揭示创伤记忆:创伤后应激障碍及其解离亚型患者前后海马的不同功能连接谱

Q4 Neuroscience
Mohammad Chaposhloo , Margaret C. McKinnon , Breanne E. Kearney , Saurabh B. Shaw , Ruth Lanius , Suzanna Becker
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引用次数: 0

摘要

创伤后应激障碍(PTSD)长期以来被许多人视为一种记忆障碍。因此,海马体脑网络一直是创伤后应激障碍神经回路研究的一个重要焦点,因为它的核心涉及情景记忆和创伤记忆的机制。灵长类动物海马在功能上沿其长轴分为前海马区(aHipp)和后海马区(pHipp),前海马区在情绪相关记忆中发挥更大作用,后海马区更多地参与认知和空间加工。这表明aHipp可能更积极地参与创伤后应激障碍。然而,关键的是,很少有研究调查这些海马体亚区在PTSD中的不同参与,并且该领域的大多数研究都是在休息时进行的,而不是在积极回忆创伤或极端情绪记忆时进行的。海马前部和后部是否在创伤相关记忆回忆中起着不同的作用,这是一个悬而未决的问题。在这里,我们通过调查三组在回忆创伤/道德损伤(MI)相关创伤记忆与中性记忆时aHipp和pHipp的活动和全脑功能连通性来解决这个问题:无分离症状的PTSD患者,称为PTSD (DS-;n = 49),分离亚型,称为PTSD (DS+;N = 19)和创伤暴露健康对照(N = 36)。创伤后应激障碍(DS+)患者在创伤记忆回忆过程中,海马前侧和后侧亚区均表现出与各脑区功能连通性异常,其中海马前侧亚区表现出比前侧更广泛的异常。例如,与PTSD (DS-)和对照组相比,PTSD (DS+)患者在回忆创伤/MI记忆时,pHipp与小脑前部、海马旁和梭状回、感觉运动皮层和枕叶早期视觉区等区域的功能连接异常。总之,这些结果表明,在创伤/ mi相关PTSD及其分离亚型中,前后海马体参与创伤记忆的不同程度,这可能与创伤记忆的非情境化和碎片化性质有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype
Post-traumatic stress disorder (PTSD) has long been viewed by many as a disorder of memory. Consequently, the hippocampal brain networks have been an important focus of research on the neural circuitry of PTSD given its core involvement in episodic memory and mechanisms underlying traumatic memory. The primate hippocampus is functionally divided along its long axis into the anterior (aHipp) and posterior parts (pHipp), with the anterior portion playing a greater role in emotion-related memories, while the posterior region is more involved in cognitive and spatial processing. This suggests that the aHipp may be more actively involved in PTSD. Critically, however, little research has investigated the differential involvement of these hippocampal subregions in PTSD, and most research in this area has been conducted during rest rather than during the active recall of traumatic or extremely emotional memories. It is an open question whether anterior and posterior hippocampal regions might play differential roles during trauma-related memory recall. Here, we addressed this question by investigating the activity and the whole-brain functional connectivity of the aHipp and pHipp during the recall of traumatic/moral injury (MI) related trauma memories versus neutral memories in three groups: those with PTSD without dissociative symptoms, referred to as PTSD (DS-; n = 49), those with the dissociative subtype, referred to as PTSD (DS+; n = 19), and trauma-exposed healthy controls (n = 36). Both anterior and posterior hippocampal subregions displayed abnormal functional connectivity with various brain regions in PTSD (DS+) during trauma memory recall, with the pHipp showing more extensive abnormalities compared to the anterior part. For example, the pHipp showed abnormal functional connectivity with areas such as the anterior cerebellum, the parahippocampal and fusiform gyri, sensorimotor cortex, and early visual areas of the occipital lobe in PTSD (DS+) compared to PTSD (DS-) and controls during the recall of traumatic/MI memories. Collectively, these results suggest differential involvement of the anterior and posterior hippocampus in the recall of traumatic memories in traumatic/MI-related PTSD and its dissociative subtype, which may relate to the decontextualized and fragmented nature of traumatic memories.
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
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