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Continuum topological derivative - A novel application tool for segmentation of CT and MRI images 连续拓扑导数--用于 CT 和 MRI 图像分割的新型应用工具
Neuroimage. Reports Pub Date : 2024-08-01 DOI: 10.1016/j.ynirp.2024.100215
Viswanath Muthukrishnan , Sandeep Jaipurkar , Nedumaran Damodaran
{"title":"Continuum topological derivative - A novel application tool for segmentation of CT and MRI images","authors":"Viswanath Muthukrishnan , Sandeep Jaipurkar , Nedumaran Damodaran","doi":"10.1016/j.ynirp.2024.100215","DOIUrl":"10.1016/j.ynirp.2024.100215","url":null,"abstract":"<div><h3>Introduction</h3><p>Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are essential tools for unraveling anatomical and tissue properties, particularly in the head and brain. CT provides high-contrast images, particularly valuable in cases such as cerebral bleeds, and also aids in estimating cranial deformities and organ shape deviations. MRI, on the other hand, offers excellent imaging of cerebral artery regions, allowing analysis of various cerebral pathologies through different sequences. Beyond detecting common head and brain disorders, these modalities play a crucial role in identifying abnormalities in orbits, middle cerebral artery territories, brain ventricles, soft tissues, and bones. A unique aspect of brain MRI is its ability to produce multiplanar brain assessments. Both head/brain CT and MRI are invaluable for studying haemorrhage cases, with segmentation of affected areas providing detailed images for further analysis. This study explores the application of a novel mathematical technique, continuum topological derivative (CTD), for CT and MR image segmentation.</p></div><div><h3>Methods</h3><p>The initial stage of Continuum Topological Derivative (CTD) segmentation involves preprocessing CT and MR images due to their susceptibility to inherent noises, such as quantum mottle, and Gaussian and Rayleigh noises, respectively. In this study, we have implemented the CTD denoising algorithm to produce denoised CT/MR images, serving as ground truth for subsequent segmentation steps. Validation of the denoised CTD CT/MR images was conducted through minimal residual value computation across all case studies. Following this, segmentation of the region of interest was performed using the CTD technique, with comparisons made against Discrete Topological Derivatives (DTD), k-mean clustering and Adaptive Threshold methods. Evaluation of the proposed CTD algorithm's effectiveness in segmentation involved calculating performance metrics such as Jaccard and dice indices to assess spatial overlap of segmented images.</p></div><div><h3>Results</h3><p>The CTD technique yields excellent segmentation results, not only for the delineated region of interest but also for volume-based cerebral blood areas and anomalies in the middle cerebral artery (MCA) and its territorial areas, which are substantiated through performance metrics and visual inspection by trained radiologist. This aids in determining the severity of stroke in affected patients. Additionally, a unique attempt is made to apply CTD to Electrical Impedance Tomography (EIT) images of the lungs for precise estimation of the breathing cycle. CTD successfully generates standardized images, demonstrating attenuation and density characteristics for cerebral cisterns, arteries, and ventricles.</p></div><div><h3>Discussion</h3><p>The denoised images obtained through CTD facilitate thorough analysis of both normal and pathological conditions, providing radiologists with enhanced capa","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000217/pdfft?md5=e00786ad1e1b5c9b31d74350ad01cd38&pid=1-s2.0-S2666956024000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FreeSurfer version-shuffling can enhance brain age predictions FreeSurfer 版本洗牌可提高脑龄预测能力
Neuroimage. Reports Pub Date : 2024-07-16 DOI: 10.1016/j.ynirp.2024.100214
Max Korbmacher , Lars T. Westlye , Ivan I. Maximov
{"title":"FreeSurfer version-shuffling can enhance brain age predictions","authors":"Max Korbmacher , Lars T. Westlye , Ivan I. Maximov","doi":"10.1016/j.ynirp.2024.100214","DOIUrl":"10.1016/j.ynirp.2024.100214","url":null,"abstract":"","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000205/pdfft?md5=caaeb79582670108a1d695dad2b0f29d&pid=1-s2.0-S2666956024000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141630667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical thickness differences between hearing and perinatally deaf cats using ultra-high field MRI 利用超高磁场核磁共振成像分析听力猫和围产期耳聋猫的皮质厚度差异
Neuroimage. Reports Pub Date : 2024-07-03 DOI: 10.1016/j.ynirp.2024.100213
Stephen G. Gordon , Alessandra Sacco , Stephen G. Lomber
{"title":"Cortical thickness differences between hearing and perinatally deaf cats using ultra-high field MRI","authors":"Stephen G. Gordon ,&nbsp;Alessandra Sacco ,&nbsp;Stephen G. Lomber","doi":"10.1016/j.ynirp.2024.100213","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100213","url":null,"abstract":"<div><p>In the absence of hearing, the plastic nature of the cerebral cortex allows select regions to be repurposed to serve the processing of remaining sensory modalities. This plasticity can be observed in many ways, including measuring the thickness differences of cortical gray matter between hearing and deaf populations to detect regional adaptations. In this study, T1-weighted images were acquired for hearing (n = 38) and perinatally-deafened (n = 31) cats using an ultra-high field 7T MRI scanner to identify normative feline cortical thickness, as well as areas of differing thickness between groups. Most significant changes to sensory-related regions demonstrated thicker cortices in the deaf compared to the hearing group, while specific non-sensory regions were found to be thinner. Furthermore, there was a modest lateralized component, finding that the gray matter of the left hemisphere was more susceptible to thickness changes following auditory deprivation. These results suggest distinct factors driving the adaptations in sensory versus non-sensory cortices in the brain following deafness, and reinforces the task-retainment model of crossmodal plasticity.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000199/pdfft?md5=798bbfe4237540f5cb1ca143a14db676&pid=1-s2.0-S2666956024000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Get ready! High urgency reduces beta band cortico-muscular coherence during motor preparation 做好准备高度紧迫性会降低运动准备过程中β带皮质-肌肉的一致性
Neuroimage. Reports Pub Date : 2024-06-30 DOI: 10.1016/j.ynirp.2024.100212
Welber Marinovic , Reon Boyd , An Nguyen
{"title":"Get ready! High urgency reduces beta band cortico-muscular coherence during motor preparation","authors":"Welber Marinovic ,&nbsp;Reon Boyd ,&nbsp;An Nguyen","doi":"10.1016/j.ynirp.2024.100212","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100212","url":null,"abstract":"<div><p>Motor preparation is a dynamic process that is tuned to task demands such as urgency. This study examined the effect of urgency to move on cortico-muscular coherence (CMC) in the beta frequency band during motor preparation. Participants (n = 25) prepared for a rapid wrist flexion movement under two distinct scenarios: high (350 ms to prepare) and low (1400 ms to prepare) urgency. Before participants performed the ballistic actions, they were required to hold a light contraction of the flexor carpi radialis muscle for 3 s. During this holding time, we simultaneously obtained EEG and EMG signals to estimate their coherence —a measure of how much brain and muscle activity is synchronized at specific rhythms— over the last 1 s of the contraction interval.</p><p>Contrary to our hypothesis, we found greater CMC in conditions of low urgency rather than high urgency. This finding suggests that participants prioritized attending to the visual stimuli, dividing their attention to capture the preparation go-signal, rather than preparing the motor system, leading to a reduction in CMC. This interpretation suggests a cognitive-motor trade-off, wherein attentional resources are allocated more to sensory processing that to motor preparedness in urgent situations.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000187/pdfft?md5=eab59dbdd1d784271be5be82c75ba2f0&pid=1-s2.0-S2666956024000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls 对酒精依赖症、赌博障碍和健康对照组的金钱奖励预期大脑反应与μ-阿片信号之间关系的探索性研究
Neuroimage. Reports Pub Date : 2024-06-27 DOI: 10.1016/j.ynirp.2024.100211
Samuel Turton , Louise M. Paterson , James FM. Myers , Inge Mick , Chen-Chia Lan , John McGonigle , Henrietta Bowden-Jones , Luke Clark , David J. Nutt , Anne R. Lingford-Hughes
{"title":"Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls","authors":"Samuel Turton ,&nbsp;Louise M. Paterson ,&nbsp;James FM. Myers ,&nbsp;Inge Mick ,&nbsp;Chen-Chia Lan ,&nbsp;John McGonigle ,&nbsp;Henrietta Bowden-Jones ,&nbsp;Luke Clark ,&nbsp;David J. Nutt ,&nbsp;Anne R. Lingford-Hughes","doi":"10.1016/j.ynirp.2024.100211","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100211","url":null,"abstract":"<div><p>Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are associated with dysregulated responses to reward which could be due to a common mechanism of dysregulated endogenous opioid signalling. We explored associations between reward anticipation responses, using the Monetary Incentive Delay (MID) functional magnetic resonance imaging (fMRI) task, and mu-opioid receptor (MOR) availability and endogenous opioid release capacity using [<sup>11</sup>C]carfentanil positron emission tomography (PET), in 13 AD, 15 GD and 14 heathy control (HC) participants. We also examined differences in MID task reward anticipation responses between AD, GD and HC participants. These were secondary exploratory analysis of data collected to examine differences in MOR PET in addiction. We did not find significant differences in MID win &gt; neutral anticipation BOLD responses compared between participant groups in a priori ROIs (ventral striatum, putamen, caudate) or whole brain analyses. We found no significant correlations between MID win &gt; neutral anticipation BOLD responses and [<sup>11</sup>C]carfentanil PET measures, except for limited negative correlations between putamen MOR availability and MID win &gt; neutral anticipation BOLD response in AD participants. Previous research has suggested a limited role of endogenous opioid signalling on MID task reward anticipation responses in AD and HCs as these responses are not modulated by opioid receptor blockade and this may explain our lack of significant correlations in HC and AD or GD participants. Our results, particularly the lack of differences in MID win &gt; neutral anticipation BOLD responses across participants groups, may be limited due to only including AD or GD participants who are abstinent or in active treatment.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000175/pdfft?md5=1661534afef59978e88e3402cec8b46b&pid=1-s2.0-S2666956024000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High angular resolution diffusion-weighted imaging and higher order tractography of the white matter tracts in the anterior thalamic area: Insights into deep brain stimulation targeting 丘脑前区白质束的高角度分辨率弥散加权成像和高阶束成像:对深部脑刺激目标定位的启示
Neuroimage. Reports Pub Date : 2024-06-14 DOI: 10.1016/j.ynirp.2024.100210
Ruhunur Özdemir , Kai Lehtimäki , Eetu Siitama , Timo Möttönen , Joonas Haapasalo , Soila Järvenpää , Hannu Eskola , Jukka Peltola
{"title":"High angular resolution diffusion-weighted imaging and higher order tractography of the white matter tracts in the anterior thalamic area: Insights into deep brain stimulation targeting","authors":"Ruhunur Özdemir ,&nbsp;Kai Lehtimäki ,&nbsp;Eetu Siitama ,&nbsp;Timo Möttönen ,&nbsp;Joonas Haapasalo ,&nbsp;Soila Järvenpää ,&nbsp;Hannu Eskola ,&nbsp;Jukka Peltola","doi":"10.1016/j.ynirp.2024.100210","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100210","url":null,"abstract":"<div><h3>Background</h3><p>Deep brain stimulation of the anterior nucleus of the thalamus (ANT) is emerging EU/US-approved form of therapy for drug-resistant focal epilepsy. Its mechanism of action is not yet fully understood, and the patient outcomes in epilepsy appear less consistent compared to for instance movement disorders. Furthermore, very little anatomy-based information, such as tractography of relevant fiber systems, exists guiding DBS therapy at present.</p></div><div><h3>Objective</h3><p>To demonstrate ANT-related fiber systems based on histology in vivo employing multi-shell/multi-tissue constrained spherical deconvolution (MSMT-CSD) based deterministic and probabilistic tractography using a sophisticated scanning protocol of 3T high angular resolution diffusion-weighted imaging (HARDI) data in healthy volunteers.</p></div><div><h3>Method</h3><p>HARDI data was acquired from five healthy volunteers in a 3T Siemens MAGNETOM Skyra Magnetic resonance imaging (MRI) machine using multiple b-values (1000, 2000, and 3000), 64 directions, and further preprocessed for tractography. MSMT-CSD-based deterministic and probabilistic tractography was performed from selected fiber systems based on existing literature.</p></div><div><h3>Results</h3><p>Multiple fiber systems were identified: The anterior thalamic radiation (ANT), the thalamo-cingulate tract, the inferior thalamic peduncle (with remote termination areas in the amygdala, the ventral tegmental area, and the occipital cortex), and the mammillothalamic tract. In addition, we observed three parallel connections to the hippocampus (via the cingulum bundle, the fornix, and the temporo-pulvinar pathway). Interestingly, different seed areas in ANT complex mimicking DBS contact locations resulted in visualization of different fiber systems.</p></div><div><h3>Discussion</h3><p>The connections of the ANT are complex and different stimulation sites are likely to affect different networks depending on lead locations and the selection of the active contact.</p></div><div><h3>Conclusions</h3><p>In-depth understanding of the network of anatomical structures related to the ANT is likely to influence therapy outcomes. A hypothetical model of neuronal networks affected by different DBS lead contact locations is proposed. A more profound understanding of neuroanatomic characteristics may guide stereotactic implantation and subsequent programming to optimize outcomes.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000163/pdfft?md5=42df558f7a40d65683ac95fcc8f6f8a5&pid=1-s2.0-S2666956024000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impairment across the ill veteran population 对静息态 fMRI 连接组学的全面研究,在考虑了患病退伍军人群体大脑功能损伤的异质性后,对海湾战争疾病的大脑功能缺陷有了新的认识
Neuroimage. Reports Pub Date : 2024-06-04 DOI: 10.1016/j.ynirp.2024.100209
Gaungming Yang , Robert W. Haley , Ying Guo , Kaundinya S. Gopinath
{"title":"Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impairment across the ill veteran population","authors":"Gaungming Yang ,&nbsp;Robert W. Haley ,&nbsp;Ying Guo ,&nbsp;Kaundinya S. Gopinath","doi":"10.1016/j.ynirp.2024.100209","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100209","url":null,"abstract":"<div><p>An estimated 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), an incompletely understood chronic medical condition, characterized by multiple symptoms indicative of brain function deficits in various domains. Epidemiologic and animal studies have associated GWI with exposure to neurotoxic chemicals such as nerve agents, organophosphate pesticides and pyridostigmine bromide. One factor that hampers mechanistic investigations into GWI is that there is considerable heterogeneity in brain impairments across the ill GW veteran population. This could reflect the underlying heterogeneity in both exposure to neurotoxic substances, as well as genetic predisposition or resistance to neurotoxicity. Only one of the validated case definitions, the Haley GWI criteria addresses this heterogeneity. It does so by breaking down GWI into three main syndrome variants (GWS1, GWS2, and GWS3) based on factor analysis of symptoms presented by GWI veterans. Resting state fMRI (rsfMRI) is a uniquely useful brain imaging technique in that in a 10-min fMRI scan it can probe numerous brain function domains simultaneously. In this study, we employed a connectomics approach and machine learning on rsfMRI data from a cohort of GW veterans to extract neuroimaging biomarkers specific to each of the three Haley GWI syndromes. Our results revealed a number of new insights into brain function impairment specific to each syndrome group. The findings indicate that these deficits may by and large be driven by brain mechanisms. We also found that pooling the data of all three syndromes in GWI group, as is done by commonly employed case definitions of GWI resulted in failure to detect the fMRI signatures of a lot of these brain impairments.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 3","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000151/pdfft?md5=90a7ac4294385e9da0aa6d7158d5a88b&pid=1-s2.0-S2666956024000151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141250888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-processing of a distributed source method for the localization of somatosensory cortex in a cohort of epilepsy patients 分布式信号源方法的后处理,用于定位一组癫痫患者的体感皮层
Neuroimage. Reports Pub Date : 2024-05-09 DOI: 10.1016/j.ynirp.2024.100204
Kevin Tyner , Matthew McCumber , Srijita Das , Carmen Urban , Anthony J. Maxin , Tiffany Chu , Mustaffa Alfatlawi , Stephen V. Gliske
{"title":"Post-processing of a distributed source method for the localization of somatosensory cortex in a cohort of epilepsy patients","authors":"Kevin Tyner ,&nbsp;Matthew McCumber ,&nbsp;Srijita Das ,&nbsp;Carmen Urban ,&nbsp;Anthony J. Maxin ,&nbsp;Tiffany Chu ,&nbsp;Mustaffa Alfatlawi ,&nbsp;Stephen V. Gliske","doi":"10.1016/j.ynirp.2024.100204","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100204","url":null,"abstract":"<div><p>Localizing eloquent cortices is crucial for many neurosurgical applications, such as epilepsy and tumor resections. Clinicians may use non-invasive methods such as magnetoencephalography (MEG) to localize these cortical regions using equivalent current dipoles (ECDs). While dipoles are clinically validated, they provide the estimated strength, location, and orientation of only one or a few sources that best describe the recorded neuromagnetic data, requiring clinicians to make subjective decisions on the spatial extent of the underlying cortical area. More accurate delineation of eloquent cortical areas using distributed source localization methods would provide additional pre-surgical information on these regions’ location and spatial distribution, which could lead to reduced post-surgical complications associated with damage to or removal of eloquent cortices. Our objective in this paper was to present a method to post-process the distributed source localization results to yield a directly interpretable, distributed region of activation. As a test case, we selected somatosensory stimulation in a retrospective cohort of focal and multi-focal epilepsy patients. Our algorithm performs source localization using a distributed method (sLORETA), followed by post-processing and blind source separation to identify the area and boundary of the cortical tissue that primarily activates in response to somatosensory stimulation. We calculated the statistical significance of localization by comparing the identified region to an anatomical atlas and random chance. While examining patients who received left (upper left, UL) and right (upper right, UR) sided median nerve stimulation, the cortical areas identified by the algorithm were in anatomically appropriate areas with a median overlap of 97.6% and 94.7%, respectively. We observe that our algorithm localized somatosensory responses better than random chance in 57/58 (98%) patients who performed the UL task (<em>p</em> &lt; 10 × 10<sup>−10</sup>, binomial test) and 49/50 (98%) patients who performed the UR task (<em>p</em> &lt; 10 × 10<sup>−10</sup>, binomial test). We compared the localization of our algorithm to current clinical methods and found that our algorithm is not inferior to dipole localization. The algorithm can successfully localize somatosensory responses on the cortical surface in anatomically appropriate regions while providing the spatial extent of cortical activation, reducing subjectivity associated with dipole localization.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 2","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000102/pdfft?md5=daec581c9dee580e19dc9c470ff876b4&pid=1-s2.0-S2666956024000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism as a biomarker for treatment success in anti-amyloid therapy: A case report 代谢作为抗淀粉样蛋白治疗成功与否的生物标志物:病例报告
Neuroimage. Reports Pub Date : 2024-04-27 DOI: 10.1016/j.ynirp.2024.100203
Kirk C. Wilhelmsen , Pierre-François D’Haese , Marc W. Haut , Gary D. Marano , Rashi I. Mehta , Xiaofei Wang , Melanie Ward , Mark Miller , Umer Najib , R. Osvaldo Navia , Cierra M. Keith , Ali Rezai
{"title":"Metabolism as a biomarker for treatment success in anti-amyloid therapy: A case report","authors":"Kirk C. Wilhelmsen ,&nbsp;Pierre-François D’Haese ,&nbsp;Marc W. Haut ,&nbsp;Gary D. Marano ,&nbsp;Rashi I. Mehta ,&nbsp;Xiaofei Wang ,&nbsp;Melanie Ward ,&nbsp;Mark Miller ,&nbsp;Umer Najib ,&nbsp;R. Osvaldo Navia ,&nbsp;Cierra M. Keith ,&nbsp;Ali Rezai","doi":"10.1016/j.ynirp.2024.100203","DOIUrl":"https://doi.org/10.1016/j.ynirp.2024.100203","url":null,"abstract":"<div><p>This case report investigates the potential use of metabolism as a sensitive biomarker in monitoring the effectiveness of anti-amyloid therapy in a patient with mild cognitive impairment due to early Alzheimer's disease. The study centers around a 74-year-old male patient treated with aducanumab, a monoclonal antibody developed for anti-amyloid therapy. Alongside an expected decline in cerebral amyloid monitored using PET amyloid tracers, we observed significant improvements in the patient's brain metabolic activity, measured via 18-fluorodeoxyglucose positron emission tomography (FDG PET). Despite limitations posed by the single-patient case study, the findings invite further research and consider the utilization of FDG PET as a surrogate for clinically meaningful changes in the treatment of early Alzheimer's disease. These findings suggest the potential for more personalized and effective therapeutic interventions.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"4 2","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000096/pdfft?md5=75b759aca7a14017053f665c49e8fb5f&pid=1-s2.0-S2666956024000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-local diffusion-based biomarkers in patients with cocaine use disorder 可卡因使用障碍患者的非局部扩散生物标志物
Neuroimage. Reports Pub Date : 2024-04-26 DOI: 10.1016/j.ynirp.2024.100202
Alfonso Estudillo-Romero , Raffaella Migliaccio , Bénédicte Batrancourt , Pierre Jannin , John S.H. Baxter
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