{"title":"视神经萎缩1：细胞和谐和年龄相关病理的传导。","authors":"Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang","doi":"10.14336/AD.2025.0017","DOIUrl":null,"url":null,"abstract":"<p><p>As the population aging, the prevalence of age-related diseases is also rising. Mitochondrial malfunction is one of the hallmarks of aging, and optic atrophy type 1 (OPA1), a protein found in the inner membrane (IM) of mitochondrial, is essential to this process. OPA1 regulates the fusion of IM and cristae structure, hence maintaining cellular energy metabolism and function. Its abnormalities may impair the multiple functions of tissues and are also closely related to various diseases. OPA1 is highly expressed in metabolically active organs, such as the brain, skeletal muscle, and heart, ensuring the normal metabolism and function of these organs. This review summarizes the physiological functions of OPA1 in these organs, along with the effect of aberrant OPA1 expression on aging related disorders. By deeply studying the mechanisms of OPA1's function in these diseases, we might achieve a more profound comprehension of the pathological processes of age-related diseases and explore potential therapeutic strategies.</p>","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies.\",\"authors\":\"Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang\",\"doi\":\"10.14336/AD.2025.0017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>As the population aging, the prevalence of age-related diseases is also rising. Mitochondrial malfunction is one of the hallmarks of aging, and optic atrophy type 1 (OPA1), a protein found in the inner membrane (IM) of mitochondrial, is essential to this process. OPA1 regulates the fusion of IM and cristae structure, hence maintaining cellular energy metabolism and function. Its abnormalities may impair the multiple functions of tissues and are also closely related to various diseases. OPA1 is highly expressed in metabolically active organs, such as the brain, skeletal muscle, and heart, ensuring the normal metabolism and function of these organs. This review summarizes the physiological functions of OPA1 in these organs, along with the effect of aberrant OPA1 expression on aging related disorders. By deeply studying the mechanisms of OPA1's function in these diseases, we might achieve a more profound comprehension of the pathological processes of age-related diseases and explore potential therapeutic strategies.</p>\",\"PeriodicalId\":7434,\"journal\":{\"name\":\"Aging and Disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14336/AD.2025.0017\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14336/AD.2025.0017","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies.
As the population aging, the prevalence of age-related diseases is also rising. Mitochondrial malfunction is one of the hallmarks of aging, and optic atrophy type 1 (OPA1), a protein found in the inner membrane (IM) of mitochondrial, is essential to this process. OPA1 regulates the fusion of IM and cristae structure, hence maintaining cellular energy metabolism and function. Its abnormalities may impair the multiple functions of tissues and are also closely related to various diseases. OPA1 is highly expressed in metabolically active organs, such as the brain, skeletal muscle, and heart, ensuring the normal metabolism and function of these organs. This review summarizes the physiological functions of OPA1 in these organs, along with the effect of aberrant OPA1 expression on aging related disorders. By deeply studying the mechanisms of OPA1's function in these diseases, we might achieve a more profound comprehension of the pathological processes of age-related diseases and explore potential therapeutic strategies.
期刊介绍：
Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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