Aging and Disease最新文献_第8页

Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration. 血浆干扰素γ与新生血管性年龄相关性黄斑变性治疗不良反应相关

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-09 DOI: 10.14336/AD.2024.1585

Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen

{"title":"Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration.","authors":"Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen","doi":"10.14336/AD.2024.1585","DOIUrl":"https://doi.org/10.14336/AD.2024.1585","url":null,"abstract":"Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly. Aging is the most important risk factor for AMD, and the aging immune system seems to be involved in pathogenesis. This study investigates the systemic aging immune profile in relation to AMD stage and treatment response. Treatment-naïve patients with neovascular AMD (nAMD), intermediate AMD and healthy controls were included in this prospective study. Participants were examined for systemic aging immune profiles and compared to AMD stage, as well as initial and one-year treatment response in nAMD patients. Flowcytometry was performed to determine T cell differentiation (naïve, central memory and effector memory) and expression of costimulatory markers (CD27, CD28, CD56). Cytokine assays were performed to measure the concentrations of plasma cytokines IFN-γ, IL-1β, IL-2, IL-6, IL-10, IL-12, IL-17, IL-22, IL-27, TNF-α. Polymorphisms of CFH and ARMS2 genes were compared in nAMD patients. Patients with nAMD had significantly higher proportions of central and effector memory CD8+ T cells compared to controls (both P &;lt 0.036). nAMD patients had significantly elevated concentrations of IFN-γ, IL-1β, IL-2, and IL-10 (all P &;lt 0.05). nAMD patients with poor initial treatment response had a significantly higher concentration of plasma IFN-γ compared to good responders (P =0.026). Patients with nAMD had a more advanced systemic aging immune profile with higher levels of T cell differentiation and plasma cytokines compared to controls. Poor initial response had elevated levels of plasma IFN-γ compared to good responders in nAMD.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging? 唐氏综合征线粒体失衡：脑加速衰老的驱动因素？

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-08 DOI: 10.14336/AD.2025.0189

Xinxin Zuo

引用次数: 0

Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association Between Malnutrition and Cognitive Decline in Disabled Elderly. 健康老龄化背景下的双重挑战：残疾老年人营养不良与认知能力下降关系的综合探讨。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-08 DOI: 10.14336/AD.2025.0337

Runyuan Yu, Lixia Wang, Yifan Liu, Yimeng Hu, Zuncheng Zheng, Xiaoyu Wang, Yuexia Chen, Yulian Liu

{"title":"Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association Between Malnutrition and Cognitive Decline in Disabled Elderly.","authors":"Runyuan Yu, Lixia Wang, Yifan Liu, Yimeng Hu, Zuncheng Zheng, Xiaoyu Wang, Yuexia Chen, Yulian Liu","doi":"10.14336/AD.2025.0337","DOIUrl":"https://doi.org/10.14336/AD.2025.0337","url":null,"abstract":"Disabled older adults represent a population requiring special attention in the context of global aging, with malnutrition and cognitive decline being prevalent and interrelated health concerns. This review systematically examines the association between malnutrition and mental deterioration in this population, with an in-depth exploration of the potential biological mechanisms underlying this relationship. Current evidence suggests that malnutrition accelerates cognitive decline through multiple pathways, including neurotransmitter synthesis impairment, insufficient cerebral energy supply, chronic inflammation and oxidative stress, blood-brain barrier dysfunction, and reduced neuroplasticity. Additionally, dysregulation of the gut-brain axis, an emerging mechanism, may influence brain health via alterations in the gut microbiota. This review aims to provide a theoretical foundation for understanding the intricate relationship between malnutrition and cognitive impairment while offering insights into optimizing health management and nutritional strategies for disabled older adults.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects. SLC7A11在纤维化中的分子机制及未来展望

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-06 DOI: 10.14336/AD.2025.0106

Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang

引用次数: 0

Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration. 绿茶减轻衰老和与年龄相关的多系统退化的标志。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-05 DOI: 10.14336/AD.2025.0398

Yusuf Yilmaz

{"title":"Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration.","authors":"Yusuf Yilmaz","doi":"10.14336/AD.2025.0398","DOIUrl":"https://doi.org/10.14336/AD.2025.0398","url":null,"abstract":"Aging is characterized by progressive multisystem deterioration driven by molecular and cellular mechanisms encapsulated in the twelve hallmarks of aging. Green tea (GT), derived from Camellia sinensis, has garnered significant scientific interest due to its rich polyphenolic composition, particularly epigallocatechin-3-gallate, and its pleiotropic health benefits. In this narrative review, we explored the multifaceted mechanisms through which GT may mitigate the aging hallmarks. Evidence from in vitro, animal, and human studies has shown that GT polyphenols can enhance DNA repair pathways, preserve telomere length, modulate epigenetic aging markers, improve proteostasis and autophagic flux, regulate nutrient-sensing networks, and rejuvenate mitochondrial function. Additionally, GT exhibits anti-inflammatory properties and may restore a physiological gut microbiota composition. Beyond molecular and cellular effects, GT consumption in humans has been associated with improved cognitive function, cardiovascular health, muscle preservation, and metabolic regulation in aging populations. Collectively, these findings highlight GT's potential as a naturally occurring geroscience intervention capable of addressing the interconnected network of aging processes more comprehensively than single-target pharmaceuticals. Future research should focus on optimizing dosing regimens, exploring synergies with other anti-aging strategies, and investigating personalized responses to GT interventions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of Sarcopenia and Cognitive Decline in Hospitalized Older Adults. 住院老年人肌肉减少症和认知能力下降的预测价值。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-05 DOI: 10.14336/AD.2025.0418

Xiaoyan Hu, Peng Sun

引用次数: 0

Exploring the Role of RhoA/ROCK Signaling in Pain: A Narrative Review. 探索RhoA/ROCK信号在疼痛中的作用：一个叙事回顾。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-04 DOI: 10.14336/AD.2024.1539

Nan Chen, Ye Tu, Dai-Qiang Liu, Yi Zhang, Yu-Ke Tian, Ya-Qun Zhou, Shao-Bing Yang

引用次数: 0

Lactylation: A Novel Epigenetic Regulator of Cellular Senescence. 乳酸化：细胞衰老的一种新的表观遗传调控因子。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-27 DOI: 10.14336/AD.2025.0277

Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song

引用次数: 0

Association Between Dementia and Optical Coherence Tomography Scan Quality. 痴呆与光学相干断层扫描质量的关系。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-27 DOI: 10.14336/AD.2024.1744

Reuben Jyong Kiat Foo, Damon Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Leopold Schmetterer, Jacqueline Chua

{"title":"Association Between Dementia and Optical Coherence Tomography Scan Quality.","authors":"Reuben Jyong Kiat Foo, Damon Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Leopold Schmetterer, Jacqueline Chua","doi":"10.14336/AD.2024.1744","DOIUrl":"https://doi.org/10.14336/AD.2024.1744","url":null,"abstract":"It is generally assumed that dementia affects the quality of optical coherence tomography (OCT) scans. However, the magnitude of this effect and its independence from other factors require further clarification. In this cross-sectional study, our aim was to evaluate the association between cognitive impairment and OCT scan quality, adjusting for key confounders, in a multiethnic cohort. 541 participants aged 50 years or older were recruited from memory clinics and the community at the National University Hospital and St. Luke's Hospital, Singapore. They were then stratified into three groups: no cognitive impairment (NCI, n=112), cognitive impairment without dementia (CIND, n=235), and dementia (n=194); OCT scan quality was subsequently assessed based on the presence and severity of artifacts. We found that dementia patients were nearly three times more likely to produce poor-quality OCT scans compared to NCI participants (adjusted odds ratio [OR]=2.90; 95% CI, 1.24-6.80). Lower cognitive scores, including Mini-Mental State Examination (MMSE) (OR=0.92; 95% CI, 0.88-0.96), Montreal Cognitive Assessment (MoCA) (OR=0.90; 95% CI, 0.86-0.94), and higher Clinical Dementia Rating (CDR) scores (OR=2.11; 95% CI, 1.43-3.10), were also independently associated with poor scan quality. In conclusion, cognitive impairment, particularly dementia, substantially increases the likelihood of poor-quality OCT scans, even after accounting for key demographic and clinical factors. Hence, strategies tailored to improve imaging in this population are essential for enhancing diagnostic accuracy and patient care.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to "P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy". “p -糖蛋白通过抑制内皮细胞自噬加重实验性缺血性卒中血脑屏障功能障碍”的勘误。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-26 DOI: 10.14336/AD.2025.10326

Liangliang Huang, Yan Chen, Rui Liu, Binbin Li, Xuan Fei, Xiang Li, Ge Liu, Yunman Li, Baohui Xu, Weirong Fang

引用次数: 0