{"title":"cbt前静息状态连通性和强迫症缓解的白质完整性：一项多模态MRI研究","authors":"Yuki Ikemizu , Yuko Isobe , Yusuke Sudo , Junko Ota , Ritu Bhusal Chhatkuli , Tubasa Sasaki , Kohei Kurita , Tokiko Yoshida , Koji Matsumoto , Masaru Kuno , Naoko Kato , Akiko Nakagawa , Eiji Shimizu , Yoshiyuki Hirano","doi":"10.1016/j.ynirp.2025.100275","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive disorder (OCD) is commonly treated with cognitive-behavioral therapy (CBT), yet many patients fail to achieve remission. Neuroimaging markers, such as pre-treatment functional and structural connectivity, may help elucidate OCD pathology and CBT mechanisms, and predict treatment outcomes. This study investigates the relationship between pre-treatment functional and structural connectivity and remission status in OCD patients following CBT.</div></div><div><h3>Methods</h3><div>Thirty-three OCD patients underwent multimodal MRI, including resting-state fMRI to assess pre-treatment functional connectivity and diffusion tensor imaging (DTI) to evaluate white matter integrity. Functional connectivity multivariate pattern analysis (fc-MVPA) identified patterns linked to treatment outcomes. TRACULA, a probabilistic tractography technique, analyzed white matter tracts, focusing on diffusion metrics such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Analysis of covariance (ANCOVA) was used to examine group differences.</div></div><div><h3>Results</h3><div>Remission was associated with significantly higher pre-treatment resting-state functional connectivity between the occipital pole and lateral occipital cortex (height threshold: p < 0.001 uncorrected and cluster threshold: p < 0.05 cluster-size FDR corrected for multiple comparisons), suggesting a role in visual processing. Differences in white matter integrity were found in the corpus callosum rostrum, left acoustic radiation, right dorsal cingulum bundle, and right superior longitudinal fasciculus II, though these results were not corrected for multiple comparisons.</div></div><div><h3>Conclusion</h3><div>Enhanced pre-treatment functional connectivity in visual processing regions and specific white matter tracts may serve as biomarkers for remission in OCD following CBT. These findings could improve understanding of CBT’s neural effects and guide personalized treatment strategies.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 3","pages":"Article 100275"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study\",\"authors\":\"Yuki Ikemizu , Yuko Isobe , Yusuke Sudo , Junko Ota , Ritu Bhusal Chhatkuli , Tubasa Sasaki , Kohei Kurita , Tokiko Yoshida , Koji Matsumoto , Masaru Kuno , Naoko Kato , Akiko Nakagawa , Eiji Shimizu , Yoshiyuki Hirano\",\"doi\":\"10.1016/j.ynirp.2025.100275\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Obsessive-compulsive disorder (OCD) is commonly treated with cognitive-behavioral therapy (CBT), yet many patients fail to achieve remission. Neuroimaging markers, such as pre-treatment functional and structural connectivity, may help elucidate OCD pathology and CBT mechanisms, and predict treatment outcomes. This study investigates the relationship between pre-treatment functional and structural connectivity and remission status in OCD patients following CBT.</div></div><div><h3>Methods</h3><div>Thirty-three OCD patients underwent multimodal MRI, including resting-state fMRI to assess pre-treatment functional connectivity and diffusion tensor imaging (DTI) to evaluate white matter integrity. Functional connectivity multivariate pattern analysis (fc-MVPA) identified patterns linked to treatment outcomes. TRACULA, a probabilistic tractography technique, analyzed white matter tracts, focusing on diffusion metrics such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Analysis of covariance (ANCOVA) was used to examine group differences.</div></div><div><h3>Results</h3><div>Remission was associated with significantly higher pre-treatment resting-state functional connectivity between the occipital pole and lateral occipital cortex (height threshold: p < 0.001 uncorrected and cluster threshold: p < 0.05 cluster-size FDR corrected for multiple comparisons), suggesting a role in visual processing. Differences in white matter integrity were found in the corpus callosum rostrum, left acoustic radiation, right dorsal cingulum bundle, and right superior longitudinal fasciculus II, though these results were not corrected for multiple comparisons.</div></div><div><h3>Conclusion</h3><div>Enhanced pre-treatment functional connectivity in visual processing regions and specific white matter tracts may serve as biomarkers for remission in OCD following CBT. These findings could improve understanding of CBT’s neural effects and guide personalized treatment strategies.</div></div>\",\"PeriodicalId\":74277,\"journal\":{\"name\":\"Neuroimage. Reports\",\"volume\":\"5 3\",\"pages\":\"Article 100275\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimage. Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666956025000431\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage. Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666956025000431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study
Background
Obsessive-compulsive disorder (OCD) is commonly treated with cognitive-behavioral therapy (CBT), yet many patients fail to achieve remission. Neuroimaging markers, such as pre-treatment functional and structural connectivity, may help elucidate OCD pathology and CBT mechanisms, and predict treatment outcomes. This study investigates the relationship between pre-treatment functional and structural connectivity and remission status in OCD patients following CBT.
Methods
Thirty-three OCD patients underwent multimodal MRI, including resting-state fMRI to assess pre-treatment functional connectivity and diffusion tensor imaging (DTI) to evaluate white matter integrity. Functional connectivity multivariate pattern analysis (fc-MVPA) identified patterns linked to treatment outcomes. TRACULA, a probabilistic tractography technique, analyzed white matter tracts, focusing on diffusion metrics such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Analysis of covariance (ANCOVA) was used to examine group differences.
Results
Remission was associated with significantly higher pre-treatment resting-state functional connectivity between the occipital pole and lateral occipital cortex (height threshold: p < 0.001 uncorrected and cluster threshold: p < 0.05 cluster-size FDR corrected for multiple comparisons), suggesting a role in visual processing. Differences in white matter integrity were found in the corpus callosum rostrum, left acoustic radiation, right dorsal cingulum bundle, and right superior longitudinal fasciculus II, though these results were not corrected for multiple comparisons.
Conclusion
Enhanced pre-treatment functional connectivity in visual processing regions and specific white matter tracts may serve as biomarkers for remission in OCD following CBT. These findings could improve understanding of CBT’s neural effects and guide personalized treatment strategies.
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