Isx-9和应激对成人海马神经发生的影响:实验考虑和未来展望。

Neurogenesis (Austin, Tex.) Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1317692
Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christie
{"title":"Isx-9和应激对成人海马神经发生的影响:实验考虑和未来展望。","authors":"Luis E B Bettio,&nbsp;Joana Gil-Mohapel,&nbsp;Anna R Patten,&nbsp;Natasha F O'Rourke,&nbsp;Ronan P Hanley,&nbsp;Karthik Gopalakrishnan,&nbsp;Jeremy E Wulff,&nbsp;Brian R Christie","doi":"10.1080/23262133.2017.1317692","DOIUrl":null,"url":null,"abstract":"<p><p>The development of synthetic small molecules capable of promoting neuronal fate in stem cells is a promising strategy to prevent the decline of hippocampal function caused by several neurological disorders. Within this context, isoxazole 9 (Isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), while also improving hippocampal function in healthy mice. We have recently demonstrated that Isx-9 is able to restore normal neurogenesis levels after procedural stress. Here, we further discuss these findings highlighting the importance of including a naïve group in studies investigating the effects of either restraint stress or mild chronic unpredictable stress (CUS) on adult hippocampal neurogenesis.</p>","PeriodicalId":74274,"journal":{"name":"Neurogenesis (Austin, Tex.)","volume":"4 1","pages":"e1317692"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23262133.2017.1317692","citationCount":"7","resultStr":"{\"title\":\"Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.\",\"authors\":\"Luis E B Bettio,&nbsp;Joana Gil-Mohapel,&nbsp;Anna R Patten,&nbsp;Natasha F O'Rourke,&nbsp;Ronan P Hanley,&nbsp;Karthik Gopalakrishnan,&nbsp;Jeremy E Wulff,&nbsp;Brian R Christie\",\"doi\":\"10.1080/23262133.2017.1317692\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The development of synthetic small molecules capable of promoting neuronal fate in stem cells is a promising strategy to prevent the decline of hippocampal function caused by several neurological disorders. Within this context, isoxazole 9 (Isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), while also improving hippocampal function in healthy mice. We have recently demonstrated that Isx-9 is able to restore normal neurogenesis levels after procedural stress. Here, we further discuss these findings highlighting the importance of including a naïve group in studies investigating the effects of either restraint stress or mild chronic unpredictable stress (CUS) on adult hippocampal neurogenesis.</p>\",\"PeriodicalId\":74274,\"journal\":{\"name\":\"Neurogenesis (Austin, Tex.)\",\"volume\":\"4 1\",\"pages\":\"e1317692\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23262133.2017.1317692\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurogenesis (Austin, Tex.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23262133.2017.1317692\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogenesis (Austin, Tex.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23262133.2017.1317692","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7

摘要

开发能够促进干细胞中神经元命运的合成小分子是预防由几种神经系统疾病引起的海马功能衰退的一种有希望的策略。在这种情况下,异恶唑9 (Isx-9)已被证明能强烈诱导海马齿状回(DG)亚颗粒带(SGZ)的细胞增殖和神经元分化,同时还能改善健康小鼠的海马功能。我们最近证明Isx-9能够在程序性应激后恢复正常的神经发生水平。在这里,我们进一步讨论了这些发现,强调了在研究约束应激或轻度慢性不可预测应激(CUS)对成人海马神经发生的影响时纳入naïve组的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.

The development of synthetic small molecules capable of promoting neuronal fate in stem cells is a promising strategy to prevent the decline of hippocampal function caused by several neurological disorders. Within this context, isoxazole 9 (Isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), while also improving hippocampal function in healthy mice. We have recently demonstrated that Isx-9 is able to restore normal neurogenesis levels after procedural stress. Here, we further discuss these findings highlighting the importance of including a naïve group in studies investigating the effects of either restraint stress or mild chronic unpredictable stress (CUS) on adult hippocampal neurogenesis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信