Maedica最新文献

{"title":"Impact of Covid-19 Pandemic on Waitlisted Preoperative General Surgical Patients in a Tertiary Care Hospital in India - Problems and Probable Solutions: an Observational Study.","authors":"Rubik Ray, Chetan Anand, Tridip Dutta Baruah, Debajyoti Mohanty, R Manju","doi":"10.26574/maedica.2024.19.2.335","DOIUrl":"10.26574/maedica.2024.19.2.335","url":null,"abstract":"<p><strong>Introduction: </strong>Among patients affected by Covid-19, a large subset included those who were on preoperative general surgical waiting list for elective operations. There are very few studies on the various factors that impacted these patients during the pandemic in India. The current study aimed to analyse the factors which hampered the surgical management of such patients and to suggest implementable solutions which can mitigate those factors in future pandemics.</p><p><strong>Materials and methods: </strong>This was a cross sectional observational study conducted from March 2021 to February 2022. Patients from the surgical register who were placed on a waiting list for routine elective procedures like hernias, gallstone disease, benign thyroid swellings, etc were included, while those with malignancy and emergencies were excluded. We sought information about their current status regarding the planned surgery, the factors which have prevented or are preventing them from accessing suitable surgical service and the current status of individually experienced symptoms.</p><p><strong>Results: </strong>There were 38 respondents. Most of the patients belonged to the age group 40-60 years and had an average waiting period of more than six months. In 20/38 patients, surgery was postponed because of Covid-19 pandemic, seven patients were admitted but operation was postponed for various reasons, while a few others suffered due to financial difficulty or lockdown restrictions. In 23/38 patients' symptoms progressed and nine patients had unbearable symptoms at the time of the study. Two of the 38 respondents underwent emergency surgery outside the institute. All subjects knew that Covid-19 patients were being treated in the institute, where most of them were still willing to continue their treatment. Three patients refused to continue treatment because of apprehension about getting Covid-19.</p><p><strong>Conclusion: </strong>Although the World Health Organization (WHO) declared the Covid-19 pandemic over, experts opine that there might be more such incidents in not-too-distant future. Our study is among the few of its kind that provides some analytical data regarding the factors which prevented the general surgical patients access to surgical service in India during the Covid-19 pandemic and to suggest some implementable strategies to mitigate the effect of those factors in future pandemics.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"335-341"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Jun Transcription Factor Oncogenic Activation in Oral Carcinoma.","authors":"Nicholas Mastronikolis, Aristeidis Chrysovergis, Vasileios Papanikolaou, Spyridoula Derka, Asimakis D Asimakopoulos, Sofianiki Mastronikoli, Evangelos Tsiambas, Loukas Manaios, Sotirios Papouliakos, Vasileios Ragos, Panagiotis Fotiades, Pavlos Pantos, Panagiotis Stathopoulos, Efthymios Kyrodimos","doi":"10.26574/maedica.2024.19.2.3502024;","DOIUrl":"10.26574/maedica.2024.19.2.3502024;","url":null,"abstract":"<p><strong>Introduction: </strong>Oral carcinogenetic is based on a variety of genomic imbalances (gross chromosome or specific gene alterations) that drive the normal oral mucosa to its neoplastic/dysplastic epithelial form and finally to a totally malignant tissue transformation. In this multi-step procedure, down-regulation of suppressor genes combined with overactivation of oncogenes are two crucial and partially early genetic events involved in the onset and progression of neoplastic/malignant epithelia transformation. More specifically, deregulation of strong transcription factors negatively affects the normal expression of a broad spectrum of genes that are involved in cell proliferation and signalling transduction to the nucleus.</p><p><strong>Objective: </strong>The purpose of the current molecular review was to explore the c-Jun (chromosome location: 1p32-p31) transcription factor transformation mechanisms to oncogene in oral squamous cell carcinoma (OSCC).</p><p><strong>Material and method: </strong>A systematic review of the literature was carried out by searching in PubMed international database. The year 2010 was set as a prominent time limit for the publication date of the articles in the majority of them, whereas specific references of great importance and historical value in the field of the c-Jun gene discovery and analysis were also included. The following keywords were used: c-Jun, oncogene, signaling pathway, oral, carcinoma, transcription. A pool of 45 important articles were selected for the present study at the basis of combining molecular knowledge with new targeted therapeutic strategies.</p><p><strong>Results: </strong>C-Jun - as a part of the c-Jun/c-Fos transcription factors' complex -critically regulates the expression levels in a variety of genes inside the cellular microenvironment. A broad spectrum of malignancies, including OSCC, demonstrate c-Jun alterations driving the gene to its oncogenic phenotype. Interestingly, c-Jun oncogenic activation is mediated by high-risk human papilloma virus (HR-HPV) persistent infection in significant subsets of these malignancies.</p><p><strong>Conclusions: </strong>C-Jun was the first oncogene - acting as a strong transcription factor - that was discovered and cloned 35 years ago. C-Jun is the living history of oncogenes and its discovery marks a significant step in the evolution of molecular biology.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"350-354"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Outcome after Surgical Management of Ruptured Versus Unruptured Anterior Circulation Aneurysms.","authors":"George Fotakopoulos, Charalabos Gatos, Grigorios Christodoulidis, Ourania Fotakopoulou, Kostas N Fountas","doi":"10.26574/maedica.2024.19.2.221","DOIUrl":"10.26574/maedica.2024.19.2.221","url":null,"abstract":"<p><strong>Objectives: </strong>The present article aimed to review the safety and the clinical and radiological outcomes of clipped ruptured and unruptured anterior circulation aneurysms.</p><p><strong>Materials and methods: </strong>The study investigated the relative articles involving the outcome after surgical management of ruptures versus unruptured anterior circulation aneurysms through electronic databases from January 1980 to January 2023. The primary outcomes were mortality and modified Rankin scale (mRS) >3.</p><p><strong>Results: </strong>Information on mRS >3 was found in six articles totalizing 2096 patients, of whom 130 subjects had ruptured and unruptured aneurysms. Data about mortality was provided by eight studies totalizing 2454 participants, of whom 140 subjects had ruptured and unruptured aneurysms.</p><p><strong>Conclusions: </strong>The current meta-analysis indicates that surgical clipping is a safe procedure for both ruptured and unruptured aneurysms of anterior circulation.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"221-228"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Morphology of the Nasolacrimal Canal in Cone Beam Computed Tomography Images and Its Relationship with Age and Gender.","authors":"Mahshid Razavi, Nasim Shams, Farzin Afshari, Sara Nanai","doi":"10.26574/maedica.2024.19.2.303","DOIUrl":"10.26574/maedica.2024.19.2.303","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal and paranasal anatomical structures are closely related to the nasolacrimal canal (NLC). As a result of this anatomical relationship, several studies have reported that nasal and paranasal sinus pathologies often play a major role in the etiology of nasolacrimal duct obstruction. The purpose of this study was to investigate the anteroposterior diameter, transverse diameter, length and angle of the bony NLC with nasal floor on the right and left by using cone beam computed tomography (CBCT) and to explore the influence of gender and age on the above-mentioned parameters.</p><p><strong>Methods: </strong>The current study was conducted by examining the archive of primary CBCT images of patients who were referred for medical imaging to a private maxillofacial radiology clinic in Ahvaz, Iran, in 2020. In axial images, anteroposterior diameter and transverse diameter of the canal in the level of infraorbital were measured. In sagittal images, the length of the NLC was evaluated from the most proximal to the most distal part. Also, to examine the canal pathway, the angle between the canal and the floor of the nasal cavity was measured. Finally, all patient data, including age, gender and canal dimensions, diameter and path, was collected in the information form and referred to the statistics consultant for analysis.</p><p><strong>Results: </strong>In the present study we included information of primary CBCT images of 126 patients who had been referred to a private maxillofacial radiology in Ahvaz, Iran, in 2020. Participants' average age was 28.22±8.13 years for women and 31.54±8.12 years for men, and a small age difference between sexes was seen. The average angle of the right canal with nasal floor was 108.29±7.96º for men and 113.70±7.57º for women, with a significant statistical difference by gender being observed. The mean values of the right channel length were 10.47±2.56 mm for women and 12.54±2.40 mm for men, and the difference between them was statistically significant. The mean values of the left canal length were 109.30±8.67 mm for women and 114.52±9.01 mm for men, and the difference between them was also statistically significant.</p><p><strong>Conclusion: </strong>This study provides useful information on the morphometric properties of the bony nasal canal. Careful anatomical knowledge about the morphology of the bony nasal canal may help physicians to plan the treatment options. As the present study raises some concerns related to the age and gender differences in nasopalatine canal morphology that may affect patients' diagnosis and treatment, dentists are recommended to use CBCT images as well as additional techniques with this regard.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant Chemotherapy: Friend or Foe.","authors":"Cristian Nicolae Popa, Vladimir Dan Bratu, Elisa Cristina Popa, Daniela Elena Dinu, Cristina Iosif, Evelina Chirita, Ioan Nicolae Mates","doi":"10.26574/maedica.2024.19.2.417","DOIUrl":"10.26574/maedica.2024.19.2.417","url":null,"abstract":"<p><strong>Introduction: </strong>Most breast cancers require neoadjuvant chemotherapy and the response to primary systemic therapy (PST) is crucial for deciding on the surgical technique and predicting patient outcomes. However, chemotherapy also brings numerous side effects, with cardiovascular issues being some of the most significant, common and challenging to manage.</p><p><strong>Case presentation: </strong>We present the case of a 71-year-old woman diagnosed with stage T2N1M0 Luminal B breast cancer. It was decided to initiate chemotherapy consisting of four cycles of FEC (5-fluorouracil 600 mg/m² on days 1 and 8, epirubicin 60 mg-90 mg/m² and cyclophosphamide 600 mg/m²), followed by four cycles of docetaxel (75 mg/m² every three weeks). Near the end of the treatment cycles, she developed new-onset angina with complex critical coronary lesions. This required assembling a multidisciplinary team to determine the optimal management strategy from cardiological, surgical, and oncological standpoints. Just when we thought we had found the optimal approach for managing ischemic heart disease, the situation became more complicated with the development of deep vein thrombosis, requiring a reassessment of the entire treatment plan.</p><p><strong>Conclusions: </strong>Neoadjuvant chemotherapy is an important weapon against breast cancer but also a veritable enemy of cardiovascular diseases. The association of two major diseases requires a multidisciplinary team capable of making the best decisions to maximize benefits and minimize adverse effects.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"417-422"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Center Experience of Genetic Testing in Patients Undergoing Breast Cancer Treatment.","authors":"Laura Mihaela Mustata, Gheorghe Peltecu, Diana Cezara Mugescu, Florina Mihaela Nedelea, Mircea Dragos Median","doi":"10.26574/maedica.2024.19.2.239","DOIUrl":"10.26574/maedica.2024.19.2.239","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer remains the most frequently diagnosed cancer in female population worldwide. However, germline mutations are responsible for a small proportion of these cases. The aim of our study is to assess how germline mutations influence the management and outcome of these patients taken into consideration both their cancer diagnosis and genetic assessment.</p><p><strong>Methods: </strong>We performed a retrospective analysis in a women's single-center during a period of six years to assess the contribution of germline mutation in the treatment, prognosis and survival of breast cancer patients. Statistics were collected from both the patients' medical records and genetics department.</p><p><strong>Results: </strong>From the total number of patients treated for breast cancer in our department between 2017 and 2022, 243 were eligible for genetic testing, comprising either BRCA1/2 or extended panel, taking into consideration their personal and family history. Of all subjects included in our study cohort, 5% were carriers of a pathogenic(P) or likely pathogenic(LP) variant of cancer susceptibility gene, of which 78% were diagnosed before the age of 50; triple negative disease was diagnosed in the majority of cases, and therefore, 62% of patients started treatment with systemic neoadjuvant chemotherapy and 32% of subjects underwent upfront surgery. Prophylactic surgery for contralateral breast and bilateral salpingo-oophorectomy was considered and performed for 20% of patients. Less than 2% of cases had metastatic disease and received PARP inhibitors, with excellent treatment response and a very low rate of mortality in the study group.</p><p><strong>Conclusion: </strong>Carriers of pathogenic variants with breast cancer diagnosis may have a greater benefit from a tailored approach, including both surgical and oncological treatment, with better long-term outcomes.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Dose or Low-Dose Corticosteroids - Which Regimen is More Effective in Patients with Moderate to Severe COVID-19? A Retrospective Study.","authors":"Alireza Kashefizadeh, Farbod Amiri, Laya Ohadi, Elham Keikha","doi":"10.26574/maedica.2024.19.2.330","DOIUrl":"10.26574/maedica.2024.19.2.330","url":null,"abstract":"<p><strong>Background: </strong>Although several studies have assessed corticosteroid therapy as a pivotal treatment for SARS-CoV-2, the net effectiveness of corticosteroids in the treatment of COVID-19 remains controversial. This study aimed to compare the conventional use of methylprednisolone and pulse therapy to determine the best method of administration of corticosteroids in patients with SARS-CoV-2.</p><p><strong>Methods: </strong>A total of 52 patients with a diagnosis of moderate to severe COVID-19 with the same conditions were retrospectively enrolled in the present study. Participants were divided into two groups based on the corticosteroid therapy regimen received during hospitalization: low-dose and high-dose methylprednisolone. Clinical outcomes, including laboratory tests, improvement of oxygen saturation, the need for invasive mechanical ventilation, length of hospital stay (LOHS) and mortality, were compared between the two groups.</p><p><strong>Results: </strong>The distribution of sex, age, oxygen saturation on admission, pattern and location of lung involvement, and other medical conditions were similar between the two groups to avoid the effect of any possible confounding factor. There were no differences in laboratory tests (P=0.389), LOHS (P=0.107), improvement of oxygen saturation (P=0.721), the need for invasive mechanical ventilation and mortality (P=0.695) between groups.</p><p><strong>Conclusion: </strong>Based on the results of this study, there was no significant difference in clinical outcomes of patients with COVID-19 between low- and high-dose corticosteroid regimens. Further research is warranted to determine the best method of administration of corticosteroids in these patients.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"330-334"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocophobia: Risk Factors, Consequences and Management - A Systematic Review of the Literature.","authors":"Angeliki Sarella, Sofoklis Stavros, Giannoula Kirkou, Maria Iliadou, Eriketi Kokkosi, Anastasia Bothou, Eirini Chasalevri, Victoria Vivilaki, Eleni Tsotra","doi":"10.26574/maedica.2024.19.2.393","DOIUrl":"10.26574/maedica.2024.19.2.393","url":null,"abstract":"<p><strong>Objective: </strong>As far as childbirth is concerned, it is well known that it constitutes a major life process for every woman. Many women experience negative emotions during pregnancy because of the normal hormonal changes. However, if fear becomes severe, it gives rise to a specific pathology termed tocophobia. Especially, tocophobia adversely affects women's pregnancy and childbirth, including increased caesarean sections. Consequently, midwives need to detect women with tocophobia in order to support them. The aim of the present systematic review was to analyze the risk factors for tocophobia, the impact of this health condition on caesarean sections and the midwife's role.</p><p><strong>Materials and methods: </strong>The present systematic review comprised 32 full-text cross-sectional, qualitative, experimental studies and cohort studies published in English between 2017 and 2022, that were obtained from PubMed and Google Scholar databases, and it was conducted according to the PRISMA guideline.</p><p><strong>Results: </strong>The present analysis found that sociodemographic, obstetric and psychological factors were associated with tocophobia. Moreover, women with severe fear had increased obstetric interventions, particularly caesarean sections. Studies have also shown that psycho-education, preparation classes and specific counselling by trained midwives are effective methods in reducing tocophobia.</p><p><strong>Conclusions: </strong>Midwives should be aware of the risk factors for tocophobia in order to detect women with fears and support them in the attempt to avoid non-urgent obstetric interventions. Antenatal and intrapartum care should be offered to women with tocophobia to reduce their fear as well as the prevalence of caesarean section and to promote vaginal birth with a positive experience.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"393-399"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Antibiotic Prevention of Catheter Mechanic and Septic Complications in Patients with Long-Term Indwelling Catheters: a Crossover Prospective Study Involving L-Methionine.","authors":"Aurel Rusu, Razvan-Ionut Popescu, Gabriel Predoiu, Razvan-Cosmin Petca, Alexandru Ciudin, Aida Petca, Justin Aurelian, Daniel Radavoi, Viorel Jinga","doi":"10.26574/maedica.2024.19.2.212","DOIUrl":"10.26574/maedica.2024.19.2.212","url":null,"abstract":"<p><p>Bacterial antimicrobial resistance (AMR) is a major public health concern in modern society caused by bacterial changes that impair the efficacy of infection-treating drugs. Non-antibiotic techniques are critical for controlling the antimicrobial resistance concern because they provide a means of alleviating symptoms without needing antibiotics. This prospective study aims to determine whether administering L-methionine reduces mechanical and bacterial problems associated with long-term indwelling urinary catheters. The trial focused on administering only L-methionine for a three-month period to patients who had long-term bladder catheters, either indwelling or suprapubic. The catheter exchange rates were categorized according to acute urinary tract infection, macroscopic haematuria and symptomatic urinary tract infection. During the time of inclusion, catheter-related incidents were recorded. The primary incident observed was acute urine retention caused by catheter obstruction in 63.6.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"212-220"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic Adenoma of Minor Salivary Glands: a Rare Case Report.","authors":"Aikaterini D Lianou, Athina Zarachi, Spyridoula Derka, Chrissa Sioka, Napoleon-Georgios Ragkos, Angelos Liontos, Evangelos Tsiambas, Asimakis Asimakopoulos, Vasileios Ragos","doi":"10.26574/maedica.2024.19.2.434","DOIUrl":"10.26574/maedica.2024.19.2.434","url":null,"abstract":"<p><p>Pleomorphic adenoma is a non-cancerous neoplasm that develops in the salivary glands. Originating from minor salivary glands, it is extremely uncommon and primarily affects females. The peak incidence is observed between 40 and 60 years of age. It usually presents as a slowly growing, painless, solid tumor that does not cause ulcers on the overlying mucosa. Here, a 47-year-old woman experienced repeated swelling on the buccal mucosa following surgical extraction of a pleomorphic adenoma three years ago. The swelling was solid with clearly defined boundaries. An excisional biopsy was conducted under general anesthesia, resulting in total mass removal. The histological evaluation revealed the existence of a recurring pleomorphic adenoma. This instance emphasizes the significance of addressing this entity as a potential etiology for persistent painless and intraoral swellings.</p>","PeriodicalId":74094,"journal":{"name":"Maedica","volume":"19 2","pages":"434-438"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}