Neurogenesis (Austin, Tex.)最新文献

Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano. 新生细胞在巨足线虫胚胎后模式生长中的作用。

Neurogenesis (Austin, Tex.) Pub Date : 2018-07-19 eCollection Date: 2018-01-01 DOI: 10.1080/23262133.2018.1469944

Maria Del Mar De Miguel-Bonet, Sally Ahad, Volker Hartenstein

引用次数: 1

There's no place like home - HGF-c-MET signaling and melanocyte migration into the mammalian cochlea 没有地方像家一样——HGF-c-MET信号和黑素细胞迁移到哺乳动物耳蜗

Neurogenesis (Austin, Tex.) Pub Date : 2018-01-01 DOI: 10.1080/23262133.2017.1317693

T. Ohyama

引用次数: 2

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Isx-9和应激对成人海马神经发生的影响:实验考虑和未来展望。

Neurogenesis (Austin, Tex.) Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1317692

Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christie

引用次数: 7

Opportunities lost and gained: Changes in progenitor competence during nervous system development. 机会的得失:神经系统发育过程中祖细胞能力的变化。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-26 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1324260

Dylan R Farnsworth, Chris Q Doe

引用次数: 8

Endogenous Brain Repair: Overriding intrinsic lineage determinates through injury-induced micro-environmental signals. 内源性脑修复:通过损伤诱导的微环境信号决定的超越内在谱系。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-23 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1297881

Kathryn S Jones, Bronwen Connor

{"title":"Endogenous Brain Repair: Overriding intrinsic lineage determinates through injury-induced micro-environmental signals.","authors":"Kathryn S Jones, Bronwen Connor","doi":"10.1080/23262133.2017.1297881","DOIUrl":"https://doi.org/10.1080/23262133.2017.1297881","url":null,"abstract":"Adult human neurogenesis has generated excitement over the last 2 decades with the idea that endogenous adult stem cells could act as a potential cell source for brain repair after injury. Indeed, many forms of experimentally induced brain injury including stroke and excitotoxic lesioning can promote proliferation from the subventricular zone and mobilise neuroblasts and oligodendrocyte progenitor cells to migrate through brain parenchyma to damaged regions. However the failure of neuroblasts to mature into appropriate neuronal subtypes for cell replacement has been an issue. Recent work by our group and others has indicated that micro-environmental signals released from areas of cell loss may be able to override intrinsic gene expression lineages and covert neuroblasts into oligodendrocyte progenitor cells. This commentary will discuss the enhanced fate plasticity of both adult neural progenitors and parenchymal NG2 cells after injury, and the importance of understanding brain-injury induced micro-environmental signals in the quest toward promoting endogenous regeneration after injury.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1297881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35073700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Different forms of structural plasticity in the adult olfactory bulb. 成人嗅球结构可塑性的不同形式。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-23 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1301850

Delphine Hardy, Armen Saghatelyan

{"title":"Different forms of structural plasticity in the adult olfactory bulb.","authors":"Delphine Hardy, Armen Saghatelyan","doi":"10.1080/23262133.2017.1301850","DOIUrl":"https://doi.org/10.1080/23262133.2017.1301850","url":null,"abstract":"The adult olfactory bulb (OB) continuously receives new interneurons that integrate into the functional neuronal network and that play an important role in odor information processing and olfactory behavior. Adult neuronal progenitors are derived from neural stem cells in the subventricular zone (SVZ) bordering the lateral ventricle. They migrate long distances along the rostral migratory stream (RMS) toward the OB where they differentiate into interneurons, mature, and establish synapses with tufted or mitral cells (MC), the principal neurons in the OB. The plasticity provided by both adult-born and pre-existing early-born neurons depends on the formation and pruning of new synaptic contacts that adapt the functioning of the bulbar network to changing environmental conditions. However, the formation of new synapses occurs over a long time scale (hours-days), whereas some changes in environmental conditions can occur more rapidly, requiring a much faster adjustment of neuronal networks. A new form of structural remodeling of adult-born, but not early-born, neurons was recently brought to light. This plasticity, which is based on the activity-dependent relocation of mature spines of GCs toward the dendrites of active principal cells, may allow a more rapid adjustment of the neuronal network in response to quick and persistent changes in sensory inputs. In this mini-review we discuss the different forms of structural plasticity displayed by adult-born and early-born neurons and the possibility that these different forms of structural remodeling may fulfill distinct roles in odor information processing.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1301850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35073701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Multiple roles of Ulk4 in neurogenesis and brain function. Ulk4在神经发生和脑功能中的多重作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-23 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1313646

Min Liu, Ping Xu, Timothy O'Brien, Sanbing Shen

{"title":"Multiple roles of Ulk4 in neurogenesis and brain function.","authors":"Min Liu, Ping Xu, Timothy O'Brien, Sanbing Shen","doi":"10.1080/23262133.2017.1313646","DOIUrl":"https://doi.org/10.1080/23262133.2017.1313646","url":null,"abstract":"Neurogenesis is essential for proper brain formation and function, and abnormal neural proliferation is an underlying neuropathology of many brain disorders. Recent advances on adult neurogenesis demonstrate that neural stem cells (NSCs) at the subventricular zone (SVZ) are largely derived during mid-embryonic neurogenesis from a subset of cells, which slow down in their pace of cell division,1 become quiescent cells and can be reactivated in need.2 The NSCs at birth constitute the stem cell pool for both postnatal oligodendrogenesis3 and adult neurogenesis.1,2 However, little is known about factors that control the size of NSC pool. The article published in Stem Cells on Jun 14, 2016 by Liu and colleagues described a member of the Unc-51-like serine/threonine kinase family, Ulk4, which plays a critical role in regulating the NSC pool size.4 Authors presented evidence of cell cycle-dependent Ulk4 expression in vitro and in vivo, and reduced NSC pool in targetedly disrupted Ulk4 newborn mice, with disturbed pathways of cell cycle regulation and WNT signaling (Fig. 1), suggesting that ULK4 may be associated with neurodevelopmental, neuropsychiatric as well as neurodegenerative diseases.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1313646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35073702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Stem cells and stroke-how glowing neurons illuminate new paths. 干细胞和中风——发光的神经元如何照亮新的道路。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-16 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1304847

Dinko Mitrečić, Ivan Alić, Dunja Gorup

引用次数: 3

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Notch/Hes信号和miR-9参与复杂的反馈相互作用，控制神经祖细胞的增殖和分化。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-12 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1313647

Beate Roese-Koerner, Laura Stappert, Oliver Brüstle

{"title":"Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation.","authors":"Beate Roese-Koerner, Laura Stappert, Oliver Brüstle","doi":"10.1080/23262133.2017.1313647","DOIUrl":"https://doi.org/10.1080/23262133.2017.1313647","url":null,"abstract":"Canonical Notch signaling has diverse functions during nervous system development and is critical for neural progenitor self-renewal, timing of differentiation and specification of various cell fates. A key feature of Notch-mediated self-renewal is its fluctuating activity within the neural progenitor cell population and the oscillatory expression pattern of the Notch effector Hes1 and its target genes. A negative feedback loop between Hes1 and neurogenic microRNA miR-9 was found to be part of this oscillatory clock. In a recent study we discovered that miR-9 expression is further modulated by direct binding of the Notch intracellular domain/RBPj transcriptional complex to the miR-9_2 promoter. In turn, miR-9 not only targets Hes1 but also Notch2 to attenuate Notch signaling and promote neuronal differentiation. Here, we discuss how the two interwoven feedback loops may provide an additional fail-save mechanism to control proliferation and differentiation within the neural progenitor cell population. Furthermore, we explore potential implications of miR-9-mediated regulation of Notch/Hes1 signaling with regard to neural progenitor homeostasis, patterning, timing of differentiation and tumor formation.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1313647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35052984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Altered neurogenesis in mouse models of Alzheimer disease. 阿尔茨海默病小鼠模型的神经发生改变。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-09 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1327002

Oliver Wirths

引用次数: 37