OBM neurobiology最新文献

{"title":"Anxiety, Stress and Depression as the Notorious Barriers to Achieving a Massive Performance among Egyptian Construction Site Workers","authors":"N. Abdelwahed, Mohammed A. Al Doghan, B. Soomro","doi":"10.21926/obm.neurobiol.2304197","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304197","url":null,"abstract":"In today's corporate landscape, optimizing performance has emerged as a formidable challenge for organizations, often hindered by formidable barriers and psychological factors. This study explores the role of anxiety, stress, and depression in attaining performance among Egyptian construction site workers. The quantitative analysis utilizes cross-sectional data collected from workers working at different construction sites in Egypt. The study concludes with findings from 298 valid cases. Leveraging the structural equation model (SEM) in a path analysis, the results unveil a stark negative impact of anxiety (p-value = 0.199), stress (p-value = 0.115), and depression (p-value = 0.209) on overall performance. Furthermore, it underscores the noteworthy predictive power of anxiety (p-value = 0.000) and stress (p-value = 0.000) on depression. These findings carry implications for both policy-makers and psychologists, offering valuable guidance for the formulation of strategies aimed at reducing anxiety, stress, and depression to catalyze enhanced performance. Besides, this study contributes a meaningful empirical perspective to the broader psychological and medical literature drawn from the unique context of construction site workers in a developing nation.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139240296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Insomnia Severity Index among University Students in Korea","authors":"Boram Lee, Yang-Eun Kim","doi":"10.21926/obm.neurobiol.2304196","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304196","url":null,"abstract":"Insomnia is the most common sleep complaint in clinical practice, affecting both the physical and mental health of patients as well as many aspects of their life quality. Young adults, especially university students, are prone to a high prevalence of poor sleep quality or insomnia. Accurate assessment of insomnia severity among university students has become an important issue. One promising screening tool to identify clinically significant insomnia in the campus setting is the Insomnia Severity Index (ISI), a seven-item self-report measure designed to assess the nature and severity of one’s insomnia. Although the ISI has been validated in primary care settings in Korea, no studies have examined its factor structure for university students. This study aimed to analyze the psychometric properties of the Korean version of the ISI. A convenience sample of 252 undergraduate students aged 18-64 attending a four-year university in South Korea was recruited for the study. The collected data underwent exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), which tested alternative models to determine the factorial structure of the ISI. Internal consistency and convergent and discriminant validity were examined. CFA findings showed that a two-factor model best fit the data. The ISI was found to be significantly correlated with higher depressive symptoms and possess adequate internal consistency. Our study confirmed that the ISI had insufficient reliability and good convergent and discriminant validity. This study generally supports the validity and factor structure of the ISI. Its two-factor structure is a psychometrically robust measure for evaluating the prevalence of insomnia.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of Chronic Pain in Post-Critical Care Patients. A Narrative Review","authors":"Evanthia Asimakopoulou, Periklis Zavridis","doi":"10.21926/obm.neurobiol.2304194","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304194","url":null,"abstract":"Chronic pain in post-critical care patients is a multifaceted issue with profound implications for patient well-being and quality of life. This review aims to address the rehabilitation of patients who suffer from chronic pain following discharge from the intensive care unit (ICU). Despite growing awareness of the prevalence and impact of this condition, significant gaps in knowledge persist regarding the optimal rehabilitation strategies for these patients. To conduct this study, an extensive literature search was undertaken, encompassing peer-reviewed articles, clinical trials, and observational studies in Medline, Scopus, and Cinahl databases, using specific keywords. Studies were identified based on their titles, abstracts, and those that met the inclusion criteria. Sixteen studies were eligible for inclusion in this review, varying in methodology, assessment tool, assessment time, or follow-up. The findings of this review illuminate the existing gaps in knowledge by synthesizing evidence on the various rehabilitation approaches employed, their effectiveness, and the factors influencing patient outcomes. So far, healthcare professionals have targeted either pain treatment, finding an analgesic medication or the proper position/exercise, or pain management, helping the patient manage life despite the unrelieved pain. Conventional pain treatment or control has been replaced by pain rehabilitation, in which a biopsychosocial approach enables healthcare professionals to provide patients with the knowledge and skills to manage their pain and disability through personal multidimensional choices. Early rehabilitation programs, quick mobilization, and greater family participation should be encouraged. The strengths of this study lie in its thorough analysis of the available literature and the provision of valuable insights into the heterogeneous nature of chronic pain in post-critical care patients. However, limitations include the limited availability of high-quality randomized controlled trials in this domain. Overall, this review contributes to an improved understanding of rehabilitation strategies for chronic pain in post-critical care patients and underscores the need for further research to enhance patient care and outcomes.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"111 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135345438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological Resources for Early Intervention in Cases of Dyscalculia: A Deductive-Inductive Categorization","authors":"Estefanía Espina, José M. Marbán, Ana Maroto","doi":"10.21926/obm.neurobiol.2304191","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304191","url":null,"abstract":"Dyscalculia is a math learning disability that significantly interferes with students' academic performance and math-related aspects of their daily lives. Early diagnosis and the design of intervention programs adapted to the needs of each case are essential. In this sense, multiple technological resources are created to address both issues. Still, it is difficult to identify which characteristics they share and which are more relevant regarding didactic suitability. Given this situation, this research proposes categorizing these resources according to the type of addressee, objective, format, and supporting scientific evidence. The categorization process has been carried out in two phases: deductive and inductive. In the first phase, a systematic review of the literature was carried out in the main scientific publication databases. Based on the review publications reading, the aspects common to the technological resources found were identified in the second phase, and the final categorization criteria were created. The result of such a procedure provides a valuable bank of technological resources for intervention in dyscalculia at early ages. However, more scientific evidence is lacking to support its efficacy and validity in educational settings.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"2009 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135366175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroleptic Malignant Syndrome in a Patient with Autism Spectrum Disorder: Case Report","authors":"Stefan Klek, Jonathan Newgren, Philip Burns, Angelika Kwak, Eric Casinelli, Tony Tu, Theodote Pontikes, Edwin Meresh","doi":"10.21926/obm.neurobiol.2304188","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304188","url":null,"abstract":"Neuroleptic Malignant Syndrome (NMS) and Malignant Catatonia (MC) are conditions with significant overlap and are classically characterized by autonomic dysfunction, rigidity, bradyreflexia, posturing, lead-pipe rigidity in the former and waxy flexibility in the latter, stereotyping, an increase in creatinine kinase, and/or leukocytosis. Onset after inciting factor ranges from days to weeks, as does resolution with appropriate treatment. The overlap in symptomatology with Autism spectrum disorder (ASD) presents a formidable diagnostic challenge in a situation that must be parsed out with alacrity and accuracy. An 18-year-old male with a history of ASD, developmental delay with limited verbal use (functional age of approximately 5 years), and intermittent explosive disorder initially presented to an outside inpatient psychiatry hospital for worsening agitation that had spanned several weeks. At the outside facility trazodone, haloperidol, and clonazepam were added to his usual home regimen of valproic acid and escitalopram. Over the course of the next two weeks, he developed lethargy, tachycardia, and hypertensive emergency at which point he was transferred to our medical center’s Emergency Department. Due to concern over infection vs NMS/MC, an initial treatment plan consisted of: strict avoidance of all antipsychotics, scheduled acetaminophen for antipyretic care, 100 cc/hr IV fluids for rhabdomyolysis, a respiratory PCR panel, blood cultures, lorazepam 2 mg IV q6h, valproic acid 250 mg IV BID PRN for agitation, and discontinuation of patient’s home escitalopram. As patient was scoring positively for catatonia per Bush-Francis rating scale with scores of up to 20 and notable for marked tremulousness, myoclonic movements, rigidity with negativism, waxy flexibility, gegenhalten, and fever, the psychiatry service recommended starting a bromocriptine trial of 2.5 mg PO every 8 hours due to worry for progression to NMS/MC due to the antipsychotics he had received at the outside psychiatric facility. After down-titrating the bromocriptine dose as his symptoms resolved and up-titrating to doses as high as 7.5 mg every 6 hours when fever and concern for lead-pipe rigidity developed over a week after his symptoms had initially resolved, after nearly a month our patient was able to successfully be titrated down to a home regimen of lorazepam 1 mg at bedtime for the next 6 months. What made this case particularly unique (other than NMS/MC and ASD sharing many characteristics) were the many logistical hurdles that had to be navigated: first, our institution does not have an in-house Medicine-Psychiatry floor or electroconvulsive therapy (ECT), the definitive treatment for NMS/MC; second, there were neither adult nor pediatric inpatient Medicine-Psychiatry facilities in our state equipped with ECT that were willing to accept our patient as a transfer due to his developmental and physiological age, respectively. This case demonstrates the significant overlap ","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135854379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bioactive Compounds Obtained from Ginkgo Biloba Against Crystal Structure of Myelin Oligodendrocyte Glycoprotein (MOG)","authors":"Aaryan Gupta, Arpita Roy, Soumya Pandit, Neha Pandey, Sarvesh Rustagi","doi":"10.21926/obm.neurobiol.2304186","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304186","url":null,"abstract":"Multiple Sclerosis (MS) spreads rapidly across the globe, causing almost 2.8 million cases worldwide. Many drugs and inhibitors, such as dronabinol and nabilone, have been used to treat MS, but there is no effective treatment for MS till now as these medications can cause severe side effects. So, we tested different compounds from <em>Ginkgo biloba</em> to inhibit the symptoms caused by MS as an herbal treatment. We targeted the Crystal structure of Myelin Oligodendrocyte Glycoprotein as it has shown some excellent results in experimental labs. In this article, the binding interactions through the molecular docking model was performed. Further compound's effectiveness through various screening protocols such as the ADME Test, Bioavailability Radar Test, and BOILED-Egg Test has been done. This study found that Amentoflavone and Isoginkgetin have the potential to inhibit the Crystal Structure of Myelin Oligodendrocyte Glycoprotein as they show the least binding energies which are -7.79 kcal/mol and -8.14 kcal/mol. To check the effectiveness of these compounds, Molecular Dynamics Simulations and in-vitro studies can be done to find some possible herbal treatments for Multiple Sclerosis.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135095052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Intentionality Modulation at the Cell Level: Low-Frequency Oscillations for Temporal Coordination in Bioengineering Systems","authors":"Igor Val Danilov","doi":"10.21926/obm.neurobiol.2304185","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304185","url":null,"abstract":"The theoretical article aims to develop knowledge about the modulation of shared intentionality at the cellular level. A hypothesis about the neurobiological processes during shared intentionality argues that this pre-perceptual communication occurs through nonlocal neuronal coupling in an ecosystem that can be described as the mother-fetus communication model. The current theoretical study analyses literature to discuss recent findings on the effect of oscillations on neuronal temporal coordination to verify whether external low-frequency oscillations can only synchronize specific local neuronal networks from peripheral and central nervous subsystems for modulating shared intentionality. The review discusses 4 findings. First, gamma oscillations are associated with the temporal coordination of local ensembles of cells. Second, there is a relationship between low-frequency brain oscillations and the temporal coordination of peripheral and central nervous subsystems. Third, delta oscillations influence neuronal activity by modulating gamma activity. Fourth, external delta and gamma oscillations increase cortical excitability. The article concludes that delta oscillations can modulate gamma oscillations in the different subsystems of the nervous system, providing temporal network coordination. An external low-frequency oscillator can coordinate only relevant local neuronal networks in various subsystems already exhibiting gamma activity.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134946115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic Factors, COVID-19-related Factors, and PTSD Symptom Clusters: Exploring Associations and Implications for Mental Health","authors":"Anita Padmanabhanunni, Tyrone Pretorius","doi":"10.21926/obm.neurobiol.2303184","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2303184","url":null,"abstract":"The COVID-19 pandemic was characterized as a continuous traumatic stressor and associated with high levels of posttraumatic stress disorder (PTSD). This study examines the associations between demographic factors, COVID-19-related factors (fear of COVID-19 and perceived stress), and PTSD, as well as the associations between PTSD and indices of mental health. The participants in the study were university students (n = 322) who completed the PTSD Checklist for the Diagnostic and Statistical Manual-5 (DSM-5), the Fear of COVID-19 Scale, the Perceived Stress Scale, short forms of the Beck Hopelessness Inventory, the Center for Epidemiological Studies Depression Scale, and the trait scale of the State-Trait Anxiety Inventory. We used multiple regression analyses to determine significant predictors of PTSD and mental health. The results revealed distinctive associations between PTSD symptom clusters and the study’s variables. Perceived stress and fear of COVID-19 emerged as the strongest predictors of all PTSD symptom clusters. Participants who tested positive for COVID-19 reported high levels of intrusive re-experiencing. Age predicted negative alterations in cognition, mood, and hyperarousal. Furthermore, negative alterations in cognition and mood were the most significant predictors of anxiety, depression, and hopelessness, while hyperarousal was a significant predictor of anxiety and depression. The findings suggest that the potential benefits of implementing a rapid assessment of mental health among students at the outset of a disease outbreak can facilitate targeted intervention efforts. In addition, interventions that enhance resilience and coping may serve a protective function in mental health outcomes. Given the central role of maladaptive cognitions in the persistence of PTSD, interventions that focus on enhancing adaptive appraisals may bolster students' capacity to cope with adversity.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135816669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How COVID-19 Ceases All Older Adult Services &amp; the Way Out for Community-Dwelling Older Adults with Chronic Pain","authors":"Mimi Mun Yee Tse, Shamay Sheung Mei Ng, Vivian Lou, Raymond SK Lo, Daphne Sze Ki Cheung, Paul H Lee, Shuk Kwan Tang, Siu Hang Leung, Percy Poo-See Tse","doi":"10.21926/obm.neurobiol.2303183","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2303183","url":null,"abstract":"The COVID-19 pandemic started at the beginning of 2020. It significantly impacted the older adults in Hong Kong, with most of the community centers and elderly centers being closed down under various restrictive measures. Thus, community-based health promotion activities were temporarily paused, which decreased older adults’ health-promoting behaviors and motivation to stay active. This research aimed to improve the quality of life and the health of older adults with chronic pain through the pain management program. This study was conducted face-to-face on the campus of Hong Kong Metropolitan University. This dyadic pain management program (DPM) was an 8-week group-based program. The DPM comprised 4 weeks of campus-based activities and 4 weeks of digital-based activities delivered via a WhatsApp group. An 80% participation rate in the campus-based activities was regarded as completing the DPM. The control group only received lesson leaflets. Pain intensity, pain self-efficacy, psychological health of pain victims, caregiver burden inventory, and a semi-structured interview were evaluated at week 1 (T0), week 8 (T1), and week 12 (T2) after randomization. The IBM-SPSS version 22 was used to perform statistical analyses. Using non-pharmacological methods and regular exercise for 12 weeks improved physical health in terms of pain intensity, pain self-efficacy, and psychological health in anxiety, depression, and stress. For caregivers, their burden decreased after the pain management program. These findings indicated that Pender’s Health Promotion Model is helpful to empower the participants and their caregivers with knowledge, skills, and power to manage their chronic pain situations. Utilizing this model as a framework, Researchers can design more effective non-pharmacological interventions for older adults to increase their engagement in health-promoting activities in the community.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135436875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affinity for Technology Relates to Group Cohesion for New, But Not Existing, Groups","authors":"Marlena R. Fraune, Danielle Langlois, Harrison R. Preusse, Jennifer Rheman, Katrina M. Ling, Katherine M. Tsui","doi":"10.21926/obm.neurobiol.2303182","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2303182","url":null,"abstract":"During the 2020 COVID-19 pandemic, governments around the world mandated shutdowns and social distancing, limiting how much people could see other people outside of their household. Because of this, people had negative mental health outcomes, and many people turned to technology to maintain connections and create new ones. In this paper, we examine the relationship between technology, mental health, and group cohesion with existing groups (N = 202) and new groups (N = 74). We surveyed U.S. participants in June 2020, two to three months after the start of mandated social distancing. Results indicated that, as predicted, higher levels of reported group cohesion typically related to better reported mental health; however, the relationship occurred differently for existing groups compared to new groups. Further, higher levels of affinity for technology did not relate to group cohesion for existing groups, but did relate to more perceived cohesion for new groups. Researchers and mental health practitioners can use these results to help people develop a sense of group cohesion with new and existing groups and improve mental health during relative social isolation; technology may be especially beneficial for people to connect with new groups compared to existing groups.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44912332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}