Neuroimage. Reports最新文献

{"title":"Action observation responses in macaque frontal cortex","authors":"Sofie De Schrijver ,&nbsp;Thomas Decramer ,&nbsp;Peter Janssen","doi":"10.1016/j.ynirp.2026.100319","DOIUrl":"10.1016/j.ynirp.2026.100319","url":null,"abstract":"<div><div>Neurons that are active during action execution and action observation (i.e. Action Observation/Execution Neurons, AOENs) are distributed across the brain in a network of parietal, motor, and prefrontal areas. In a previous study, we showed that most AOENs in ventral premotor area F5c, where they were discovered three decades ago, responded in a highly phasic way during the observation of a grasping action, did not require the perception of causality or a meaningful action, and even responded to static frames of the action videos. To assess whether these characteristics are shared with AOENs in other areas of the AOE network, we performed the first large-scale neural recordings during action execution and action observation in multiple frontal areas including dorsal premotor (PMd) area F2, primary motor (M1) cortex, ventral premotor area F5p, frontal eye field (FEF) and 45B. In all areas, AOENs displayed highly phasic responses during specific epochs of the action video and, in addition, strong responses to a moving object, similar to F5c. In addition, the population dynamics in PMv, PMd and M1 showed a shared representation between action execution and action observation, with an overlap that was as large as the overlap between action execution and passive viewing of translation movements. These results pose important constraints on the interpretation of action observation responses in frontal cortical areas.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100319"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegeneration and energy depletion in MS: Links between tissue integrity loss and microvascular changes in white matter disease","authors":"Linda Sundvall ,&nbsp;Mikkelsen Irene Klærke ,&nbsp;Brian Hansen ,&nbsp;Simon Fristed Eskildsen ,&nbsp;Mette Madsen Hjørringgaard ,&nbsp;Mikkel Karl Emil Nygaard ,&nbsp;Peter Vestergaard Rasmussen ,&nbsp;Thor Petersen ,&nbsp;Leif Østergaard","doi":"10.1016/j.ynirp.2025.100309","DOIUrl":"10.1016/j.ynirp.2025.100309","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Disturbances in cerebral oxygen delivery and utilization are increasingly recognized as key features, and potential contributors to, neuronal damage in multiple sclerosis (MS). We recently discovered microvascular changes, which are thought to limit oxygen extraction, in MS-related white matter (WM) lesions compared to unspecific WM lesions. It is unclear whether such microvascular changes antedate demyelinating changes in MS, or whether they are secondary to subsequent disease changes, such as inflammation, tissue edema, and blood-brain barrier break-down. Diffusion kurtosis imaging (DKI) is sensitive to early MS-related disease changes, including altered myelin integrity, cellularity, and edema detecting deviations from Gaussian diffusion that serve as indirect markers of tissue integrity. The purpose of this study was to examine whether regions with altered DKI metrics overlap with regions with microvascular changes in MS patients, and to compare microvascular changes with parallel DKI changes in both MS-related lesions and unrelated WM lesions to learn more about their microstructural correlates.&lt;/div&gt;&lt;div&gt;In this cross-sectional study, we assessed microstructural damage in 54 MS patients and 26 non-diseased symptomatic controls (SC) using diffusion kurtosis imaging (DKI) and explored the relationship between these findings and microvascular flow patterns and oxygen delivery measured by dynamic susceptibility contrast-enhanced MRI (DSC-MRI).&lt;/div&gt;&lt;div&gt;MRI at 3T included three-dimensional (3D) T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), 3D magnetization-prepared 2 rapid acquisition gradient-echo (MP2RAGE), post-contrast 3D T1-weighted images, DSC-MRI, and DKI. White matter lesions (WMLs) were manually outlined as MS-characteristic T2-FLAIR lesions, MS contrast-enhancing lesions and nonspecific lesions T2-FLAIR lesions. DKI-derived structural parameters, mean kurtosis (MK) and mean diffusivity (MD), were extracted from lesion masks and normal-appearing white matter (NAWM) and correlated with DSC-derived vascular parameters mean transit time (MTT), and the distribution of capillary transit times (CTH). Finally, an extended flow-diffusion model of oxygen transport was employed to evaluate tissue oxygen availability based on local blood flow and microvascular flow patterns.&lt;/div&gt;&lt;div&gt;After adjusting for age and sex, NAWM in MS showed higher MD (+2.4 %, p = 0.01) and lower MK (−2.8 %, p = 0.01) compared with SC without concurrent changes in perfusion or oxygenation. Unspecific T2-FLAIR lesions demonstrated higher MD relative to NAWM (+13 %, p &lt; 0.001) and reduced MK (−6.7 %, p &lt; 0.001), but no microvascular impairment. By contrast, MS T2-FLAIR lesions showed more pronounced structural alterations, with higher MD than unspecific lesions (+13 %, p = 0.01) and markedly reduced MK (−16 %, p = 0.02), accompanied by increased CTH (+31 %, p = 0.02) and prolonged MTT (+32 %, p = 0.02), consistent with impaired oxygen extract","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100309"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the three-dimensional morphology of unruptured intracranial aneurysms","authors":"Maarten J. Kamphuis ,&nbsp;Phebe J. Groenheide ,&nbsp;Laura T. van der Kamp ,&nbsp;Margot van Genderen ,&nbsp;Ruben P.A. van Eijk ,&nbsp;Jeroen Hendrikse ,&nbsp;Gabriel J.E. Rinkel ,&nbsp;Mervyn D.I. Vergouwen ,&nbsp;Ynte M. Ruigrok ,&nbsp;Irene C. van der Schaaf","doi":"10.1016/j.ynirp.2026.100328","DOIUrl":"10.1016/j.ynirp.2026.100328","url":null,"abstract":"<div><h3>Objective</h3><div>Women have a higher rupture risk of intracranial aneurysms than men. One possible explanation is that aneurysm volume and shape irregularity, both linked to rupture risk, may differ between women and men. We investigated this with 3-dimensional morphological aneurysm parameters.</div></div><div><h3>Methods</h3><div>In a random sample of consecutive patients with unruptured intracranial aneurysms diagnosed between 2008 and 2018, we quantified volume and shape parameters describing global (sphericity, elongation, and flatness) and local shape (shape index and curvedness) on CT or MR angiography scans. We compared these parameters between women and men (reference) with univariable and multivariable linear regression analysis (global parameters) and binary logistic regression analysis (local parameters). The multivariable analysis was adjusted for the confounders: age, hypertension, smoking status, aneurysm size, location, and imaging modality.</div></div><div><h3>Results</h3><div>We included 326 patients (239 women [73%], mean age 58 years [SD 12 years]). Women had smaller aneurysm volumes than men in multivariable analysis (β −0.30 SD, 95%CI -0.55 to −0.06). The global shape parameters sphericity, elongation, and flatness were comparable between sexes. Of the local shape parameters, women had higher aneurysm shape index (OR 2.38, 95%CI 1.03 to 5.49) and lower curvedness (OR 0.50, 95%CI 0.29 to 0.88) in multivariable analysis.</div></div><div><h3>Conclusions</h3><div>Women have intracranial aneurysms with smaller volumes and shape characteristics associated with lower rupture risk. Therefore, factors other than aneurysm morphology are likely responsible for the higher risk of aneurysm rupture in women.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state","authors":"C.D. Richard ,&nbsp;B. Porjesz ,&nbsp;J.L. Meyers ,&nbsp;A. Bingly ,&nbsp;D.B. Chorlian ,&nbsp;C. Kamarajan ,&nbsp;G. Pandey ,&nbsp;A. Anokhin ,&nbsp;S. Brislin ,&nbsp;W. Kuang ,&nbsp;A.K. Pandey ,&nbsp;S. Kinreich","doi":"10.1016/j.ynirp.2026.100320","DOIUrl":"10.1016/j.ynirp.2026.100320","url":null,"abstract":"<div><div>Considerable evidence from functional neuroimaging and EEG coherence studies indicates that individuals afflicted with alcohol use disorder (AUD) manifest aberrant patterns of connectivity, particularly in frontal brain regions. Phase-amplitude coupling (PAC) is another form of functional connectivity, reflecting the association between the phase at one frequency and amplitude changes at a higher frequency. Significant PAC differences have been reported for other substance use disorders, but it has not yet been investigated in AUD. We compared frontomedial PAC strength during resting state, eyes closed, in adult participants with severe AUD and age-matched unaffected controls from the Collaborative Study on the Genetics of Alcoholism (COGA). Comodulograms of PAC estimates between phase frequencies (0.1–13 Hz) and amplitude frequencies (4–50 Hz) were calculated for all participants. PAC differences between AUD and unaffected groups were assessed at each phase-amplitude frequency pair in comodulograms to identify clusters of significant test results, reporting only those clusters satisfying all validation and significance testing steps. Severe AUD was associated with clusters of significantly greater PAC in alpha-gamma domains of both men and women. Candidate clusters were found in theta-gamma domains of both sexes, but were only significant greater in men with AUD. Significant PAC clusters were found in the delta-gamma domain of both sexes, though women with AUD showed significant decreases in contrast to greater PAC found in men with AUD. The significant PAC clusters identified in this exploratory study could provide new insights into the dysregulation of brain connectivity underlying AUD.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100320"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation between neuroinflammation, amyloid-β load, grey matter loss and brain activity in visual object recognition regions in Alzheimer's Disease","authors":"Lília Jorge ,&nbsp;Nádia Canário ,&nbsp;Ricardo Martins ,&nbsp;Antero Abrunhosa ,&nbsp;Isabel Santana ,&nbsp;Miguel Castelo-Branco","doi":"10.1016/j.ynirp.2025.100305","DOIUrl":"10.1016/j.ynirp.2025.100305","url":null,"abstract":"<div><div>The regional impact of amyloid-β (Aβ) load and neuroinflammation on brain integrity and function is essential to understand the pathophysiology of Alzheimer's disease (AD), yet it is still lacking in the current literature, particularly in regions involved in visual object recognition.</div><div>Here, using a multimodal approach, we investigated AD-related neuropathological changes and their impact on task-related responses in core visual object recognition areas of the ventral stream: FFA, FBA, LOCv, PPA and VWFA. We combined 11C-PK11195 PET measures of neuroinflammation, 11C-PIB PET measures of Aβ load, MRI structural measures of grey matter and functional MRI (fMRI) BOLD response, using a visual recognition task, in 20 AD patients and 17 Aβ negative healthy controls. Mixed repeated-measure ANOVAS were computed to assess which regions differed between groups for each data modality, and partial correlation tests were used to explore associations across modalities.</div><div>We found in mild AD patients higher levels of atrophy and Aβ, as compared to relatively preserved visual activation and neuroinflammation levels. An association between Aβ levels and neuronal response was found in right LOCv, possibly suggesting an early transient subclinical impact of Aβ on brain function. We also found an interesting pattern of hemispheric asymmetry, with concurrent atrophy and Aβ load in the left hemisphere.</div><div>Overall, these findings suggest differential vulnerability to pathological processes along the visual ventral stream in AD, characterized by relatively preserved functional response and neuroinflammatory status, alongside increased leftward susceptibility to GM atrophy and Aβ deposition.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment","authors":"Karla Batista Garcia-Ramo ,&nbsp;Spencer Finn ,&nbsp;Theodore S. Aliyianis ,&nbsp;Adam Falah ,&nbsp;Brooke C. Beattie ,&nbsp;Donald Brien ,&nbsp;Garima Shukla ,&nbsp;Lysa Boissé-Lomax ,&nbsp;Stephen H. Scott ,&nbsp;Jason P. Gallivan ,&nbsp;Gavin P. Winston","doi":"10.1016/j.ynirp.2026.100330","DOIUrl":"10.1016/j.ynirp.2026.100330","url":null,"abstract":"<div><h3>Background</h3><div>Subjects with temporal lobe epilepsy (TLE) often experience cognitive impairment in different domains. Currently, the mechanisms underlying neuropsychological dysfunction in TLE remain poorly understood. The main objective is to characterize the multivariate relationship between brain connectivity patterns and cognitive impairment detected by robotic testing in subjects with TLE.</div></div><div><h3>Methods</h3><div>Kinarm robotic technology was used to evaluate motor, cognitive, and sensory domains of healthy controls and individuals with TLE. Structural connectivity (SC) and functional connectivity (FC) were obtained from multi-shell diffusion MRI and resting-state fMRI, respectively. After principal component analysis for dimension reduction of connectivity features, sparse canonical correlation analyses were used to identify the patterns of multivariate association between brain connectivity and cognitive dysfunctions.</div></div><div><h3>Results</h3><div>Patients with TLE demonstrated worse performance mainly in the domains of memory, executive function and attention, and to a lesser extent in the perceptual-motor domain. We found that memory and executive function alterations were associated with an intra-hemispheric SC pattern between somatomotor network and default, limbic and frontoparietal networks. We also found that an intra-hemispheric SC pattern of the posterior parietal cortex was related to perceptual-motor and attention skills with FC between this region and the precentral ventral region of DAN and frontal operculum insula of VAN also associated to impairment in these domains.</div></div><div><h3>Conclusions</h3><div>This study identifies multivariate patterns of structural and functional connectivity that correlate with domain-specific cognitive impairment, as measured by robotic screening, in individuals with TLE. These findings support the conceptualization of TLE as a network disorder, contextualizing multidomain cognitive deficits within a network-level framework rather than interrogating specific functional circuits. This may in the future permit more personalized treatments or prediction of cognitive changes in response to planned treatment changes.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100330"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys","authors":"Noa Peeleman ,&nbsp;Myles Mc Laughlin ,&nbsp;Tom Theys ,&nbsp;Mathieu Vandenbulcke ,&nbsp;Peter Janssen","doi":"10.1016/j.ynirp.2026.100331","DOIUrl":"10.1016/j.ynirp.2026.100331","url":null,"abstract":"<div><h3>Background</h3><div>The hippocampus and medial temporal lobe are crucial for spatial memory, and their dysfunction is linked to Alzheimer's disease (AD), with changes detectable even in preclinical stages. Recently, neuromodulation has gained interest as a potential treatment due to its beneficial effects on AD pathology and cognitive performance. However, outcomes vary significantly based on stimulation parameters and study conditions, and evidence from large animal models remains limited.</div></div><div><h3>Objective</h3><div>To assess whether epicranial current stimulation (ECS) at 40 Hz can improve non-navigational spatial memory and hippocampal activations.</div></div><div><h3>Methods</h3><div>Three rhesus macaques were implanted with spiral platinum electrodes bilaterally on the skull and were trained in a non-navigational spatial memory task. ECS was applied at 40 Hz or at 10 Hz and performance across multiple sessions was evaluated. We further performed ECS during fMRI to examine the spread of activations caused by ECS across the brain in a block-design experiment.</div></div><div><h3>Results</h3><div>ECS at 40 Hz improved performance in a non-navigational spatial memory task, while 10 Hz ECS had minimal or negative effects. Concurrent ECS-fMRI showed extensive brain activations at 40 Hz, including significant hippocampal activations, which was not observed at 10 Hz.</div></div><div><h3>Conclusions</h3><div>Our results show that ECS could be a minimally-invasive and effective approach to improve memory performance and activate the hippocampus. ECS could represent a potential treatment for patients suffering from memory impairment.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100331"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural and biomarker correlates of the Parkinson's Disease–Cognitive Rating Scale in Huntington's disease","authors":"Saul Martinez-Horta ,&nbsp;Arnau Puig-Davi ,&nbsp;Frederic Sampedro ,&nbsp;Jesús Pérez-Pérez ,&nbsp;Carla Franch-Martí ,&nbsp;Gonzalo Olmedo-Saura ,&nbsp;Elisa Rivas-Asensio ,&nbsp;Anna Vazquez-Oliver ,&nbsp;Laura Pérez-Carasol ,&nbsp;Andrea Horta-Barba ,&nbsp;Javier Pagonabarraga ,&nbsp;Jaime Kulisevsky","doi":"10.1016/j.ynirp.2025.100311","DOIUrl":"10.1016/j.ynirp.2025.100311","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological correlates of brief screening tools adapted for HD.</div></div><div><h3>Objectives</h3><div>This study investigates the neuroanatomical and fluid biomarker correlates of performance on the Parkinson's Disease–Cognitive Rating Scale (PD-CRS), aiming to validate it as a clinically and biologically grounded tool for cognitive assessment in HD.</div></div><div><h3>Methods</h3><div>Fifty-two symptomatic gene-expansion carriers (CAG &gt;39) underwent cognitive (PD-CRS), motor (UHDRS), and behavioral (PBA) assessments. Plasma neurofilament light chain (NfL) levels were measured via Simoa as a marker of neurodegeneration. Voxel-based morphometry (VBM) was used to identify gray matter volume (GMV) correlates of PD-CRS scores. Linear regressions evaluated relationships among PD-CRS, GMV, and NfL, including subdomain-level and stage-stratified analyses based on HD-ISS classification.</div></div><div><h3>Results</h3><div>PD-CRS scores were significantly associated with GMV in frontostriatal, paralimbic, parietal, and occipital regions. NfL levels correlated with both cognitive scores and GMV in key regions, supporting their value as biomarkers of neurodegeneration. Subdomain analyses revealed region-specific associations (e.g., visuospatial tasks with posterior cortices, fluency with striatum). Perseveration, motor severity, and education predicted PD-CRS performance (adjusted R² = 0.799). PD-CRS remained the strongest GMV predictor (adjusted R² = 0.519), particularly in later disease stages.</div></div><div><h3>Conclussions</h3><div>The PD-CRS reflects biologically meaningful aspects of cognitive dysfunction in HD, with robust associations to structural and molecular disease markers. These findings support its use as a practical and sensitive tool for clinical and research applications.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visuomotor training induces network reorganisation of frontal eye field and cuneus connectivity: A task-based fMRI study","authors":"Fahad Alharshan ,&nbsp;Abdulrahman Aloufi ,&nbsp;Fiona J. Rowe ,&nbsp;Georg Meyer","doi":"10.1016/j.ynirp.2025.100316","DOIUrl":"10.1016/j.ynirp.2025.100316","url":null,"abstract":"<div><div>Short-term visuomotor training is known to induce functional and structural plasticity, yet its effects on task-based functional connectivity (FC), particularly within attentional and visuomotor networks, remain underexplored. This study investigated whether such training induces task-specific network-level reorganisation, focusing on the cuneus and frontal eye field (FEF) as seeds within the dorsal attention network.</div><div>Fourteen healthy adults completed a 6-week voluntary eye movement training programme originally developed for visual field rehabilitation. Functional MRI data were acquired pre- and post-training and analysed using both seed-to-voxel and region-to-region (ROI-to-ROI) FC approaches.</div></div><div><h3>Results</h3><div>revealed significantly increased connectivity between the FEF and posterior occipital cortex, and between the cuneus and cerebellar regions. Crucially, these changes were dose-dependent, showing a significant association with individual improvements in reaction time, highlighting a functional link between network reorganisation and behavioural gains.</div><div>These findings provide novel evidence that short-term training enhances consolidated, task-specific FC across sensory-motor and attentional hubs. They complement earlier reports of task-based activation and microstructural plasticity in the same cohort and brain areas, establishing task-based FC as a sensitive, functional marker of learning-induced brain adaptation across the entire dorsal attentional-motor circuit.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No evidence for modulation of frontal brain activity asymmetry by a single session of EEG feedback","authors":"Atakan M. Akil ,&nbsp;Renáta Cserjési ,&nbsp;Tamás Nagy ,&nbsp;Zsolt Demetrovics ,&nbsp;H.N. Alexander Logemann","doi":"10.1016/j.ynirp.2025.100308","DOIUrl":"10.1016/j.ynirp.2025.100308","url":null,"abstract":"<div><div>Recent studies suggest that frontal hemispheric asymmetry may underlie various mental health disorders, and frontal alpha asymmetry (FAA), which reflects cortical activity and inactivity between the left and right frontal lobes, could be a potential biomarker for these conditions. In this research, we investigated whether a single session of electroencephalogram (EEG) feedback (EF) can modulate and shift FAA. We designed a preregistered, triple-blind randomized-controlled trial to address this gap in the literature. Sixty-five healthy individuals (<em>M</em>_age = 24.55, <em>SD</em>_age = 7.63) were recruited for the experiment. First, we assessed baseline resting-state FAA over a 10-min period, consisting of 5 min each under eyes-open and eyes-closed conditions. Subsequently, participants were assigned to one of two 30-min-long EF protocols, designed to modulate cortical activity by enhancing activation in either the right or left frontal hemisphere. FAA was reassessed immediately after the completion of the feedback intervention. The results indicated that a single session of EF does not modulate FAA; therefore, it should be considered with caution regarding causal inferences. However, the absence of effects may also be attributed to the form of feedback used, as well as individual differences in baseline brain activity and neurocognitive/psychological profiles.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"6 1","pages":"Article 100308"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}