Aging and Disease最新文献_第7页

Pericytes in the Development and Progression of Brain Diseases. 周细胞在脑部疾病发生发展中的作用。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-27 DOI: 10.14336/AD.2025.0028

Qingbin Wu, Xinyi Cui, Xiaochen Yuan, Jianqun Han, Hongwei Li, Ruijuan Xiu

引用次数: 0

Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice. lanat苷C，一种新型的抗衰老药物，改善小鼠动脉粥样硬化。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-25 DOI: 10.14336/AD.2025.1219

Eok-Cheon Kim, Youlim Son, Seon-Hui Kim, Soo-Ji Kim, So-Young Park, Jae-Ryong Kim

引用次数: 0

Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies. 视神经萎缩1：细胞和谐和年龄相关病理的传导。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-24 DOI: 10.14336/AD.2025.0017

Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang

引用次数: 0

Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy. 溶酶体作为衰老过程中代谢信号和器官生理的动态调节因子：从机制到治疗。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-22 DOI: 10.14336/AD.2025.0275

Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu

{"title":"Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy.","authors":"Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu","doi":"10.14336/AD.2025.0275","DOIUrl":"https://doi.org/10.14336/AD.2025.0275","url":null,"abstract":"Lysosomes are degradation centers and signaling hubs that in cells and play important roles in cellular homeostasis, development, and aging. Growing evidence has also implicated the role of lysosome-related mechanisms in the aging process. Meanwhile, the potential impact of lysosomal dysfunction on the production of inflammatory molecules, cellular metabolic status, and mitochondrial function is becoming increasingly significant. In this review, we provide a comprehensive overview of the physiological roles of lysosomes and their association with aging. At the cellular level, lysosomal dysfunction and cellular senescence show strong correlations. Herein, we elucidated the precise mechanisms by which lysosomal dysfunction contributes to various cellular physiological processes, as well as its potential implications in age-related hallmarks. More importantly, we discuss how lysosomal homeostasis is disrupted in several age-related diseases, including atherosclerosis, heart diseases, cancer, neurodegenerative diseases, metabolic disorders, and motor system diseases. Thus, a deeper understanding of lysosomal function may provide fundamental insights into human physiology and age-related diseases. Furthermore, these discoveries emphasize the role of the lysosome in the development of novel therapeutic strategies.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments. 缺氧预处理减轻急性缺氧诱导的MS/VDB胆碱能细胞丧失和记忆障碍。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-21 DOI: 10.14336/AD.2025.0175

Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren

{"title":"Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments.","authors":"Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren","doi":"10.14336/AD.2025.0175","DOIUrl":"https://doi.org/10.14336/AD.2025.0175","url":null,"abstract":"Cholinergic cells originating from the medial septal nucleus (MS) and the vertical and horizontal limbs of the diagonal band of Broca (VDB and HDB, respectively) are critical for supporting a variety of memory and cognitive functions. However, the viability of cholinergic cells has not been explored in the context of acute hypoxia (AH). This study aimed to investigate the effects of AH on cholinergic cells in these nuclei and to test whether hypoxic preconditioning (HPC)-a previously established neuroprotective therapy-could prevent cholinergic cell loss, cognitive dysfunction, and hippocampal synaptic dysfunction in mice exposed to AH. We found that cholinergic cell loss occurred in the MS/DB after AH. HPC prevented this effect and also improved AH-induced cognitive dysfunction and hippocampal synaptic dysfunction. Overall, our findings highlight the significant role of cholinergic cells in AH-induced memory impairments and suggest that the preservation of cholinergic cell viability may provide a mechanism by which HPC improves memory impairments and preserves the function of memory-processing brain structures after AH.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPA1 Enhances Microglial Amyloid-β Clearance and Alleviates Cognitive Impairments in an Alzheimer's Disease Model. 在阿尔茨海默病模型中，OPA1增强小胶质淀粉样蛋白-β清除并减轻认知障碍

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-20 DOI: 10.14336/AD.2025.0082

Qing Wang, Mengqi Dong, Xue Xia, Xinyu Bao, Mengsha Hu, Lei Ye, Yun Xu

引用次数: 0

PCSK9 in Vascular Aging and Age-Related Diseases. PCSK9在血管老化和年龄相关疾病中的作用

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-18 DOI: 10.14336/AD.2024.1713

Dong Tan, Xin Yang, Jing Yang, Gang Fan, Guozuo Xiong

引用次数: 0

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation. 中医药衍生Geroprotector配方的llm和AI生命模型。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-17 DOI: 10.14336/AD.2024.1697

Fedor Galkin, Feng Ren, Alex Zhavoronkov

{"title":"LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation.","authors":"Fedor Galkin, Feng Ren, Alex Zhavoronkov","doi":"10.14336/AD.2024.1697","DOIUrl":"https://doi.org/10.14336/AD.2024.1697","url":null,"abstract":"Traditional Chinese Medicine (TCM) represents a vast repository of therapeutic knowledge, but its integration with modern drug discovery remains challenging due to fundamental differences in theoretical frameworks. We developed an AI agent-driven framework combining Precious3GPT (P3GPT), a multi-omics transformer model, with the BATMAN-TCM2 database of TCM compound-target interactions to bridge this gap. As a proof-of-concept, we used P3GPT-generated cross-species and cross-tissue signatures to screen TCM compounds, herbs, and formulas to identify novel natural geroprotectors. The cross-species analysis identified 13 conserved aging-associated genes, leading to the identification of 34 TCM compounds with significant target overlap and enabling identification of HUA SHAN WU ZI DAN and other TCM formulations as a promising historical formula. Our work demonstrates the feasibility of using AI to systematically bridge TCM and modern pharmacology, enabling rational design of multi-component formulations targeting age-related processes across multiple tissues and species. This approach provides a framework for modernizing traditional medicine while maintaining its holistic therapeutic principles. To help other teams integrate AI experimentation in their research process, we publicly release all materials and codebase used in this work, including the multi-agent system, cross-species and cross-tissue signatures of aging, as well as TCM databases formatted for AI interactions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities. 揭示同型半胱氨酸在痴呆中的作用：与阿尔茨海默病没有特定的联系，但与白质高强度有关。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-15 DOI: 10.14336/AD.225.0020

Théodore Decaix, Matthieu Lilamand, Karl Götze, François Mouton-Liger, Emmanuel Cognat, Jacques Hugon, Elodie Bouaziz-Amar, Louise Sindzingre, Julien Dumurgier, Claire Paquet

{"title":"Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities.","authors":"Théodore Decaix, Matthieu Lilamand, Karl Götze, François Mouton-Liger, Emmanuel Cognat, Jacques Hugon, Elodie Bouaziz-Amar, Louise Sindzingre, Julien Dumurgier, Claire Paquet","doi":"10.14336/AD.225.0020","DOIUrl":"https://doi.org/10.14336/AD.225.0020","url":null,"abstract":"Hyperhomocysteinemia (HHcy) is an established risk factor for cognitive impairment. The specific role of HHcy in the pathophysiology of Alzheimer's disease (AD) is debated, as most of the suspected mechanisms overlap with those of vascular dementia (VD). The aim of this study was to explore the association between plasma homocysteine (Hcy) levels and cerebrospinal fluid (CSF) biomarkers of AD, as well as brain magnetic resonance imaging (MRI) features. Cross-sectional observational analysis from a single-center tertiary memory clinic. We first assessed the association between Hcy in tertiles and the CSF AD biomarkers (according to the Amyloid (A) Tau (T) Neurodegeneration (N) classification) with further adjustments for age and sex. Then, we analyzed the relationship between HHcy and hippocampal atrophy (Scheltens scale) and white matter lesions (WML) (Fazekas scale) on brain MRI. We included 507 patients [mean age 68.9 (standard deviation=8.9)] with mean plasma Hcy at 13.3 (4.7) μmol/L in this study. There was no significant association between Hcy tertiles and CSF AD biomarkers. Plasma Hcy levels showed no correlation with any CSF AD biomarkers. The severity of WML increased with higher Hcy tertiles (p&;lt0.0001). Patients with a CSF AD (A+T+) profile exhibited elevated mean Hcy levels when they presented moderate to severe WML (p&;lt0.0001). Our findings challenge the link between Hcy and AD pathophysiology while highlighting a significant connection between Hcy and microvascular cognitive impairment. Further longitudinal studies are needed to validate these conclusions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities. 癌症中NK细胞衰老：从分子机制到治疗机会。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-12 DOI: 10.14336/AD.2025.0053

Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

{"title":"NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities.","authors":"Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo","doi":"10.14336/AD.2025.0053","DOIUrl":"https://doi.org/10.14336/AD.2025.0053","url":null,"abstract":"P Natural killer (NK) cells function as crucial effectors in the innate immune response against tumors. Nevertheless, NK cell senescence, characterized by phenotypic and functional changes, substantially compromises their antitumor immune response. This review provides a comprehensive summary of the molecular mechanisms governing NK cell senescence and its implications for cancer immunotherapy. We propose a refined definition of NK cell senescence based on distinct biomarkers, including elevated CD57 expression, reduced cytotoxicity, and altered cytokine secretion. Moreover, we investigate the complex interactions between the tumor microenvironment (TME) and NK cell senescence, highlighting the influence of chronic inflammation, immunosuppressive cytokines, and persistent tumor antigenic stimulation. Additionally, this review underscores the potential utility of senescent NK cells as biomarkers for assessing antitumor efficacy and examines the adverse effects of NK cell senescence on cancer immunotherapy. Lastly, we summarize current approaches to mitigate NK cell senescence, such as gene editing techniques and cytokine modulation, which may enhance the efficacy of NK cell-based immunotherapies. By establishing a comprehensive framework for understanding NK cell senescence within the TME, this review aims to guide future research and the development of innovative therapeutic strategies targeting senescent NK cells to improve cancer immunotherapy outcomes.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0