, acetone, ethanol, and water) of polyphenols from Cistus creticus L. The results were compared with the ones obtained from a single-solvent extraction (ethanol, water, and 50% ethanol: water). According to the results, each solvent used for extraction had a significant effect on the yield of extracted polyphenols and the antioxidant activity of the extracts. The highest extraction yield for successive extraction was achieved with ethanol (95.33 mg GAE/g), whereas a comparable amount could also be extracted with 50% ethanol: water mixture single-solvent extraction (96.51 mg GAE/g). The ethanolic and aqueous extracts had the highest antioxidant activity as indicated by their lowest IC50 values in the DPPH assay, specifically 350.99 μg/mL for ethanolic extract of successive extraction and 341.18 μg/mL for 50% ethanol: water mixture of single-solvent extraction, followed by the extract produced using acetone. However, the acetone extract contained more flavonoids than the other two extracts up to 28.03 mg QE/g. The results obtained were in line with those for the single-solvent extraction. It is concluded that using a range of solvents in succession is a more efficient way of extracting higher amounts of antioxidant compounds with varying antioxidant activity.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47471149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1