神经板边界形成中的信号通路和组织相互作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-02-23 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1292783
Carolin Schille, Alexandra Schambony
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引用次数: 12

摘要

神经嵴是一个短暂的细胞群,在脊椎动物胚胎中产生多种组织和器官的各种细胞类型。神经嵴细胞起源于神经板边缘,这是一个位于未来神经板外侧边缘的区域。与相邻组织,非神经外胚层,神经板和未来背外侧中胚层,在时间和空间上协调的相互作用是神经板边界规范所必需的。信号分子,即BMP、Wnt和FGF配体及其拮抗剂来源于这些组织,并相互作用诱导神经板边界特异性基因的表达。本综述的重点是目前对NPB区域如何形成的理解,并强调了BMP和Wnt信号通路的协调相互作用和精确的组织通信的需要,这是定义合格外胚层中潜在NC所必需的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Signaling pathways and tissue interactions in neural plate border formation.

Signaling pathways and tissue interactions in neural plate border formation.

Signaling pathways and tissue interactions in neural plate border formation.

The neural crest is a transient cell population that gives rise to various cell types of multiple tissues and organs in the vertebrate embryo. Neural crest cells arise from the neural plate border, a region localized at the lateral borders of the prospective neural plate. Temporally and spatially coordinated interaction with the adjacent tissues, the non-neural ectoderm, the neural plate and the prospective dorsolateral mesoderm, is required for neural plate border specification. Signaling molecules, namely BMP, Wnt and FGF ligands and corresponding antagonists are derived from these tissues and interact to induce the expression of neural plate border specific genes. The present mini-review focuses on the current understanding of how the NPB territory is formed and accentuates the need for coordinated interaction of BMP and Wnt signaling pathways and precise tissue communication that are required for the definition of the prospective NC in the competent ectoderm.

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