Sox2: A multitasking networker.

Neurogenesis (Austin, Tex.) Pub Date : 2014-10-29 eCollection Date: 2014-01-01 DOI:10.4161/23262125.2014.962391
Simone Reiprich, Michael Wegner
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引用次数: 5

Abstract

The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided the first detailed analysis of Sox2 expression and function during development of oligodendrocytes, the myelin-forming cells of the CNS. Surprisingly, we found evidence for a role of Sox2 as differentiation factor and found it to act through modulation of microRNA levels. Thus, we add new facets to the functional repertoire of Sox2 and throw light on the networking activity of this multitasking developmental regulator.

Abstract Image

Sox2:多任务网络。
转录因子Sox2是干细胞和前体细胞中的多能性因子,其表达通常与未分化状态相关。提出的作用模式包括经典转录因子和影响组蛋白修饰和染色质结构的预模式因子。最近,我们首次详细分析了Sox2在少突胶质细胞(中枢神经系统的髓鞘形成细胞)发育过程中的表达和功能。令人惊讶的是,我们发现了Sox2作为分化因子作用的证据,并发现它通过调节microRNA水平起作用。因此,我们为Sox2的功能库添加了新的方面,并阐明了这种多任务发育调节因子的网络活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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