Neurotrauma reports最新文献_第10页

Characterizing Sex Differences in Mitochondrial Dysfunction After Severe Traumatic Brain Injury in Mice. 小鼠严重颅脑损伤后线粒体功能障碍的性别差异特征。

Neurotrauma reports Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0046

Olivia J Kalimon, Hemendra J Vekaria, Gopal V Velmurugan, W Brad Hubbard, Patrick G Sullivan

{"title":"Characterizing Sex Differences in Mitochondrial Dysfunction After Severe Traumatic Brain Injury in Mice.","authors":"Olivia J Kalimon, Hemendra J Vekaria, Gopal V Velmurugan, W Brad Hubbard, Patrick G Sullivan","doi":"10.1089/neur.2023.0046","DOIUrl":"10.1089/neur.2023.0046","url":null,"abstract":"Traumatic brain injury (TBI) is caused by an impact or penetrating injury to the head resulting in abnormal brain function. Mitochondrial dysfunction is an important hallmark of TBI and has been thoroughly studied in male rodent models of brain injury, but relatively little is known about these outcomes in females. These studies were designed to examine sex as a biological variable for mitochondria-related outcomes after the severe controlled cortical impact (CCI) mouse model of TBI. Synaptic and non-synaptic mitochondria were isolated from the sham- or CCI-injured cortex as well as the hippocampus ipsilateral to the craniotomy 3, 12, 24, or 48 h post-surgery, and then bioenergetics were measured. Subtle variations were observed in the timeline of mitochondrial dysfunction between sexes. Non-synaptic cortical mitochondria from injured females showed early impairment at 12 h post-CCI compared to mitochondria from injured males at 24 h post-CCI. Contrastingly, in the synaptic fraction, mitochondria from injured males showed early impairment at 12 h post-CCI, whereas mitochondria from injured females showed impairment at 24 h post-CCI. Based on bioenergetic impairments at 24 h post-CCI, synaptic and non-synaptic mitochondrial calcium loading was also measured at this time point. Consistent with bioenergetic data at 24 h, non-synaptic mitochondria from injured males had increased calcium loading compared to uninjured control, but this effect was not observed in females. Finally, histological assessment of cortical tissue sparing in each sex was measured at 7 days post-injury. There was a lack of sex-based differences in cortical tissue sparing after severe CCI. Overall, there were some subtle sex differences in mitochondrial outcomes after CCI, but these findings were not statistically significant. This study highlights the importance of utilizing both sexes when measuring mitochondrial function after severe CCI.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"627-642"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms. 在有轻度颅脑损伤史和创伤后应激障碍症状的军事APOE-4携带者中，花生四烯酸衍生的氧化脂质和Anandamide水平升高。

Neurotrauma reports Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0045

Aurore Nkiliza, Claire J C Huguenard, Gregory J Aldrich, Scott Ferguson, Adam Cseresznye, Teresa Darcey, James E Evans, Michael Dretsch, Michael Mullan, Fiona Crawford, Laila Abdullah

{"title":"Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.","authors":"Aurore Nkiliza, Claire J C Huguenard, Gregory J Aldrich, Scott Ferguson, Adam Cseresznye, Teresa Darcey, James E Evans, Michael Dretsch, Michael Mullan, Fiona Crawford, Laila Abdullah","doi":"10.1089/neur.2023.0045","DOIUrl":"10.1089/neur.2023.0045","url":null,"abstract":"Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, blood biomarkers are still needed to help with a differential diagnosis of mild TBI (mTBI) and post-traumatic stress disorder (PTSD) at chronic post-injury time points. Owing to the association between phospholipid (PL) dysfunction and chronic consequences of TBI, we hypothesized that examining bioactive PL metabolites (oxylipins and ethanolamides) would help identify long-term lipid changes associated with mTBI and PTSD. Lipid extracts of plasma from active-duty soldiers deployed to the Iraq/Afghanistan wars (control = 52, mTBI = 21, PTSD = 34, and TBI + PTSD = 13) were subjected to liquid chromatography/mass spectrometry analysis to examine oxylipins and ethanolamides. Linear regression analyses followed by post hoc comparisons were performed to assess the association of these lipids with diagnostic classifications. Significant differences were found in oxylipins derived from arachidonic acid (AA) between controls and mTBI, PTSD, and mTBI + PTSD groups. Levels of AA-derived oxylipins through the cytochrome P450 pathways and anandamide were significantly elevated among mTBI + PTSD patients who were carriers of the apolipoprotein E E4 allele. These studies demonstrate that AA-derived oxylipins and anandamide may be unique blood biomarkers of PTSD and mTBI + PTSD. Further, these AA metabolites may be indicative of an underlying inflammatory process that warrants further investigation. Future validation studies in larger cohorts are required to determine a potential application of this approach in providing a differential diagnosis of mTBI and PTSD in a clinical setting.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"643-654"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood-Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation. 在从损伤后睡眠碎片中恢复的过程中，出现了发散性空间学习、增强的神经元转录和血脑屏障破坏。

Neurotrauma reports Pub Date : 2023-09-21 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0018

Zoe M Tapp, Cindy Ren, Kelsey Palmer, Julia Kumar, Ravitej R Atluri, Julie Fitzgerald, John Velasquez, Jonathan Godbout, John Sheridan, Olga N Kokiko-Cochran

{"title":"Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood-Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation.","authors":"Zoe M Tapp, Cindy Ren, Kelsey Palmer, Julia Kumar, Ravitej R Atluri, Julie Fitzgerald, John Velasquez, Jonathan Godbout, John Sheridan, Olga N Kokiko-Cochran","doi":"10.1089/neur.2023.0018","DOIUrl":"https://doi.org/10.1089/neur.2023.0018","url":null,"abstract":"Traumatic brain injury (TBI) causes pathophysiology that may significantly decrease quality of life over time. A major propagator of this response is chronic, maladaptive neuroinflammation, which can be exacerbated by stressors such as sleep fragmentation (SF). This study determined whether post-TBI SF had lasting behavioral and inflammatory effects even with a period of recovery. To test this, male and female mice received a moderate lateral fluid percussion TBI or sham surgery. Half the mice were left undisturbed, and half were exposed to daily SF for 30 days. All mice were then undisturbed between 30 and 60 days post-injury (DPI), allowing mice to recover from SF (SF-R). SF-R did not impair global Barnes maze performance. Nonetheless, TBI SF-R mice displayed retrogression in latency to reach the goal box within testing days. These nuanced behavioral changes in TBI SF-R mice were associated with enhanced expression of neuronal processing/signaling genes and indicators of blood-brain barrier (BBB) dysfunction. Aquaporin-4 (AQP4) expression, a marker of BBB integrity, was differentially altered by TBI and TBI SF-R. For example, TBI enhanced cortical AQP4 whereas TBI SF-R mice had the lowest cortical expression of perivascular AQP4, dysregulated AQP4 polarization, and the highest number of CD45+ cells in the ipsilateral cortex. Altogether, post-TBI SF caused lasting, divergent behavioral responses associated with enhanced expression of neuronal transcription and BBB disruption even after a period of recovery from SF. Understanding lasting impacts from post-TBI stressors can better inform both acute and chronic post-injury care to improve long-term outcome post-TBI.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"613-626"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Neurological Emergencies Presenting to Multiple Urban Level 1 Trauma Centers. 多个城市一级创伤中心神经系统急诊的性别差异。

IF 1.8

Neurotrauma reports Pub Date : 2023-09-12 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0050

Linda Papa, John J Cienki, Jason W Wilson, Virginia Axline, Emily A Coyle, Ryan C Earwood, Josef G Thundiyil, Jay G Ladde

{"title":"Sex Differences in Neurological Emergencies Presenting to Multiple Urban Level 1 Trauma Centers.","authors":"Linda Papa, John J Cienki, Jason W Wilson, Virginia Axline, Emily A Coyle, Ryan C Earwood, Josef G Thundiyil, Jay G Ladde","doi":"10.1089/neur.2023.0050","DOIUrl":"10.1089/neur.2023.0050","url":null,"abstract":"Previous studies have suggested that there are sex differences in the treatment and outcome of neurological emergencies; however, research identifying the role these sex differences play in the management of neurological emergencies is lacking. More knowledge of the way sex factors into the pathophysiology of neurological emergencies will be helpful in improving outcomes for these patients. The aim of this cross-sectional study was to assess the prevalence and management of neurological emergencies while evaluating sex differences in the diagnosis and treatment of these emergencies. We analyzed a cohort of 530 adult patients from four level 1 trauma centers over a period of 4 weeks who had a chief complaint of a neurological emergency, including seizures, cerebrovascular events, headache disorders, traumatic brain injuries, and central nervous system infections. Among patients with neurological emergencies, a significantly lower proportion of female patients underwent neurosurgery and were admitted to the intensive care unit compared to male patients, but there were no significant differences between sexes in the time of symptom onset, type of hospital transportation, amount of neuroimaging performed, admission rates, hospital length of stay, and disposition from the emergency department. Although female patients were more likely to have a chief complaint of headache compared to traumatic injuries in male patients, this was not statistically significant. A significantly higher proportion of female patients had health insurance coverage than male patients.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"605-612"},"PeriodicalIF":1.8,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographic and Clinical Characteristics of Persons With Spinal Cord Injury in Bangladesh: Database for the International Spinal Cord Injury Community Survey 2023. 孟加拉国脊髓损伤患者的人口统计学和临床特征：2023年国际脊髓损伤社区调查数据库。

Neurotrauma reports Pub Date : 2023-09-06 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0040

Taslim Uddin, Mohammad Tariqul Islam, Mohammad Hossain, Mohammad Sohrab Hossain, A K M Salek, M Jahidul Islam, Shahidul Haque, Hasna Raihan Rahim, Md Shahadat Hossain, Md Hassanuzzaman, Monirul Islam, Moin Uddin Hossain Khan, Sharif Ahmed, Khurshid Mahmud, Md Rakibul Hasan, Anika Tasnim, M Atiqul Haque

{"title":"Demographic and Clinical Characteristics of Persons With Spinal Cord Injury in Bangladesh: Database for the International Spinal Cord Injury Community Survey 2023.","authors":"Taslim Uddin, Mohammad Tariqul Islam, Mohammad Hossain, Mohammad Sohrab Hossain, A K M Salek, M Jahidul Islam, Shahidul Haque, Hasna Raihan Rahim, Md Shahadat Hossain, Md Hassanuzzaman, Monirul Islam, Moin Uddin Hossain Khan, Sharif Ahmed, Khurshid Mahmud, Md Rakibul Hasan, Anika Tasnim, M Atiqul Haque","doi":"10.1089/neur.2023.0040","DOIUrl":"https://doi.org/10.1089/neur.2023.0040","url":null,"abstract":"The study aims to explore the demographic and clinical characteristics of persons with spinal cord injury (SCI) in Bangladesh. A total of 3035 persons with SCI spanning from 2018 to 2022 were included in this cross-sectional study. Information about demographic and clinical variables was obtained from the medical records and verified through telephone calls to ensure accuracy and consistency. Approximately half (48.30%) of the study participants were located in Dhaka Division. The average age of persons with SCI was 38.3 years, with a standard deviation of 15.9 years, and the largest proportion (33.4%) fell within the age range of 18-30 years. Males outnumbered females by nearly 2.5 times. In the study, 59.6% had suffered traumatic injuries, whereas 40.4% had SCI attributable to disease-related causes; 58.1% were diagnosed with tetraplegia and 40.1% with paraplegia. Fall from height (42.1%) and road traffic trauma (27%) were the most common causes of traumatic injuries. Degenerative myelopathy (41.1%) was the most frequent cause of non-traumatic SCI, followed by tumors (27.7%) and tuberculosis (TB; 14.8%). Both traumatic (58.3%) and degenerative (56.7%) causes of SCI commonly affected the cervical spine, whereas TB (24.4%) and tumors (47.5%) had a higher incidence of affecting the dorsal spine. In the absence of a registry or national database for patients with SCI in Bangladesh, this study would serve as representative data for future studies.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"598-604"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Effects of Buprenorphine on Endoplasmic Reticulum Stress, Abnormal Protein Accumulation, and Cell Loss After Pediatric Mild Traumatic Brain Injury in Mice. 丁丙诺啡对小鼠轻度脑损伤后内质网应激、异常蛋白质积累和细胞损失的性别特异性影响。

Neurotrauma reports Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0051

Megan B Faulkner, Mariam Rizk, Zahraa Bazzi, Robert C Dysko, Zhi Zhang

{"title":"Sex-Specific Effects of Buprenorphine on Endoplasmic Reticulum Stress, Abnormal Protein Accumulation, and Cell Loss After Pediatric Mild Traumatic Brain Injury in Mice.","authors":"Megan B Faulkner, Mariam Rizk, Zahraa Bazzi, Robert C Dysko, Zhi Zhang","doi":"10.1089/neur.2023.0051","DOIUrl":"https://doi.org/10.1089/neur.2023.0051","url":null,"abstract":"Traumatic brain injury (TBI) in children often leads to poor developmental outcomes attributable to progressive cell loss caused by secondary injuries, including endoplasmic reticulum (ER) stress. Buprenorphine (BPN) is commonly used in children for pain management; however, the effects of BPN on ER stress in the pediatric population are still inconclusive. This study investigated the sex-specific effects of BPN on ER stress, abnormal protein accumulation, and cell loss in a mouse impact acceleration model of pediatric TBI. On post-natal day 20-21 (P20-21), male and female littermates were randomized into sham, TBI + saline and TBI + BPN groups. BPN (0.075 mg/kg) was administered to TBI + BPN mice at 30 min after injury and then every 6-12 h for 2 days. The impact of BPN was evaluated at 1, 3, and 7 days post-injury. We found that TBI induced more prominent ER stress pathway activation at 1 and 3 days post-injury in males, compared to females, whereas abnormal protein accumulation and cell loss were more severe in females at 7 days post-injury, compared with males. Although BPN partially ameliorated abnormal protein accumulation and cell loss in both males and females, BPN only decreased ER stress pathway activation in males, not in females. In conclusion, BPN exhibits sex-specific effects on ER stress, abnormal protein accumulation, and cell loss in a time-dependent manner at the acute phase after pediatric TBI, which provides the rationale to assess the potential effects of BPN on long-term outcomes after pediatric TBI in both males and females.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"573-585"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Brain Injuries Impact on School One Month and One Year After Injury. 外伤性脑损伤对学校的影响。

Neurotrauma reports Pub Date : 2023-08-10 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2022.0069

Erik B Philipson, Joan Machamer, Sureyya Dikmen, Nancy Temkin

{"title":"Traumatic Brain Injuries Impact on School One Month and One Year After Injury.","authors":"Erik B Philipson, Joan Machamer, Sureyya Dikmen, Nancy Temkin","doi":"10.1089/neur.2022.0069","DOIUrl":"10.1089/neur.2022.0069","url":null,"abstract":"Traumatic brain injury (TBI) is a major cause of death and disability among the American population, but the impact TBIs have on the school experience of high school, and post-secondary students, is poorly understood. In this study, a cohort of 79 students, ages 15-22, with mild-to-severe TBIs, were retrospectively identified from the University of Washington Traumatic Brain Injury Database and Sample Repository. The Sickness Impact Profile (SIP) was used to determine the frequency at which schooling was impacted by a TBI and identify the most common self-reported issues students faced in their return to school. At 1 month post-injury, 70% of students either had not returned to school as a result of their TBI or had returned to school but experienced issues related to their TBI. The most-reported issues at 1 month were a difficulty keeping up with school work as a result of it taking longer to complete assignments, tiring easily, having to take frequent rests, and grades that were not as good as they used to be. At 1 year post-injury, the number of students whose TBIs were affecting their school situation dropped 20 percentage points to 49%. The most reported issues at 1 year were forgetting more quickly what was learned in class and having more difficulty understanding new concepts and material. These findings indicate that TBIs have a profound effect on a student's school experiences up to at least 1 year post-injury.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"507-514"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypothalamus and Pineal Gland in Rats: An Exploratory Study 爆炸暴露诱导大鼠下丘脑和松果体昼夜节律时钟基因急性改变的探索性研究

Neurotrauma reports Pub Date : 2023-08-01 DOI: 10.1089/neur.2023.0048

Manoj Govindarajulu, Mital Y. Patel, Jishnu K S Krishnan, Joseph B. Long, Peethambaran Arun

引用次数: 0

Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice. 突触结合蛋白1调节雄性载脂蛋白E Epsilon 4小鼠脊髓不完全损伤后的功能恢复。

IF 1.8

Neurotrauma reports Pub Date : 2023-07-27 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0023

Carlos A Toro, Jens Hansen, Mustafa M Siddiq, Kaitlin Johnson, Jiqing Cao, Adriana Pero, Ravi Iyengar, Dongming Cai, Christopher P Cardozo

{"title":"Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice.","authors":"Carlos A Toro, Jens Hansen, Mustafa M Siddiq, Kaitlin Johnson, Jiqing Cao, Adriana Pero, Ravi Iyengar, Dongming Cai, Christopher P Cardozo","doi":"10.1089/neur.2023.0023","DOIUrl":"10.1089/neur.2023.0023","url":null,"abstract":"Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ∼14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for poor outcomes after traumatic spinal cord injury (SCI) and spinal cord diseases such as cervical myelopathy. To date, there is no intervention to promote recovery of function after SCI/spinal cord diseases that is specifically targeted at ApoE4-associated impairment. Studies in the human and mouse brain link ApoE4 to elevated levels of synaptojanin 1 (synj1), a lipid phosphatase that degrades phosphoinositol 4,5-bisphosphate (PIP2) into inositol 4-monophosphate. Synj1 regulates rearrangements of the cytoskeleton as well as endocytosis and trafficking of synaptic vesicles. We report here that, as compared to ApoE3 mice, levels of synj1 messenger RNA and protein were elevated in spinal cords of healthy ApoE4 mice associated with lower PIP2 levels. Using a moderate-severity model of contusion SCI in mice, we found that genetic reduction of synj1 improved locomotor function recovery at 14 days after SCI in ApoE4 mice without altering spared white matter. Genetic reduction of synj1 did not alter locomotor recovery of ApoE3 mice after SCI. Bulk RNA sequencing revealed that at 14 days after SCI in ApoE4 mice, genetic reduction of synj1 upregulated genes involved in glutaminergic synaptic transmission just above and below the lesion. Overall, our findings provide evidence for a link between synj1 to poor outcomes after SCI in ApoE4 mice, up to 14 days post-injury, through mechanisms that may involve the function of excitatory glutaminergic neurons.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"464-477"},"PeriodicalIF":1.8,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Subarachnoid Hemorrhage on the Cardiac Autonomic Function During Rehabilitation in Children After Severe Traumatic Brain Injury. 蛛网膜下腔出血对儿童重型颅脑损伤康复期心脏自主功能的影响。

Neurotrauma reports Pub Date : 2023-07-14 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0032

Gilad Sorek, Sharon Shaklai, Isabelle Gagnon, Kathryn Schneider, Mathilde Chevignard, Nurit Stern, Yahaloma Fadida, Liran Kalderon, Michal Katz-Leurer

{"title":"Impact of Subarachnoid Hemorrhage on the Cardiac Autonomic Function During Rehabilitation in Children After Severe Traumatic Brain Injury.","authors":"Gilad Sorek, Sharon Shaklai, Isabelle Gagnon, Kathryn Schneider, Mathilde Chevignard, Nurit Stern, Yahaloma Fadida, Liran Kalderon, Michal Katz-Leurer","doi":"10.1089/neur.2023.0032","DOIUrl":"10.1089/neur.2023.0032","url":null,"abstract":"This study aimed to investigate the impact of traumatic subarachnoid hemorrhage (tSAH) on cardiac autonomic control system (CACS) function in children after severe traumatic brain injury (TBI) during the subacute rehabilitation period. Thirty-three participants, 8-18 years of age, 42 (14-149) days after severe TBI at the beginning of the subacute rehabilitation, were included in the study. Six participants were diagnosed with tSAH during acute medical care (tSAH group). Heart rate variability (HRV) was assessed by the standard deviation of the N-N interval (SDNN) and the square root of the mean square differences of successive R-R interval (RMSSD) using a Polar RS800CX device while sitting at rest for 5 min. A second assessment was performed 8 weeks later. No significant difference between the tSAH and non-tSAH groups were found in the demographic and functional characteristics or injury severity. However, in comparison to the non-tSAH group, the tSAH group had lower SDNN (23.9 [10.5-47.3] vs. 43.9 [21.8-118.8], respectively; p = 0.005) and RMSSD values (11.8 [5.9-24.5] vs. 29.6 [8.9-71.7], respectively; p = 0.004). Neither group demonstrated changes in HRV values at rest in the second assessment, whereas the significant difference in SDNN (p = 0.035) and RMSSD (p = 0.008) remained. Children diagnosed with SAH after severe TBI presented poorer CACS function during the subacute rehabilitation. Given that reduced HRV values may be a marker for potential heart disease, the medical team should be aware of the influence of existing tSAH. Future studies with larger sample sizes and longer follow-up periods are warranted to further investigate this topic. ClinicalTrials.gov number: NCT03215082.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":"4 1","pages":"458-462"},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0