Neurogenesis (Austin, Tex.)最新文献_第10页

Young systemic factors as a medicine for age-related neurodegenerative diseases. 年轻的系统性因子作为药物治疗与年龄相关的神经退行性疾病。

Neurogenesis (Austin, Tex.) Pub Date : 2015-02-03 eCollection Date: 2015-01-01 DOI: 10.1080/23262133.2015.1004971

Lida Katsimpardi, Lee L Rubin

{"title":"Young systemic factors as a medicine for age-related neurodegenerative diseases.","authors":"Lida Katsimpardi, Lee L Rubin","doi":"10.1080/23262133.2015.1004971","DOIUrl":"https://doi.org/10.1080/23262133.2015.1004971","url":null,"abstract":"It is widely known that neurogenesis, brain function and cognition decline with aging. Increasing evidence suggests that cerebrovascular dysfunction is a major cause of cognitive impairment in the elderly but is also involved in age-related neurodegenerative diseases. Finding ways and molecules that reverse this process and ameliorate age- and disease-related cognitive impairment by targeting vascular and neurogenic deterioration would be of great therapeutic value. In Katsimpardi et al. we reported that young blood has a dual beneficial effect in the aged brain by restoring age-related decline in neurogenesis as well as inducing a striking remodeling of the aged vasculature and restoring blood flow to youthful levels. Additionally, we identified a youthful systemic factor, GDF11 that recapitulates these beneficial effects of young blood. We believe that the identification of young systemic factors that can rejuvenate the aged brain opens new roads to therapeutic intervention for neurodegenerative diseases by targeting both neural stem cells and neurogenesis as well as at the vasculature. ","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":" ","pages":"e1004971"},"PeriodicalIF":0.0,"publicationDate":"2015-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2015.1004971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34741075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans. 胚胎和成年龟脑室增殖性区的放射状胶质细胞。

Neurogenesis (Austin, Tex.) Pub Date : 2014-12-02 eCollection Date: 2014-01-01 DOI: 10.4161/23262125.2014.970905

Brian K Clinton, Christopher L Cunningham, Arnold R Kriegstein, Stephen C Noctor, Verónica Martínez-Cerdeño

{"title":"Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans.","authors":"Brian K Clinton, Christopher L Cunningham, Arnold R Kriegstein, Stephen C Noctor, Verónica Martínez-Cerdeño","doi":"10.4161/23262125.2014.970905","DOIUrl":"https://doi.org/10.4161/23262125.2014.970905","url":null,"abstract":"To better understand the role of radial glial (RG) cells in the evolution of the mammalian cerebral cortex, we investigated the role of RG cells in the dorsal cortex and dorsal ventricular ridge of the turtle, Trachemys scripta elegans. Unlike mammals, the glial architecture of adult reptile consists mainly of ependymoradial glia, which share features with mammalian RG cells, and which may contribute to neurogenesis that continues throughout the lifespan of the turtle. To evaluate the morphology and proliferative capacity of ependymoradial glia (here referred to as RG cells) in the dorsal cortex of embryonic and adult turtle, we adapted the cortical electroporation technique, commonly used in rodents, to the turtle telencephalon. Here, we demonstrate the morphological and functional characteristics of RG cells in the developing turtle dorsal cortex. We show that cell division occurs both at the ventricle and away from the ventricle, that RG cells undergo division at the ventricle during neurogenic stages of development, and that mitotic Tbr2+ precursor cells, a hallmark of the mammalian SVZ, are present in the turtle cortex. In the adult turtle, we show that RG cells encompass a morphologically heterogeneous population, particularly in the subpallium where proliferation is most prevalent. One RG subtype is similar to RG cells in the developing mammalian cortex, while 2 other RG subtypes appear to be distinct from those seen in mammal. We propose that the different subtypes of RG cells in the adult turtle perform distinct functions. ","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"1 1","pages":"e970905"},"PeriodicalIF":0.0,"publicationDate":"2014-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23262125.2014.970905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34742467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling. CREB/CREM信号对胚胎神经前体增殖和组蛋白乙酰化的调控。

Neurogenesis (Austin, Tex.) Pub Date : 2014-11-26 eCollection Date: 2014-01-01 DOI: 10.4161/23262125.2014.970883

Rosanna Parlato, Claudia Mandl, Gabriele Hölzl-Wenig, Birgit Liss, Kerry L Tucker, Francesca Ciccolini

{"title":"Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling.","authors":"Rosanna Parlato, Claudia Mandl, Gabriele Hölzl-Wenig, Birgit Liss, Kerry L Tucker, Francesca Ciccolini","doi":"10.4161/23262125.2014.970883","DOIUrl":"https://doi.org/10.4161/23262125.2014.970883","url":null,"abstract":"The transcription factor CREB (cAMP-response element binding protein) regulates differentiation, migration, survival and activity-dependent gene expression in the developing and mature nervous system. However, its specific role in the proliferation of embryonic neural progenitors is still not completely understood. Here we investigated how CREB regulates proliferation of mouse embryonic neural progenitors by a conditional mutant lacking Creb gene in neural progenitors. In parallel, we explored possible compensatory effects by the genetic ablation of another member of the same gene family, the cAMP-responsive element modulator (Crem). We show that CREB loss differentially impaired the proliferation, clonogenic potential and self-renewal of precursors derived from the ganglionic eminence (GE), in comparison to those derived from the cortex. This phenotype was associated with a specific reduction of histone acetylation in the GE of CREB mutant mice, and this reduction was rescued in vivo by inhibition of histone deacetylation. These observations indicate that the impaired proliferation could be caused by a reduced acetyltransferase activity in Creb conditional knock-out mice. These findings support a crucial role of CREB in controlling embryonic neurogenesis and propose a novel mechanism by which CREB regulates embryonic neural development. ","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"1 1","pages":"e970883"},"PeriodicalIF":0.0,"publicationDate":"2014-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23262125.2014.970883","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34742466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Meis: New friends of Pax. 梅斯:帕克斯的新朋友。

Neurogenesis (Austin, Tex.) Pub Date : 2014-11-21 eCollection Date: 2014-01-01 DOI: 10.4161/23262133.2014.976014

Dorothea Schulte

{"title":"Meis: New friends of Pax.","authors":"Dorothea Schulte","doi":"10.4161/23262133.2014.976014","DOIUrl":"https://doi.org/10.4161/23262133.2014.976014","url":null,"abstract":"The generation of neuronal diversity in the mammalian brain is a multistep process, beginning with the regional patterning of neural stem- and progenitor cell domains, the commitment of these cells toward a general neuronal fate, followed by the selection of a particular neuronal subtype and the differentiation of postmitotic neurons. Each of these steps as well as the transitions between them require precisely controlled changes in transcriptional programs. Although a large number of transcription factors are known to regulate neurogenesis in the embryonic and adult central nervous system, the sheer number of neuronal cell types in the brain and the complexity of the cellular processes that accompany their production suggest that transcription factors act cooperatively to control individual steps in neurogenesis. In fact, combinatorial regulation by sets of transcription factors has emerged as a versatile mode to control cell fate specification. Here, I discuss our recent finding that members of the MEIS-subfamily of TALE-transcription factors, originally identified as HOX cofactors in non-neural tissues, function in concert with PAX-proteins in the regulation of cell fate specification and neuronal differentiation in the embryonic and adult brain. ","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"1 1","pages":"e976014"},"PeriodicalIF":0.0,"publicationDate":"2014-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23262133.2014.976014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34644574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells. Np95在小鼠胚胎至成年大脑中的表达特征:神经干/前体细胞增殖的新标记。

Neurogenesis (Austin, Tex.) Pub Date : 2014-11-17 eCollection Date: 2014-01-01 DOI: 10.4161/23262133.2014.976026

Naoya Murao, Taito Matsuda, Hirofumi Noguchi, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashima

{"title":"Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells.","authors":"Naoya Murao, Taito Matsuda, Hirofumi Noguchi, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashima","doi":"10.4161/23262133.2014.976026","DOIUrl":"https://doi.org/10.4161/23262133.2014.976026","url":null,"abstract":"Nuclear protein 95 KDa (Np95, also known as UHRF1 or ICBP90) plays an important role in maintaining DNA methylation of newly synthesized DNA strands by recruiting DNA methyltransferase 1 (DNMT1) during cell division. In addition, Np95 participates in chromatin remodeling by interacting with histone modification enzymes such as histone deacetylases. However, its expression pattern and function in the brain have not been analyzed extensively. We here investigated the expression pattern of Np95 in the mouse brain, from developmental to adult stages. In the fetal brain, Np95 is abundantly expressed at the midgestational stage, when a large number of neural stem/precursor cells (NS/PCs) exist. Interestingly, Np95 is expressed specifically in NS/PCs but not in differentiated cells such as neurons or glial cells. Furthermore, we demonstrate that Np95 is preferentially expressed in type 2a cells, which are highly proliferative NS/PCs in the dentate gyrus of the adult hippocampus. Moreover, the number of Np95-expressing cells increases in response to kainic acid administration or to voluntary running, which are known to enhance the proliferation of adult NS/PCs. These results suggest that Np95 participates in the process of proliferation and differentiation of NS/PCs, and that it should be a useful novel marker for proliferating NS/PCs, facilitating the analysis of the complex behavior of NS/PCs in the brain. ","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"1 1","pages":"e976026"},"PeriodicalIF":0.0,"publicationDate":"2014-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/23262133.2014.976026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34742468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

microRNA regulation of neural precursor self-renewal and differentiation. microRNA对神经前体自我更新和分化的调控。

Neurogenesis (Austin, Tex.) Pub Date : 2014-11-17 eCollection Date: 2014-01-01 DOI: 10.4161/23262133.2014.976018

Laura I Hudish, Bruce Appel

引用次数: 2

Sox2: A multitasking networker. Sox2:多任务网络。

Neurogenesis (Austin, Tex.) Pub Date : 2014-10-29 eCollection Date: 2014-01-01 DOI: 10.4161/23262125.2014.962391

Simone Reiprich, Michael Wegner

引用次数: 5

Establishment of a radial glia-like mouse fetal hypothalamic neural stem cell line (AC1) able to differentiate into neuroendocrine cells. 能分化为神经内分泌细胞的小鼠胎儿下丘脑神经干细胞(AC1)的建立。

Neurogenesis (Austin, Tex.) Pub Date : 2014-07-28 eCollection Date: 2014-01-01 DOI: 10.4161/neur.29950

Anna Cariboni, Luciano Conti, Valentina Andrè, Davide Aprile, Jacopo Zasso, Roberto Maggi

引用次数: 6

Multiple facets of CBP in forebrain interneuron development CBP在前脑中间神经元发育中的多个方面

Neurogenesis (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/neur.29168

Jing Wang

引用次数: 0

MicroRNA-mediated regulation of the neurogenic-to-gliogenic competence transition of neural stem/progenitor cells microrna介导的神经干细胞/祖细胞神经原性向胶质原性转变的调控

Neurogenesis (Austin, Tex.) Pub Date : 2014-01-01 DOI: 10.4161/neur.29542

H. Naka-Kaneda, T. Shimazaki, H. Okano

{"title":"MicroRNA-mediated regulation of the neurogenic-to-gliogenic competence transition of neural stem/progenitor cells","authors":"H. Naka-Kaneda, T. Shimazaki, H. Okano","doi":"10.4161/neur.29542","DOIUrl":"https://doi.org/10.4161/neur.29542","url":null,"abstract":"Multipotent neural stem/progenitor cells (NSPCs) produce various types of neurons and glial cells during the development of the central nervous system (CNS); however, NSPCs are not always able to generate all types of neural cells. The formation of complex neural networks relies on proper cytogenesis from NSPCs, which is under strict spatiotemporal regulation by intrinsic and extrinsic mechanisms. The neurogenesis-to-gliogenesis switch, a major event during CNS development, is largely dependent on the cell-autonomous temporal specification of NSPCs. The results of several previous studies suggest that developmental stage-dependent changes in the epigenetic status of proneural and astrocytic genes correlate with the temporal identity transition of developing NSPCs. These changes are related to alterations in the responsiveness of NSPCs to extrinsic neurogenic or gliogenic factors. Here, we discuss our recent findings that microRNA-mediated regulation of competence and relationships between multi-layered molecular regulatory systems control the temporal specification of NSPCs during CNS development.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"7 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/neur.29542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70643711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1