Neurogenesis (Austin, Tex.)最新文献_第2页

The expanding role of the Ehmt2/G9a complex in neurodevelopment. Ehmt2/G9a复合物在神经发育中的扩展作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-02 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1316888

Steven J Deimling, Jonathan B Olsen, Vincent Tropepe

引用次数: 19

The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain. 衰老对成年斑马鱼脑淀粉样蛋白β42诱导的神经变性和再生的影响。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-02 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1322666

Prabesh Bhattarai, Alvin Kuriakose Thomas, Yixin Zhang, Caghan Kizil

{"title":"The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain.","authors":"Prabesh Bhattarai, Alvin Kuriakose Thomas, Yixin Zhang, Caghan Kizil","doi":"10.1080/23262133.2017.1322666","DOIUrl":"https://doi.org/10.1080/23262133.2017.1322666","url":null,"abstract":"Alzheimer disease is the most prevalent neurodegenerative disease and is associated with aggregation of Amyloid-β42 peptides. In mammals, Amyloid-β42 causes impaired neural stem/progenitor cell (NSPC) proliferation and neurogenesis, which exacerbate with aging. The molecular programs necessary to enhance NSPC proliferation and neurogenesis in our brains to mount successful regeneration are largely unknown. Therefore, to identify the molecular basis of effective brain regeneration, we previously established an Amyloid-β42 model in adult zebrafish that displayed Alzheimer-like phenotypes reminiscent of humans. Interestingly, zebrafish exhibited enhanced NSPC proliferation and neurogenesis after microinjection of Amyloid-β42 peptide. Here, we compare old and young fish to address the effects of aging on regenerative ability after Amyloid-β42 deposition. We found that aging does not affect the rate of NSPC proliferation but reduces the neurogenic response and microglia/macrophage activation after microinjection of Amyloid-β42 in zebrafish, suggesting an important link between aging, neuroinflammation, regenerative neurogenesis and neural stem cell plasticity.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1322666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35124506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Building a central nervous system: The neural stem cell lineage revealed. 构建中枢神经系统:揭示神经干细胞谱系。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-28 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1300037

Wenjun Xu, Nishanth Lakshman, Cindi M Morshead

引用次数: 24

Nervous system development relies on endosomal trafficking. 神经系统的发育依赖于内体运输。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-27 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1316887

Ivan Mestres, Ching-Hwa Sung

引用次数: 2

What is CAR doing in the middle of the adult neurogenic road? CAR在成人神经源性过程中做了什么?

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-27 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1304790

Sara Salinas, Felix Junyent, Nathalie Coré, Harold Cremer, Eric J Kremer

引用次数: 4

A brief history of the study of nerve dependent regeneration. 神经依赖性再生研究简史。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-10 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1302216

Johanna E Farkas, James R Monaghan

引用次数: 49

The importance of constructive feedback: Implications of top-down regulation in the development of neural circuits. 建设性反馈的重要性:自上而下调控在神经回路发育中的意义。

Neurogenesis (Austin, Tex.) Pub Date : 2017-03-03 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1287553

Andrew D Thompson, Chinfei Chen

{"title":"The importance of constructive feedback: Implications of top-down regulation in the development of neural circuits.","authors":"Andrew D Thompson, Chinfei Chen","doi":"10.1080/23262133.2017.1287553","DOIUrl":"https://doi.org/10.1080/23262133.2017.1287553","url":null,"abstract":"Neural circuits in sensory pathways develop through a general strategy of overproduction of synapses followed by activity-driven pruning to fine-tune connectivity for optimal function. The early visual pathway, consisting of the retina → visual thalamus → primary visual cortex, has served for decades as a powerful model system for probing the mechanisms and logic of this process. In addition to these feedforward projections, the early visual pathway also includes a substantial feedback component in the form of corticothalamic projections from the deepest layer of primary visual cortex. The role of this feedback in visual processing has been studied extensively in mature animals, yet historically, its role in development has received comparatively little attention. Recent technological advances allowing for selective manipulation of neural activity in development led to the uncovering of a role for feedback in guiding the refinement of the forward projection from retina to visual thalamus. Here we discuss the implications of feedback exerting influence on the development of sensory pathways. We propose several possible advantages to constructing neural circuits with top-down regulation, and discuss the potential significance of this finding for certain neurologic disorders.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1287553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34846429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Toward a better understanding of enteric gliogenesis. 为了更好地理解肠道胶质形成。

Neurogenesis (Austin, Tex.) Pub Date : 2017-03-02 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1293958

Baptiste Charrier, Nicolas Pilon

引用次数: 17

Amyloid Precursor Protein family as unconventional Go-coupled receptors and the control of neuronal motility. 淀粉样前体蛋白家族作为非常规go偶联受体与神经元运动的控制。

Neurogenesis (Austin, Tex.) Pub Date : 2017-03-01 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1288510

Jenna M Ramaker, Philip F Copenhaver

{"title":"Amyloid Precursor Protein family as unconventional Go-coupled receptors and the control of neuronal motility.","authors":"Jenna M Ramaker, Philip F Copenhaver","doi":"10.1080/23262133.2017.1288510","DOIUrl":"https://doi.org/10.1080/23262133.2017.1288510","url":null,"abstract":"Cleavage of the Amyloid Precursor Protein (APP) generates amyloid peptides that accumulate in Alzheimer Disease (AD), but APP is also upregulated by developing and injured neurons, suggesting that it regulates neuronal motility. APP can also function as a G protein-coupled receptor that signals via the heterotrimeric G protein Gαo, but evidence for APP-Gαo signaling in vivo has been lacking. Using Manduca as a model system, we showed that insect APP (APPL) regulates neuronal migration in a Gαo-dependent manner. Recently, we also demonstrated that Manduca Contactin (expressed by glial cells) induces APPL-Gαo retraction responses in migratory neurons, consistent with evidence that mammalian Contactins also interact with APP family members. Preliminary studies using cultured hippocampal neurons suggest that APP-Gαo signaling can similarly regulate growth cone motility. Whether Contactins (or other APP ligands) induce this response within the developing nervous system, and how this pathway is disrupted in AD, remains to be explored.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1288510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34836668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Signaling pathways and tissue interactions in neural plate border formation. 神经板边界形成中的信号通路和组织相互作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-02-23 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1292783

Carolin Schille, Alexandra Schambony

引用次数: 12