Maedica最新文献

{"title":"The impact of Low-Anterior Resection Syndrome (LARS) on the Quality of Life in Rectal Cancer Survivors: a Narrative Review.","authors":"Floris Stanculea, Claudiu-Octavian Ungureanu, Daniela Roca, Octav Ginghina, Raul Mihailov, Florin Grama, Niculae Iordache","doi":"10.26574/maedica.2025.20.1.56","DOIUrl":"10.26574/maedica.2025.20.1.56","url":null,"abstract":"<p><p>Low anterior rectal cancer is based on oncological radicality and recurrence rates, which translate to survival. Rectal dysfunction occurred in at least one-quarter of patients. This dysfunction is a myriad of symptoms referred to as low anterior resection syndrome (LARS). In this review, we analyzed the definitions, risk factors and pathophysiological mechanisms of LARS. A better understanding of this syndrome can lead to improved prevention and treatment of LARS.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Request for the Addition of an Erratum Regarding First Authors' Affiliation to \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania.","authors":"","doi":"10.26574/maedica.2025.20.1.140","DOIUrl":"https://doi.org/10.26574/maedica.2025.20.1.140","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.26574/maedica.2024.19.2.342.][This corrects the article DOI: 10.26574/maedica.2021.16.1.102.][This corrects the article DOI: 10.26574/maedica.2024.19.4.848.].</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"140"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Arthroscopic Surgery in the Management of Synovial Giant Cell Tumors: a Case Report.","authors":"Christos Konstantinidis, Alkisti Konstantinou, Sotiris Plakoutsis, Christos Kotsias, Vasileios Panagiotopoulos, Christos Koukos, Evangelos Anagnostou, Emilios E Pakos, Dimitrios Vardakas, Dimitrios Giotis","doi":"10.26574/maedica.2025.20.1.132","DOIUrl":"10.26574/maedica.2025.20.1.132","url":null,"abstract":"<p><p>Giant cell tumors of the synovial membrane are benign but locally aggressive lesions that primarily affect synovial joints. Histologically, they are characterized by the proliferation of histiocytes, multinucleated giant cells and prominent hemosiderin deposition. Clinically, patients often experience joint pain, swelling and restricted movement, which can significantly impact their mobility and quality of life. Traditionally, open surgical excision has been the standard approach for managing these tumors. However, advancements in minimally invasive techniques, particularly arthroscopic surgery, have emerged as effective alternatives. Arthroscopy offers several benefits, including reduced postoperative pain, quicker recovery and minimal surgical trauma, while still allowing for complete tumor removal. This article presents a case of a giant cell tumor of the synovial membrane in the knee of a female patient, highlighting the successful use of arthroscopic treatment and the favorable postoperative outcomes. By presenting this case, we aim to emphasize the growing role of arthroscopic intervention in managing these tumors, further supporting its integration into clinical practice.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"132-136"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal Perforation and Pneumothorax Complicating Nasogastric Tube Insertion in an Elderly Female with Senile Dementia and Hiatal Hernia: A Case Report.","authors":"Danilo Coco, Silvana Leanza","doi":"10.26574/maedica.2025.20.1.127","DOIUrl":"10.26574/maedica.2025.20.1.127","url":null,"abstract":"<p><p>This case report describes a unique and rare complication of nasogastric tube insertion in an 80-year-old female patient with a history of senile dementia and hiatal hernia. The patient presented to the emergency department with symptoms of fever, dyspnea and vomiting. Upon arrival, the nursing staff performed a nasogastric tube insertion, which inadvertently led to esophageal perforation and subsequent pneumothorax. To manage the pneumothorax and pleural effusion, the nasogastric tube was intentionally left in the pleural cavity as a temporary drain. This case highlights the importance of careful assessment, appropriate technique, and immediate recognition of potential complications during nasogastric tube insertion, especially in vulnerable populations such as the elderly with pre-existing conditions.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"127-131"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penetrating Brain Injury through a Pre-existing Skull Defect: Case Report.","authors":"Vlad Cristian Dobrea, Berbescu Bogdan, Iulian Brezean","doi":"10.26574/maedica.2025.20.1.124","DOIUrl":"10.26574/maedica.2025.20.1.124","url":null,"abstract":"<p><p><b>Background:</b> Pulmonary metastases from colorectal cancer (CRC) present a complex therapeutic challenge. Robotic-assisted thoracic surgery (RATS) is increasingly utilized for its precision and minimally invasive advantages. <b>Case presentation:</b>We report the case of a 55-year-old male diagnosed with T1N0M0 rectal adenocarcinoma, who underwent abdominoperineal resection without adjuvant chemotherapy. Fourteen months later, positron emission tomography-computed tomography (PET-CT) identified bilateral pulmonary metastases. A robotic-assisted wedge resection of the right upper lobe nodule was performed at the Thoracic Surgery Department of GHRMSA \"Emile Muller\", Mulhouse, France. Lymphadenectomy was not conducted, which was consistent with current evidence suggesting limited benefit in CRC metastases. The patient's overall survival was 18 months from the initial diagnosis to the first metastasectomy. <b>Conclusion:</b>Robotic-assisted metastasectomy offers a safe, precise and efficient option for managing pulmonary metastases from CRC. This case highlights the role of molecular profiling in prognostication and the evolving surgical approaches in metastatic CRC.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"124-126"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Morbidity and Mortality Among Elderly and Octogenarian Patients Undergoing Major Abdominal Surgery.","authors":"Aikaterini Fotopoulou, Nikolaos Garmpis, Myrto Keramida, Dimitrios Mantas","doi":"10.26574/maedica.2025.20.1.3","DOIUrl":"10.26574/maedica.2025.20.1.3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The global population is aging and life expectancy is increasing rapidly. As a consequence, the need of major abdominal surgeries increases as well. However, due to the advanced age, such surgeries are characterized by high morbidity and mortality rates, which proportionately increase with age.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate perioperative morbidity and mortality rates and identify their relative prognostic factors among elderly and octogenarian patients undergoing major abdominal surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and method: &lt;/strong&gt;A total of 321 patients who underwent major abdominal surgery in the Second Department of Propaedeutic Surgery of Laiko General Hospital in Athens, Greece, were prospectively reviewed. The sample was divided into two groups. Group A included 254 (79.1%) elderly patients aged 65 to 79 years and Group B, 67 (20.9%) patients aged 80 years and over. Data was collected between June 2021 and June 2024 via patients' medical records using a recording form which included demographic and medical characteristics, morbidity factors such as duration of hospitalization, Dindo-Clavien classification, need of transfer to the intensive care unit (ICU) and survival outcome.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no difference in baseline characteristics, including gender (p=0.094) and preoperative ASA (American Society of Anesthesiologists) classification (p=0.096), between the two groups. Absence of comorbidities was found only in Group A (p=0.010), while in Group B there were higher percentages of patients with more than two comorbidities, especially pathological ones (p=0.011), compared with Group A (p=0.006). Regarding the type of surgery (emergency or elective), there was no difference between the two study groups (p&gt;0.05), but colectomy and gastrectomy were more prevalent among patients in Group B, while hepatectomy and pancreatectomy were more prevalent in Group A (p=0.018). We found no difference in perioperative morbidity factors, including duration of hospitalization (p=0.841), the need for ICU transfer (p=0.166) and perioperative complications based on Dindo-Clavien classification (p=0.228). However, fatality rates were higher in Group B than Group A (10.4% vs. 3.5%, p=0.030), with correlation analysis showing a positive correlation between Group B and mortality (rs=0.129, p=0.021), indicating that age ≥80 years was directly affecting mortality. Morbidity factors were found to be independent risk factors of each other (p&lt;0.05) for both study groups and ASA score was a direct predictor for morbidity among octogenarian patients, while the type of surgery was a direct predictor for ICU transfer among the elderly ones (p&lt;0.05). Postoperative complications were a direct predictor of mortality for both groups (p&lt;0.001), while ASA classification (p=0.011) and hospitalization duration (p&lt;0.001) were direct mortality predictors for the elderly subjects and ICU transfer for octogenarian ","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Opioid Receptors in the Modulation of Inflammatory Pain: a Narrative Review.","authors":"Nader-Mugurel Jafal, Smaranda Stoleru, Carmen Orban, Ion-Gigel Fulga","doi":"10.26574/maedica.2025.20.1.72","DOIUrl":"10.26574/maedica.2025.20.1.72","url":null,"abstract":"<p><p>Opioid receptors are key modulators of pain, with both central and peripheral subtypes contributing to analgesia. While central opioid receptors have been extensively studied, peripheral opioid receptors, located on sensory nerve terminals and immune cells, have gained attention for their ability to provide localized analgesia and anti-inflammatory effects without central side effects such as respiratory depression and sedation. This narrative review explores the classification, localization, and activation of peripheral opioid receptors, emphasizing their role in inflammatory pain modulation. These receptors are upregulated in inflamed tissues, enhancing analgesic efficacy. Their activation modulates nociceptive signaling through inhibition of excitatory neurotransmitter release, potassium channel activation, and immune regulation. Peripherally acting opioid receptor agonists offer targeted pain relief, while selective antagonists mitigate opioid-induced constipation without affecting central analgesia. Preclinical studies, including carrageenaninduced inflammation models, have reinforced the potential of peripheral opioid receptor targeting in pain therapy. Future research should focus on optimizing these agents for clinical use, improving drug delivery systems, and integrating them into multimodal pain management strategies.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying Cone Beam Computed Tomography to Examine Maxillary Sinus Septa and Figuring Out the Occurrence of Morphological Patterns.","authors":"Mahshid Razavi, Seyyedeh Elham Mousavi, Amin Bakhshi","doi":"10.26574/maedica.2025.20.1.34","DOIUrl":"10.26574/maedica.2025.20.1.34","url":null,"abstract":"<p><p><b>Introduction and objective:</b> A comprehensive examination of anatomical characteristics, particularly the maxillary sinus septa, is crucial for the efficacy of sinus interventions. The current research employed cone beam computed tomography (CBCT) to figure out the position of the maxillary sinus septa and the prevalence of particular morphological patterns. <b>Material and method:</b>This descriptive-analytical retrospective study was conducted in 2020. The sample size (n=108 samples) was determined by a census method, where all CBCT images of the maxillary arches of patients visiting the Radiology Department of the Faculty of Dentistry, Ahvaz University of Medical Sciences, Iran, during the years 2018-2019, were included in the present study. All images were obtained and stored using the NewTom VGi (QR, Verona, Italy) system under automatic exposure conditions. Data were collected by the researcher using a checklist and then analyzed using SPSS version 22 at a significance level of 0.05. <b>Results:</b>The results indicated that the prevalence of septa was 21.3%, with the majority (8.3%) on the inferior wall. The distribution of septa was similar between genders and across the molar and premolar regions. The direction of septa was vertical in 60% of cases, with no significant difference between genders (P>0.05). Vascular structures were present in 40% of cases, with no significant gender-related differences (P>0.05). The maxillary sinus septa were 5.51±9.34 mm long and 4.94±1.09 mm apart from the vascular structures. <b>Conclusions:</b>It is hoped that the results of this study may help reduce the risk of complications during sinus lift surgeries, particularly in terms of minimizing the occurrence of severe bleeding.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Knowledge of Neonatal Birth Asphyxia - a Review of Recent Literature and Novel Approach.","authors":"Ioana Luciana Badila Constantin, Vlad Dima, Corina Gabriela Zaharie","doi":"10.26574/maedica.2025.20.1.90","DOIUrl":"10.26574/maedica.2025.20.1.90","url":null,"abstract":"<p><p>As neonatal intensive care has developed, there has been a growing focus on reducing mortality and morbidity. Hypoxic-ischemic injury remains the primary cause of neonatal brain dysfunction. Recently, notable advancements have been made in neuroprotection, particularly with the introduction of therapeutic hypothermia. Furthermore, identifying specific biomarkers has constituted another significant advance in neuroprotection, allowing clinicians to screen infants for brain injury, monitor disease progression, identify affected regions and assess the efficacy of neuroprotective trials. Erythropoietin (EPO) has demonstrated potential in the treatment of perinatal hypoxia, particularly in the reduction of neurological damage and improvement of outcomes in neonates with hypoxic-ischemic encephalopathy. While further research is required to ascertain the optimal usage, the existing evidence suggests that EPO could be a valuable component of a comprehensive treatment plan, potentially in conjunction with therapeutic hypothermia.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"90-98"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for Furthermore Psychological Disorders in Women with PCOS and the Relation to Hyperandrogenemia and Insulin Resistance: a Systematic Review.","authors":"Sofia Thomaidi, Sophia Kalantaridou, George Papaioannou, Georgios Valsamakis","doi":"10.26574/maedica.2025.20.1.65","DOIUrl":"10.26574/maedica.2025.20.1.65","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a complex hormone issue that is faced by many women. It usually shows up as high levels of male hormones, problems with ovulation and small cysts on the ovaries. Studies point out that women with PCOS might deal with more mental health problems, although the proof is not rock solid. This summary looks at the ties between PCOS and things like eating disorders, signs of bipolar disorder, autism, schizophrenia and issues with sex. Results suggest that things like insulin resistance and being overweight might add to feeling mentally upset. Also, a diet causing long-term inflammation may make anxiety and stress worse.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"20 1","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}