Neurogenesis (Austin, Tex.)最新文献

Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano. 新生细胞在巨足线虫胚胎后模式生长中的作用。

Neurogenesis (Austin, Tex.) Pub Date : 2018-07-19 eCollection Date: 2018-01-01 DOI: 10.1080/23262133.2018.1469944

Maria Del Mar De Miguel-Bonet, Sally Ahad, Volker Hartenstein

引用次数: 1

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Isx-9和应激对成人海马神经发生的影响:实验考虑和未来展望。

Neurogenesis (Austin, Tex.) Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1317692

Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christie

引用次数: 7

Multiple roles of Ulk4 in neurogenesis and brain function. Ulk4在神经发生和脑功能中的多重作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-23 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1313646

Min Liu, Ping Xu, Timothy O'Brien, Sanbing Shen

{"title":"Multiple roles of Ulk4 in neurogenesis and brain function.","authors":"Min Liu, Ping Xu, Timothy O'Brien, Sanbing Shen","doi":"10.1080/23262133.2017.1313646","DOIUrl":"https://doi.org/10.1080/23262133.2017.1313646","url":null,"abstract":"Neurogenesis is essential for proper brain formation and function, and abnormal neural proliferation is an underlying neuropathology of many brain disorders. Recent advances on adult neurogenesis demonstrate that neural stem cells (NSCs) at the subventricular zone (SVZ) are largely derived during mid-embryonic neurogenesis from a subset of cells, which slow down in their pace of cell division,1 become quiescent cells and can be reactivated in need.2 The NSCs at birth constitute the stem cell pool for both postnatal oligodendrogenesis3 and adult neurogenesis.1,2 However, little is known about factors that control the size of NSC pool. The article published in Stem Cells on Jun 14, 2016 by Liu and colleagues described a member of the Unc-51-like serine/threonine kinase family, Ulk4, which plays a critical role in regulating the NSC pool size.4 Authors presented evidence of cell cycle-dependent Ulk4 expression in vitro and in vivo, and reduced NSC pool in targetedly disrupted Ulk4 newborn mice, with disturbed pathways of cell cycle regulation and WNT signaling (Fig. 1), suggesting that ULK4 may be associated with neurodevelopmental, neuropsychiatric as well as neurodegenerative diseases.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"4 1","pages":"e1313646"},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1313646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35073702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Stem cells and stroke-how glowing neurons illuminate new paths. 干细胞和中风——发光的神经元如何照亮新的道路。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-16 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1304847

Dinko Mitrečić, Ivan Alić, Dunja Gorup

引用次数: 3

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Notch/Hes信号和miR-9参与复杂的反馈相互作用，控制神经祖细胞的增殖和分化。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-12 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1313647

Beate Roese-Koerner, Laura Stappert, Oliver Brüstle

{"title":"Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation.","authors":"Beate Roese-Koerner, Laura Stappert, Oliver Brüstle","doi":"10.1080/23262133.2017.1313647","DOIUrl":"https://doi.org/10.1080/23262133.2017.1313647","url":null,"abstract":"Canonical Notch signaling has diverse functions during nervous system development and is critical for neural progenitor self-renewal, timing of differentiation and specification of various cell fates. A key feature of Notch-mediated self-renewal is its fluctuating activity within the neural progenitor cell population and the oscillatory expression pattern of the Notch effector Hes1 and its target genes. A negative feedback loop between Hes1 and neurogenic microRNA miR-9 was found to be part of this oscillatory clock. In a recent study we discovered that miR-9 expression is further modulated by direct binding of the Notch intracellular domain/RBPj transcriptional complex to the miR-9_2 promoter. In turn, miR-9 not only targets Hes1 but also Notch2 to attenuate Notch signaling and promote neuronal differentiation. Here, we discuss how the two interwoven feedback loops may provide an additional fail-save mechanism to control proliferation and differentiation within the neural progenitor cell population. Furthermore, we explore potential implications of miR-9-mediated regulation of Notch/Hes1 signaling with regard to neural progenitor homeostasis, patterning, timing of differentiation and tumor formation.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"4 1","pages":"e1313647"},"PeriodicalIF":0.0,"publicationDate":"2017-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1313647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35052984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Altered neurogenesis in mouse models of Alzheimer disease. 阿尔茨海默病小鼠模型的神经发生改变。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-09 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1327002

Oliver Wirths

引用次数: 37

The expanding role of the Ehmt2/G9a complex in neurodevelopment. Ehmt2/G9a复合物在神经发育中的扩展作用。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-02 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1316888

Steven J Deimling, Jonathan B Olsen, Vincent Tropepe

引用次数: 19

The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain. 衰老对成年斑马鱼脑淀粉样蛋白β42诱导的神经变性和再生的影响。

Neurogenesis (Austin, Tex.) Pub Date : 2017-05-02 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1322666

Prabesh Bhattarai, Alvin Kuriakose Thomas, Yixin Zhang, Caghan Kizil

{"title":"The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain.","authors":"Prabesh Bhattarai, Alvin Kuriakose Thomas, Yixin Zhang, Caghan Kizil","doi":"10.1080/23262133.2017.1322666","DOIUrl":"https://doi.org/10.1080/23262133.2017.1322666","url":null,"abstract":"Alzheimer disease is the most prevalent neurodegenerative disease and is associated with aggregation of Amyloid-β42 peptides. In mammals, Amyloid-β42 causes impaired neural stem/progenitor cell (NSPC) proliferation and neurogenesis, which exacerbate with aging. The molecular programs necessary to enhance NSPC proliferation and neurogenesis in our brains to mount successful regeneration are largely unknown. Therefore, to identify the molecular basis of effective brain regeneration, we previously established an Amyloid-β42 model in adult zebrafish that displayed Alzheimer-like phenotypes reminiscent of humans. Interestingly, zebrafish exhibited enhanced NSPC proliferation and neurogenesis after microinjection of Amyloid-β42 peptide. Here, we compare old and young fish to address the effects of aging on regenerative ability after Amyloid-β42 deposition. We found that aging does not affect the rate of NSPC proliferation but reduces the neurogenic response and microglia/macrophage activation after microinjection of Amyloid-β42 in zebrafish, suggesting an important link between aging, neuroinflammation, regenerative neurogenesis and neural stem cell plasticity.","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"4 1","pages":"e1322666"},"PeriodicalIF":0.0,"publicationDate":"2017-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1322666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35124506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Building a central nervous system: The neural stem cell lineage revealed. 构建中枢神经系统:揭示神经干细胞谱系。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-28 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1300037

Wenjun Xu, Nishanth Lakshman, Cindi M Morshead

引用次数: 24

What is CAR doing in the middle of the adult neurogenic road? CAR在成人神经源性过程中做了什么?

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-27 eCollection Date: 2017-01-01 DOI: 10.1080/23262133.2017.1304790

Sara Salinas, Felix Junyent, Nathalie Coré, Harold Cremer, Eric J Kremer

引用次数: 4