Neurotrauma reports最新文献

{"title":"Epidemiology of Traumatic Cervical Spinal Cord Injury in Southeast Norway.","authors":"Mona Strøm, Jalal Mirzamohammadi, Thomas Glott, Tor Brommeland, Hege Linnerud, Pål Andre Rønning, Syed Ali Mujtaba Rizvi, Donata Biernat, Tor Arnøy Austad, Marianne Efskind Harr, Mads Aarhus, Eirik Helseth","doi":"10.1089/neur.2025.0013","DOIUrl":"10.1089/neur.2025.0013","url":null,"abstract":"<p><p>A traumatic cervical spinal cord injury (cSCI) is a severe consequence of trauma to the cervical spine with high mortality and morbidity rates. Epidemiological studies of traumatic cSCIs are necessary for planning preventive measures and health care resource allocation. This is a retrospective database study of 387 consecutive patients with traumatic cSCI admitted to hospitals in Southeast Norway between 2015 and 2022. The estimated incidence of traumatic cSCI was 1.6 per 100,000 per year. The incidence rates adjusted for standard European and global populations were 1.7 and 1.1 per 100,000 per year, respectively. The median patient age was 64 years, 75% were males, 40% had severe comorbidities, 65% of injuries were caused by falls, 25% were ethanol influenced, 44% had multiple traumas, and 96% were admitted to the Neurotrauma Center (NTC). In patients with C0-C2 injury, an odontoid fracture with dislocation of the odontoid fragment was most frequent. The most frequent subaxial injuries were, according to the AO Spine subaxial cervical spine injury classification system, minor nonstructural injuries (type A0) and translational injuries (type C). Eleven percent of patients were diagnosed with cSCIs at C0-C2, and 89% of cSCIs were subaxial. According to the American Spinal Injury Association (ASIA) Impairment Scale (AIS), 17% of cSCIs were classified as A, 12% B, 24% C, and 47% D. Forty-three percent of patients were classified as central cord syndrome, which was significantly associated with subaxial injuries and preinjury degenerative cervical spinal stenosis. Compromised respiration due to the cSCI itself was diagnosed in 17% of patients and was predominant in patients with complete cSCIs (AIS A or B) and high cervical injuries. These data will be helpful in planning the capacity of NTCs in the future. Interventions to prevent falls in elderly individuals and to increase awareness of ethanol as a risk factor for severe cSCIs are needed.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"539-550"},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Prevalence of Deep Vein Thrombosis in Patients with Spinal Cord Injury: A Systematic Review and Meta-Analysis.","authors":"Kai Wang, Kunbin Li, Baochao Fan, Yingchun Gu, Xiaopeng Wen, Zhiyuan Wu, Xianli Yao, Pingge Sun, Bing Jiao, Xiaoxing Li, Yage Liu, Liming Lu","doi":"10.1089/neur.2024.0144","DOIUrl":"10.1089/neur.2024.0144","url":null,"abstract":"<p><p>A meta-analysis of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI) was performed using five databases (PubMed, Embase, the Cochrane Library, Web of Science, and Scopus) from 2000 to March 2023. Observational descriptive studies investigating the prevalence of DVT among patients with SCI were included. Data were retrieved by author, country, continent, gender, age, sample source, and additional variables. Risk of bias was evaluated using the Joanna Briggs Institute Critical Appraisal Instrument for Studies Reporting Prevalence. Data and random-effects models were used to synthesize existing findings. Among 45 studies, the overall pooled estimated prevalence of DVT was 14.53% (95% confidence interval [CI], 11.22 - 17.84%) in patients with SCI (<i>n</i> = 87,294), including 14.77% (95% CI, 11.19 - 18.35%) in patients with acute SCI and 19.02% (95% CI, 11.51 - 26.53%) in patients with SCI older than 18 years. A total of 26 studies from hospitals showed that the combined prevalence estimate of DVT in patients with SCI was 16.41% (95% CI, 11.36 - 21.45%), and in 19 studies from rehabilitation institutions was 12.33% (95% CI, 8.25 - 16.42%). Moreover, the prevalence of DVT in patients with SCI is influenced by factors such as regional distribution, demographic characteristics, the extent of nerve damage, the level of the lesion, and the implementation of thromboprophylaxis. We estimated the overall pooled prevalence of DVT after SCI in distinctive characteristics. These findings can provide a reference for future epidemiological studies of DVT in patients with SCI. Given the substantial variety of the included studies (e.g., diagnostic methodologies, demographic characteristics), our results should be interpreted with caution.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"491-505"},"PeriodicalIF":1.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Fragmentation as a Diagnostic Biomarker of Traumatic Brain Injury.","authors":"Grant S Mannino, Christian R Baumann, Mark R Opp, Rachel K Rowe","doi":"10.1089/neur.2025.0050","DOIUrl":"10.1089/neur.2025.0050","url":null,"abstract":"<p><p>Sleep disturbances are among the most prevalent and persistent consequences of traumatic brain injury (TBI), yet they remain underutilized as clinical indicators of injury status. In this perspective, we propose that sleep fragmentation-defined as the frequency of transitions between sleep and wakefulness-represents a functional, scalable, and underrecognized diagnostic biomarker of TBI. Drawing on empirical findings from a mouse model of diffuse TBI, we show that summary measures of sleep fragmentation and duration can reliably distinguish injured from uninjured animals using dimensionality reduction and machine learning techniques. Current biomarkers such as glial fibrillary acidic protein and neurofilament light chain provide valuable insights into structural damage but offer limited information about how injury affects behavior and day-to-day function. Sleep-based metrics, by contrast, reflect neural network integrity and capture ongoing physiological disruption. Critically, these metrics can be collected non-invasively, longitudinally, and in real-world settings using actigraphy, making them a practical complement to blood-based diagnostics that require biological sampling and specialized laboratory infrastructure. Our analysis demonstrates that sleep metrics collected over 48 h post-injury-specifically the number of sleep-wake transitions-carry a strong diagnostic signal. Sleep metrics offer a behaviorally grounded complement aligned with the goals of precision medicine and functional assessment. With further validation, these features may also support monitoring recovery or stratifying injury severity. This perspective highlights sleep fragmentation as a non-invasive diagnostic biomarker for TBI with the potential to enhance individualized monitoring and support early detection efforts in both research and clinical settings.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"482-490"},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.","authors":"Gergely David, Alice Motovylyak, Felix Schlegel, Zsofia Kovacs, Christian Kündig, Angela R Filous, Jan M Schwab, Matthew D Budde, Jan Klohs, Patrick Freund","doi":"10.1089/neur.2025.0011","DOIUrl":"10.1089/neur.2025.0011","url":null,"abstract":"<p><p>In acute human spinal cord injury (SCI), magnetic resonance imaging (MRI) reveals progressive neuroanatomical changes at the lesion site and in remote regions. Here, we aimed to elucidate the structural underpinnings of these neuroanatomical changes and to characterize their spatiotemporal distribution in a rat contusion SCI model, using both histology and MRI. First, rats subjected to a thoracic contusion SCI (T8) and sham-operated rats were sacrificed at 56 days post-injury (dpi), and SMI-32 immunohistochemistry was used to assess remote axonal degeneration at cervical segments C2-C5. Second, to evaluate the effect of severity and time since injury on axonal degeneration, rats of varying injury severity were sacrificed at 2, 30, and 90 dpi, respectively, followed by SMI-32 immunohistochemistry. Third, <i>ex vivo</i> structural MRI and diffusion tensor imaging were performed rostral to the injury site (C3-T6) at 90 dpi. Histological evidence of axonal degeneration emerged as early as 2 dpi rostral to the injury site, persisting at 90 dpi. Severity-dependent degeneration occurred within the fasciculus gracilis and the periphery of the medio- and ventrolateral columns. Corresponding MRI changes, including lower fractional anisotropy in these regions and smaller gray matter area, were detected. In contrast, the dorsal corticospinal tract exhibited lower fractional anisotropy without clear histological abnormalities, potentially due to atrophy-related mislocalization. This highlights the value of correlative, multimodal approaches and the need for further methodological refinement. The number of SMI-32+ axonal profiles correlated negatively, while gray matter area and fractional anisotropy correlated positively with locomotion assessed by Basso, Beattie, and Bresnahan scores. This study demonstrates in independent experiments that neuroanatomical MRI changes observed after SCI, occurring remote from the injury site, are linked to axonal degeneration. Experimental SCI offers translational insights into underlying mechanisms and potential avenues for neuroprotective or rehabilitative approaches.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"443-464"},"PeriodicalIF":1.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quiet Stance Postural Control in Women Who Have a History of Brain Injury from Intimate Partner Violence: A Preliminary Study.","authors":"Bradi R Lorenz, Shambhu P Adhikari, Jonathan D Smirl, Colin Wallace, Quinn Malone, Brian H Dalton, Paul van Donkelaar","doi":"10.1089/neur.2025.0015","DOIUrl":"10.1089/neur.2025.0015","url":null,"abstract":"<p><p>Intimate partner violence (IPV) frequently results in brain injury (IPV-BI) among survivors, with potential long-term effects for both physical and psychological health. This study aimed to examine the impact of chronic IPV-BI on postural control with (eyes open, [EO]) and without (eyes closed, [EC]) visual cues. We hypothesized that more exposure to a history of IPV-BI would be associated with greater postural control disruptions. During quiet stance, a force plate recorded forces and moments from which center of pressure (COP) variables were calculated to assess postural control. In addition, we sought to explore the relationship between psychological factors with assessments including indices of post-traumatic stress disorder (PTSD) (Clinician-Administered PTSD Scale), depression (Beck's Depression Inventory), and anxiety (Beck's Anxiety Inventory). Forty women survivors of IPV between the ages of 20 and 50 years participated, with the extent of exposure to IPV-BI measured using the Brain Injury Severity Assessment (BISA) tool on a scale of 0-8. Mediolateral (ML) COP displacement amplitude and variability, as well as anteroposterior (AP) COP velocity, was greater with EC than EO (<i>p</i> < 0.05). When participants were stratified into those with a low (0-2) and high (6-8) BISA score, participants in the high BISA (6-8) group exhibited greater COP area, ML COP amplitude and variability than those in the low BISA group (0-2; <i>p</i> < 0.05). Multiple linear regression analysis revealed that, independent of BISA score, PTSD symptoms contributed to changes in balance variables during the EO condition (<i>p</i> < 0.05). Taken together, our findings indicate the extent of exposure to a previous history of IPV-BI is linked to impairments in postural control as assessed by a variety of COP parameters. Given that standing balance is critical for function and mobility during activities of daily living, postural control assessments could serve as a valuable tool in diagnosing chronic IPV-BI. Thus, our study emphasizes the need for further research to better understand the physiological and psychological factors related to IPV-BI.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"413-424"},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for Withdrawal of Life-Sustaining Treatment in the Analysis of Traumatic Brain Injury Studies.","authors":"Brian C Healy, Brian L Edlow, Yelena G Bodien","doi":"10.1089/neur.2025.0010","DOIUrl":"10.1089/neur.2025.0010","url":null,"abstract":"<p><p>Studies that aim to evaluate outcomes after severe traumatic brain injury (TBI) must account for patients who die after withdrawal of life-sustaining treatment (WLST). If we are willing to assume that some of the patients who die of WLST might have had a good outcome at 6 months, the choice of analytic approach may impact the results. In this study, 6-month clinical outcomes for patients with TBI were simulated under six different scenarios related to WLST. Each scenario represents different assumptions related to the decision to choose WLST and how that decision relates to the 6-month clinical outcome. For each simulated dataset and scenario, three analytic approaches were used to estimate the probability of a good outcome at 6 months: complete case analysis, worst-case imputation, and inverse probability weighted analysis. The bias of the estimate from each of the approaches was used to compare the performance of the analysis approaches. When the probability of WLST was equal for all patients (i.e., covariates were not factored into the WLST decision), both the complete case analysis and the inverse probability weighted analysis were unbiased. When only patients who would have a poor outcome at 6 months were eligible to have WLST, only the worst-case imputation analysis was unbiased. When the probability of WLST was a function of observed patient characteristics that were also related to 6-month outcome (e.g., age, injury severity), only the inverse probability weighted analysis was unbiased. Finally, when the probability of missingness was related to an unobserved patient characteristic, none of the approaches were unbiased. If some patients who die of WLST might have had a good outcome, inverse probability weighting could be considered to decrease bias associated with censoring or imputing poor outcomes for participants with WLST.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"435-441"},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats.","authors":"Toru Asari, Sunao Tanaka, Damien D Pearse, Juan Pablo de Rivero Vaccari, Toshitada Sawada, Yasuyuki Ishibashi, Robert W Keane, W Dalton Dietrich","doi":"10.1089/neur.2025.0044","DOIUrl":"10.1089/neur.2025.0044","url":null,"abstract":"<p><p>Spinal cord injury (SCI) triggers an inflammatory response that is partially mediated by the inflammasome and the production of pro-inflammatory cytokines. We have previously shown that pannexin-1 is involved in the activation of the inflammasome, and that probenecid inhibits this caspase-1-mediated inflammatory process. In this study, we employed an <i>in vivo</i> model of contusive SCI to investigate the therapeutic effect of acute probenecid administration on histopathological and functional outcomes following SCI. Adult female Fischer rats (<i>n</i> = 46) underwent moderate thoracic SCI produced by dropping a 10 g weight from a height of 12.5 mm onto the exposed cord at T9, assigned three different groups, PBS administration group, and 1, 10, 100 mg/kg probenecid group, those were injected subcutaneously 15 min and 12 h after SCI. The sham group (<i>n</i> = 11) was the group that only had a laminectomy and did not have SCI. Histopathological analysis by Luxol Fast Blue/hematoxylin and eosin staining revealed that the penumbra volume was significantly reduced in the probenecid 100 mg/kg group compared with the PBS group. CatWalk gait analysis was performed at 7 weeks after SCI, which showed significant differences in coordination between the PBS and the probenecid 100 mg/kg-treated groups. Acute administration of probenecid after SCI resulted in the preservation of penumbra formation and coordination function in a thoracic SCI rat model. This report suggests that probenecid, an inhibitor of pannexin-1, has the potential to prevent secondary injury after SCI and improve outcomes following SCI.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"425-434"},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Injection of Ghrelin (OXE-103) Improves Subacute Concussion Symptom Burden and Quality of Life.","authors":"Michael Rippee, Michael Wyand, Jamie Chen, Amelia Kirchhoff-Rowald, Suzanne Hunt, Vishal Bansal","doi":"10.1089/neur.2025.0038","DOIUrl":"10.1089/neur.2025.0038","url":null,"abstract":"<p><p>Concussions remain the leading form of traumatic brain injury. Despite this, there is a paucity of pharmacologic and evidence-based treatments. The objective of this study was to investigate the benefit of Ghrelin (OXE-103) as a novel treatment for subacute concussion. The study consisted of an open-label treatment arm (OXE-103) with a nontreatment concurrent control arm receiving standard of care (SOC-only). Participants had a documented concussion, within 28 days of injury, and a Post-Concussion Symptom Scale (PCSS) of 20 or more. A total of 19 subjects completed the study: 13 treatments and 6 SOC. Treatment consisted of OXE-103 40 μg/kg twice daily by self-injection for 14 days. Main Outcome Measures were change in PCSS and Quality of Life after Brain Injury-Overall Scale (QOLIBRI-OS). Outcome measures were assessed at days 1, 4, 8, 11, 15, 21, and 44. A secondary outcome was 20% improvement on either which was considered a clinically meaningful response. We found a decrease in PCSS from baseline with OXE-103 (median -34 [interquartile range {IQR}: -44, -24]) at day 44 versus SOC (median -7 [IQR: -22, 16]) at day 44. We also found an improvement in QOLIBRI-OS from baseline with OXE-103 (median 21 [IQR: 12.5, 50]) at day 44 versus SOC (2 [IQR: -25, 20.8]) at day 44. 85% (95% confidence interval [CI]: 53, 98) of subjects treated with OXE-103 had a clinically meaningful response at day 44 on PCSS versus 33% (95% CI: 4, 78) of subjects in the SOC arm. When looking at improvement in QOLIBRI-OS, 85% (95% CI: 53, 98) of subjects treated with OXE-103 had a clinically meaningful response at day 44 versus 33% (95% CI: 4, 78) in the SOC arm. We conclude that subjects treated with OXE-103 showed improved PCSS and QOLIBRI-OS scores compared to those receiving only standard therapy. We recognize the limitations of this study, including small sample size and lack of randomization. The results indicate that OXE-103 is a potential therapeutic agent to treat patients with ongoing concussion symptoms. A larger, multicenter, randomized, placebo-controlled trial would be an important next step.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"402-412"},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Neurobehavioral and Neuropathological Consequences of Repeated Blast Exposure in P301S Transgenic Tau Rats.","authors":"Claire Robey, Antigone Grillakis, Anya Fan, Jiong Liu, Laura B Tucker, Amanda H Fu, Yeonho Kim, Joseph T McCabe","doi":"10.1089/neur.2024.0168","DOIUrl":"10.1089/neur.2024.0168","url":null,"abstract":"<p><p>Repeated blast traumatic brain injury (rbTBI) is linked to dementia risk, potentially due to abnormal tau accumulation, although a definitive causal relationship remains elusive. This study aims to develop a model of rbTBI-induced tauopathy. We utilized wild-type (WT) rats and rats that are heterozygous for the mutated P301S human tau gene (Tg12099 +/-), the presence of which increases the propensity to develop tau neuropathology. At 2-3 months of age, rats were exposed to five blasts using the Advanced Blast Simulator or sham procedures. Behavioral and histological outcomes were evaluated at 10 and 15 months post-injury, respectively. The open field test revealed increased activity in blast-injured animals compared with sham. Tg12099 +/- females exhibited greater travel distances than WT females, while male activity levels did not differ by genotype. The novel object recognition test indicated impaired recognition memory in blast-injured animals, which was unrelated to genotype. There was a greater accumulation of phosphorylated tau in several brain regions of Tg12099 +/- rats compared with WT rats, yet no observable blast injury effect. Blast did not alter astro- and microgliosis, but increased astrogliosis was observed in Tg12099 +/- rats compared with WT rats in a region-dependent manner. We observed sex-dependent changes in microgliosis within the Tg12099 +/- group, with male Tg12099 +/- rats exhibiting increased IBA1 immunostaining compared with females. No such sex difference was observed in WT rats. Our findings suggest that while rbTBI can induce persistent behavioral deficits in rats, it does not exacerbate neuropathology in Tg12099 rats.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"374-390"},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Community Effort to Develop Common Data Elements for Pre-Clinical Spinal Cord Injury Research.","authors":"Britt A Fedor, Abel Torres-Espin, Romana Vavrek, Maryann E Martone, John L Bixby, John C Gensel, Vance Lemmon, Jeffrey S Grethe, J Russel Huie, Adam R Ferguson, Karim Fouad","doi":"10.1089/neur.2025.0021","DOIUrl":"10.1089/neur.2025.0021","url":null,"abstract":"<p><p>For nearly 350 years, the process of disseminating scientific knowledge has remained largely unchanged. Scientists conduct experiments, analyze the data, and publish their findings in the form of scientific articles. Since the turn of the century, this process has been challenged by numerous open science and data sharing efforts to enhance transparency, reproducibility, and replicability of scientific research. Big data approaches, together with machine learning and artificial intelligence, are frequently used to gain insight into the ever-growing complexity of biological systems and biomedical research. To utilize these approaches and harness the continuously increasing computational power requires data to be both machine readable and, ideally, harmonized across studies. Therein lies the challenge: understanding how to organize and describe data is a critical skill for scientists, yet one that is rarely explicitly taught. Common data elements (CDEs), standardized definitions, and reporting structures for data represent a practical solution to this challenge. With the goal of creating a common language to describe and share pre-clinical spinal cord injury (SCI) research data, the open data commons for SCI, in collaboration with the National Institute of Neurological Disorders and Stroke, kicked off this process with the \"Preclinical SCI Common Data Elements (CDE) Workshop,\" held in conjunction with the National Neurotrauma Symposium in San Francisco, California in June 2024. In this report, we discuss the workshop proceedings, summarize the input provided by the SCI research community, share insights from related CDE efforts, and provide a pragmatic approach to creating CDEs for pre-clinical SCI research.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"6 1","pages":"391-401"},"PeriodicalIF":1.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}