Neuroimage. Reports最新文献

Headache-specific hyperexcitation sensitises and habituates on different time scales: An event related potential study of pattern-glare 头痛特异性超兴奋在不同时间尺度上的敏感性和习惯性：模式眩光的事件相关电位研究

Neuroimage. Reports Pub Date : 2025-06-24 DOI: 10.1016/j.ynirp.2025.100271

Cihan Dogan , Claire E. Miller , Tom Jefferis , Margarita Saranti , Austyn J. Tempesta , Andrew J. Schofield , Ramaswamy Palaniappan , Howard Bowman

{"title":"Headache-specific hyperexcitation sensitises and habituates on different time scales: An event related potential study of pattern-glare","authors":"Cihan Dogan , Claire E. Miller , Tom Jefferis , Margarita Saranti , Austyn J. Tempesta , Andrew J. Schofield , Ramaswamy Palaniappan , Howard Bowman","doi":"10.1016/j.ynirp.2025.100271","DOIUrl":"10.1016/j.ynirp.2025.100271","url":null,"abstract":"<div><div>Cortical hyperexcitability is a key pathophysiological feature in several neurological disorders, including migraine, epilepsy, tinnitus, and Alzheimer's disease. We examined the temporal characteristics of Event Related Potentials (ERPs) in a healthy population using the Pattern Glare Test, a diagnostic tool used to assess patients with sensitivity to cortical hyperexcitability. In pre-experiment questionnaires, participants reported their susceptibility to a range of symptoms. A factor analysis over these responses identified three variables, with the one we investigate in this paper loading strongly on headache symptoms, e.g. headache frequency. We investigated two timeframes: habituation over the course of the entire experiment and sensitization over the course of a sequence of stimulus presentations. We found evidence of hyperexcitability at electrodes over visual cortex, for the aggravating stimulus (grating of ∼3 cycles/deg). Participants higher on the headache factor exhibited a higher degree of habituation and sensitization, with evidence that the level of sensitization habituated through the course of the experiment. These findings suggest that the same experimental paradigm and analysis should be performed on a clinically diagnosed population.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative susceptibility mapping of paramagnetic rim lesions in early multiple sclerosis: A cross-sectional study of brain age and disability 早期多发性硬化症顺磁边缘病变的定量易感性图谱：脑年龄和残疾的横断面研究

Neuroimage. Reports Pub Date : 2025-06-21 DOI: 10.1016/j.ynirp.2025.100277

Lars Skattebøl , Rigmor Lundby , Mathias H. Øverås , Piotr Sowa , Elisabeth G. Celius , Hanne F. Harbo , Wibeke Nordhøy , Einar A. Høgestøl , Gro O. Nygaard

{"title":"Quantitative susceptibility mapping of paramagnetic rim lesions in early multiple sclerosis: A cross-sectional study of brain age and disability","authors":"Lars Skattebøl , Rigmor Lundby , Mathias H. Øverås , Piotr Sowa , Elisabeth G. Celius , Hanne F. Harbo , Wibeke Nordhøy , Einar A. Høgestøl , Gro O. Nygaard","doi":"10.1016/j.ynirp.2025.100277","DOIUrl":"10.1016/j.ynirp.2025.100277","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic inflammation in multiple sclerosis is associated with neurodegeneration and progressive functional decline. Quantitative susceptibility mapping (QSM) is an MRI technique that visualizes paramagnetic rim lesions (PRLs), which are indicative of chronic inflammation. In this cross-sectional study, we explored the prevalence of PRLs in multiple sclerosis and assessed their associations with clinical disability, tissue magnetic susceptibility, and brain age predictions.</div></div><div><h3>Methods</h3><div>All participants from the NOR-MS study with a 3T MRI T1-weighted magnetization-prepared rapid gradient echo and QSM were included (n = 42, mean age = 39.4 years, 59.5 % females, median disease duration = 0.1 years [IQR: 0.02–5.42]). The presence and characteristics of PRLs were evaluated by an experienced neuroradiologist. PRL and non-PRL susceptibility were categorized into separate groups through manual segmentation and voxel-wise analysis. We utilized a validated simple fully convolutional network and T1-weighted images to estimate brain age, and its derivative – brain age gap (BAG). Clinical disability was assessed using the Expanded Disability Status Scale (EDSS).</div></div><div><h3>Results</h3><div>PRLs were identified in 14.3 % (n = 6) of study participants, and correlated with EDSS (rho = 0.86, p = 0.03). The mean paramagnetic rim susceptibility was 25.6 ± 14.1 parts per billion and correlated with EDSS (rho = 0.93, p = 0.008). EDSS was significantly higher in the PRL-positive group (median EDSS 2.25 vs 1.5, p = 0.02). The PRL-positive group exhibited a mean 5.6-year higher BAG (p = 0.01) than the PRL-negative group.</div></div><div><h3>Conclusion</h3><div>PRLs were present in a significant subset of study participants with MS and were associated with greater disability and higher BAG.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100277"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter changes with rehabilitation in children with Co-occurring autism spectrum disorder and developmental coordination disorder 自闭症谱系障碍和发育协调障碍患儿脑白质随康复的变化

Neuroimage. Reports Pub Date : 2025-06-16 DOI: 10.1016/j.ynirp.2025.100272

Melika Kangarani-Farahani , Jill G. Zwicker

{"title":"White matter changes with rehabilitation in children with Co-occurring autism spectrum disorder and developmental coordination disorder","authors":"Melika Kangarani-Farahani , Jill G. Zwicker","doi":"10.1016/j.ynirp.2025.100272","DOIUrl":"10.1016/j.ynirp.2025.100272","url":null,"abstract":"<div><h3>Purpose</h3><div>Up to 88 % of children with autism spectrum disorder (ASD) experience motor difficulties consistent with developmental coordination disorder (DCD). Cognitive Orientation to daily Occupational Performance (CO-OP) intervention is effective for children with co-occurring ASD and DCD to learn motor skills, but it is unknown if treatment-induced brain changes occur in this clinical population. Our objectives were to: (1) investigate changes in white matter microstructure in children with ASD + DCD after CO-OP intervention; (2) determine whether these brain changes are maintained three months after intervention; and (3) explore the relationship of white matter changes with improvements in motor function.</div></div><div><h3>Methods</h3><div>In this quasi-experimental study, 24 children with ASD + DCD (aged 8–12 years) underwent an initial MRI and were randomly assigned to either a treatment or waitlist group. The treatment group received CO-OP intervention (once weekly for 10 weeks), had a second MRI post-intervention, and a follow-up scan three months later. The waitlist group waited three months for their second MRI, received the intervention, and then had a post-treatment scan. Diffusion tensor imaging data were analyzed using tract-based spatial statistics.</div></div><div><h3>Results</h3><div>Children with ASD + DCD showed increased fractional anisotropy in cerebellar white matter in vermal lobule VI and middle cerebellar peduncle after CO-OP (Cohen's d = 0.88 and 0.85, respectively). Brain changes were maintained three months post-intervention. Regression analysis found no relationship between white matter changes and motor outcomes.</div></div><div><h3>Conclusions</h3><div>Improvements in cerebellar white matter pathways in children with ASD + DCD highlight the efficacy of CO-OP interventions as a therapeutic approach for this clinical population.</div></div><div><h3>Clinical trials registration</h3><div>ClinicalTrials.gov ID: NCT04119492.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative MRI-based decision model for early-stage parkinsonism diagnosis: a pilot feasibility study 基于定量mri的早期帕金森病诊断决策模型：初步可行性研究

Neuroimage. Reports Pub Date : 2025-06-14 DOI: 10.1016/j.ynirp.2025.100273

Laura Nunez-Gonzalez , Elise G.P. Dopper , Anke W. van der Eerden , Samy Abo Seada , Agnita J.W. Boon , Marcel M. Verbeek , Bastiaan R. Bloem , Frederick Jan Anton Meijer , Juan Antonio Hernandez-Tamames

引用次数: 0

Representative scale-invariant characteristics of male and female brains in magnetic resonance images 磁共振图像中男性和女性大脑的代表性尺度不变特征

Neuroimage. Reports Pub Date : 2025-06-11 DOI: 10.1016/j.ynirp.2025.100267

Matthew Toews , Talía Vázquez Romaguera , William Wells III , Nikos Makris

引用次数: 0

Exploring the impact of transcutaneous vagus nerve stimulation in subjects with and without burnout: Potential benefits for executive function and neural processing 探索经皮迷走神经刺激对倦怠和非倦怠受试者的影响：对执行功能和神经处理的潜在益处

Neuroimage. Reports Pub Date : 2025-05-29 DOI: 10.1016/j.ynirp.2025.100268

Mia Pihlaja , Kaisa M. Hartikainen

{"title":"Exploring the impact of transcutaneous vagus nerve stimulation in subjects with and without burnout: Potential benefits for executive function and neural processing","authors":"Mia Pihlaja , Kaisa M. Hartikainen","doi":"10.1016/j.ynirp.2025.100268","DOIUrl":"10.1016/j.ynirp.2025.100268","url":null,"abstract":"<div><h3>Introduction</h3><div>Many brain disorders and conditions, including occupational burnout, are linked with challenges in executive function (EF). Yet, there is a lack of treatments geared at restoring them. We have previously demonstrated that VNS enhances EF in patients with epilepsy and that transcutaneous VNS (tVNS) modulates the underlying neural processes in healthy subjects. In this study, we investigated the immediate impact of tVNS on EF in subjects with and without occupational burnout.</div></div><div><h3>Material and methods</h3><div>We hypothesized that tVNS enhances EF, as reflected in both behavioral and neural levels. Subjects with (n = 27) and without burnout (n = 24) performed an integrated computer-based test of EF, the Executive Reaction Time (RT) test. At the same time, EEG was recorded and tVNS or sham stimulation was delivered to each subject in an alternating manner. Event-related potentials, N2 and P3, peak and interpeak amplitudes, and latencies were used to evaluate the speed and allocation of neural processes linked with EFs and errors and RTs to assess performance.</div></div><div><h3>Results</h3><div>Frontal N2-P3 interpeak latency (IPL) in the NoGo condition was shorter with active tVNS (m = 157.6 ms (IQR = 59.2 ms)) than with sham (m = 169.6 ms (IQR = 88.4 ms), p = 0.01). Further, active tVNS reduced total errors in healthy subjects.</div></div><div><h3>Conclusion</h3><div>Active tVNS resulted in partly accelerated neural processing in the context of response inhibition in both groups and enhanced EF performance in subjects without burnout. We suggest that tVNS enhances neural processes underlying EFs in specific situations. Even though caution is warranted, tVNS shows some promise as a potential cognitive enhancer.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100268"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional near-infrared spectroscopy (fNIRS) detects brain changes for apathy and pain in patients with Alzheimer's disease and related dementias: An exploratory study 功能性近红外光谱（fNIRS）检测阿尔茨海默病及相关痴呆患者的冷漠和疼痛的大脑变化：一项探索性研究

Neuroimage. Reports Pub Date : 2025-05-29 DOI: 10.1016/j.ynirp.2025.100266

Allison J. Huff , Juyoung Park , Samuel Montero-Hernandez , Lindsey Park , Chiyoung Lee , Luca Pollonini , Hyochol Ahn

{"title":"Functional near-infrared spectroscopy (fNIRS) detects brain changes for apathy and pain in patients with Alzheimer's disease and related dementias: An exploratory study","authors":"Allison J. Huff , Juyoung Park , Samuel Montero-Hernandez , Lindsey Park , Chiyoung Lee , Luca Pollonini , Hyochol Ahn","doi":"10.1016/j.ynirp.2025.100266","DOIUrl":"10.1016/j.ynirp.2025.100266","url":null,"abstract":"<div><div>Alzheimer's Disease and Related Dementias (ADRD) are degenerative and progressive in nature and are often accompanied by chronic pain and neuropsychiatric symptoms, which can be early signs and aggravators of ADRD. This exploratory study explores the relationship between self-reported pain, neuropsychiatric symptoms, and pain-evoked cortical hemodynamic changes measured using functional near-infrared spectroscopy (fNIRS) in the prefrontal and primary motor and somatosensory brain cortices bilaterally, stratified by high or low cognitive function in individuals with ADRD. This study analyzed baseline data of 40 individuals with mild to moderate ADRD with knee osteoarthritis.</div><div>Baseline data from 40 individuals with mild to moderate ADRD and knee osteoarthritis were analyzed. Measures included self-reported pain, depression, and apathy, along with fNIRS-derived cerebral hemodynamic responses to sub-threshold thermal pain stimulation across five brain regions. The study revealed significant negative correlations for oxyhemoglobin and apathy in the right prefrontal cortex associated with low cognitive function (p = .04) and significant positive correlations for oxyhemoglobin and apathy in the right somatosensory region (p = .04) and for oxyhemoglobin and pain in the medial prefrontal cortex (p = .04) associated with higher cognitive function. Study findings suggest that fNIRS may provide valuable biomarkers for apathy and depression in individuals with ADRD and chronic osteoarthritic pain, with differential patterns based on cognitive function, suggesting neuropsychiatric symptoms may manifest differently depending on the patient's cognitive status. Future studies should explore its utility in larger, diverse samples and clinical interventions targeting neuropsychiatric symptoms.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers 与同龄人相比，镰状细胞病儿童和年轻人的脑动脉管腔增大

Neuroimage. Reports Pub Date : 2025-05-09 DOI: 10.1016/j.ynirp.2025.100265

Josiah B. Lewis , Melanie E. Fields , Michael M. Binkley , Anita Zhou , Amy Mirro , Amy Ouyang , Niket Gupta , Yasheng Chen , Slim Fellah , Alyssa E. Smith , Igor Dedkov , Monica L. Hulbert , Andria L. Ford , Hongyu An , Jin-Moo Lee , Manu S. Goyal , Kristin P. Guilliams

{"title":"Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers","authors":"Josiah B. Lewis , Melanie E. Fields , Michael M. Binkley , Anita Zhou , Amy Mirro , Amy Ouyang , Niket Gupta , Yasheng Chen , Slim Fellah , Alyssa E. Smith , Igor Dedkov , Monica L. Hulbert , Andria L. Ford , Hongyu An , Jin-Moo Lee , Manu S. Goyal , Kristin P. Guilliams","doi":"10.1016/j.ynirp.2025.100265","DOIUrl":"10.1016/j.ynirp.2025.100265","url":null,"abstract":"<div><div>Children with sickle cell disease (SCD) may develop large vessel narrowing, but studies suggest vessels may also be enlarged, possibly related to increased cerebral blood flow (CBF). We used MRI to investigate whether the cross-sectional total inflow vessel luminal area (TIVLA) proximal to the circle of Willis (carotid arteries + basilar artery) would be increased in SCD compared to age- and sex-matched peers after adjusting for CBF. Across 36 children with SCD (19 female, median age 10.7 [8.0–14.5] years and 43 controls (26 female, median age 12.7 [9.2–18.2] years) matched by age (<em>p</em> = 0.13) and sex (<em>p</em> = 0.50), the median TIVLA in the SCD group (35.9 mm<sup>2</sup> [30.7, 39.5]) was larger than controls (30.5 mm<sup>2</sup> [27.8, 35.4], <em>p</em> = 0.002). In a mixed model including age, sex, hemoglobin, CBF, SCD status, and an interaction between hemoglobin and SCD status, CBF (β = 0.11, CI 0.02–0.20, <em>p</em> = 0.02), SCD (β = 28.02, CI 5.62–50.42, <em>p</em> = 0.015), and the interaction between SCD and hemoglobin (β = −2.48, CI −4.49 to −0.47, <em>p</em> = 0.018) were all significantly associated with increased TIVLA. Notably, TIVLA as a measure of arterial lumens is larger in children with SCD, even after adjusting for CBF in the mixed model. This implies disease-specific normative values may be needed to detect early vasculopathy.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 2","pages":"Article 100265"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample 在日本样本中使用结构MRI的VBM分析评估与MMSE相关的局部脑区域

Neuroimage. Reports Pub Date : 2025-04-29 DOI: 10.1016/j.ynirp.2025.100264

Yoichi Sawada , Toru Satoh , Hideaki Saba , Yoshiki Kato , Tomoko Kuwada , Sayoko Shima , Kana Murakami , Megumi Sasaki , Yudai Abe , Kaori Harano

{"title":"Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample","authors":"Yoichi Sawada , Toru Satoh , Hideaki Saba , Yoshiki Kato , Tomoko Kuwada , Sayoko Shima , Kana Murakami , Megumi Sasaki , Yudai Abe , Kaori Harano","doi":"10.1016/j.ynirp.2025.100264","DOIUrl":"10.1016/j.ynirp.2025.100264","url":null,"abstract":"<div><div>The global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (MMSE) is commonly used for cognitive screening, yet its limitations—such as ceiling effects and educational biases—may hinder the early identification of subtle cognitive impairments. This cross-sectional study employed voxel-based morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) to explore brain regions positively correlated with MMSE scores in a cohort of 510 participants. Significant gray matter volume (GMV) reductions were observed in the bilateral lateral frontal lobes, left medial frontal lobe, left hippocampus, left anterior cingulate cortex (ACC), and bilateral inferior temporal gyri in association with lower MMSE scores. Participants were classified into three groups—Normal Cognition (NC), MCI, and Dementia (D)—based on MMSE cutoff values. Compared to the NC group, the MCI group exhibited significant GMV reductions in the left hippocampus, left parahippocampal gyrus, left ACC, and right ventromedial prefrontal cortex (vmPFC). The D group showed further GMV reductions in the bilateral hippocampus and left inferior temporal gyrus compared to the MCI group. These findings highlight the clinical utility of VBM-based structural MRI in assessing localized brain atrophy associated with cognitive decline, supporting its potential role in early diagnosis and intervention for MCI. Further research integrating longitudinal studies and multimodal biomarkers is warranted to enhance diagnostic accuracy.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 2","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain MRI before and at term equivalent age predicts motor and cognitive outcomes in very preterm infants 足月前和足月时的脑MRI预测极早产儿的运动和认知结果

Neuroimage. Reports Pub Date : 2025-04-19 DOI: 10.1016/j.ynirp.2025.100262

Alex M. Pagnozzi , Kerstin Pannek , Roslyn N. Boyd , Liza van Eijk , Joanne M. George , Samudragupta Bora , DanaKai Bradford , Michael Fahey , Michael Ditchfield , Atul Malhotra , Paul B. Colditz , Jurgen Fripp

{"title":"Brain MRI before and at term equivalent age predicts motor and cognitive outcomes in very preterm infants","authors":"Alex M. Pagnozzi , Kerstin Pannek , Roslyn N. Boyd , Liza van Eijk , Joanne M. George , Samudragupta Bora , DanaKai Bradford , Michael Fahey , Michael Ditchfield , Atul Malhotra , Paul B. Colditz , Jurgen Fripp","doi":"10.1016/j.ynirp.2025.100262","DOIUrl":"10.1016/j.ynirp.2025.100262","url":null,"abstract":"<div><div>Brain Magnetic Resonance Imaging (MRI) of high-risk infants in the neonatal period (from 26 weeks postmenstrual age to Term Equivalent Age (TEA)) is increasingly being used for the detection of brain injuries, and the early prognostication of adverse outcomes such as Cerebral Palsy (CP). While most imaging is performed around TEA in clinical practice for infants born preterm (<37 weeks of gestation), this would often require families to return to hospital for imaging. In this work, we extract structural biomarkers from MRI acquired both before and at TEA in a cohort of very preterm infants from the PPREMO and PREBO studies (n = 100), to determine if either time-point, or both combined, are predictive of both Bayley Scales of Infant and Toddler Development – Third Edition (Bayley-III) and the Neuro-sensory Motor Developmental Assessment (NSMDA) at 2 years. Using multivariable regression, moderately strong and statistically significant associations were found between brain structure on both early and TEA MRIs with 2-year outcomes (r = 0.39–0.55 for early MRI, r = 0.37–0.49 for Term MRI, r = 0.37–0.56 for early and TEA MRI combined). Importantly, brain biomarkers associated with early childhood outcomes from MRIs were identified, including white and grey matter volumes, deep grey matter and cerebellar volumes, and gyrification and surface area across the whole cortex. Early MRI showed the best prognostic accuracy along with combining timepoints, indicating the potential clinical benefit of Early MRI in predicting adverse outcomes.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 2","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0