Meis: New friends of Pax.

Neurogenesis (Austin, Tex.) Pub Date : 2014-11-21 eCollection Date: 2014-01-01 DOI:10.4161/23262133.2014.976014
Dorothea Schulte
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引用次数: 5

Abstract

The generation of neuronal diversity in the mammalian brain is a multistep process, beginning with the regional patterning of neural stem- and progenitor cell domains, the commitment of these cells toward a general neuronal fate, followed by the selection of a particular neuronal subtype and the differentiation of postmitotic neurons. Each of these steps as well as the transitions between them require precisely controlled changes in transcriptional programs. Although a large number of transcription factors are known to regulate neurogenesis in the embryonic and adult central nervous system, the sheer number of neuronal cell types in the brain and the complexity of the cellular processes that accompany their production suggest that transcription factors act cooperatively to control individual steps in neurogenesis. In fact, combinatorial regulation by sets of transcription factors has emerged as a versatile mode to control cell fate specification. Here, I discuss our recent finding that members of the MEIS-subfamily of TALE-transcription factors, originally identified as HOX cofactors in non-neural tissues, function in concert with PAX-proteins in the regulation of cell fate specification and neuronal differentiation in the embryonic and adult brain.

Abstract Image

梅斯:帕克斯的新朋友。
哺乳动物大脑中神经元多样性的产生是一个多步骤的过程,从神经干细胞和祖细胞区域的区域模式开始,这些细胞向一般神经元命运的承诺,然后是特定神经元亚型的选择和有丝分裂后神经元的分化。这些步骤中的每一步以及它们之间的转换都需要在转录程序中精确控制变化。虽然已知有大量的转录因子调节胚胎和成人中枢神经系统的神经发生,但大脑中神经元细胞类型的数量和伴随其产生的细胞过程的复杂性表明,转录因子协同作用,控制神经发生的各个步骤。事实上,转录因子组合调控已成为控制细胞命运规范的一种通用模式。在这里,我讨论了我们最近的发现,meis - tale转录因子亚家族的成员,最初被鉴定为非神经组织中的HOX辅助因子,在胚胎和成人大脑中与pax蛋白协同调节细胞命运规范和神经元分化。
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