Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献_第9页

Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital 黑芸苔籽提取物在苯巴比妥小鼠肝组织中的抗增殖活性

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.826

Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh

{"title":"Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital","authors":"Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh","doi":"10.32947/ajps.v22i1.826","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.826","url":null,"abstract":"Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and drug resistance to currently available \u0000treatments. Previous studies showed that a high intake of Brassica vegetables has been associated to a decreased risk of a number of malignancies. The aim of this study is the evaluation of antiproliferative activity of Brassica nigra seeds extract in mice exposed to phenobarbital. Brassica nigra seeds where extracted; phytochemical analysis of the extract was done that including phytochemical screening tests and Gas chromatography-mass spectrometry (GC-MS) analysis. Antiproliferative activity of hydro alcoholic Brassica seeds extract has been studied by 800mg/kg and compare with control group (given normal saline), phenobarbital group (Phenobarbital 75mg/kg) and combination group (Brassica extract 800mg/kg+ Phenobarbital 75mg/kg). The GC-MS analysis revealed the presence of isothiocynate compound. Histologically phenobarbital induced severe hepatocellular proliferation (hyperplasia and hypertrophy), glass ground cytoplasm, while Brassica seeds extract produce improvement in histopathological changes that include mild scattered proliferation picture and eosinophilic cytoplasm. In comparison to phenobarbital group, Combination groups pretreated with Brassica nigra seeds for 14 days and phenobarbital for 7 days caused significant reduction relative liver weight and alanine aminotransferase (ALT) Brassica nigra seeds extract have isothiocynate as main compound it showed antiproliferative action on the liver tissue, implying that it may have a promising effect in minimizing the risk of liver cancer.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79930903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and study of antimicrobial activity of some tetrahydrocarbazole derivatives substituted with NSAID 非甾体抗炎药取代四氢咔唑衍生物的合成及抗菌活性研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-06-30 DOI: 10.32947/ajps.v22i2.857

Mustafa H. Mahdi, A. Dawood, D. Q. Shaheed

引用次数: 1

Effect of pioglitazone treatment on serum chemerin and vaspin levels in polycystic ovary syndrome. 吡格列酮治疗对多囊卵巢综合征患者血清趋化素和血管素水平的影响。

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.789

Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim

{"title":"Effect of pioglitazone treatment on serum chemerin and vaspin levels in polycystic ovary syndrome.","authors":"Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim","doi":"10.32947/ajps.v21i1.789","DOIUrl":"https://doi.org/10.32947/ajps.v21i1.789","url":null,"abstract":"Abdominal fat synthesizes a variety of adipokines, including vaspin and chemerin, that affect the resistance to insulin. This research was conducted to demonstrate the effect of pioglitazone, one insulin sensitizer used to decrease insulin resistance, on these adipokines in \u0000 \u0000obese patients with polycystic ovary (PCOS). Twenty-five obese women with PCOS were treated with pioglitazone 15mg/bid for 12 weeks. Modifications in fasting blood glucose (FBG), serum fasting insulin (FSI), chemerin and vaspin serum levels, follicle stimulation hormone (FSH), luteinizing hormone (LH), testosterone (T), and in baseline and post-therapy were assessed. Body mass index decreased without any substantial variance after 12 weeks of pioglitazone therapy (P> 0.05). T, FSI, HOMA-IR, LH, and FBG levels have decreased considerably (P≤0.01, P≤0.05) after the therapy. No substantial variations were found in FSH (P>0.05). Serum chemerin and vaspin levels were observed no significant difference than before treatment (P>0.05) in obese women with polycystic ovarian syndrome cases.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74489784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-occurrence of Wilson disease and Auto-Immune Hepatitis in 14-year-old female: A case report 14岁女性肝豆状核变性合并自身免疫性肝炎1例

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.803

Fadwa Ghassan Hameed, Inam Sameh Arif, Mohammed Mahmood Mohammed, Hala S. Arif

引用次数: 1

Effect of human insulin and insulin analogue on some inflammatory markers and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents 人胰岛素和胰岛素类似物对伊拉克1型糖尿病儿童和青少年某些炎症标志物和总抗氧化能力的影响

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.804

Noor Wafaa Hashim, Kadhim Ali Kadhim, Abbas Mahdi Rahmah

{"title":"Effect of human insulin and insulin analogue on some inflammatory markers and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents","authors":"Noor Wafaa Hashim, Kadhim Ali Kadhim, Abbas Mahdi Rahmah","doi":"10.32947/ajps.v21i2.804","DOIUrl":"https://doi.org/10.32947/ajps.v21i2.804","url":null,"abstract":"Background: Both human insulin and insulin analogue used in the treatment of type 1 diabetes mellitus. The modification in amino acids sequences of human insulin lead to produce analogue form which have a pharmacokinetic and pharmacodynamics effect near to normal human endogenous \u0000 \u0000insulin release. \u0000Aim of study: This study designed to compare between the effect of each type of insulin on high sensitive C-reactive protein and interleukin-6 and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents. \u0000Study design: The study was enrolled on fifty-one Iraqi type 1 diabetic children and adolecence age range (6-18) year. The patients allocated into two groups, Group (1) includes 20 patients assigned to receive conventional human insulin (regular and NPH), and Group (2) includes 20 patients assigned to receive insulin analogue (insulin aspart and glargine) for three months. The inflammatory and antioxidant markers measured at baseline and after three months of intervention. \u0000Results: After three months of treatment, both insulin groups did not affect high sensetive C_reactive protein (hs-CRP) significantly from baseline to 3 months. Only insulin analogue reduced Interleukin-6 (IL-6) significantly, while human insulin reduced level of IL-6 but it was not statistically significant. Both therapies reduced total antioxidant capacity (TAOC) significantly; however, insulin analogue had higher reduction percentage (15.1% vs. 5.7%) compared to the conventional insulin. \u0000Conclusion: Only insulin analogue reduced IL-6 significantly. Both types of insulins did not effect on hs-CRP. Both therapies reduce TAOC significantly.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83170610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Strategies in anti-adhesion therapy: A review article 抗粘连治疗策略综述

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.799

Fitua Al-Saedi

引用次数: 0

Development and validation of bioanalytical method for the determination of valsartan in human plasma 测定人血浆中缬沙坦的生物分析方法的建立与验证

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i4.795

S. H. Ramadhan

{"title":"Development and validation of bioanalytical method for the determination of valsartan in human plasma","authors":"S. H. Ramadhan","doi":"10.32947/ajps.v21i4.795","DOIUrl":"https://doi.org/10.32947/ajps.v21i4.795","url":null,"abstract":"A bioanalytical method which utilizes high performance liquid chromatography with mass spectrometry method has been developed and validated for the quantification of valsartan in human plasma. The samples were processed by precipitation with formic acid then extracted with diethyl ether. Benazepril \u0000 \u0000was used as an internal standard. The chromatographic separation is performed through C18 column with a mobile phase consisting of deionized water, acetonitrile and formic acid, followed by mass spectrometric detection in the positive ionization mode. The proposed method was specific and had been validated in the linear range of 50.0 – 5000.0 ng/ml for valsartan. The validation results were as follows: the intra-day and inter-day precision were 3.46 to 8.33% and 5.85 to 7.05% respectively, the intra-day and inter-day accuracy were 93.53 to 107.13% and 95.26 to 104.0% respectively. The recovery for valsartan and benazepril was 81.4% and 113.7% respectively. Also, stability was studied and the results obtained for short-term stability 99.24 to 102.32%, for freeze / thaw stability 99.75 to 99.95% and for long-term stability 98.24 to 103.03%. It can be concluded that the method can be applied in pharmacokinetic bioequivalence studies.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88834522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of oral capsules containing apigenin nanocrystals prepared by ultrasonication 超声法制备芹菜素纳米晶口服胶囊的制备与评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i3.793

Mahmood A. Haiss, Nidhal K. Maraie

{"title":"Preparation and evaluation of oral capsules containing apigenin nanocrystals prepared by ultrasonication","authors":"Mahmood A. Haiss, Nidhal K. Maraie","doi":"10.32947/ajps.v21i3.793","DOIUrl":"https://doi.org/10.32947/ajps.v21i3.793","url":null,"abstract":"This work aims to enhance dissolution rate, increase absorption and bioavailability of Apigenin by formulating it as nanocrystal suspension employing ultrasonic technology. Two different diluents; (5%, 10%) microcrystalline cellulose (MCC) and (2%, 3%) anhydrous lactose were used to prepare hard gelatin \u0000capsules for two optimum types for apigenin nanocrystals prepared in our laboratory utilizing ultrasonication technique using 1% tween 80 (F6) and 2% poloxamer 188 (F20). The results showed that the marketed capsules (containing MCC) had about half the dissolution rate than all the prepared nanocrystals capsules formulas, and the nanocrystals prepared with poloxamer gave 90% release within 20 minutes and 100% release with 2 hours with excellent flow properties with no effect of the added diluents while the addition of diluents improved significantly the release of nanocrystals capsules (F6) with 1% tween 80 with good flow properties. The results suggested that utilizing apigenin nanocrystals prepared by ultrasonication technique may improve drug absorption and bioavailability with a reduced required dose.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81426730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impact of Vitamin D on The Development of Multiple Sclerosis (Review article) 维生素D对多发性硬化发展的影响(综述文章)

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i3.792

Aseel Ghassan Daoud, Huda Jaber Waheed, Mayssaa Essam Abdala

引用次数: 0

Phytochemical study and thin layer chromatography of Ficusreligiosa leaves extract cultivated in Iraq 伊拉克栽培榕叶提取物的植物化学研究及薄层色谱分析

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.807

Noor S Jaafar, Maha N Hamad, Duha A Alshammaa, Zainab S Noori

引用次数: 0