Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association Between Malnutrition and Cognitive Decline in Disabled Elderly.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Runyuan Yu, Lixia Wang, Yifan Liu, Yimeng Hu, Zuncheng Zheng, Xiaoyu Wang, Yuexia Chen, Yulian Liu
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引用次数: 0

Abstract

Disabled older adults represent a population requiring special attention in the context of global aging, with malnutrition and cognitive decline being prevalent and interrelated health concerns. This review systematically examines the association between malnutrition and mental deterioration in this population, with an in-depth exploration of the potential biological mechanisms underlying this relationship. Current evidence suggests that malnutrition accelerates cognitive decline through multiple pathways, including neurotransmitter synthesis impairment, insufficient cerebral energy supply, chronic inflammation and oxidative stress, blood-brain barrier dysfunction, and reduced neuroplasticity. Additionally, dysregulation of the gut-brain axis, an emerging mechanism, may influence brain health via alterations in the gut microbiota. This review aims to provide a theoretical foundation for understanding the intricate relationship between malnutrition and cognitive impairment while offering insights into optimizing health management and nutritional strategies for disabled older adults.

健康老龄化背景下的双重挑战:残疾老年人营养不良与认知能力下降关系的综合探讨。
在全球老龄化的背景下,残疾老年人是一个需要特别关注的群体,营养不良和认知能力下降是普遍存在的和相互关联的健康问题。本综述系统地研究了这一人群中营养不良和智力退化之间的关系,并深入探讨了这种关系背后的潜在生物学机制。目前的证据表明,营养不良通过多种途径加速认知能力下降,包括神经递质合成障碍、大脑能量供应不足、慢性炎症和氧化应激、血脑屏障功能障碍和神经可塑性降低。此外,肠-脑轴失调是一种新兴的机制,可能通过肠道微生物群的改变影响大脑健康。本综述旨在为理解营养不良与认知障碍之间的复杂关系提供理论基础,同时为优化残疾老年人的健康管理和营养策略提供见解。
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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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