Association Between Dementia and Optical Coherence Tomography Scan Quality.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Reuben Jyong Kiat Foo, Damon Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Leopold Schmetterer, Jacqueline Chua
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Abstract

It is generally assumed that dementia affects the quality of optical coherence tomography (OCT) scans. However, the magnitude of this effect and its independence from other factors require further clarification. In this cross-sectional study, our aim was to evaluate the association between cognitive impairment and OCT scan quality, adjusting for key confounders, in a multiethnic cohort. 541 participants aged 50 years or older were recruited from memory clinics and the community at the National University Hospital and St. Luke's Hospital, Singapore. They were then stratified into three groups: no cognitive impairment (NCI, n=112), cognitive impairment without dementia (CIND, n=235), and dementia (n=194); OCT scan quality was subsequently assessed based on the presence and severity of artifacts. We found that dementia patients were nearly three times more likely to produce poor-quality OCT scans compared to NCI participants (adjusted odds ratio [OR]=2.90; 95% CI, 1.24-6.80). Lower cognitive scores, including Mini-Mental State Examination (MMSE) (OR=0.92; 95% CI, 0.88-0.96), Montreal Cognitive Assessment (MoCA) (OR=0.90; 95% CI, 0.86-0.94), and higher Clinical Dementia Rating (CDR) scores (OR=2.11; 95% CI, 1.43-3.10), were also independently associated with poor scan quality. In conclusion, cognitive impairment, particularly dementia, substantially increases the likelihood of poor-quality OCT scans, even after accounting for key demographic and clinical factors. Hence, strategies tailored to improve imaging in this population are essential for enhancing diagnostic accuracy and patient care.

痴呆与光学相干断层扫描质量的关系。
一般认为痴呆会影响光学相干断层扫描(OCT)的质量。然而,这种影响的程度及其与其他因素的独立性需要进一步澄清。在这项横断面研究中,我们的目的是评估认知障碍与OCT扫描质量之间的关系,并在多种族队列中调整关键混杂因素。541名年龄在50岁或以上的参与者是从新加坡国立大学医院和圣卢克医院的记忆诊所和社区招募的。然后将他们分为三组:无认知障碍(NCI, n=112),认知障碍无痴呆(CIND, n=235)和痴呆(n=194);随后根据伪影的存在和严重程度评估OCT扫描质量。我们发现,与NCI参与者相比,痴呆患者产生低质量OCT扫描的可能性几乎是其三倍(校正优势比[OR]=2.90;95% ci, 1.24-6.80)。认知评分较低,包括简易精神状态检查(MMSE) (OR=0.92;95% CI, 0.88-0.96),蒙特利尔认知评估(MoCA) (OR=0.90;95% CI, 0.86-0.94)和更高的临床痴呆评分(CDR)评分(OR=2.11;95% CI, 1.43-3.10),也与扫描质量差独立相关。综上所述,认知障碍,特别是痴呆症,大大增加了低质量OCT扫描的可能性,即使在考虑了关键的人口统计学和临床因素之后。因此,量身定制的策略,以提高成像在这一人群是必不可少的,以提高诊断的准确性和病人的护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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