Neurotrauma reports最新文献_第9页

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

Neurotrauma reports Pub Date : 2024-01-03 eCollection Date: 2024-01-01 DOI: 10.1089/neur.2024.29004.ack

引用次数: 0

Near-Infrared Spectroscopy and Continuous Glucose Monitoring During Therapeutic Hypothermia 治疗性低温期间的近红外光谱和连续葡萄糖监测

Neurotrauma reports Pub Date : 2024-01-01 DOI: 10.1089/neur.2023.0053

Giulia Vagelli, Francesca Garbarino, M. Calevo, G. Brigati, Luca Ramenghi

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Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury 创伤后帕金森病--创伤性脑损伤幸存者中新出现的帕金森病的系统性综述

Neurotrauma reports Pub Date : 2024-01-01 DOI: 10.1089/neur.2023.0104

Catherine Rojvirat, Gabriel R. Arismendi, Erin Feinstein, Maynard Guzman, Bruce A. Citron, V. Delic

引用次数: 0

Exploring Functional Connectivity in Chronic Spinal Cord Injury Patients With Neuropathic Pain Versus Without Neuropathic Pain 探索有神经病理性疼痛与无神经病理性疼痛的慢性脊髓损伤患者的功能连接性

Neurotrauma reports Pub Date : 2024-01-01 DOI: 10.1089/neur.2023.0070

Shreya Mandloi, Mashaal Syed, Isaiah Ailes, Omid Shoraka, Benjamin Leiby, Jingya Miao, S. Thalheimer, Joshua Heller, Feroze B. Mohamed, A. Sharan, J. Harrop, L. Krisa, Mahdi Alizadeh

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Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury 创伤性脑损伤小鼠模型的终生慢性睡眠障碍

Neurotrauma reports Pub Date : 2024-01-01 DOI: 10.1089/neur.2023.0107

Andrew R. Morris, Erwin K. Gudenschwager Basso, Miguel A. Gutierrez-Monreal, Rawad Daniel Arja, Firas H. Kobeissy, Christopher G. Janus, Kevin K.W. Wang, Jiepei Zhu, Andrew C. Liu

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Sex Differences in Sleep Architecture After Traumatic Brain Injury: Potential Implications on Short-Term Episodic Memory and Recovery 创伤性脑损伤后睡眠结构的性别差异：对短期记忆和恢复的潜在影响

Neurotrauma reports Pub Date : 2024-01-01 DOI: 10.1089/neur.2023.0093

Stefanie N. Howell, G. Griesbach

引用次数: 0

Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse. 一名 19 岁虐待儿童患者的创伤性脑病综合征和 Tauopathy。

Neurotrauma reports Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0078

Mike Rueb, Katrin Rauen, Inga Katharina Koerte, Alexandra Gersing, Henrik Zetterberg, Joel Simrén, Matthias Brendel, Kristina Adorjan

{"title":"Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse.","authors":"Mike Rueb, Katrin Rauen, Inga Katharina Koerte, Alexandra Gersing, Henrik Zetterberg, Joel Simrén, Matthias Brendel, Kristina Adorjan","doi":"10.1089/neur.2023.0078","DOIUrl":"10.1089/neur.2023.0078","url":null,"abstract":"The majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline. Tau positron emission tomography (PET) with 220 MBq of [18F]PI-2620 revealed increased focal signal at the frontal and parietal white/gray matter border. Brain magnetic resonance imaging (MRI) showed a cavum septum pellucidum, reduced left-sided hippocampal volume, and a left midbrain lesion. Cerebrospinal fluid results showed elevated total and p-tau. Neurocognitive testing at admission showed memory deficits clearly below average, and hampered dysfunctions according to the slow processing speed with a low mistake rate, indicating the acquired, thus secondary, attentional deficits. We diagnosed the patient with a TES suggestive of chronic traumatic encephalopathy and classified him as having subtle/mild functional limitation with a most likely transition to mild dementia within the TES criteria. This report underlines child abuse as a relevant criterion in diagnosing TES in cases with repetitive hits to the head. In addition to clinical markers, we show the relevance of fluid tau biomarkers and tau-PET to support the diagnosis of TES according to the recently published diagnosis criteria for TES.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrovascular Pressure Reactivity Measures: Index Comparison and Clinical Outcome in Patients With Traumatic Brain Injury Treated According to an Intracranial Pressure-Focused Management: Rejection of the Null Hypothesis. 脑血管压力反应性测量：指数比较与以颅内压为中心的治疗方法治疗脑外伤患者的临床结果：拒绝零假设。

Neurotrauma reports Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0074

Axel Risinger Liljegren, Camilla Brorsson, Marcus Karlsson, Lars-Owe D Koskinen, Nina Sundström

{"title":"Cerebrovascular Pressure Reactivity Measures: Index Comparison and Clinical Outcome in Patients With Traumatic Brain Injury Treated According to an Intracranial Pressure-Focused Management: Rejection of the Null Hypothesis.","authors":"Axel Risinger Liljegren, Camilla Brorsson, Marcus Karlsson, Lars-Owe D Koskinen, Nina Sundström","doi":"10.1089/neur.2023.0074","DOIUrl":"10.1089/neur.2023.0074","url":null,"abstract":"The aim was to investigate whether the pressure reactivity indices PRx, long-PRx (L-PRx), and pressure reactivity (PR) are interchangeable as measures of vascular reactivity, and whether they correlate with clinical outcome when an intracranial pressure (ICP)-targeted treatment regimen is applied in patients with traumatic brain injury (TBI). Patients with TBI (n = 29) that arrived at the hospital within 24 h of injury were included. PRx and L-PRx were derived from Pearson correlations between mean arterial pressure (MAP) and ICP over a short- and long-time interval. PR was the regression coefficient between the hourly mean values of ICP and MAP. Indices were compared to each other, parameters at admission, and outcome assessed by the extended Glasgow Outcome Scale-Extended (GOSE) at 6 and 12 months. PRx and L-PRx had the strongest correlation with each other (R = 0.536, p < 0.01). A correlation was also noted between L-PRx and PR (R = 0.475, p < 0.01), but not between PRx and PR. A correlation was found between age and PRx (R = 0.482, p = 0.01). No association with outcome for any of the indices was found. PRx/L-PRx and L-PRx/PR were moderately correlated with each other. Age was associated with PRx. None of the indices correlated with outcome when our ICP treatment regime was applied. Part of our null hypothesis, that the three indices are associated with outcome, must be rejected. There was, however, an association between some of the indices. To further understand the relation of treatment regimes and pressure reactivity indices, a larger, randomized study is warranted.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous Spinal Cord Stimulation to Stabilize Seated Systolic Blood Pressure in Persons With Chronic Spinal Cord Injury: Protocol Development. 经皮脊髓刺激稳定慢性脊髓损伤患者的坐位收缩压：方案开发。

Neurotrauma reports Pub Date : 2023-12-19 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0063

Caitlyn G Peters, Noam Y Harel, Joseph P Weir, Yu-Kuang Wu, Lynda M Murray, Jorge Chavez, Fiona E Fox, Christopher P Cardozo, Jill M Wecht

{"title":"Transcutaneous Spinal Cord Stimulation to Stabilize Seated Systolic Blood Pressure in Persons With Chronic Spinal Cord Injury: Protocol Development.","authors":"Caitlyn G Peters, Noam Y Harel, Joseph P Weir, Yu-Kuang Wu, Lynda M Murray, Jorge Chavez, Fiona E Fox, Christopher P Cardozo, Jill M Wecht","doi":"10.1089/neur.2023.0063","DOIUrl":"10.1089/neur.2023.0063","url":null,"abstract":"Transcutaneous spinal cord stimulation (tSCS) is an emerging therapeutic strategy to target spinal autonomic circuitry to normalize and stabilize blood pressure (BP) in hypotensive persons living with chronic spinal cord injury (SCI). Our aim is to describe our current methodological approach to identify individual tSCS parameters that result in the maintenance of seated systolic blood pressure (SBP) within a pre-defined target range. The parent study is a prospective, randomized clinical trial in which eligible participants will undergo multiple mapping sessions to optimize tSCS parameter settings to promote stable SBP within a target range of 110-120 mm Hg for males and 100-120 mm Hg for females. Parameter mapping includes cathode electrode placement site (T7/8, T9/10, T11/12, and L1/2), stimulation frequency (30, 60 Hz), current amplitudes (0-120 mA), waveform (mono- and biphasic), pulse width (1000 μs), and use of carrier frequency (0, 10 kHz). Each participant will undergo up to 10 mapping sessions involving different electrode placement sites and parameter settings. BP will be continuously monitored throughout each mapping session. Stimulation amplitude (mA) will be increased at intervals of between 2 and 10 mA until one of the following occurs: 1) seated SBP reaches the target range; 2) tSCS intensity reaches 120 mA; or 3) the participant requests to stop. Secondary outcomes recorded include 1) symptoms related to autonomic dysreflexia and orthostatic hypotension, 2) Likert pain scale, and 3) skin appearance after removal of the tSCS electrode. Clinical Trials Registration: NCT05180227.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury. 终生暴露于爆炸环境与患有或未患有轻度脑外伤的军人和退伍军人的白质完整性无关。

Neurotrauma reports Pub Date : 2023-12-14 eCollection Date: 2023-01-01 DOI: 10.1089/neur.2023.0043

Sara M Lippa, Ping-Hong Yeh, Jan E Kennedy, Jason M Bailie, John Ollinger, Tracey A Brickell, Louis M French, Rael T Lange

{"title":"Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury.","authors":"Sara M Lippa, Ping-Hong Yeh, Jan E Kennedy, Jason M Bailie, John Ollinger, Tracey A Brickell, Louis M French, Rael T Lange","doi":"10.1089/neur.2023.0043","DOIUrl":"10.1089/neur.2023.0043","url":null,"abstract":"This study examines the impact of lifetime blast exposure on white matter integrity in service members and veterans (SMVs). Participants were 227 SMVs, including those with a history of mild traumatic brain injury (mTBI; n = 124), orthopedic injury controls (n = 58), and non-injured controls (n = 45), prospectively enrolled in a Defense and Veterans Brain Injury Center (DVBIC)/Traumatic Brain Injury Center of Excellence (TBICoE) study. Participants were divided into three groups based on number of self-reported lifetime blast exposures: none (n = 53); low (i.e., 1-9 blasts; n = 81); and high (i.e., ≥10 blasts; n = 93). All participants underwent diffusion tensor imaging (DTI) at least 11 months post-injury. Tract-of-interest (TOI) analysis was applied to investigate fractional anisotropy and mean, radial, and axial diffusivity (AD) in left and right total cerebral white matter as well as 24 tracts. Benjamini-Hochberg false discovery rate (FDR) correction was used. Regressions investigating blast exposure and mTBI on white matter integrity, controlling for age, revealed that the presence of mTBI history was associated with lower AD in the bilateral superior longitudinal fasciculus and arcuate fasciculus and left cingulum (βs = -0.255 to -0.174; ps < 0.01); however, when non-injured controls were removed from the sample (but orthopedic injury controls remained), these relationships were attenuated and did not survive FDR correction. Regression models were rerun with modified post-traumatic stress disorder (PTSD) diagnosis added as a predictor. After FDR correction, PTSD was not significantly associated with white matter integrity in any of the models. Overall, there was no relationship between white matter integrity and self-reported lifetime blast exposure or PTSD.","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0